• Bulletin of the Korean Chemical Society
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• v.34 no.6
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• pp.1835-1838
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• 2013

Polypyrrole-Gold (PPy/Au) segment nanowires are prepared using anodized aluminum oxide (AAO) templates and assembled into a curved superstructure. Since the shape of the obtained superstructures can be designed to be capsule-like with inner space for containing materials, and their openings and closures can be controlled with external stimuli, these structures can be useful for a large variety of applications. Inner space of capsule-like superstructures is an important factor for their applications, and the volume of the inner space can be assessed using the generalized equation suggested by J. K. Lim (Bull. Korean Chem. Soc. 33, 2699 (2012)). In this paper, we introduce a new approach to obtain correct and simplified equation without redundant assumption which was used to induce the previous equations, and recalculate the volume of the inner space in the capsule-like superstructure using a new equation.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.288-288
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• 1996

The microcapsules containing ethanol in a water-soluble polymer shell could be formed by the spray-drying technique. A mixed solution of ethanol, water and a water-soluble polymer is spray-dried at the lowest possible temperature to obtain a powder product in which the water is substantially removed and the ethanol is encapsulated in water-soluble polymer shell because of the hydrophillic property of polymer and permeability difference between ethanol and water. In this study, the effect of sodium lauryl sulfate (SLS) on the ethanol content, ethanol encapsulation efficiency and yield were investigated to maximize the microencapsulation of ethanol.

• Food Industry And Nutrition
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• v.8 no.2
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• pp.51-55
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• 2003

송이 향을 오랫동안 유지하기 위한 기초자료를 얻을 목적으로 일반적으로 많이 이용되는 감자전분을 matrix로 사용하여 송이 향의 주성분인 1-octen-3-ol을 미세캡슐화 하는 조건을 조사한 결과는 다음과 같다. 전분농도5.5% 이하 용액의 점도는 $60^{\circ}C$에서 420 cP이하를 나타내었고 6.0% 이상의 용액은 820cP 이상을 나타내어 이 농도를 경계하여 점도의 변화가 뚜렷하게 구별되었다. 균질화하기 전과 후의 감자전분용액의 점도변화에서는 감자전분에 emulsifier와 1-octen-3ol을 첨가하여 균질화한 에멀젼 용액의 점도가 균질화하기 전 용액의 점도보다1/2 이하 값을 나타내어 균질화 공정이 용액의 점도를 낮추었다. 감자전분용액의 농도가 높을수록 1-octen-3-ol의 잔존량이 많았다.

• Textile Coloration and Finishing
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• v.7 no.3
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• pp.15-21
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• 1995

Polyurethane microcapsules containing dibutylphthalate(DBP) were perpared by the interfacial polymerization using diisocyanates and polyois. Effects of chemical structure of PU, dispersing agent and polymerization time on the mean diameter of microcapsules were investigated. The releasing of DBP from microcapsules depended on the chemical structure of PU and solvents. The diameter decreased with increasing dispersing agent concentration, and it is decreased in the order of the dispersing agents using gelatine > PVA > arabic gum at the same concentration. A slight increase in the diameter was observed when the ratio C$H_2$/OOCNH of PU was increased. As the ratio C$H_2$/OOCNH of PU was increased, the amount of extracted DBP for hexane using as a extracting solvent was decreased, however, it was not changed for THF.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2000.04a
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• pp.20-25
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• 2000

아세트아미노펜(파라세타몰)은 p-aminophenol 유도체로서 (그림 1) 두통, 치통, 신경통 등의 통증에 널리 사용되는 해열진통제인데 아스피린과 같은 정도의 해열 진통 효과를 나타내며, 이것은 중추신경계의 체온조절 중추에 작용하여 피부혈관을 확장함으로써 열의 확산을 증가시키는 해열작용과 시상 및 대뇌피질에의 통각역치를 높여 진통작용을 하는 것으로 추정 된다. 아세트아미노펜은 백색의 결정 또는 결성성 가루로 물에 조금 녹고 메탄올 또는 에탄올에 잘 녹으며 수산화나트륨 시액에 녹고 에텔에는 매우 녹기 어렵다 (표1). 대한약전에서는 정제가, 미국약전에는 캅셀제, 좌제, 경구현탁액제, 발포성 건조시럽, 정제 등이 수재되어 있고, 세계 각국에서 OTC 제품으로 1정당 160mg의 츄잉정까지 판매되고 있다. 그러나, 시판되고 있는 정제등은 붕해되어 용출되는데 오랜시간이 소요되어 대한약전에는 약 30분간에 80%이상의 용출기준이 설정되어 있으며, 독특한 쓴맛 때문에 microencapsulation 한 제피세립을 사용하고 있으나 역시 1 정당 300mg 이상의 확산정이나 속용정은 존재하지 않는다. 이것을 개선하기 위하여 붕해속도가 빠르고 특히 진통효과가 빠르며 물없이 구강내에서 간편히 녹여 복용하거나 또는 씹어서 또는 물과 함께 복용할 수 도 있는 $\ulcorner$알카펜$\lrcorner$ 속용정을 개발하게 되었다 (그림2).

• Archives of Pharmacal Research
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• v.13 no.4
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• pp.293-297
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• 1990

Sustained release microspheres containing phenylpropanolamine HCI (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium strate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponage-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster relase in hP 1. 2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.

• Journal of Dairy Science and Biotechnology
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• v.23 no.1
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• pp.27-37
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• 2005

The development of functional foods started booming from several years ago in the world. The size of functional materials are in the range of micrometer level. This size can be much smaller into nanometer level to be more effective. We face some problems from the materials, such as flavor, taste, color, viscosity, etc. in functional materials. The problems can be solved by micro / nanoencapsulation technique. This paper showed some results of the research related on the technique for functional milks and dairy products. The nono / microcapsules are the form of liquid instead of solid. Coating materials used were fatty acid esters, and core materials were lactase, iron, ascorbic acid. isoflavone, and chitooligosaccharide. The ranges of capsules are from 100 nm to 200 ${\mu}$m. The sample milks added nano/microcapsules were homogeneous and prevented the defects of core materials. It was observed that nano / microcapsules in milk and dairy products were effective as functional material without defaults. It was indicated that targeted functional foods can be developed further in various foods by nanotechnology.

• Proceedings of the KOSOMBE Conference
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• v.1993 no.05
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• pp.7-14
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• 1993

Nowadays, microspheres are expected to be applied to biomedical areas and many studies are being performed. For biomedical applications, many kinds of microspheres were synthesized by emulsion polymerization, emulsifier-free emu]sion polymerization, and emulsifier-free emulsion polymerization with ionic surface-active comonomers. Further synthesis techniques about microencapsulation and magnetic microspheres are introduced. Among the practical applications of microspheres, some interesting subjects are introduced. These include solid-phase immunoassays, labeling and identification of lymphocyte populations, extracorporeal and hemoperfusion systems, drug delivery systems, and immunomagnetic cell separation. In addition, basic theories, problems and research trends are also introduced.

• Journal of Pharmaceutical Investigation
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• v.18 no.4
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• pp.187-195
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• 1988

Poorly permeable $Eudragit^{\circledR}$ RS 100 polymer was used as a wall material for the microencapsulation of zipeprol dihydrochloride by a phase separation method from chloroform-cyclohexane system with 5% polyisobutylene in cyclohexane, and microcapsules obtained were evaluated in vitro by particle size analysis, scanning electron microscopy, drug release test and in vivo bioavailability test in rats. The mechanism of drug release from microcapsules appeared to fit Higuchi matrix model kinetics. The area under the first moment of plasma concentration-time curve of the microcapsules obtained was considerably increased (p<0.05) as compared with that from zipeprol dihydrochloride oral solution. Therefore, it may be suggested that $Eudragit^{\cirledR}$ RS 100 coated zipeprol dihydrochloride microcapsules can be used as a sustained release medication.

• 한국약용작물학회:학술대회논문집
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• 2012.05a
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• pp.197-198
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• 2012