• 제목/요약/키워드: Microparticle

검색결과 128건 처리시간 0.029초

Extravasating Neutrophil-derived Microparticles Preserve Vascular Barrier Function in Inflamed Tissue

  • Lim, Kihong;Sumagin, Ronen;Hyun, Young-Min
    • IMMUNE NETWORK
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    • 제13권3호
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    • pp.102-106
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    • 2013
  • Emerging evidence suggests that gap formation and opening of the endothelial junctions during leukocyte extravasation is actively controlled to maintain the integrity of the vascular barrier. While the role for endothelial cells to this process has been well defined, it is not clear whether leukocytes are also actively contributing to endothelial barrier function. We have recently showed that extravasating leukocytes deposit microparticles on the subendothelium during the late stages of extravasation, which is LFA-1 dependent. Using multiphotonintravital microscopy (MP-IVM) of mouse cremaster muscle vessels in the current work, we show that microparticle formation and deposition maintains the integrity of the microvascular barrier during leukocyte extravasation. Inhibition of neutrophil-derived microparticle formation resulted in dramatically increased vascular leakage. These findings suggest that deposition of microparticles during neutrophil extravasation is essential for maintaining endothelial barrier function and may result in temporal difference between neutrophil extravasation and an increase in vascular leakage.

Advanced Retention and Drainage Technology Offers Improved Performance and Operational Cost Savings

  • Freeman William L.
    • 한국펄프종이공학회:학술대회논문집
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    • 한국펄프종이공학회 2006년도 PAN PACIFIC CONFERENCE vol.2
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    • pp.239-243
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    • 2006
  • Papermaking has changed remarkably during the past 20 years, creating huge pressures on retention and drainage programs. During this time, technology has advanced from single PAM flocculants to inorganic microparticle-based programs and then to micropolymer-based programs. In today's evolving fine paper market, retention and drainage programs have to meet increased demands in many areas, such as increased speed, GAP formers, dilution headboxes, higher ash levels, reduced furnish quality, lower cost, and increased machine efficiency. Hercules recently introduced a new technology that offers performance and stability improvements and operational cost savings as compared to existing advanced technologies. $PerForm(R)$ SP Advanced Retention and Drainage Technology consists of a family of products based on a structured organic particulate that offers papermakers the ultimate flexibility for management of wet end chemistry. This paper compares $PerForm(R)$ SP Advanced Retention and Drainage Technology to inorganic microparticle and micropolymer technologies and provides multiple case histories on machines that demonstrate the benefits of the technology. In these case histories, the PerForm SP is shown to provide improved retention and drainage that results in improved performance and operational cost savings to the mill.

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나선형 미세채널 내부에 형성되는 딘와류 이용한 미세입자 분리소자 (Microparticle Separator based on Dean Vortex in Spiral Microchannel)

  • 변강일;김형진;김병희;서영호
    • 한국생산제조학회지
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    • 제23권6호
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    • pp.555-560
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    • 2014
  • This paper presents a microparticle separator using a spiral microchannel. A particle separator based on the dean vortex was designed, fabricated, and characterized. Two different spiral microchannels were fabricated. Width and initial radius of rotation in the spiral microchannel were fixed to $300{\mu}m$ and 1.75 mm, respectively. Two different depths of the microchannels were designed at $50{\mu}m$ and $80{\mu}m$. In this experimental study, the equilibrium position of microparticles was monitored by using fluorescent microbeads. In the case of a low dean number (<1.0), lift force and dean drag force were similar, indicating that microbeads were distributed to almost all areas across microchannels. However, in the case of a high dean number (>1.0), dean drag force rather than lift force was dominant, indicating that microbeads moved toward the inner wall of the spiral microchannel.

미세입자의 정밀제어를 위한 표면탄성파 장치의 특성연구 및 설계 (Characteristic Analysis and Design of a Precise Manipulation of Microparticle using Surface Acoustic Wave Device)

  • 김동준;엄진우;고병한;박노철;박영필
    • 한국소음진동공학회논문집
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    • 제25권10호
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    • pp.660-666
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    • 2015
  • Surface acoustic wave(SAW) device is used for transporting and patterning micro-scale particles such as cells. In this research, velocity of particles was investigated moved by SAW device with two types of interdigital electrode transducers(IDTs) under various conditions. SAW devices which have single IDTs and double IDTs were designed and fabricated. On the previous studies, resultant velocities of particles were predicted considering output power and power ratio between IDTs-shape. For more accurate prediction, power loss in SAW device and a power difference between two types of IDTs-shape were considered. Maximum error between the test results and predicted values was 5 % so the power loss must be considered in the velocity prediction of the particles.

Mechanisms of microparticle propulsion by laser ablation

  • Gojani, A.B.;Menezes, V.;Yoh, J.J.;Takayama, K.
    • 한국추진공학회:학술대회논문집
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    • 한국추진공학회 2008년 영문 학술대회
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    • pp.837-841
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    • 2008
  • Propulsion of gene coated micro-particles is desired for non-intrusive drug delivery inside biological tissue. This has been achieved by the development of a device that uses high power laser pulses. The present paper looks at the mechanisms of micro-particle acceleration. Initially, a high power laser pulse is focused onto the front side of a thin aluminium foil leading to its ablation. The ablation front drives a compression wave inside the foil, thus leading to the formation of a shock wave, which will later reflect from the rear side of the foil, due to acoustic impedance mismatch. The reflected wave will induce an opposite motion of the foil, characterized by a very high speed, of the order of several millimeters per microsecond. Micro-particles, which are deposited on the rear side of the foil, thus get accelerated and ejected as micro-projectiles and are able to penetrate several hundreds of micrometers inside tissue-like material. These processes have been observed experimentally by using high-speed shadowgraphy and considered analytically.

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Development of Crosslinked Cational Starches and Evaluation of Their Performance in the Microparticle Retention System

  • Kim, Tae-Young;Lee, Hak-Lae
    • 펄프종이기술
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    • 제31권5호
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    • pp.24-30
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    • 1999
  • Crosslinked corn starches were prepared to increase their molecular weights and their performance as a component of Compozil system was evaluated and compared with that of potato starches. It was shown that greater improvements in retention and strength properties could be achieved when crosslinded cationic corn starches rather than conventional cationic potato starches were used especially at high conductivity because of their molecular rigidity.

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