• Journal of the Korean Society of Clothing and Textiles
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• v.26 no.2
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• pp.181-192
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• 2002

The purpose of this study is to clarify the expression of conceptual image by which the modern graphic artists use for creating new visual images and the characteristics in expression of the major fashion images in fashion illustration. In the present study, major findings on the basis of the analysis of expression of visual images in fashion illustration since 1980s are as follow: The conceptual image expression in the visual arts is based on the eight techniques. They are dual image, operation of image, copying·reproduction of image, deconstruction of image, pictorial image, symbolization of image, mystification of image, and making humorous image. Since 1980s, the major fashion images in fashion illustration are mainly classified as classic image, humor image, fantastic image, natural image, avant-garde image, simple image, casual image and feminine image. The characteristics in expression of these images in fashion illustration are; 1) fortification of dual image in classic image, 2) activation in humor image 3) grotesque fantastic image, 4) the modernization of natural image, etc. In addition that, the image of avant-garde is expressed by Postermodernism, Deconstructionism, Techno etc. since 1980s. Also, simple image of the modern composition, casual image of daily life, and feminine image which is emphasized with eroticism are also included in these characteristic in expression of images since 1980s.

• Journal of Magnetics
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• v.21 no.1
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• pp.141-147
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• 2016

Staphylococcus aureus cultures exposed to rotating magnetic field (RMF) were studied in order to analyse the possible induced changes in staphylococcal enterotoxin genes (se) expression. Liquid cultures of S. aureus strains carrying different se were exposed to the RMF of magnetic frequency 50 Hz and magnetic induction 34 mT for 10 h at $37^{\circ}C$. Three time points of bacterial growth cycle were considered for RNA extractions. Gene expression analyses were evaluated using real-time quantitative PCR method. The present study confirmed, that the RMF can stimulate the growth rate of S. aureus cultures in comparison to the unexposed controls, while the stimulation is not strain dependent. The studies have also shown, that the RMF, depending on the exposure time but regardless the bacterial strain, can influence on the expression of various se. In general, except for sea, as a result of bacterial exposure to the RMF through subsequent growth phases, the expression of se decreased, reaching the values below results recorded for unexposed controls. In the case of sea expression remained at a lower level as compared to the control, regardless the time of exposition.

• Molecules and Cells
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• v.22 no.3
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• pp.262-268
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• 2006

During endometrial differentiation the extracellular matrix (ECM) changes dramatically to prepare for implantation of the embryo. However, the genes regulating the ECM build-up in the uterine endometrium during early pregnancy are not well known. Using the PCR-select cDNA subtraction method, dermatopontin was identified in the uterus of a pregnant mouse on day 4 of gestation. Dermatopontin mRNA increased dramatically on day 3, and was at its highest level at the time of implantation. Administration of RU 486 significantly inhibited mRNA expression by day 4 of gestation, but ICI 182,780 did not. Progesterone markedly induced dermatopontin expression in ovariectomized uteri within 4 h of administration, whereas estrogen had little effect. In silico analysis revealed progesterone receptor binding sites in the dermatopontin promoter region. Decidualization did not induce expression of dermatopontin; instead dermatopontin mRNA became strongly localized at the interimplantation site. In situ hybridization revealed that expression gradually decreased in the luminal epithelial cells as pregnancy progressed, whereas it increased in the stromal cells. The pattern of localization and the changes of intensity of dermatopontin mRNA coincided with those of collagen. Collectively, these results strongly suggest that dermatopontin expression is steroid-dependent. They also suggest that, at the time of implantation, dermatopontin expression is primarily regulated spatio-temporally by progesterone via progesterone receptors, and is modulated by the decidual response during implantation. Dermatopontin may be one of the regulators used to remodel the uterine ECM for pregnancy.

• KOGO NEWS
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• v.6 no.1
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• pp.29-33
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• 2006

Gene set analysis is a new concept and method. to analyze and interpret microarray gene expression data and tries to extract biological meaning from gene expression data at gene set level rather than at gene level. Compared with methods which select a few tens or hundreds of genes before gene ontology and pathway analysis, gene set analysis identifies important gene ontology terms and pathways more consistently and performs well even in gene expression data sets with minimal or moderate gene expression changes. Moreover, gene set analysis is useful for comparing multiple gene expression data sets dealing with similar biological questions. This review briefly summarizes the rationale behind the gene set analysis and introduces several algorithms and tools now available for gene set analysis.

• Korean Institute of Interior Design Journal
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• v.15 no.6 s.59
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• pp.60-67
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• 2006

In modem days when architectural materials have grave impacts on overall design expression, materials for architecture, especially finishing materials have become the most essential elements for the design expression, as architectural space and form have been. When it comes to the architectural materials, they can be conceived by visual and tactile sensory system and perceptional system which based on memory and experience. This study confirms how materials bring into effect on architecture in the sense of its design. The main subject of this analysis is expression method of architectural finishing materials. Also, this study finds out the relationship between finishing materials and the images of materials by analyzing the effect factor of architectural material expression with the perspectives of materials, formal and environments and by examining roles of the architectural materials in design. The material factor, in the expression of materiality, is how to make tectonic space and to vary the surface of building as finishing material design. The formal factor is related to set up the new direction in the architectural form and to create the dynamic and informal space. And the social and cultural environment as the effect factor gives new situation and context to architectural material expression. This principle enables us to use architectural materials as one of the important elements which express the whole characteristics of the area.

• Korean Institute of Interior Design Journal
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• v.27 no.3
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• pp.33-40
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• 2018

As the standard for the value of modern people's life increases, hotels make efforts for the users' qualitative and mental satisfaction. As an approach to hotel space design differentiated for new experiences for travelers, a design that reflects the placeness is needed so that people can experience the local culture and historical meaning of the place. Thus, this study divides the components of placeness into physical factors, socio-cultural factors, and semantic factors. As for methods for the design expression of placeness formation, physical factors are classified as the connection to surrounding environments, center, passage, and area. Socio-cultural factors are classified as cultural experiences in the place. Semantic factors are classified as symbolism and historicity. For a case analysis in this study, overseas four-star hotels or higher, where placeness stood out are analyzed, based on the above-extracted components of placeness. As a result of the analysis, the hotels in the cases showed an aspect of expression that emphasized semantic factors despite there were differences in the detailed expression method, depending on the designers. The expression of the place that reflected locality and temporality showed the connection of time, connecting the past with the present. In the future, only the design expression based on the historical and symbolic meanings of the place will be the experience that remains in the users' memories, very precisely.

• ALGAE
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• v.22 no.2
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• pp.131-139
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• 2007

The expression of genes responding to cold stress in a freshwater alga, Spirogyra varians, was studied by using differential expression gene (DEG) method. A gene strongly up-regulated in 4°C was isolated and designated as SVCR2 (Spirogyra varians cold regulated) gene. The cDNA encoding SVCR2 was cloned using λZAP cDNA library of Spirogyra varians. The deduced amino acid had a sequence similarity with trans-membrane protein in Arabidopsis thaliana (Q9M2D2, 52.7%). Northern blot analysis demonstrated that transcript level of SVCR2 increased about 10 fold under low temperature (4°C), compared with that cultured at warm (20°C) conditions. The expression of SVCR2 was also affected by light conditions. When the plants were exposed to high light (HL) (1200 μmol photon m–2 s–1), the expression of SVCR2 began within 2 hrs. This gene expression lasted for 4 hrs and decreased afterwards. Under the blue light (470 nm) condition, the expression of this gene was induced in same way as HL treatment, even under less than 100 μmol photon m–2 s–1. But red light (650 nm) and UV-A irradiation did not affect the expression of SVCR2.

• Molecules and Cells
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• v.42 no.8
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• pp.579-588
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• 2019

Gene set enrichment analysis (GSEA) is a popular tool to identify underlying biological processes in clinical samples using their gene expression phenotypes. GSEA measures the enrichment of annotated gene sets that represent biological processes for differentially expressed genes (DEGs) in clinical samples. GSEA may be suboptimal for functional gene sets; however, because DEGs from the expression dataset may not be functional genes per se but dysregulated genes perturbed by bona fide functional genes. To overcome this shortcoming, we developed network-based GSEA (NGSEA), which measures the enrichment score of functional gene sets using the expression difference of not only individual genes but also their neighbors in the functional network. We found that NGSEA outperformed GSEA in identifying pathway gene sets for matched gene expression phenotypes. We also observed that NGSEA substantially improved the ability to retrieve known anti-cancer drugs from patient-derived gene expression data using drug-target gene sets compared with another method, Connectivity Map. We also repurposed FDA-approved drugs using NGSEA and experimentally validated budesonide as a chemical with anti-cancer effects for colorectal cancer. We, therefore, expect that NGSEA will facilitate both pathway interpretation of gene expression phenotypes and anti-cancer drug repositioning. NGSEA is freely available at www.inetbio.org/ngsea.

• KSBB Journal
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• v.16 no.4
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• pp.381-388
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• 2001

A program for integrated gene expression profile analysis such as hierarchical clustering, K-means, fuzzy c-means, self-organizing map(SOM), principal component analysis(PCA), and singular value decomposition(SVD) was made for DNA chip data anlysis by using Matlab. It also contained the normalization method of gene expression input data. The integrated data anlysis program could be effectively used in DNA chip data analysis and help researchers to get more comprehensive analysis view on gene expression data of their own.

• Korean Institute of Interior Design Journal
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• v.13 no.5
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• pp.56-65
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• 2004

This study divides the expression techniques of Zaha Hadid into various types who has manipulated her targeted drawings as her unique design tools in the process of architectural design, analyzes them in terms of the vanishing point, visual point for observation and object of observation and attempts to figure out how the multi-visual expression is applied in the conception of form and space and method of observation. By doing so, this study will suggest the characteristics of the expression techniques using multi-visual. Through the above study, the utilization and characteristics of multi-visual expression of the architecture design process of Zaha Hadid are summarized as follows. Firstly, Zaha Hadid utilizes the strained multi-visual perspective technique which can look out over the interaction between masses simultaneously at multi-angles by changing a perspective drawing of vanishing point 1, 2, and 3. Secondly, it utilizes a landscape perspective technique and embodies an Idea of landscape's spatial arrangement through it as the means to search a dynamic relation of architecture, city, land, and space. Thirdly, there is a projected expression using X-ray perspective technique to make the relations between inside and outside of building to three-dimension volume. Zaha Hadid has used the expression techniques using multi-visual by utilizing various points and has developed and used them as her creative tools for idea. By means of escaping from the expression techniques of simple revival, she has used a new expression technique that can represent recognized space. In the past, the content could change the expression techniques in architecture; however, the liberation of architectural expression techniques can change the content in modern times when require new attempts.