• 제목/요약/키워드: Micro Needle

검색결과 85건 처리시간 0.025초

염화마그네슘 첨가율에 따른 산화마그네슘 경화체의 물리 및 역학적 특성 (Physical and Mechanical Properties of Magnesium Oxide Matrix depending on Addition Ratio of Magnesium Chloride)

  • 김헌태;정병열;이상수;송하영
    • 한국건축시공학회지
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    • 제14권4호
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    • pp.308-313
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    • 2014
  • 최근 주거건축물의 장수명화를 위해 건축물을 내부공간구성을 벽식구조에서 라멘구조로 변화하면서 경량복합패널의 사용이 증가하는 추세이다. 따라서 본 연구에서는 염화마그네슘 첨가율에 따른 산화마그네슘 경화체의 공학적 특성을 연구하여 경량복합패널의 표면재로 사용하기 위한 기초적 자료로 사용하고자 한다. 실험결과, 염화마그네슘 첨가량이 증가함에 따라 유동성은 증가되었으며, 공기량은 감소하였고, 초결과 종결은 느려졌다. 휨강도와 압축강도에서는 염화마그네슘 첨가율 40%의 시험체가 가장 높은 강도를 발현하였으며, 흡수율의 경우 염화마그네슘 첨가율 20%의 시험체가 가장 낮은 흡수율을 나타내었다. 길이변화에서는 염화마그네슘 첨가율이 증가함에 따라 팽창양이 증가하는 경향을 나타내었으며, 미시구조를 관찰한 결과 바늘형상의 수화생성물을 볼 수 있었다. 이 수화생성물이 광물성 섬유조직 형태를 가지고 있어 높은 휨강도를 발현한 것으로 판단되며, 또한 팽창의 원인으로 판단된다.

다중 알긴산 입자제조를 위한 원심력 기반 미세유체 반응기 개발 (Development of a Centrifugal Microreactor for the Generation of Multicompartment Alginate Hydrogel)

  • 정주언;송강;강성민
    • 공업화학
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    • 제34권1호
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    • pp.23-29
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    • 2023
  • 미세유체 반응기(microfluidic reactor)는 다양한 분야에 적용할 수 있는 새로운 기능성 재료합성을 위해 상당한 발전이 이루어지고 있다. 지난 10년 동안, 미세유체 반응기는 크기, 모양, 조성 및 표면 특성과 같은 물리화학적 (physicochemical) 매개변수를 제어할 수 있는 최종 사용자를 위한 방법론이 주목을 받고 있다. 본 연구에서는 원심력 기반의 미세유체 반응기를 개발하였으며 이를 통해 유도되는 원심력을 이용하여 유체의 흐름을 제어하고 합성되는 다기능성 입자의 다양한 크기 및 조성제어를 수행하였다. 원심력 기반 미세유체 반응기는 실험실에서 쉽게 구할 수 있는 미세바늘, 미세원심분리 튜브, 대용량 원심분리 튜브의 조립을 통해 제작된다. 원심분리기의 회전 속도, 알긴산 전구체의 농도, 칼슘이온의 농도, 그리고 주사침과 칼슘 수용액 간의 거리와 같은 실험적 제어변수 조절을 통해 쉽고 재현성 있게 크기제어가 이루어진 미세입자의 합성이 가능할 뿐만 아니라 복잡한 기술이나 첨단 장비 없이 대량생산이 가능하였다.

아말감의 구강내 부식 및 인공 부식에 관한 연구 (A STUDY ON IN VIVO AND IN VITRO AMALGAM CORROSION)

  • 임병목;권혁춘;엄정문
    • Restorative Dentistry and Endodontics
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    • 제22권1호
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    • pp.1-33
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    • 1997
  • The objective of this study was to analyze the in vitro and in vivo corrosion products of low and high copper amalgams. The four different types of amalgam alloy used in this study were Fine cut, Caulk spherical, Dispersalloy, and Tytin. After each amalgam alloy and Hg were triturated according to the directions of the manufacturer by means of the mechanical amalgamator(Amalgam mixer. Shinhung Co. Korea), the triturated mass was inserted into a cylindrical metal mold which was 12mm in diameter and 10mm in height. The mass was condensed by 150Kg/cm compressive force. The specimen was removed from the mold and aged at room temperature for about seven days. The standard surface preparation was routinely carried out by emery paper polishing under running water. In vitro amalgam specimens were potentiostatically polarized ten times in a normal saline solution at $37^{\circ}C$(potentiostat : HA-301. Hukuto Denko Corp. Japan). Each specimen was subjected to anodic polarization scan within the potential range -1700mV to+400mV(SCE). After corrosion tests, anodic polarization curves and corrosion potentials were obtained. The amount of component elements dissolved from amalgams into solution was measured three times by ICP AES(Inductive Coupled Plasma Atomic Emission Spectrometry: Plasma 40. Perkim Elmer Co. U.S.A.). The four different types of amalgam were filled in occlusal and buccal class I cavities of four human 3rd molars. After about five years the restorations were carefully removed after tooth extraction to preserve the structural details including the deteriorated margins. The occlusal surface, amalgam-tooth interface and the fractured surface of in vivo amalgam corrosion products were analyzed. In vivo and in vitro amalgam specimens were examined and analyzed metallographically by SEM(Scanning Electron Microscope: JSM 840. Jeol Co. Japan) and EDAX(Energy Dispersive Micro X-ray Analyser: JSM 840. Jeol Co. Japan). 1. The following results are obtained from in vitro corrosion tests. 1) Corrosion potentials of all amalgams became more noble after ten times passing through the in vitro corrosion test compared to first time. 2) After times through the test, released Cu concentration in saline solution was almost equal but highest in Fine cut. Ag and Hg ion concentration was highest in Caulk spherical and Sn was highest in Dispersalloy. 3) Analyses of surface corrosion products in vitro reveal the following results. a)The corroded surface of Caulk spherical has Na-Sn-Cl containing clusters of $5{\mu}m$ needle-like crystals and oval shapes of Sn-Cl phase, polyhedral Sn oxide phase. b)In Fine cut, there appeared to be a large Sn containing phase, surrounded by many Cu-Sn phases of $1{\mu}m$ granular shapes. c)Dispersalloy was covered by a thick reticular layer which contained Zn-Cl phase. d)In Tytin, a very thin, corroded layer had formed with irregularly growing Sn-Cl phases that looked like a stack of plates. 2. The following results are obtained by an analysis of in vivo amalgam corrosion products. 1) Occlusal surfaces of all amalgams were covered by thick amorphous layers containing Ca-P elements which were abraded by occlusal force. 2) In tooth-amalgam interface, Ca-P containing products were examined in all amalgams but were most clearly seen in low copper amalgams. 3) Sn oxide appeared as a polyhedral shape in internal space in Caulk spherical and Fine cut. 4) Apical pyramidal shaped Sn oxide and curved plate-like Sn-Cl phases resulted in Dispersalloy. 5) In Tytin, Sn oxide and Sn hydroxide were not seen but polyhedral Ag-Hg phase crystal appeared in internal space which assumed a ${\beta}_l$ phase.

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마이크로 멀티니들을 이용한 고주파 피부미용 의료기기를 위한 출력 장치 개발 (Developed an output device for high-frequency cosmetic medical equipment using micro multi-needle)

  • 김준태;주규태;차은종;김명미;정진형
    • 한국정보전자통신기술학회논문지
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    • 제14권5호
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    • pp.394-402
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    • 2021
  • 고령사회의 진입과 인간의 평균 수명이 연장되고, 여성의 사회적 진출 및 남성들의 외모에 대한 관심증가, 미디어 매체를 통한 K-문화가 전 세계적으로 관심을 받으면서 자연스럽게 관심은 K-Bueaty에 집중되고 있다. 최근, 의료관광 분야의 점유를 보면 성형 및 피부과와 같은 피부미용 의료관광의 경우 중국, 일본 등 아시아뿐만 아니라 북미, 유럽 등에서 인기를 누리고 있다. 사람의 노화를 가장 먼저 외면적으로 확인할 수 있는 부위는 바로 얼굴의 피부 주름이다. 깨끗하고 주름이 없으면서 탄력성 있는 건강한 피부는 대부분의 사람들이 원하는 바람이다. 대표적으로 집속형초음파자극(HIFU:High Intensity Focused Ultrasound)와 저주파, 고주파(RF:Radio Frequency), 미세전류를 이용한 갈바닉 테라피, 급속 냉각을 이용한 크라이오 테라피 등 피부의 컨디션과 상태에 따라 관리하는 방식이 달라지며, 같은 기전을 이용한 의료기기 및 피부미용 기기의 시술 역시 출력 및 자극 부위 등에 따라 시술의 효과가 차이가 난다. 본 연구는 수많은 피부미용 의료기기 및 미용기기 중 마이크로니들을 이용한 침습형 고주파 피부 의료기기를 개발하고자 국제규격인 IEC 60601-2(의료기기개별기준규격)및 MFDS(Ministry of Food and Drug Safety : 식품의약품안전처)에서 고시한 고주파 자극기 기준 규격을 준수한 고주파 출력 장치를 설계 및 개발하였다. 회로 설계는 Class-A Topology를 이용한 증폭장치(AMP:Amplifier)와 Half-Bridge Topology를 이용한 전원장치로 이루어져 있다. 개발된 고주파 출력 장치를 측정한 결과 평균 63.86%의 효율을 얻었으며, 최대출력은 116.7W, 50.67dBm으로 측정되었다.

운동훈련(運動訓練)에 대(對)한 심폐기능(心肺機能)의 적응(適應)에 관(關)한 연구(硏究) (Cardio-pulmonary Adaptation to Physical Training)

  • 조강하
    • The Korean Journal of Physiology
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    • 제1권1호
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    • pp.103-120
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    • 1967
  • As pointed out by many previous investigators, the cardio-pulmonary system of well trained athletes is so adapted that they can perform a given physical exercise more efficiently as compared to non-trained persons. However, the time course of the development of these cardio-pulmonary adaptations has not been extensively studied in the past. Although the development of these training effects is undoubtedly related to the magnitude of an exercise load which is repeatedly given, it would be practical if one could maintain a good physical fitness with a minimal daily exercise. Hence, the present investigation was undertaken to study the time course of the development of cardio-pulmonary adaptations while a group of non-athletes was subjected to a daily 6 to 10 minutes running exercise for a period of 4 weeks. Six healthy male medical students (22 to 24 years old) were randomly selected as experimental subjects, and were equally divided into two groups (A and B). Both groups were subjected to the same daily running exercise (approximately 1,000 kg-m). 6 days a week for 4 weeks, but the rate of exercise was such that the group A ran on treadmill with 8.6% grade for 10 min daily at a speed of 127 m/min while the group B ran for 6 min at a speed of 200 m/min. In order to assess the effects of these physical trainings on the cardio-pulmonary system, the minute volume, the $O_2$ consumption, the $CO_2$ output and the heart rate were determined weekly while the subject was engaged in a given running exercise on treadmill (8.6% grade and 127 m/min) for a period of 5 min. In addition, the arterial blood pressure, the cardiac output, the acid-base state of arterial blood and the gas composition of arterial blood were also determined every other week in 4 subjects (2 from each group) while they were engaged in exercise on a bicycle ergometer at a rate of approximately 900 kg m/min until exhaustion. The maximal work capacity was also determined by asking the subject to engage in exercise on treadmill and ergometer until exhaustion. For the measurement of minute volume, the expired gas was collected in a Douglas bag. The $O_2$ consumption and the $CO_2$ output were subsequently computed by analysing the expired gas with a Scholander micro gas analyzer. The heart rate was calculated from the R-R interval of ECG tracings recorded by an Offner RS Dynograph. A 19 gauge Cournand needle was inserted into a brachial artery, through which arterial blood samples were taken. A Statham $P_{23}AA$ pressure transducer and a PR-7 Research Recorder were used for recording instantaneous arterial pressure. The cardiac output was measured by indicator (Cardiogreen) dilution method. The results may be summarized as follows: (1) The maximal running time on treadmill increased linearly during the 4 week training period at the end of which it increased by 2.8 to 4.6 times. In general, an increase in the maximal running time was greater when the speed was fixed at a level at which the subject was trained. The mammal exercise time on bicycle ergometer also increased linearly during the training period. (2) In carrying out a given running exercise on treadmill (8.6%grade, 127 m/min), the following changes in cardio·pulmonary functions were observed during the training period: (a) The minute volume as well as the $O_2$ consumption during steady state exercise tended to decrease progressively and showed significant reductions after 3 weeks of training. (b) The $CO_2$ production during steady state exercise showed a significant reduction within 1 week of training. (c) The heart rate during steady state exercise tended to decrease progressively and showed a significant reduction after 2 weeks of training. The reduction of heart rate following a given exercise tended to become faster by training and showed a significant change after 3 weeks. Although the resting heart rate also tended to decrease by training, no significant change was observed. (3) In rallying out a given exercise (900 kg-m/min) on a bicycle ergometer, the following change in cardio-vascular functions were observed during the training period: (3) The systolic blood pressure during steady state exercise was not affected while the diastolic blood Pressure was significantly lowered after 4 weeks of training. The resting diastolic pressure was also significantly lowered by the end of 4 weeks. (b) The cardiac output and the stroke volume during steady state exercise increased maximally within 2 weeks of training. However, the resting cardiac output was not altered while the resting stroke volume tended to increase somewhat by training. (c) The total peripheral resistance during steady state exercise was greatly lowered within 2 weeks of training. The mean circulation time during exorcise was also considerably shortened while the left heart work output during exercise increased significantly within 2 weeks. However, these functions_at rest were not altered by training. (d) Although both pH, $P_{co2}\;and\;(HCO_3-)$ of arterial plasma decreased during exercise, the magnitude of reductions became less by training. On the other hand, the $O_2$ content of arterial blood decreased during exercise before training while it tended to increase slightly after training. There was no significant alteration in these values at rest. These results indicate that cardio-pulmonary adaptations to physical training can be acquired by subjecting non-athletes to brief daily exercise routine for certain period of time. Although the time of appearance of various adaptive phenomena is not identical, it may be stated that one has to engage in daily exercise routine for at least 2 weeks for the development of significant adaptive changes.

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