• Journal of Preventive Medicine and Public Health
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• 제49권1호
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• pp.1-17
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• 2016

The Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea in 2015 has drawn public attention regarding the legal regulation of infectious disease control in Korea. This paper discusses the interpretive and legislative concerns regarding the Infectious Disease Prevention and Control Act, its ordinance and enforcement regulations, as well as public statements from the relevant administrative agency. Future improvements are also proposed.

• Journal of Preventive Medicine and Public Health
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• 제48권6호
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• pp.271-273
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• 2015

Quaternary prevention should be implemented to minimize harm to patients because the ultimate goal of medicine is to prevent disease and promote health. Primary care physicians have a major responsibility in quaternary prevention, and the establishment of clinical epidemiology as a distinct field of study would create a role charged with minimizing patient harm arising from over-medicalization.

• 한국병원경영학회지
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• 제20권3호
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• pp.56-63
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• 2015

• 한국재난정보학회:학술대회논문집
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• 한국재난정보학회 2015년 정기학술대회
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• pp.298-299
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• 2015

본 논문은 2013년 5월 국제바이러스 분류 위원회에서 중동호흡기증후군을 일으키는 신종 코로나바이러스를 메르스코로나바이러스(MERS-CoV)라 명명한 후, 2015년 5월 국내에 감염자가 들어와 이후 확산되고, 중동 호흡기 증후군 환자 발생 후 국내 첫 사망자가 발생한 일개 병원 지역응급의료센터 내원 후 확산을 막기 위하여 시행하였던 경험들을 공유하고자 한 내용이다.

• Journal of Microbiology and Biotechnology
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• 제29권12호
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• pp.2014-2021
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• 2019

Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to the genus Betacoronavirus and causes severe morbidity and mortality in humans especially when infected patients have underlying diseases such as chronic obstructive pulmonary disease (COPD). Previously, we demonstrated that MERS-CoV-encoded ORF8b strongly inhibits MDA5- and RIG-I-mediated induction of the interferon beta (IFN-β) promoter activities. Here, we report that ORF8b seemed to regulate MDA5 or RIG-I differentially as protein levels of MDA5 were significantly down-regulated while those of RIG-I were largely unperturbed. In addition, ORF8b seemed to efficiently suppress phosphorylation of IRF3 at the residues of 386 and 396 in cells transfected with RIG-I while total endogenous levels of IRF3 remained largely unchanged. Furthermore, ORF8b was able to inhibit all forms of RIG-I; full-length, RIG-I-1-734, and RIG-I-1-228, the last of which contains only the CARD domains. Taken together, it is tempting to postulate that ORF8b may interfere with the CARD-CARD interactions between RIG-I and MAVS. Further detailed analysis is required to delineate the mechanisms of how ORF8b inhibits the MDA5/RIG-I receptor signaling pathway.

• 한국직업건강간호학회지
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• 제27권2호
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• pp.77-88
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• 2018

Purpose: This study aimed to investigate the degree of role conflict and its ambiguity, and fatigue in clinical nurses and to analyze the effect of these on their self-resilience in order to provide fundamental data for improving their working environment after the Middle East Respiratory Syndrome outbreak. Methods: After the collection of data from 258 clinical nurses in five general hospitals, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression were performed using IBM SPSS Statistics 20.0. Results: A significant positive correlation was found between nurses' role conflict and ambiguity and fatigue; while a negative correlation was found between nurses' role conflict and ambiguity and self-resilience. A significant negative correlation was found between fatigue and self-resilience. According to the study results, the factor that affected clinical nurses' self-resilience the most was role conflict and its ambiguity, followed by marital status, fatigue, educational level, religion, and related tasks, which together accounted for 38% of self-resilience in clinical nurses. Conclusion: To improve weaknesses in nursing care after the Middle East Respiratory Syndrome outbreak, the scope of nursing care was changed upon the expansion of integrated nursing and care-giving services. Therefore, in the rapidly changing environment of nursing, policies to improve nursing performance, as well as successful reaction capability, are suggested.

• 한국직업건강간호학회지
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• 제26권4호
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• pp.207-217
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• 2017

Purpose: This study aimed to evaluate the workplace response system (WRS) against infectious disasters (IDs) based on the response attitudes and capacity of occupational health nurses (OHNs) who worked during the 2015 Middle East Respiratory Syndrome (MERS) outbreak in South Korea. Methods: Fifty-one participants who had worked as OHNs at the time of the 2015 MERS outbreak were surveyed from November 20 to December 10, 2016. Data were collected using a self-report questionnaire and analyzed using descriptive statistics and McNemaer's test. Results: According to the survey results, the following were lacking in the WRS: a dedicated ID-response team, manuals, related education programs for OHNs, and health education programs for workers. Results also confirmed that workers were vulnerable to new infectious diseases because of the lack of health checkups and support for workers before and after business trips abroad. Among the respondents, 98.0% answered affirmatively that an ID was important for health management in the workplace, but 64.7% answered that it was difficult to manage an ID. The perceived capacity items to respond to IDs ranged from 3.0 points to 3.3 points. This scores were generally high. Conclusion: As the WRS is currently insufficient, it is necessary to develop an adequate WRS to IDs by addressing the identified problems.

• 한국산학기술학회논문지
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• 제18권10호
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• pp.185-196
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• 2017

본 연구의 목적은 메르스 환자 간호에 대한 간호사의 실제적인 경험을 파악하기 위함이다. 본 연구에 참여한 대상자는 S시 1개 상급종합병원에서 메르스 환자 간호에 참여한 간호사 9명이며, 자료 수집을 위해 심층 면담이 수행되었다. 자료수집 기간은 2015년 8월부터 2016년 3월까지였다. 수집된 자료는 Colaizzi의 현상학적 방법에 따라 절차에 맞게 분석하였다. 도출된 5개의 범주는 다음과 같다. '1. 신종 감염병 전염 위험성에 따른 불안과 부담', '2. 메르스 환자 간호사라는 이유로 느끼는 사회적 고립', '3. 준비되지 않은 치료환경 문제에 부딪힘', '4. 힘겨운 메르스 환자 간호과정을 이겨냄', '5. 신종 감염병 대책 마련에 대해 성찰함'이었다. 이와 같은 결과는 메르스 환자를 포함한 다양한 감염병 환자를 담당하는 간호사의 부정적 영향 뿐 아니라, 긍정적인 경험을 도출했다는데 의의가 있다. 이를 바탕으로 심리사회적 부정적 영향을 감소시키고, 긍정적인 적응을 향상시키는데 근거로 활용될 수 있을 것이며, 간호사를 포함한 보건의료 종사자가 신종 감염병 환자를 간호하기 위한 인력, 부서 및 실무지침 마련이 필요하다고 생각된다.

• 한국산학기술학회논문지
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• 제17권2호
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• pp.427-435
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• 2016

최근 중동 호흡기 증후군의 발현으로 손 씻기가 강조되고 있는 실정이다. 본 연구의 목적은 중동호흡기 증후군의 예방을 위하여 손 씻기의 빈도에 영향을 미치는 요인을 파악하기 위하여 기질불안, 건강통제위, 건강증진행위의 관계를 분석하였다. 314명의 간호 대학생들에게 중동 호흡기 증후군을 예방하는 방법, 손 씻는 횟수, 기질불안, 건강통제위, 건강증진행위에 대하여 설문조사하였고, 수집된 자료는 Pearson correlation, 다중회귀분석으로 분석하였다. 손 씻기 수행 빈도에 영향을 미치는 요인으로는 손 씻기 중요도 이였으며, 손 씻기 중요도에 영향을 미치는 요인은 내적통제위로 나타났다. 또한, 대부분의 간호 대학생이 손 씻기가 중동 호흡기 증후군의 가장 중요한 예방법으로 인지하였다. 이에 손 씻기의 중요성과 내적 통제위를 강화한 건강교육을 진행해야 할 것이다.

• Biomolecules & Therapeutics
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• 제28권4호
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• pp.311-319
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• 2020

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a newly emerging viral disease with fatal outcomes. However, no MERS-CoV-specific treatment is commercially available. Given the absence of previous structure-based drug discovery studies targeting MERS-CoV fusion proteins, this set of compounds is considered the first generation of MERS-CoV small molecule fusion inhibitors. After a virtual screening campaign of 1.56 million compounds followed by cell-cell fusion assay and MERS-CoV plaques inhibition assay, three new compounds were identified. Compound numbers 22, 73, and 74 showed IC₅₀ values of 12.6, 21.8, and 11.12 µM, respectively, and were most effective at the onset of spike-receptor interactions. The compounds exhibited safe profiles against Human embryonic kidney cells 293 at a concentration of 20 µM with no observed toxicity in Vero cells at 10 µM. The experimental results are accompanied with predicted favorable pharmacokinetic descriptors and drug-likeness parameters. In conclusion, this study provides the first generation of MERS-CoV fusion inhibitors with potencies in the low micromolar range.