• 동남아시아연구
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• 제24권2호
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• pp.207-251
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• 2014

This study explores the mobility patterns of Korean Early Study Aborad (ESA, hereafter) students in Singapore through a follow-up longitudinal case study, which was initially conducted about five years before this study. This study takes up transnational migration approach, focusing on family strategies and mobilization, which steered their mobility. Interviews with seven original families as well as 7 families additionally recruited in Singapore in 2012 were collected and analyzed by NVivo 9. In short, this study found that transnational mobility is composed of mobilities at global, regional and local levels. There were four types of mobilities; continuation of stay in Singapore, move from a third county to Singapore, return to Korea, and, what this research calls, fluid mobility. Examining the process of these mobilities shows that we need to consider at least three factors (performance of children's schooling; change of family circumstances; context of reception for both Singapore and Korea) as basic backgrounds. On this basis, the interplay between the context of receptions when aspirations for children's advancement by these transnational families made either facilitate or constrain their mobilities: contexts of Singapore and Korea may play a role of hurdle or trampoline. Also, local context of Singapore largely facilitate mobilities of Korean ESA families at both local and global levels.

• Membrane and Water Treatment
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• 제14권2호
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• pp.95-106
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• 2023

In the developing country like India, groundwater is the main sources for household, irrigation and industrial use. Its contamination poses hydro-geological and environmental concern. The hazardous waste sites such as landfills can lead to contamination of ground water. The contaminants existing at such sites can eventually find ingress down through the soil and into the groundwater in case of leakage. It is necessary to understand the process of migration of pollutants through sub-surface porous medium for avoiding health risks. On this backdrop, the present paper investigates the behavior of pollutants' migration through porous media. The laboratory experiments were carried out on a soil-column model that represents porous media. Two different types of soils (standard sand and red soil) were considered as the media. Further, two different solutes, i.e., non-reactive and reactive, were used. The experimental results are simulated through numerical modeling. The percentage variation in the experimental and numerical results is found to be in the range of 0.75- 11.23 % and 0.84 - 1.26% in case of standard sand and red soil, respectively. While a close agreement is observed in most of the breakthrough curves obtained experimentally and numerically, good agreement is seen in either result in one case.

• 한국토양비료학회지
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• 제30권4호
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• pp.314-327
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• 1997

점적 관개시 근권에서의 토양 수분 이동 현상을 2차원 원통 좌표를 이용하여 모델링 하였다. 엽면 증산, 다양한 형태의 지면 증발, 관개율의 증가로 인한 지면에서의 물 고임 현상등을 고려하였다. 모델은 유한 차분법을 이용한 수치해로 풀었다. 여러가지 비교의 결과로부터 본 연구에서 개발된 모델은 근권에서의 토양 수분 이동 현상을 잘 묘사한다고 볼 수 있었다. 모델의 민감도 분석을 통해서 몇가지 유익한 사실을 발견하였다. 토양 수분이 연직 방향으로 이동하는 속도가 더 큰 것으로 보아 자동 관개용 토양 수분 측정 센서를 설치할 경우, 관개점의 연직하방이 좋은 측점임을 알 수 있었다. 습윤대의 형태가 단지(pot) 모양으로 되는 것은 지면 증발로 인한것임을 알 수 있었다. 또한, 토양의 포화 수리 전도도가 습윤대의 확산에 큰 영향을 주는 것을 알 수 있었고, 관개 중단 후에도 연직 방향의 확산은 계속됨을 알 수 있었다.

• 대한한방내과학회지
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• 제34권1호
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• pp.31-45
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• 2013

Objectives : Gokgisaeng (Korean mistletoe) is used for the treatment of inflammatory and cancer diseases in traditional Korean medicine and its major component lectins have been reported to induce nitric oxide (NO) in RAW 264.7 macrophages, and also induce apoptosis of various types of cancer cells, although its modulatory effects on cancer cell migration and macrophage activation is poorly understood. The aim of this study is to clarify molecular mechanisms of action responsible for the anti-inflammatory and antitumor migration potentials of Korean mistletoe extract (KME). Methods : We investigated the anti-inflammatory activity of KME on NO production and inducible nitric oxide synthase (iNOS) expression by lipopolysaccharide (LPS) in both RAW 264.7 macrophages and rat C6 glioma cells, and also evaluated inhibitory efficacy on glioma cell growth and migration. For assessment, XTT assay, nitrite assay, RT-PCR, scratch-wound and Boyden chamber assay, and western blot analysis were performed. Results : Previously reported, unlike the efficacy of Gokgisaeng lectin, KME inhibited NO production and iNOS expression, and suppressed pro-inflammatory mediators including IL-$1{\beta}$, IL-6, COX-2, iNOS in LPS-stimulated RAW 264.7 cells. Furthermore, KME suppressed tumor cell growth and migration, and it also inhibited LPS-induced NO release and iNOS activation by down-regulating expression of protein kinase C (PKC) and phosphorylation of ERK in C6 glioma cells. Conclusions : Our research findings provide evidence that KME can play a significant role in blocking pro-inflammatory reaction and malignant progression of tumors through the suppression of NO/iNOS by down-regulating of inflammatory signaling pathways, PKC/ERK.

• 한국환경농학회지
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• 제33권4호
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• pp.334-343
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• 2014

본 연구는 봄철 논습지에 도래하는 도요 물떼새류의 도래패턴과 서식지 이용 특성을 파악하고자 수행되었다. 조사는 한국 중서부지역에 위치한 아산만 일대의 농경지에서 2014년 4월 21일부터 5월 30일까지 2~3일 간격으로 총 18회 수행 되었다. 조사 기간 동안 관찰된 도요 물떼새류는 총 15종 7,852개체였다. 대상 종들의 시기별 도래 특성은 본답에 물을 대기 시작하는 4월 중반부터 관찰되었고 5월 초까지 지속적으로 종수와 개체수가 증가하는 경향이 나타났으며 5월 후반으로 가면서 종수와 개체수는 감소하였다. 농경지의 물리적 구조에 따른 서식지 이용 특성은 종별 차이가 나타났으며, 대부분의 종에서 본답과 논둑은 수로나 농로에 비해 선호성이 높게 나타났다. 본답의 미소서식지 선호성은 지역 농업인의 농업 관리에 의해 다양하게 나타났으며, 도요 물떼새류의 종별 서식지의 선호성 차이가 명확히 나타났다. 대부분 종은 무논의 본답 형태에서 관찰되었고, 써레질 후 5 cm 이하로 물을 얕게 댄 형태인 본답의 이용이 가장 높았다. 반면 물을 대지 않은 건답의 형태인 수확 후 추경한 형태는 이용을 하지 않았다. 결론적으로 봄철 논습지는 도요 물떼새류에게 중간 기착지로서 중요한 기능을 하는 것으로 나타났다.

• Nutrition Research and Practice
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• 제14권2호
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• pp.127-133
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• 2020

BACKGROUND/OBJECTIVES: Non-small cell lung cancer is mostly recognized among other types of lung cancer with a poor prognosis by cause of chemotherapeutic resistance and increased metastasis. Luteolin has been found to decrease cell metastasis. However, its underlying mechanisms remain unresolved. The objective of this study was to examine the effect (and its mechanism) of luteolin on the migration and invasion of human non-small cell lung cancer A549 cells. MATERIALS/METHODS: Cell viability was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Wound healing and transwell assays were evaluated to assess migration and invasion, respectively. Western blot analysis and immunofluorescence were further performed to investigate the role of luteolin and its mechanisms of action. RESULTS: Administration with up to 40 μM luteolin showed no cytotoxic activity on lung cancer A549 cells or non-cancer MRC-5 cells. Additionally, luteolin at 20-40 μM significantly suppressed A549 cells' migration, invasion, and the formation of filopodia in a concentration-dependent manner at 24 h. This is similar with western blot analysis, which revealed diminished the phosphorylated focal adhesion kinase (pFAK), phosphorylated non-receptor tyrosine kinase (pSrc), Ras-related C3 botulinum toxin substrate 1 (Rac1), cell division control protein 42 (Cdc42), and Ras homolog gene family member A (RhoA) expression levels. CONCLUSIONS: Overall, our data indicate that luteolin plays a role in controlling lung cancer cells' migration and invasion via Src/FAK and its downstream Rac1, Cdc42, and RhoA pathways. Luteolin might be considered a promising candidate for suppressing invasion and metastasis of lung cancer cells.

• The Korean Journal of Physiology and Pharmacology
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• 제21권3호
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• pp.287-292
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• 2017

Vitiligo is an intriguing depigmentary disorder and is notoriously difficult to be treated. The ultimate goal of vitiligo treatment is to replenish the lost melanocytes by immigration from hair follicle and to restore the normal function of melanogenesis by residual melanocytes. There are two types of topical calcineurin inhibitors called tacrolimus and pimecrolimus, and are recommended as the first-line treatments in vitiligo. Although pimecrolimus is efficacious for the repigmentation of vitiligo, its intrinsic mechanisms have never been investigated in vitro. This research aimed to study the ability of pimecrolimus on stimulating melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression. Results showed that pimecrolimus at the dosages of 1, 10, $10^2$nM were neither mitogenic nor cytotoxic to melanocytes. The addition of pimecrolimus at 10, $10^2$ and $10^3nM$ significantly increased intracellular tyrosinase activity, which was consistent with the elevated content of melanin content at the same concentrations. The peak effect was seen at 72 h in response to $10^2$nM pimecrolimus. Results of the wound scratch assay and Transwell assays indicate that pimecrolimus is effective in facilitating melanocyte migration on a collagen IV-coated surface. In addition, MITF protein yield reached the highest by pimecrolimus at $10^2nM$. In brief, pimecrolimus enhances melanin synthesis as well as promotes migration of melanocytes directly, possibly via their effects on MITF protein expression.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5533-5537
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• 2013

MicroRNA-10b (miR-10b) has been reported to play an important role in some types of cancer, but the effects and possible mechanisms of action of miR-10b in the metastasis of nasopharyngeal carcinoma cells (NPC) have not been explored. The aim of the present study was to investigate the function of miR-10b in nasopharyngeal carcinoma and to determine the molecular mechanisms underlying its action. The MTT assay was used to assess proliferation of CNE-2Z cells. Wound healing and transwell migration assays were applied to assess cell migration and invasion, while and expression of E-cadherin and MMP-9 were detected using Western blot analysis. Real-time PCR was employed to detect the expression of genes related to migration and invasion and the $2^{-{\Delta}{\Delta}Ct}$ method was used to calculate the degree of expression. MTT assay showed the expression of miR-10b to have no effect on the proliferation of NPC cell lines. The wound healing assay showed that miR-10b mimics promoted the mobility and invasion of NPC cell lines. Inhibitors of miR-10b reduced the ability of NPC cell lines to migrate and invade. In addition, the expression of genes related to migration and invasion, such as E-cadherin, vimentin, and MMP-9, were confirmed to be different in the CNE-2Z NPC cell line transfected with miR-10b mimics and with miR-10b inhibitors. In the present study, miR-10b was found to upregulate the expression of MMP-9 and knockdown of miR-10b was found to significantly downregulate the expression of E-cadherin. On the whole, these results showed that miR-10b plays an important role in the invasion and metastasis of NPC cells.

• 한국정보통신학회논문지
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• 제16권7호
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• pp.1567-1574
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• 2012

이동에이전트의 노드 이주 방법은 분산 시스템의 전체 성능에 큰 영향을 줄 수 있는 요소가 되므로, 이러한 이동 에이전트의 센서 네트워크 내에서의 효율적 이주를 위한 방법이 요구되며, 이를 위하여 다양한 센서 네트워크 구성요소들(서버, 싱크 및 센서노드들) 관련 데이터들을 수집 및 저장하여 일관된 네이밍 서비스를 제공해야 할 필요가 있다. 따라서 본 논문에서는 센서데이터 서버의 정보가 저장되는 MetaData와 싱크노드들과 그들에 연결되어있는 센서노드들의 다양한 정보가 저장되는 SubMetaData 부분으로 나누어 메타테이블을 설계 구현하고, 이러한 메타테이블의 정보들을 이용한 RMI 기반의 네이밍 기법을 적용하여 능동규칙 이동에이전트의 정 방향 이주 방법을 구현함으로써 효율적인 센서 네트워크 응용 환경 구축 가능성을 제시하였다. 또한, 본 논문에서는 네이밍 에이전트를 J2EE 모델 기반의 RMI-IIOP(Internet Inter-ORB Protocol) 기술을 적용하여 설계 및 구현함으로써, 새로운 센서 네트워크 환경에 적합한 등록, 해제 및 검색 등을 수행할 수 있도록 하였다.

• 대한지리학회지
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• 제52권1호
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• pp.105-122
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• 2017

이 연구는 1930년 국세조사 인구자료를 기초로 14개 부, 41개 지정면을 도시지역으로 설정하여, 도시로의 인구이동과 그 출발지 유형, 입지를 분석하여 당시 도시화 과정을 이해하는 것을 목적으로 하였다. 이를 위해서 당시 도시지역에 유입된 인구의 출생지를 출발지로 간주하고 그 유형과 입지를 우선 분석하였다. 분석결과, 1930년의 부와 지정면은 유입인구의 출발지에 따라 전국적 범위의 출생자들이 장거리 이동한 곳, 인접지역 출생자들이 단거리 이동한 곳 및 두 가지의 중간적 성격을 가지는 곳 등으로 구분될 수 있었다. 그리고 일제의 효율적 식민 지배를 위해 새롭게 개발된 도시일수록 전국적 장거리 이동자의 유입지라는 성격이 두드러졌지만, 전통적인 도시기능을 수행했던 곳들도 주변 인구가 유입되면서 지역의 중심도시로 빠르게 성장하였다. 이에 대해서 이 연구는 식민 도시화라는 정주체계와 전통적 정주체계의 이중적 구조가 이중적 도시화와 인구이동을 발생시켰을 가능성이 있음을 제안한다.