• 대한기계학회논문집A
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• 제29권3호
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• pp.418-424
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• 2005

We present the design, fabrication and experimental results of 4-bit digital microinjectors, whose ejected droplet volumes are adjusted by the digital operation of a 4-bit microheater array. We design the reference microinjectors as well as its comparative test structures. In the fabrication process, we use a five-mask micromachining process and the total chip size of the fabricated microinjector is $7,640{\mu}m{\times}5,260{\mu}m.$ We measure the ejected droplet volumes and velocities, which are adjusted from $12.1{\pm}1.0~55.6{\pm}14.7pl\;and\;2.3{\pm}0.1~15.7{\pm}0.8m/s.$ respectively, depending on the 15 possible combinations of 4-bit microheater array. We also experimentally characterize the effect of geometric variation including the microheater size, inter-microheater gap, microchannel width and sequential operation of microheater array on the ejected droplet volume and velocity. Among these parameters, we find that the microheater size is the most dominant parameter affected to the ejected droplet volumes and velocities. Thus, the present microinjector has a potential for application to the high-resolution inkjet printers with multiple gray levels or high-precision fluid injectors with variable volume control.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 1997년도 춘계학술발표회 및 학술연구발표요지
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• pp.47-47
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• 1997

• 대한기계학회:학술대회논문집
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• 대한기계학회 2005년도 창립60주년 기념 추계 학술대회
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• pp.207.2-207.2
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• 2005

• 대한기계학회논문집A
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• 제29권1호
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• pp.67-73
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• 2005

The paper presents a single-heater microfluid injector, whose ejected droplet volume is adjusted by digital current path control for a single microheater. The previous droplet volume adjustable methods have used the digital current control for multiple heaters or the analog current control for a single heater, while the present method uses the digital current control for a single microheater. Two different microinjectors, having a rectangular heater and a circular hearter, are designed and fabricated in the chip area of $7.64\;mm{\times}5.26\;mm$. The fabricated microinjectors have been tested and characterized for the number, size, shape and lifetime of the generated bubbles as well as for the volume and velocity of the ejected droplets. The input power for the rectangular heater and the circular heater has been varied in the ranges of $8.7{\sim}24.9{\mu}W\;and\;8.1{\sim}43.8{\mu}W$, respectively. The projected area of the generated bubble has been changed in the ranges of $440{\sim}l,3600{\mu}m^2\;and\;800{\sim}3,300{\mu}m^2$ for the rectangular heater and the circular heater, respectively. The microinjector with the rectangular heater ejects three discrete levels of the droplet in the volume range of $9.4{\sim}20.7pl$ with the velocity range of $0.8{\sim}1.7m/s$, while the microinjector with the circular heater achieves five discrete levels of the droplet in the volume range of $7.4{\sim}27.4pl$ with the velocity range of $0.5{\sim}2.8m/s$.

• 대한기계학회논문집B
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• 제26권6호
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• pp.868-874
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• 2002

A high-impulse, low-power, digital microthruster has been developed using low-boiling-temperature liquid propellant with high-viscosity fluid plug. The viscous fiction force of the fluid plug increases the blast pressure and the low-boiling-temperature liquid propellant is intended to reduce input power consumption. The three-layer microthruster has been fabricated by surface micromachining as well as bulk micromachining in the size of 7$\times$13$\times$1.5㎣. A digital output impulse bit of 6.4$\times$10$^{-8}$ Nsec has been obtained from the fabricated microthruster using perfluoro normal hexane (FC72) propellant and oil plug, resulting in about ten times increase of the impulse bit using one hundredth electrical input energy compared to the conventional multiple-shot microthruster.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집C
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• pp.59-63
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• 2001

A high-impulse, low-power, continuous-shot microthruster has been developed using low boiling temperature liquid-propellant with high viscous fluid-plug. The viscous friction force of the fluid-plug increases the blast pressure and the low boiling temperature liquid-propellant is intended to reduce input power consumption. The three-layer microthruster has been fabricated by surface micromachining as well as bulk micromachining in the size of $7{\times}13{\times}1.5mm^{3}$. A continuous output impulse bit of $6.4{\times}10^{-8}N{\cdot}sec$ has been obtained from the fabricated microthruster using perfluoro normal hexane (FC72) propellant and oil plug, resulting in about ten times increase of the impulse bit using one hundredth electrical input energy compared to the conventional continuous microthruster.

• Journal of Korean Neurosurgical Society
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• 제29권10호
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• pp.1309-1315
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• 2000

Objectives : We performed an in vivo experiment to investigate the effect of $^{166}Holmium$ and $^{166}Holmium$-chitosan complex($^{166}Ho$-CHICO) on the normal brain of rats and to determine the sublethal dose of $^{166}Ho$-CHICO. Materials and Methods : $^{166}Ho$ is a beta and gamma ray emitter. $^{166}Ho$-CHICO is a novel radio-pharmaceutical complex with chitosan to facilitate the transport of $^{166}Ho$ obtained from Korea Atomic Energy Research Center(Taejon, Korea). It is in acidic form and becomes gel state at alkaline pH. One hundred and seventy consecutive rats were divided into four groups : $^{166}Ho$ treated(n＝50), $^{166}Ho$-CHICO treated(n＝57), saline treated(n＝5) and chitosan treated(n＝5) groups. $^{166}Ho$ and $^{166}Ho$-CHICO were injected into the rat brain stereotactically with various doses of 0.1mCi/$20{\mu}l$, 0.2mCi/$20{\mu}l$, 0.3mCi/$20{\mu}l$, and 0.4mCi/$20{\mu}l$ using an automated microinjector. Nuclear imaging, histopathological and hematological studies were performed in 10 rats in each group at 1 day, 3days, 7 days, 1 month and 3 months after the injections. Results : An infiltration of inflammatory cells and necrotic changes were noted in $^{166}Ho$ treated group at 1 week after the injection. A wedge-shaped tissue defect due to necrosis, lined with infiltrated glial cells in $^{166}Ho$ treated group and a cystic defect lined with reactive astroglial cells in $^{166}Holmium$-CHICO treated group at 3 months after the injection were observed. $^{166}Ho$ alone without chitosan leaked out and caused necrotic lesion on the cerebral surface but $^{166}Holmium$-CHICO treated group did not show this feature. As the dose of $^{166}Ho$ increased, the mortality rates were also increased. The mortality rate of the $^{166}Holmium$-CHICO group was higher than the $^{166}Ho$ treated group at a dose of 0.4mCi/$20{\mu}l$/300g. There was no detectable radioactivity due to the leakage or extravasation from the injected site of the brain on the scintigraphy performed at 1 hour, 24 hours and 48 hours after the injection. There was also no detectable activity of $^{166}Holmium$-CHICO in other organs including spleen, liver and kidney. Conclusions : $^{166}Ho$-CHICO did not leak out to the critical cortical surface of the brain from the injection site and induced radiation changes of the parenchyma around the injection site without cortical damage. The sublethal dose of $^{166}Ho$-CHICO for the normal brain in rats was determined to be 0.2mCi/$20{\mu}l$/300g.