• Journal of the Korean Society of Radiology
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• v.6 no.1
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• pp.63-71
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• 2012

This study aimed to evaluate the accuracy of breast cancer diagnosis of digital mammography which is in the highest interest of breast imaging test, and to investigate the characteristics of breast cancer patients. For this purpose, 57 breast cancer patients who underwent breast imaging test were examined between May 2010 and June 2011. The average age of the breast cancer patients was 50.8 years old, and the most frequently occurring location was the upper outer quadrant (UOQ), accounting for 33.3%. By age, the highest occurrence rate of breast cancer was the age group of 40~49, accounting for 42.1%. As for the breast composition of the breast cancer patients, fatty breast accounted for 31.6% (18/57) and dense breast for 68.4% (39/57), indicating that nearly 70% of the breast cancer patients have dense breast. It was found that the detection rate of breast cancer was the highest (45.3%) when both microcalcification and mass are simultaneously present in the radiographic lesion of the breast imaging. In dense breast, the mass without microcalcification was lower in detection rate than fatty breast. Accordingly, the mass is the cause of raising the false negative rate in dense breast. The findings show that the false negative rate of digital mammography was 7.0% and the sensitivity 93.0%. Also, the false negative rate of dense breast was 12.8%, and the sensitivity 87.2%, indicating that the sensitivity to breast cancer in this study was higher than the dense breast of previously reported screen film mammography.

• Journal of radiological science and technology
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• v.31 no.1
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• pp.61-69
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• 2008

Diagnosis of breast ultrasound is better than mammography in the early detection of breast cancer, but, it is difficult to detect microcalcification. We studied on detection for calcification of breast tissue using acoustic resonance and power doppler with 7.5 MHz linear probe in breast ultrasound. We first constructed breast tissue phantom made of gelatin and saw breast, and then observed calcification by the change of external vibration. Calcification injected breast tissue phantom visualized the difference for brightness and region of color in ROI regions of power doppler. Acoustic resonance almost never visualized in low frequency regions, plateau constituted in about 300-400 Hz and colors vanished according to the increase of frequency.

• Journal of radiological science and technology
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• v.41 no.2
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• pp.149-155
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• 2018

Quantitative analysis was performed to confirm that moire artifact was removed without loss of image when using grid suppression software in the diagnosis of micro lesions. we showed that grid suppression images can be morphologically different from original images as they are significantly lower than those of the optimized grid in the similarity analysis with reference images in mammographic phantom images. We were confirmed that images of microcalcification with smaller signal than noise were lost because the pixel values of all lesions increased significantly after the grid suppression, The change in contrast using the NORMI 13 X-ray test phantom was reduced to 30% of the reference image, This result was significantly lower than the 90% when using the optimized grid. In conclusion, the use of grid suppression software in clinical images should be carefully considered because of the possibility of misdiagnosis due to micro lesion loss and morphological changes.

• Proceedings of the Korea Multimedia Society Conference
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• 2012.05a
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• pp.14-17
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• 2012

현재 유방암으로 인한 사망률이 급증하고 있다. 이러한 유방암의 위험성을 줄일 수 있는 치료 방법으로 수년간 많은 연구가 진행되어 왔다. 특히 마모그래피의 연장 선상이라 할 수 있는 CAD 시스템의 개발에 대한 연구가 진행 중에 있다. 미세석회화 검출에 적합한 CAD 시스템의 구현을 위해서 미세석회화를 분할하는 다양한 방법들이 연구되어 왔다. 기존의 미세석회화 분할 방법들 중에서 마모그램 영상에서 그레이 레벨 또는 컨트라스트를 임계화하는 방법을 많이 사용하고 있다. 이 방법은 간단하고 빠르다는 장점을 가지지만, 관찰하는 사람에 따라 변동성이 높다. 변동성이 크다는 단점으로 인해 다양한 마모그램 영상들에서 최적의 성능을 얻어내는 데는 한계가 있다. 본 논문에서는 관찰자에 의해서 컨트라스트 임계값을 정하는 방법이 아닌, 마모그램 영상에 따라 적응적으로 임계값을 자동적으로 설정하는 방법을 제안한다. 실험 결과를 보면 기존의 임계화 방법은 마모그램 영상마다 적합한 컨트라스트 임계값 변동이 크다. 그러나 제안된 방법은 마모그램 영상에 적합한 임계값을 찾아준다.

• Journal of Information Processing Systems
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• v.13 no.4
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• pp.703-715
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• 2017

Mammogram images are sensitive in nature and even a minor change in the environment affects the quality of the images. Due to the lack of expert radiologists, it is difficult to interpret the mammogram images. In this paper an algorithm is proposed for a computer-aided diagnosis system, which is based on the wavelet based adaptive sigmoid function. The cascade feed-forward back propagation technique has been used for training and testing purposes. Due to the poor contrast in digital mammogram images it is difficult to process the images directly. Thus, the images were first processed using the wavelet based adaptive sigmoid function and then the suspicious regions were selected to extract the features. A combination of texture features and gray-level co-occurrence matrix features were extracted and used for training and testing purposes. The system was trained with 150 images, while a total 100 mammogram images were used for testing. A classification accuracy of more than 95% was obtained with our proposed method.

• The Korean Journal of Cytopathology
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• v.7 no.2
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• pp.157-162
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• 1996

Fine needle aspiration(FNA) is an effective tool in diagnosing mammary carcinoma. We experienced 7 cases of histologically confirmed mammary mucinous carcinoma among 3,052 aspirated cases of breast from 1992 to 1996 in Asan Medical Center. The average age of the patient was 48(33-64) years. The mean size of the lesions was $1.6(0.7{\sim}3)cm$, and they were palpated as well-defined, firm to hard masses. The cytologic features that may be useful in making a FNA diagnosis of mucinous carcinoma of the breast were analysed. Mucinous background and tumor cell clusters with occasional single cells were observed in all cases. Among them, two cases showed abundant scattered single cells, whereas only few single cells were seen in the other two cases. Tumor cells exhibited mild pleomorphism in four cases and moderate pleomorphism in three cases. Nucleoli tended to be not prominent and are observed in three cases, rarely noted in other three cases and not seen in one. There was microcalcification in four cases(57%). In conclusion, mucinous background and clustered tumor cells showing mild to moderate pleomorphism with characteristic clinical findings allow us to diagnose mucinous carcinoma of the breast.

• Journal of Yeungnam Medical Science
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• v.9 no.2
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• pp.269-274
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• 1992

Authers retrospectively analyzed ultrasonographic findings of 12 cases of breast carcinomas which were proven pathologocally at Yeungnam University Hospital from March 1992 to August 1992. Classically, breast carcinomas were described as irregular and lobulated hypoechoic solid masses with inhomogenous internal echoes and frequent attenuation of the sound beam. And other additional ultrasonographic findings were echogenic rim, disruptions of superficial layer, microcalcification, skin thickening and so on. In our studies, not all of these findings of breast carcinomas were found in each case, but most of these findings were noted. However, several studies have demonstrated considerable overlap in the ultrasonographic appearance of benign lesions and carcinoma. Thus, accurate sonographic determination of the type of solid mass is not possible with current ultrasonographic imaging techniques and criteria. For more accurate diganosis of breast lesions, sonographic and other imaging techniqes are interpreted together.

• Journal of the Korean Society of Radiology
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• v.14 no.3
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• pp.253-259
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• 2020

Mammography has the advantage of being economical, simple and effective in detecting microcalcification, but breast is a highly sensitive organ and is accompanied by the risk of an over-exposure. While accurate dose assessments are important to prevent this, current breast dose assessments are limited to breast implant patients. This purpose of this study was to identify dose variations due to tube voltages by forming a mock-up with breast implants for an accurate dosimetric assessment on breast implant patients. As a result, doses from the presence of breast implants were smaller than those from the absence of the mammal. As the result of the change of the voltage to 26, 28, 30, and 32 kV, the imcreased tube voltage included larger dose regardless of the presence of Breast implant. Therefore, it is believed that diagnosis recommendations for breast implants will be possible if further studies on internal and external bioretical imaging and quality assessment are carried out as the basis for this study.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3229-3232
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• 2015

Background: Triple-negative breast cancer (TNBC) is known to be associated with aggressive biologic features and a poor clinical outcome. Therefore, early detection of TNBC without missed diagnosis is a requirement to improve prognosis. Preoperative ultrasound features of TNBC may potentially assist in early diagnosis as characteristics of disease. Purpose: To retrospectively evaluate the sonographic features of TNBC compared to ER (+) cancers which include HER(-) and HER2 (+), and HER2 (+) cancers which are ER (-). Materials and Methods: From June 2012 through June 2014, sonographic features of 321 surgically confirmed ER (+) cancers (n=214), HER2 (+) cancers (n=66), and TNBC (n=41) were retrospectively reviewed by two ultrasound specialists in consensus. The preoperative ultrasound and clinicopathological features were compared between the three subtypes. In addition, all cases were analyzed using morphologic criteria of the ACR BI-RADS lexicon. Results: Ultrasonographically, TNBC presented as microlobulated nodules without microcalcification (p=0.034). A lower incidence of ductal carcinoma in situ (p<0.001), invasive tumor size that is>2 cm (p=0.011) and BI-RADS category 4 (p<0.001) were significantly associated with TNBC. With regard to morphologic features of 41 TNBC cases, ultrasonographically were most likely to be masses with irregular (70.7%) microlobulated shape (48.8%), be circumscribed (17.1%) or have indistinct margins (17.1%) and parallel orientation (68.9%). Especially TNBC microlobulated mass margins were more more frequent than with ER (+) (2.0%) and HER2 (+) (4.8%) cancers. Conclusions: TNBC have specific characteristic in sonograms. Ultrasonography may be useful to avoid missed diagnosis and false-negative cases of TNBC.

• Korean Journal of Head & Neck Oncology
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• v.15 no.2
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• pp.177-181
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• 1999

Objective: The clinical significance of mass screening for thyroid carcinoma remains unclear. This study was carried out to clarify the value of mass screening for thyroid carcinoma. Materials and Methods: From December 1997 through July 1998, a total of 1,401 subjects who were enrolled to receive breast screening or follow-up examination for breast cancer were included in this study. Thyroid glands were examined by 10 MHz ultrasonography by one experienced radiologist. The patients with thyroid nodules were classified into 2 groups according to their potential risk of malignancy by ultrasonographic findings(high-risk : hypoechogenicity, microcalcification, irregular margin, taller than wider shape). High-risk patients were advised to undergo fine-needle aspiration biopsy and thyroidectomy. The characteristics of the thyroid cancers detected by ultrasonographic mass screening were compared by those of clinical thyroid cancer excluding male patients during the same period. Results: Thyroid nodules were detected in 353(25.2%) of the subjects and 259(73.4%) were listed in the low-risk group and 94(26.6%) in high-risk group. Among 94 patients in the high-risk group, 43 underwent thyroidectomy and 37 turned out to have thyroid carcinomas. Thus, the detection rates for carcinoma were 2.6% of all subject, 10.5% of the detected nodules, 36.4% of the high risk women and 86.0% of the operated cases. The tumor size was significantly smaller in the mass-screening group than in the clinical cancer group(p<0.05). However, there was no statistical differences between two groups in the prevalences of neck node involvement and extracapsular invasion and the patients distributions by AMES score, MACIS score and TNM stage. Conclusion: Ultrasonogrpahic mass screening may be useful for the early detection of thyroid carcinoma in women who are scheduled to have breast examination.