• BMB Reports
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• v.45 no.3
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• pp.153-158
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• 2012

Geft is a guanine nucleotide exchange factor, which can specifically activate Rho family of small GTPase by catalyzing the exchange of bound GDP for GTP. Geft is highly expressed in the excitable tissue as heart and skeletal muscle and plays important roles in many cellular processes, such as cell proliferation, migration, and cell fate decision. However, the in vivo role of Geft remains unknown. Here, we generated a Geft conditional knockout mouse by flanking exons 5-17 of Geft with loxP sites. Cre-mediated deletion of the Geft gene in heart using Mef2c-Cre transgenic mice resulted in a dramatic decrease of Geft expression. Geft knockout mice develop normally and exhibit no discernable phenotype, suggesting Geft is dispensable for the development of the second heart field in mouse. The Geft conditional knockout mouse will be a valuable genetic tool for uncovering the in vivo roles of Geft during development and in adult homeostasis.

• Journal of Internet Computing and Services
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• v.11 no.3
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• pp.65-74
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• 2010

In the ubiquitous healthcare, automated diagnosis is commonly achieved by an agent system to provide intelligent decision support and fast diagnosis result. Mobile agent technology is used for efficient load distribution by migrating processes to a less loaded node which is considered in our design of a ubiquitous healthcare system. This paper presents a framework for ubiquitous healthcare technologies which mainly focuses on mobile agents that serve the on-demand processes of an automated diagnosis support system. Considering the efficient utilization of resources, a balanced clustering for the load distribution of processes within nodes is proposed. The proposed algorithm selects overloaded nodes to migrate processes to near nodes until the load variance of the system is minimized. Our proposed balanced clustering efficiently distributes processes to all nodes considering message overheads by performing the migration to the near nodes.

• International Journal of Contents
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• v.13 no.2
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• pp.29-34
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• 2017

Cloud computing is becoming an effective and efficient way of computing resources and computing service integration. Through centralized management of resources and services, cloud computing delivers hosted services over the internet, such that access to shared hardware, software, applications, information, and all resources is elastically provided to the consumer on-demand. The main enabling technology for cloud computing is virtualization. Virtualization software creates a temporarily simulated or extended version of computing and network resources. The objectives of virtualization are as follows: first, to fully utilize the shared resources by applying partitioning and time-sharing; second, to centralize resource management; third, to enhance cloud data center agility and provide the required scalability and elasticity for on-demand capabilities; fourth, to improve testing and running software diagnostics on different operating platforms; and fifth, to improve the portability of applications and workload migration capabilities. One of the key features of cloud computing is elasticity. It enables users to create and remove virtual computing resources dynamically according to the changing demand, but it is not easy to make a decision regarding the right amount of resources. Indeed, proper provisioning of the resources to applications is an important issue in IaaS cloud computing. Most web applications encounter large and fluctuating task requests. In predictable situations, the resources can be provisioned in advance through capacity planning techniques. But in case of unplanned and spike requests, it would be desirable to automatically scale the resources, called auto-scaling, which adjusts the resources allocated to applications based on its need at any given time. This would free the user from the burden of deciding how many resources are necessary each time. In this work, we propose an analytical and efficient VM-level scaling scheme by modeling each VM in a data center as an M/M/1 processor sharing queue. Our proposed VM-level scaling scheme is validated via a numerical experiment.

• The Journal of Society for e-Business Studies
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• v.18 no.2
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• pp.47-67
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• 2013

With the emergence of indirect procurement, it has become a global trend for companies to outsource their maintenance, repair, and operating (MRO) supplies to procurement service providers (PSPs). Due to the variety of MRO items, evaluation of numerous suppliers in various industries is a particularly complex task for PSPs. Due to this complexity, many PSPs still evaluate and select suppliers based on the sourcing managers' subjective knowledge. Through the case of adopting a supplier evaluation system, this research is to find the managerial issues organizations should consider when they transform sourcing managers' knowledge into the system. We interpret the issues based on the Technology-Organization-Environment (TOE) framework. This case conclusively shows the importance of positive feedback loop between the users and the information system for the performance improvement of the system.

• The KIPS Transactions:PartA
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• v.8A no.2
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• pp.133-146
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• 2001

In a dynamic load distribution policies, each node gathers the current system sates information before making a decision on load balancing. Load balancing policies based on this strategy can suffer from processor thrashing. In this paper, we propose a new algorithm which attempts to decrease the frequency of the processor thrashing, the algorithm is based on the integration of three components. The first, the algorithm of which determine the size of jobs be transferred. The second, negotiation protocol with obtains a mutual agreement between a sender and a receiver on the transferring job size. And the third, a symmetrically-initiated location policy. The algorithm proposed in this paper used Siman IV as simulation tool to prove the improvement of performance. I analyzed the result of simulation, and compared with related works. The mean response time shows that there are no difference with existing policy, but appear a outstanding improvement in high load. The thrashing coefficient that shows the average response time, CPU overhead and the thrashing ratio at both the receiving and sending node has been used in the analysis. A significant improvement in the average response time and the CPU overhead ratio was detected using our algorithm when an overhead occurred in the system over other algorithm. The thrashing coefficient differed in the sending node and the receiving node of the system. Using our algorithm, the thrashing coefficient at the sending node showed more improvement when there was an overhead in the system, proving to be more useful. Therefore, it can be concluded that the thrashing ratio can be reduce by properly setting the maximum and minimum value of the system’s threshold queue.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.9
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• pp.4103-4121
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• 2018

Quality of Service (QoS) awareness is recognized as a key point for the success of Internet of Things (IOT).Realizing the full potential of the Internet of Things requires, a real-time task scheduling algorithm must be designed to meet the QoS need. In order to schedule tasks with diverse QoS requirements in cloud environment efficiently, we propose a task scheduling strategy based on dynamic priority and load balancing (DPLB) in this paper. The dynamic priority consisted of task value density and the urgency of the task execution, the priority is increased over time to insure that each task can be implemented in time. The scheduling decision variable is composed of time attractiveness considered earliest completion time (ECT) and load brightness considered load status information which by obtain from each virtual machine by topic-based publish/subscribe mechanism. Then sorting tasks by priority and first schedule the task with highest priority to the virtual machine in feasible VMs group which satisfy the QoS requirements of task with maximal. Finally, after this patch tasks are scheduled over, the task migration manager will start work to reduce the load balancing degree.The experimental results show that, compared with the Min-Min, Max-Min, WRR, GAs, and HBB-LB algorithm, the DPLB is more effective, it reduces the Makespan, balances the load of VMs, augments the success completed ratio of tasks before deadline and raises the profit of cloud service per second.

• Journal of Soil and Groundwater Environment
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• v.27 no.spc
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• pp.64-74
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• 2022

The conceptual site model (CSM) is used as a key tool to support decision making in risk based management of contaminated sites. In this work, CSM was applied in Jeonju Industrial Complex where site investigation for groundwater contamination was conducted. Site background information including facility types, physical conditions, contaminants spill history, receptor exposure, and ecological information were collected and cross-checked with tabulated checklist necessary for CSM application. The CSM for contaminants migration utilized DNAPL transport model and narrative CSMs were constructed for source to receptor pathway, ecological exposure route, and contaminants fate and transport in the form of a diagram or flowchart. The component and uncertainty of preliminary CSM were reviewed using the data gap analysis while taking into account the purpose of the survey and the site management stage at the time of the survey. Through this approach, the potential utility of CSM was demonstrated in the site management process, such as assessing site conditions and planning follow-up survey work.

• Computers and Concrete
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• v.31 no.3
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• pp.185-195
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• 2023

Antalya is located south part of minor Asia, one of the biggest cities in Türkiye. As a result of population growth and vast migration to Antalya, many parts of the city that were not suitable for construction due to its geological conditions have become urban areas, and most of these urban areas are full of poorly engineered buildings. Poor engineering has been combined with unplanned urbanization, that causes utter vulnerability to disasters in Antalya. When an earthquake-prone city, Antalya faces with an earthquake risk, fear arises in society. To overcome this problem, it has become necessary to investigate the building stock, expressed in hundreds of thousands, in a fast and reliable way and then perform an urban transformation to create the perception of structural safety. However, the excessive building stock, labor, and economic problems made the implementation stage challenging and revealed the necessity of finding alternative solutions in the field. The present study presents a novel approach for assessment and model based on a rapid visual inspection method to transform areas under earthquake risk in Türkiye. The approach aimed to rank the interventions for decision-making mechanisms by making comparisons in the scale hierarchy. In the present study, to investigate the proposed approach, over 26,000 buildings were examined in Antalya, which is the fifth largest city in Türkiye that has a population of over 2.5 Million. In the results of the study, the risk classification was defined in the framework of building, block, street, neighborhood, and district scales.

• IMMUNE NETWORK
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• v.21 no.1
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• pp.11.1-11.10
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• 2021

Coronavirus causes an infectious disease in various species and crosses the species barriers leading to the outbreak of zoonotic diseases. Due to the respiratory diseases are mainly caused in humans and viruses are replicated and excreted through the respiratory tract, the nasal fluid and sputum are mainly used for diagnosis. Early diagnosis of coronavirus plays an important role in preventing its spread and is essential for quarantine policies. For rapid decision and prompt triage of infected host, the immunochromatographic assay (ICA) has been widely used for point of care testing. However, when the ICA is applied to an expectorated sputum in which antigens are present, the viscosity of sputum interferes with the migration of the antigens on the test strip. To overcome this limitation, it is necessary to use a mucolytic agent without affecting the antigens. In this study, we combined known mucolytic agents to lower the viscosity of sputum and applied that to alpha and beta coronavirus, porcine epidemic diarrhea virus (PEDV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively, spiked in sputum to find optimal pretreatment conditions. The pretreatment method using tris(2-carboxyethyl)phosphine (TCEP) and BSA was suitable for ICA diagnosis of sputum samples spiked with PEDV and MERS-CoV. This sensitive assay for the detection of coronavirus in sputum provides an useful information for the diagnosis of pathogen in low respiratory tract.

• The Journal of Fisheries Business Administration
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• v.18 no.1
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• pp.59-97
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• 1987

Tuna and tuna fishing extend over most of the tropical waters of the world oceans, especially, this study of the Indian Ocean and the fish and the fishing vessels are highly mobile. No country can deal in isolation with the problems of its tuna fishery and of any tuna fishery in its waters, without collaborating with other countries. This cooperation is often best established through some formal international mechanism. The essential requirements are for information-on the resources, the fishery, the trade-and to identify where management actions are needed to consore the resources or to maintain the economic or social function of the fishery. These will also usually require some form of international mechanism. With the changes in the Law of the Sea, the siuuation in respect of management of tuna-considered among the highly migratory species, requirng special treatment-has also changed. At present there are both uncertainty regarding tuna management and political arguments as to how such management can be best implemented. Bearing this in mind, together with the fact that only few tuna stocks have shown clear evidence of serious depletion through over-exploitation, present emphasis will be placed on information requirements. This study included compiling the data necessary to review the state of stoks in the Indian Ocean tuna fishing grounds. Information on the resources-where the fish are, their quantity, their movements, etc. is important, whether in planning development of new fisheries, or considering the need for collaboration with other countries (in ascertaining to what extent their catches may affect catches of the natoinal fleet) or for conservation measures. A major source of information is the statistics of for conservation measures. A major source of information is the statistics of catch and fishing effort from existing commercial vessels. These need to be assembled for all fisheries on the same stock on an oceanwide basis. The statistical data also need to be analysed and intepreted, and combined with biological data(e.g., on growth, mortality and migration rates) to provide information that is intelligible and useful for administrators and other decision-makers. This must also be undertaken on a resource-wide or ocean-wide basis. Finally, because of the world-wide similarities in the methods of datching, processing and marketing fish, there is a particular tut not exclusive need in those countries just beginning to develop their tuna fisheries-to have ready access to a syntheis of information on tuna, tuna biology and tuna fisheries and tuna fisheries economics and management on the Indian Ocean.