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Methodologic Aspect of LINAC-based Stereotactic Radiosurgery (선형가속기 기반 뇌정위 방사선 수술기법)

  • Choi, Tae Jin
    • Progress in Medical Physics
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    • v.23 no.3
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    • pp.127-137
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    • 2012
  • A conversing beam is firstly designed for radiosurgery by a neurosugern Lars Leksell in 1949 with orthogonal x-rays tube moving through horizontal moving arc to focusing the beam at target center. After 2 decades he composits 201 source of the Co-60 for gamma knife which beams focused at locus. Sveral linac-based stereotactic radiosurgery using the circular collimated beam which size range for 0.4~4.0 cm in a diameter by non-coplanar multiarc have been developed over the decades. The irregular lesions can be treated by superimposing with several spherical shots of radiation over the tumour volume. Linac based techniques include the use of between 4 and 11 non-co-planar arcs and a dynamic rotation technique and use photon beam energies in the range of 6~10 MV. Reviews of the characteristics of several treatment techniques can be found in the literature (Podgorsak 1989, Schell 1991). More in recent, static conformal beams defined by custom shaped collimators or a mini- or micro-multileaf collimator (mMLC) have been used in SRS. Finally, in the last few years, intensity-modulated mMLC SRS has also been introduced. Today, many commercial and in-house SRS programs have also introduced non-invasive immobilization systems include the cyberknife and tomotherapy and proton beam. This document will be compared the characteristics of dose distribution of radiosurgery as introduced gamma knife, BrainLab include photon knife in-house SRS program and cyberknife in currently wide used for a cranial SRS.

Regeneration of symmetric protoplast fusion between cabbage (Brassica oleracea L.) and radish (Raphanus sativus L.) (양배추와 무의 동형 원형질체 융합을 이용한 식물체의 재분화)

  • In, Dong-Su;Song, Min-Jung;Jang, In-Chang;Min, Byung-Whan;Nahm, Seok-Hyeon;Shin, Jong-Sub;Lee, See-Woo;Harn, Chee-Hark
    • Journal of Plant Biotechnology
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    • v.35 no.2
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    • pp.121-126
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    • 2008
  • Protoplasts from cabbage and radish were isolated and fused symmetrically by PEG treatment. The PEG treated mixture of high concentrated protoplasts produced lots of micro-calli after $2{\sim}3$ weeks. The microcalli developed to normal calli and shoots were regenerated from the calli. A total of 218 shoots were regenerated, but none of them contained the NWB-CMS specific DNA marker, indicating that the transfer of the radish NWB-CMS character into cabbage did not occur. However, ISSR analysis revealed that the cell fusion between protoplasts from radish and cabbage was occurred (3 out of 208 plantlet). The fused regenerants possessed the characteristics of source plants used for protoplast fusion. After vernalization, three regenerants were flowered with white petal color as seen in radish. Only three seeds were able to obtain from one regenerant by backcrossing with the cabbage pollen.

Water Quality and Particle Size Distributions of Bridge Road Runoff in Storm Event (강우시 교량도로 유출수 수질 및 입경분포)

  • Cho, Yong-Jin;Lee, Jun-Ho;Bang, Ki-Woong;Choi, Chang-Su
    • Journal of Korean Society of Environmental Engineers
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    • v.29 no.12
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    • pp.1353-1359
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    • 2007
  • Water quality constituents, and particle size distributions were characterized in urban bridge road runoff, Bridge road runoff contains significant loads of micro-particles, heavy metals and organic constituents. Bridge road runoff was monitored on four sites of four and six lanes bridge road areas along with traffic volume. A total seven storm events were monitored to characterize the bridge road runoff. The quantity of road runoff and quality constituents, including chemical oxygen demand(COD), suspended solids(SS), total nitrogen(T-N), ortho-phosphorus$(PO_4-P)$, total phosphorus(T-P), and particle size distribution were analyzed. The results indicate that the concentrations of SS, COD, T-N and T-P ranges were $35\sim2,390$ mg/L, $40\sim1,274$ mg/L, $0.03\sim21.25$ mg/L, and $0.05\sim4.58$ mg/L, respectively. And the results showed that the mean range of particle size and $D_{90}$ for bridge road runoff were $4.75\sim14.05{\mu}m$ and $17.33\sim58.15{\mu}m$, respectively.

Exposure and Toxicity Assessment of Ultrafine Particles from Nearby Traffic in Urban Air in Seoul, Korea

  • Yang, Ji-Yeon;Kim, Jin-Yong;Jang, Ji-Young;Lee, Gun-Woo;Kim, Soo-Hwan;Shin, Dong-Chun;Lim, Young-Wook
    • Environmental Analysis Health and Toxicology
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    • v.28
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    • pp.7.1-7.9
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    • 2013
  • Objectives We investigated the particle mass size distribution and chemical properties of air pollution particulate matter (PM) in the urban area and its capacity to induce cytotoxicity in human bronchial epithelial (BEAS-2B) cells. Methods To characterize the mass size distributions and chemical concentrations associated with urban PM, PM samples were collected by a 10-stage Micro-Orifice Uniform Deposit Impactor close to nearby traffic in an urban area from December 2007 to December 2009. PM samples for in vitro cytotoxicity testing were collected by a mini-volume air sampler with $PM_{10}$ and $PM_{2.5}$ inlets. Results The PM size distributions were bi-modal, peaking at 0.18 to 0.32 and 1.8 to $3.2{\mu}m$. The mass concentrations of the metals in fine particles (0.1 to $1.8{\mu}m$) accounted for 45.6 to 80.4% of the mass concentrations of metals in $PM_{10}$. The mass proportions of fine particles of the pollutants related to traffic emission, lead (80.4%), cadmium (69.0%), and chromium (63.8%) were higher than those of other metals. Iron was the dominant transition metal in the particles, accounting for 64.3% of the $PM_{10}$ mass in all the samples. We observed PM concentration-dependent cytotoxic effects on BEAS-2B cells. Conclusions We found that exposure to $PM_{2.5}$ and $PM_{10}$ from a nearby traffic area induced significant increases in protein expression of inflammatory cytokines (IL-6 and IL-8). The cell death rate and release of cytokines in response to the $PM_{2.5}$ treatment were higher than those with $PM_{10}$. The combined results support the hypothesis that ultrafine particles from vehicular sources can induce inflammatory responses related to environmental respiratory injury.

Characterization of Membrane Fouling and It's Optimal Chemical Cleaning Method in MF Process using D dam water (D댐수를 이용한 정밀여과 공정에서 막오염 특성 및 최적 화학세정방법 조사)

  • Kim, Chung H.;Lim, Jae L.;Lee, Byung G.;Chae, Seon H.;Park, Min G.;Park, Sang H.
    • Journal of Korean Society of Water and Wastewater
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    • v.21 no.5
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    • pp.559-569
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    • 2007
  • The purposes of this study were to find the main foulant of membrane and the optimal chemical cleaning method for MF(microfiltration) drinking water treatment system using D dam water as water source. The MF pilot plant which can treat maximum $500m^3/d$ consisted of 3 racks and was operated for 10 months under various operation conditions. After 10 months operation, $1^{st}$ and $2^{nd}$ rack of membrane pilot plant system were cleaned chemically and the degree of the restoration of the fouled membrane in terms of the pure water flux was detemnined. Inorganic compounds which contained in chemical cleaning waste was analyzed by Inductively Coupled Plasma (ICP). One membrane module for 3rd rack was disjointed and membrane fouling materials, especially inorganic compounds were investigated by Electron Probe Microanlysis (EPMA) to elucidate the reason of TMP increase. And also, the various chemical reagents (1N HCl or $H_2SO_4$, oxalic acid as acid and 0.3% NaOCl as alkali) were tested by combination of acid and alkali to determine the optimal chemical cleaning method for the MF system using micro-modules manufactured using the disjointed module. It was verified that the inside and outside of membrane module was colorized with black. As a result of the quantitative and semi-qualitative analysis of membrane foulant by ICP, most of inorganic foulant was manganese which is hard to remove by inorganic acid such as HCI. Especially, it was observed by EPMA that Mn was attached more seriously in inside surface of membrane than in outside surface of that. It was supposed that Mn fouling in inside surface of membrane might be caused by the oxidation of soluble manganese (Mn(II)) to insoluble manganese ($MnO_2$) by chlorine containing in backwashing water. The optimal cleaning method for the removal of manganese fouling was consecutive cleaning with the mixture of 1N HCl and 1% of oxalic acid, 0.3% NaOCl, and 1N HCl showing 91% of the restoration of the fouled membrane.

Oxidation of Organic Compounds Using $TiO_2$ Photocatalytic Membrane Reactors ($TiO_2$ 광촉매 막반응기를 이용한 유기물의 산화)

  • 현상훈;심세진;정연규
    • Membrane Journal
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    • v.4 no.3
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    • pp.152-162
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    • 1994
  • The photodegradation efficiency of formic acid on $TiO_2$ photocatalytic membranes was investigated. A new titania membrane reactors for purification of water combining microfiltration with photocatalytic degradation of organic compounds were developed. Titania membrane tubes(average pore size of $0.2\mu m$) were prepared by the slip casting, and porous thin films of $TiO_2$ were formed on the tube surface by the sol-gel process to increase the surface area, and consequently to increase photodegradation efficiency of organic compounds. The UV light with the wavelength of 365 nm was used as a light source for photocatalytic reactions. The photodegradation efficiency of the organic compounds was strongly dependent on the flux of the solution, the microstructure of the membrane (sol pH), and the amount of $O_2$ supplied. The effects of the primary oxidant such as $H_2O_2$ and dopants such as $Nb_2O_5$ on the photodegradation efficiency were also investigated. The results showed that more than 80% of formic acid could be degraded using membrane coated with a $TiO_2$ sol of pH 1.45. The photodegradation efficiency could be improved by about 20% when adding $H_2O_2$ in feed solution or doping $TiO_2$ membranes with $Fe_2O_3$.

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A Study of High-Quality Factor Solenoid-Type RF Chip Inductor Utilizing Amorphous $Al_2O_3$ Core Material (비정질 $Al_2O_3$ 코아 재료를 이용한 Solenoid 형태의 고품질 RF chip 인덕터에 관한 연구)

  • Lee, Jae-Wook;Jung, Young-Chang;Yun, Eui-Jung;Hong, Chol-Ho
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.37 no.6
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    • pp.34-42
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    • 2000
  • Recently, there is a growing need to develope small-size RF chip inductors operating to GHz to realize high-performance, micro-fabricated wireless communication products. For the development of high-performance RF chip inductors, however, the ferrite-based chip inductors can not be used above 300MHz due to the limitation of the permeability of this material. In this work, small-size, high-performance RF chip inductors utilizing amorphous $Al_2O_3$ core material were investigated. Copper (Cu) with 40${\mu}m$ diameter was used as the coils and the chip inductor size fabricated in this work is $2.1mm{\times}1.5mm{\times}1.0mm$. The external current source was applied after bonding Cu coil leads to gold pads electro-plated on the bottom edges of a core material. The composition of core materials was measured using a EDX. High frequency characteristics of the inductance (L), quality factor (Q), and impedance (Z) of developed inductors were measured using an RF Impedance/Material Analyzer (HP4291B with HP16193A test fixture). The developed inductors have the self-resonant frequency (SRF) of 1 to 3.5 GHz and exhibit L of 22 to 150 nH. The L of the inductors decreases with increasing the SRF. The Z of the inductors has the maximum value at the SRF and the inductors have the quality factor of 70 to 97 in the frequency range of 500 MHz to 1.5 GHz.

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A 4-bit optical true time-delay for phased array antennas using 2×2 optical MEMS switches and fiber-optic delay lines (2×2 광 MEMS 스위치와 광섬유 지연선로를 이용한 위상배열 안테나용 4-비트 광 실시간 지연선로)

  • 정병민;윤영민;신종덕;김부균
    • Korean Journal of Optics and Photonics
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    • v.15 no.4
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    • pp.385-390
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    • 2004
  • In this paper, we designed a 4-bit optical true time-delay(TTD) for phased array antennas(PAAs), which is composed of a wavelength-fixed optical source, 2 ${\times}$ 2 optical MEMS switches, and fiber-optic delay lines. A 4-bit TTD with a unit time delay difference of 6 ps for 10-GHz PAAs has been implemented. Measurement results on time delay show an error of -0.4 ps at maximum, corresponding to a radiation angle error of less than 1.63$^{\circ}$. Thus, the TTD implemented in this research performs in excellent agreement with theory. Each TTD line, composed of MEMS switches and fiber-optic delay lines, connected to the corresponding antenna element has insertion loss in between 1.36 ㏈ and 2.40 ㏈ depending upon the setup of the switches. On the other hand, the insertion loss difference between TTD lines was 0.32 ㏈ at maximum for a fixed radiation angle. The TTD structure proposed in this paper might be more reliable and economical than those previously proposed using tunable wavelength sources if proper power equalization either with gain control of RF amplifiers or variable attenuators is achieved.

Paleomagnetic Study on Cretaceous Rocks in Haenam Area (해남지역의 백악기 암석에 대한 고지자기 연구)

  • 임무택;이윤수;강희철;김주용;박인화
    • Economic and Environmental Geology
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    • v.34 no.1
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    • pp.119-131
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    • 2001
  • A mean characteristic remanent magnetization was obtained for the first time in Korea from volcanic and pyroclastic sedimentary rocks distributed in Haenam Area, located in southwestern part of the Korean Peninsula. The age of the prevailing rocks in this area belongs mostly to Late Cretaceous, with a few exceptions of Early Cretaceous, mainly based on K/Ar whole rock age dating. Characteristic remanent magnetizations of these have both normal and reverse polarities with antipodal direction, which were interpreted to be the primary remanent magnetizations obtained by the ambient Earth's magnetic field at the time of formation of the concerned rocks. The source magnetic minerals of the remanent magnetization has been identified as magnetite. The mean direction of characteristic remanent magnetization obtained from the Late Cretaceous rocks in this study is Dm/Im=21.4 supper(o)/57.1 supper(o) (${\alpha}_{95}=13.4^{\circ}$, k=350.0). The paleomagnetic pole position calculated from this result for the Late Cretaceous, is $72.5^{\circ}N/199.9^{\circ}E$ (dp/dm= $14.2^{\circ}/19.5^{\circ}E$), which matches well with those of 80 Ma ($76.2^{\circ}N/198.9^{\circ}E$) and 90 Ma ($76.2^{\circ}N/200.1^{\circ}E$) of the Eurasian Continent's APWP (Apparent Polar Wander Path). This result strongly indicates that the studied area, belonging to the Eurasian Continent, have suffered very little geotectonic movement after the Late Cretaceous. The deflection of declination of remanence from Early Cretaceous rocks in the study area may indicate that the micro-block was counterclockwisely rotated with vertical axis between the late of Early Cretaceous and the early of Late Cretaceous.

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A Preliminary Study on the Potential Source of Cadmium in the Boseong-Jangheung Mine District (전남 보성-장흥 광화대의 잠정적 카드뮴원에 대한 예비연구)

  • Heo, Chul-Ho;So, Chil-Sup;Yun, Seong-Taek;Shim, Sang-Kyun
    • Economic and Environmental Geology
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    • v.30 no.1
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    • pp.61-65
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    • 1997
  • Cadmium occurs as a minor element in sphalerite ((Zn, Fe)S) from the Boseong-Jangheung gold-silver mine district. We analyzed the abundance of cadmium in sphalerite using an electron probe micro analyzer (EPMA) and discussed the natural sources of cadmium in terms of bedrock geochemistry, in order to preliminarily reconnoiter the potential cadmium contamination in mine districts. Cadmium contents of sphalerites from the Au-Ag mines (Bodeok, Mundeok, Jeonbo, Boknae, Keumsan) in the Boseong-Jangheung district are considerably high, compared with cadmium contents of sphalerites (average = 0.5 wt.% Cd, maximum = 4.4 wt.% Cd) in the world. Sphalerites from the Keumsan mine (average = 9.49 wt.% Cd, maximum=11.22 wt. Cd) are highly enriched in cadmium. Our data suggest that the Boseong-Jangheung area is an important potential site of cadmium contamination in Korea. Based on bedrock geochemistry, natural causes of cadmium enrichment in sphalerite from the mine district are thought to be the mixing of cadmium leached from organic-rich, metasedimentary rocks (including coal) and/or black shales. From this study, we propose that the pinpointing of potential sites of pollution by toxic heavy metals can be done effectively through detailed reconnaisance study on mineralogical compositions of ore minerals such as sphalerite from the mine area.

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