• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.429.1-429.1
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• 2014

We present a method of surface functionalization of a single layer graphene for linking and detecting MDA-MB-231 human breast cancer cell. The methodology is done by utilizing 1-pyrenebutanoic acid and succinimidyl ester for immobiling CD44 antibodies. This work shows that the single layer graphene is an efficient fixing substance to capture the MDA-MB-231 human breast cancer cell, selectively. The immobilization method of the cancer cell on the graphene layer will be an effective cell counting system. Moreover usage of the linking with non-covalent bonding is expected to develope a sensor scheme of electrical cell-detecting diagnosis system.

• Korean Journal of Mathematics
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• v.22 no.4
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• pp.633-644
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• 2014

We get one theorem that there exists a unique solution for the fourth order semilinear elliptic Dirichlet boundary value problem when the number 0 and the coefficient of the semilinear part belong to the same open interval made by two successive eigenvalues of the fourth order elliptic eigenvalue problem. We prove this result by the contraction mapping principle. We also get another theorem that there exist at least two solutions when there exist n eigenvalues of the fourth order elliptic eigenvalue problem between the coefficient of the semilinear part and the number 0. We prove this result by the critical point theory and the variation of linking method.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10a
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• pp.137-140
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• 1996

Finding line segments in an intensity image has been one of the most fundamental issues in computer vision. In complex scenes, it is hard to detect the locations of point features. Line features are more robust in providing greater positional accuracy. In this paper we present a robust "line features extraction" algorithm which extracts line feature in a single pass without using any assumptions and constraints. Our algorithm consists of five steps: (1) edge scanning, (2) edge normalization, (3) line-blob extraction, (4) line-feature computation, and (5) line linking. By using edge scanning, the computational complexity due to too many edge pixels is drastically reduced. Edge normalization improves the local quantization error induced from the gradient space partitioning and minimizes perturbations on edge orientation. We also analyze the effects of edge processing, and the least squares-based method and the principal axis-based method on the computation of line orientation. We show its efficiency with some real images.al images.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.4
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• pp.826-832
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• 2003

This paper presents a new linking methodology of direct load control(DLC) and unit commitment(UC) considering system spinning reserve characteristics. To consider system spinning reserve characteristics, we formulate new constraints. And to link DLC and UC, we employed 3-Dimensional dynamic programming which has DLC state, UC state, and stage. As a result, economical DLC and UC schedule of the power system is possible. This method is applied to the test system, and the usefulness of the method is verified.

• Korean Journal of Applied Biomechanics
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• v.14 no.2
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• pp.1-14
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• 2004

This study was intended to contribute to allowing athletes to raise a technical understanding of two motions of high difficulty such as the Swallow motion and the Nakayama motion and enhance their competitive power by analysing the kinematical factors required to link those two motions on the competitive scene on the rings for current national athletes. For this purpose, the game of the ring event was videotaped for male heavy gymnasts participating in the final elimination match of the 2004 Athens Olympic Games. This study attempted to select the performing motions of the final 1st-and 2nd-place athletes performing the linking motions from the Swallow motion and the Nakayama motion using the DLT(direct linear transformation) method. As a result, it arrived at the following conclusion : A1 properly performed the flexing and extending movements using the angular velocity of the segment and joint as the switching motion using the body at the time of linking the motion from the Swallow skill to the Nakayama skill. A2 was evaluated to perform the skill taking the form of depending on the force at the static state. Therefore, it is thought that A1 should take care of shaking at the time of using the elasticity of the body. It is thought that in case of A2 the proper use of the elasticity of the body take care of shaking at the switching motion while taking advantage of the force will contribute to his competitive power.

• Macromolecular Research
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• v.16 no.3
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• pp.189-193
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• 2008

Thermal cross-linking method of poly(vinyl alcohol) (PVA) using poly(acrylic acid) (PAA) was carried out on PVA/PAA hydrogels. The level of gelation was measured in the PVA/PAA hydrogels with various PAA contents. The swelling behavior at various pHs showed that the swelling kinetics and water contents of the PVA/PAA hydrogels reached equilibrium after 30 h, and the time to reach the equilibrium state decreased with increasing PAA content in the hydrogel. The water content increased with increasing pH of the buffer solution. The permeation and release of the drug were tested using indomethacin as a model drug. The permeated and released amounts of the drug increased with decreasing the PAA content because of the low free volume in the hydrogel due to the higher cross-linking density. The kinetic profile of drug release at various pHs showed that all samples reached the equilibrium state within the 5 h.

• Korean Management Science Review
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• v.28 no.1
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• pp.141-158
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• 2011

This study concerns with an applicability of the management science approach to the score adjustment among the College Scholastic Aptitude Test(CSAT) optional subjects. A linear programming model is developed to minimize the sum of score distortions between optional subjects. Based on the analysis of the 377,089 CSAT(2010) applicants' performances in social science test section, this study proposes a new approach for the score equating or linking method of the educational measurement theory. This study makes up for the weak points in the previous linear programming model. First, the model utilize the standard score which we can get. Second, the model includes a goal programming concept which minimizes the gap between the adjusting goal and the result of the adjustment. Third, the objective function of the linear programing is the weighted sum of the score distortion and the number of applicants. Fourth, the model is applied to the score adjustment problem for the whole 11 optional subjects of the social science test section. The suggested linear programming model is a generalization of the multi-tests linking problem. So, the approach is consistent with the measurement theory for the two tests and can be applied to the optional three or more tests which do not have a common anchor test or a common anchor group. The college admission decision with CSAT score can be improved by using the suggested linear programming model.

• KSBB Journal
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• v.26 no.4
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• pp.352-356
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• 2011

The detection of biomarkers is an important issue for disease diagnosis. However, many systems are not suitable to detect the biomarker itself directly. For direct detection of biomarker proteins in human serum, a new affinity-capture method using aptamers combined with the mass spectrometry was suggested. Since signals from protein samples cannot be amplified, modified chromatin immunoprecipitation (ChIP) and subsequent cross-linking with formaldehyde between aptamers and target proteins were used not to lose the captured target proteins, which allowed us to perform a harsh washing step to remove the non-specifically bound proteins. As a model system, a thrombin aptamer was used as a bait and thrombin as a target protein. Using our modified ChIP and affinity-capture method, non-specific binding proteins on the beads decreased significantly, suggesting that our new method is efficient and can be applied to developing diagnosis systems for various biomarkers.

• Geomechanics and Engineering
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• v.28 no.5
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• pp.437-454
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• 2022

The hydro-mechanical (HM) two-way sequential coupling in the TOUGH2-FLAC3D linking algorithm is validated completely and successfully in both M to H and H to M directions, which are initiated by mechanical surface loading for geomechanical validation and hydrological groundwater pumping for hydrogeological validation, respectively. For such complete and successful validation, a TOUGH2-FLAC3D linked numerical model is developed first by adopting the TOUGH2-FLAC3D linking algorithm, which uses the two-way (fixed-stress split) sequential coupling scheme and the implicit backward time stepping method. Two geomechanical and two hydrogeological validation problems are then simulated using the linked numerical model together with basic validation strategies and prerequisites. The second geomechanical and second hydrogeological validation problems are also associated with the Mandel effect and the Noordbergum and Rhade effects, respectively, which are three phenomenally well-known but numerically challenging HM effects. Finally, sequentially coupled numerical solutions are compared with either analytical solutions (verification) or fully coupled numerical solutions (benchmarking). In all the four validation problems, they show almost perfect to extremely or very good agreement. In addition, the second geomechanical validation problem clearly displays the Mandel effect and suggests a proper or minimum geometrical ratio of the height to the width for the rectangular domain to maximize agreement between the numerical and analytical solutions. In the meantime, the second hydrogeological validation problem clearly displays the Noordbergum and Rhade effects and implies that the HM two-way sequential coupling scheme used in the linked numerical model is as rigorous as the HM two-way full coupling scheme used in a fully coupled numerical model.

• The Journal of the Korea Contents Association
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• v.14 no.9
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• pp.556-566
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• 2014

Objectives : The goal of this paper is to enhance the percentage of linkages between an acupuncture point ontology and an acupuncture treatment ontology. Methods : Terms of the effect from acupuncture points and terms of the treatment method from diseases are selected in the ontologies. We have disassembled the terms into minimum meaning units and then linked them again. Results : By linking terms of the effect and terms of the treatment method, the meaninful information on the acupuncture point and treatment ontology is increased. Conclusions : The links between points for acupuncture points and treatment methods for diseases could improve the information in the ontologies. This also enables the knowledge representation for the use of acupuncture points with accompanied symptoms, causes of disease, and treatment methods.