• 한국임상수의학회지
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• 제25권5호
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• pp.379-384
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• 2008

The objective of this study was to determine output power for skin incision in 0.3 mm spot diameter $CO_2$ laser by measuring (1) the wound depth, (2) initial dermal tissue damage, (3) degree of wound healing at different power (4W, 5W and 6W) in beagle dogs. Three healthy 2-year-old beagle dogs were used. Four 2 cm straight skin incisions were made with 0.3 mm spot diameter $CO_2$ laser on the each dog's both side of dorsal midline in three beagle dogs. The skin incisions were performed for $10{\sim}15$ seconds for same dosage. And then each wound was closed with surgical stapler. At 0, 3, 7 and 14 days after initial wounding, each wound was taken for histological observation. On macroscopic and microscopic observation, initial incisional wound did not show difference in three group. And also re-epithelialization, dermal tissue damage and inflammatory response did not show significant difference among groups. This study reveals that 4W, 5W and 6W may be suitable output power in 0.3 mm spot diameter $CO_2$ laser for the skin incision in beagle dogs.

• 대한수의학회지
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• 제46권1호
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• pp.63-66
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• 2006

This case was found in Holstein cow suffering from dystocia. The twin calves in uterus were dead and removed by fetotomy. Gross anatomical analysis of thoracopagus siamese calf was carried out. Two normal heads were present on two necks, however, the twins were fused in the thoracic region. There were four forelimbs and an abnormal orientation of ribs. Two separate vertebral columns along the length of the animal ended with two tails. A single pericardium lay on the midline when opening the thorax. However, there were two almost completely hearts within the pericardial sac. Two heart were joined by a common cavernous venous sinuous. There were two sets of lungs. Each twins had a separate esophagus that entered a separated stomach. A large liver was fused and connected into two duodenums. The pelvis, large intestines and urinary tracts were separated. The twins are female and have a full complement of limb.

• Molecules and Cells
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• 제38권11호
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• pp.1013-1021
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• 2015

Most of the axons in the vertebrate nervous system are surrounded by a lipid-rich membrane called myelin, which promotes rapid conduction of nerve impulses and protects the axon from being damaged. Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS characterized by infiltration of immune cells and progressive damage to myelin and axons. One potential way to treat MS is to enhance the endogenous remyelination process, but at present there are no available treatments to promote remyelination in patients with demyelinating diseases. Sulfasalazine is an anti-inflammatory and immune-modulating drug that is used in rheumatology and inflammatory bowel disease. Its anti-inflammatory and immunomodulatory properties prompted us to test the ability of sulfasalazine to promote remyelination. In this study, we found that sulfasalazine promotes remyelination in the CNS of a transgenic zebrafish model of NTR/MTZ-induced demyelination. We also found that sulfasalazine treatment reduced the number of macrophages/microglia in the CNS of demyelinated zebrafish larvae, suggesting that the acceleration of remyelination is mediated by the immunomodulatory function of sulfasalazine. Our data suggest that temporal modulation of the immune response by sulfasalazine can be used to overcome MS by enhancing myelin repair and remyelination in the CNS.

• 대한소아치과학회지
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• 제29권3호
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• pp.313-317
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• 2002

어린이는 성인과 다른 악관절 구조를 가지고 있으며 이로 말미암아 견고한 중심교합위를 얻지 못하거나 이원교합(dual bite)의 경우가 많다. 이러한 경향이, 편측저작 등의 치열변화를 초래할 수 있는 습관과 합쳐져 골격적 변화를 초래하게 될 경우, 안면 비대칭이 유도될 수 있다. 이러한 경우의 치료로서 교합유도를 통한 관절의 안정화와 그에 맞는 교합의 재형성을 통한 관절 및 교합의 안정화가 필요하다. 안면 비대칭을 주소로 내원한 5세 어린이에서 편측저작 습관으로 말미암은 우측 편측 구치부 절단교합과 2.5mm의 정중선 불일치가 있었다. 저자들은 activator를 이용하여 악관절 및 교합을 정상위치로 유도한 후 유구치를 주조금관으로 수복하여 양호한 결과를 얻었다.

• 동아시아식생활학회지
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• 제22권1호
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• pp.75-87
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• 2012

We investigated the physicochemical properties, pasting characteristics on the rapid visco analyzer, dough characteristics on a mixograph, product characteristics, and attributes of color and hardness of products made from a wheat bagel premix and rice bagel premix according to storage period and temperature. The pH and moisture content of stored rice bagel premix and wheat bagel premix, significantly decreased, depending on the storage temperature and time. The average of water retention capacity, alkaline water retention capacity, sedimentation value, and pelshenke value all significantly decreased temperature increases and increasing storage time. he initial pasting temperature and breakdown depending on the storage temperature and time showed a significant difference, but peak viscosity and setback with increasing storage time and temperature were not significantly different. The initial pasting temperature did not significantly affect the rice bagel premix. The midline peak time and band at 8 min of mixing time of the wheat bagel premix and rice bagel premix did not differ significantly. In product attributes, the cost of wheat bagel premix rice bagel premix and the L, a, and b value in color of wheat bagel premix showed significant difference. The hardness of wheat bagel premix according to storage time and the hardness of rice bagel premix depending on storage temperature significant difference. Therefore, storage time and temperature of wheat bagel premix and rice bagel premix and does not show significant differences. merchant can get regular and consistent, it is expected to lead to the promotion of rice consumption. Futhermore, research on better method to improve it's characteristics instead of wheat bagel premix is expected to.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1993년도 제27차 학술대회 초록집
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• pp.106-106
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• 1993

후두암은 두경부 영역의 가장 빈번한 악성종양으로 예후가 비교적 양호한 질환이다. 그러나 경부임파절로의 전이빈도는 원발병소의 위치에 따라 매우 다른 것으로 되어 있고, 특히 성문상부암의 경우에는 경부임파절 전이가 매우 많은 것으로 되어 있다. 이에 저자는 1986년 부터 1992년 까지 본 병원에서 후두암으로 진단되어 일차 수술을 시행하였던 111례중 성문상부암 49례을 대상으로 성문상부암의 경부임파절 전이 빈도 및 병기에 따른 경부 곽청술의 필요성에 대하여 후향적 분석을 시행하였다. 결과적으로 성문상부암 중에서 외측에 속하는 피열후두개추벽에서 발생한 환자에서 정중위(후두개)에서 발생한 환자보다 경부임파절전이 빈도가 높았다. 그리고 경부 임파절 전이률은 T 병기에 관계없이 평균 51.0%이었다. 따라서 성문상부암, 특히 T2이상인 경우에는 경부곽청술이 필요하다고 사료된다.

• Annals of Clinical Neurophysiology
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• 제8권2호
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• pp.163-170
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• 2006

Backgrounds: MEG can measure the task-specific neurophysiologic activity with good spatial and time resolution. Language lateralization using noninvasive method has been a subject of interest in resective brain surgery. We purposed to develop a paradigm for language lateralization using MEG and validate its feasibility. Methods: Magnetic fields were obtained in 12 neurosurgical candidates and one volunteer for language tasks, with a 306 channel whole head MEG. Language tasks were word listening, reading and picture naming. We tested two word listening paradigms: semantic decision of meaning of abstract nouns, and recognition of repeated words. The subjects were instructed to silently name or read, and respond with pushing button or not. We decided language dominance according to the number of acceptable equivalent current dipoles (ECD) modeled by sequential single dipole, and the mean magnetic field strength by root mean square value, in each hemisphere. We collected clinical data including Wada test. Results: Magnetic fields evoked by word listening were generally distributed in bilateral temporoparietal areas with variable hemispheric dominance. Language tasks using visual stimuli frequently evoked magnetic field in posterior midline area, which made laterality decision difficult. Response during task resulted in more artifacts and different results depending on responding hand. Laterality decision with mean magnetic field strength was more concordant with Wada than the method with ECD number of each hemisphere. Conclusions: Word listening task without hand response is the most feasible paradigm for language lateralization using MEG. Mean magnetic field strength in each hemisphere is a proper index for hemispheric dominance.

• 대한치과보철학회지
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• 제37권2호
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• pp.185-199
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• 1999

This study was peformed to investigate the distribution and magnitude of stress at supporting tissue of abutment teeth and residual ridge tissue with remaining unilateral posterior teeth. Four types of removable partial dentures that included clasp retained removable partial denture, attachment retained removable partial denture, telescopic removable partial denture, and swing-lock partial denture were designed, and strain gauge was used for stress analysis. Each prosthesis was subjected to simulated vertical and oblique load. The following conclusions were drawn from this study. 1. The clasp retained removable partial denture generally distributed simulated vertical force more evenly to the supporting structure. 2. The stress at buccal side of 1st premolar was the lowest in swing-lock partial denture and that was highest in attchment retained removable partial denture. The stress at lingual side of 1st premolar was the lowest in telescopic partial denture. 3. In clasp retained removable partial denture, stress was lower at load site and ridge crest at mid-line, but it was higher at 1st premolar area on vertical load. 4. In attachment removable partial denture, stresses at buccal side of 1st premolar. lingual side of 1st premolar on vertical load, and ridge crest at midline on oblique load were higher. 5. In telescopic removable partial denture, stress at lingual side of 1st premolar was the least in all removable partial dentures, but the stress at load site was higher. 6. In swing-lock removable partial denture, stress at buccal side of 1st premolar was the lowest, and stresses at load site and distal end of residual ridge crest were higher.

• 대한소아치과학회지
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• 제32권3호
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• pp.437-443
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• 2005

상악 중절치는 만곡이 주로 일어나는 치아로 만곡에 의해 치아가 매복된 경우 인접치아가 기울어지거나 정중선이 편위되는 등의 교정적 문제를 일으킬 수 있다. 이러한 치아의 만곡은 외상과 낭종, 기타 원인으로 발생하며 치아의 형태나 치근의 만곡도, 악골 내의 위치, 자발적인 맹출 가능성 등을 고려하여 치료를 결정해야 한다. 치아가 순설측으로 만곡된 경우는 자발적인 맹출이 어려우므로 발치를 포함한 보철적 처치나 발치 후 재식술, 외과적 치관노출을 동반한 교정적 처치 등을 고려해 볼 수 있다. 본 증례는 치근이 순측으로 만곡되어 매복하고 있는 상악 중절치를 폐쇄맹출법을 이용해 교정적으로 견인하여 양호한 치료결과를 얻었기에 보고하고자 한다.

• 대한치과마취과학회지
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• 제3권1호
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• pp.34-37
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• 2003

Postoperative stroke is uncommon even in elderly patients, who have a higher incidence of all types of postoperative complications. The mechanism of postoperative stroke is not certain, but can be explained by intravascular clottings originated from thrombus or embolus or by intracranial hemorrhage. In a 66-year-old male patient with current hypertension medication, who underwent both neck dissection for malignancy metastasis under general anesthesia, the left hemiparesis and delayed emergency were found postoperatively. After transferred to intensive care unit, he got the thrombolytic therapy and then the therapies to decrease the swelling of the brain on the diagnosis of cerebral infarction in the vascular distribution of the middle cerebral artery. A brain MRI definitely showed the midline deviation to the left of the right brain hemisphere due to the progressing edematous changes. As he got worse, the emergency neurosurgical operation was proposed but rejected by his family. He died at postoperative 3 days. In this hypertensive patient. perioperative stroke could be originated from the surgical stimuli on major vessels, which were inevitable in neck dissection during the operation. We report this case of the postoperative stroke, which could be highly possible to be associated with extensive head and neck surgery.