• 대한의생명과학회지
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• 제18권3호
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• pp.260-267
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• 2012

Obesity is associated with cardiovascular risk factors, such as dyslipidemia, hypertension and diabetes. However the presence of the obesity related deranged metabolic profiles varies widely among obese individuals. These individuals, known as 'metabolically healthy obese phenotype (MHO)', despite having excessive body fatness, display favorable metabolic profiles characterized by insulin sensitivity, no hypertension, as well as less dyslipidemia, less inflammation. The purpose of this study was to compare cardiac characterization and clinical profile of MHO and Non-MHO (nonmetabolically healthy obese) subjects in men. We measured treadmill exercise capacity (METs) and maximum blood pressure (BP) in 210 subjects through a medical checkup at J General Hospital. Metabolic syndrome was defined according to the modified Adult Treatment Panel III definition criteria. Both MHO and Non-MHO subjects showed statistically significant changes in the left ventricular mass index (P<.001, P<.01, respectively), A-velocity (P<.01, P<.001, respectively), E/A ratio (P<.01, P<.001, respectively), E'-velocity (P<.001, P<.001, respectively), HOMA-IR (P<.01, P<.001, respectively) and maximum systolic BP (P<.01, respectively) compared with the MH-NO (metabolically healthy non obese) subjects. In conclusion, MHO participants were at increased risk of cardiovascular disease and partly metabolic disorder.

• 대한임상검사과학회지
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• 제49권3호
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• pp.248-255
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• 2017

대사적으로 건강한 비만인(metabolically healthy obese, MHO)은 대사적 합병증을 동반하지 않으며, 과도한 체지방에도 불구하고 인슐린 감수성을 유지하는 비만의 표현형이다. 이 연구는 20세 이상 70세 이하의 남성을 대상으로 비만과 대사적 이상 유무에 따라 MHNO, MHO와 MAO군으로 분류하여 간 효소의 차이를 알아보고 대사적으로 건강한 비만남성에서 간 효소가 대사적 이상을 예측할 수 있는 지표인지 그 임상적 의의를 확인하고자 하였다. Executive Summary of The Third Report of The National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) 진단기준으로 대사적 이상을 평가하였으며, 비만 진단기준은 WHO에서 제시하는 아시아인의 기준을 따라 세 군으로 분류하였다. 최종 연구 대상자 9,683명 중 대사적으로 건강한 정상체중군(metabolically healthy non obese, MHNO) 2,878명, 대사적으로 건강한 비만군(metabolically healthy obese, MHO) 5,427명, 대사적으로 이상이 있는 비만군(metabolically abnormal obese, MAO) 1,378명 이었다. AST, ALT, GGT는 MAO군보다 MHO군에서 통계적으로 유의하게 낮았으나(각각 p<0.001), MHO군은 MHNO군보다는 간 효소치가 높게 나타났다(각각 p<0.001). 또한 간 효소는 대사증후군 위험요인과 관련이 있으며, 허리둘레, 공복혈당, 총콜레스테롤, 중성지방, HDL-C은 AST, ALT, GGT에 영향을 미치는 위험요인으로 나타났다. 결론적으로 대사적으로 건강한 비만남성에서 간 효소가 대사적 이상을 예측할 수 있는 지표인 것을 확인하였다.

• Nutrition Research and Practice
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• 제13권6호
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• pp.488-497
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• 2019

BACKGROUND/OBJECTIVES: There are various factors that affect metabolic abnormalities related to obesity. The purpose of this study is to analyze the differences in dietary intakes and body compositions of obese women according to metabolic risks and to classify them as metabolically healthy obese (MHO) or metabolically abnormal obese (MAO). SUBJECTS/METHODS: This study was conducted on 59 obese Korean women aged 19 to 60 years. NCEP-ATPIII criteria were applied and the women classified as MHO (n = 45) or MAO (n = 14). Body composition of each subject was measured by using dual-energy x-ray absorptiometry (DEXA). Three-day food records were used to analyze dietary intake. Eating habits and health-related behaviors were determined through questionnaires. Indirect calorimetry was used to measure resting metabolic rate and respiratory rate. RESULTS: The average age of the subjects was 43.7 years. The analysis of body composition according to phenotype revealed significantly higher body fat mass (P < 0.05), arm fat mass (P < 0.05), and android fat mass (P < 0.05), as measured by DEXA, in the MAO group than in the MHO group. There was no significant difference in the dietary intake of the two groups. However, eating behaviors differed. Compared to the MHO group, the MAO women had a shorter meal time (less than 10 minutes), a preference of oily foods, and a tendency to eat until full. Therefore, the eating habits of MHO women were more positive than those of MAO women. CONCLUSIONS: The results suggest that fat distribution in each body region affects various metabolic abnormalities. A high level of arm fat mass in obese Korean women may increase metabolic risk. In addition, eating habits of obese Korean women are considered to be environmental factors affecting the metabolic phenotype of obese Korean women.

• 대한의생명과학회지
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• 제24권3호
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• pp.245-252
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• 2018

Heart rate recovery (HRR) is simply an indicator of autonomic balance and is a useful physiological indicator to predict cardiovascular morbidity and mortality. The purpose of this study was to compare the differences in HRR between metabolically healthy obesity group and metabolically unhealthy obesity and to ascertain whether heart rate recovery is a predictor of metabolic syndrome. Metabolic syndrome was defined according to the standards of the National Cholesterol Education Program Adult Care Panel III. Obesity was assessed according to WHO Asian criteria. It was classified into three groups of metabolically healthy non-obesity group (MHNO, n=113), metabolically healthy obesity group (MHO, n=66), metabolically unhealthy obesity (MUO, n=18). Exercise test was performed with Bruce protocol using a treadmill instrument. There was no difference in HRR between MHO and MUO ($32.71{\pm}12.25$ vs $25.53{\pm}8.13$), but there was late HRR in MUO than MHNO ($25.53{\pm}8.13$ vs $34.51{\pm}11.80$). HRR in obese was significantly correlated with BMI (r=-0.342, P=0.004), waist circumference (r=-0.246, P=0.043), triglyceride (r=-0.350, P=0.003), HbA1c (r=-0.315, P=0.009), insulin (r=-0.290, P=0.017) and uric acid (r=-0.303, P=0.012). HRR showed a lower prevalence of abdominal obesity, hypertriglyceridemia, and low HDL-cholesterol in the third tertile than in the first tertile. In conclusion, MHO had no difference in vagal activity compared with MHNO, but MUO had low vagal activity. HRR is associated with metabolic parameters and is a useful predictor of abdominal obesity, hypertriglyceridemia, and low HDL-cholesterolemia.

• International Journal of Contents
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• 제13권3호
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• pp.49-58
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• 2017

This is a descriptive research study that classified Korean adults with obesity into those with Metabolically Healthy Obesity and those with Metabolically Unhealthy Obesity based on the data from the fifth and sixth South Korea's National Health and Nutrition Examination Surveys, designed due to the development of information and communication technology, to examine the impacts of obese adults' health behavior factors and mental health factors on their metabolic state. With respect to data analysis, the collected data were analyzed by complex sample statistics. The results of this study can be summarized as follows: Men who were smoking at the time of the survey had a 1.29 times higher probability of inclusion in the MUO group than in the MHO group. Women who had a high stress cognition rate had a 1.02 times higher probability of inclusion in the MUO group than in the MHO group. This study is significant as it provides the basic data for establishing strategies of nursing intervention for the promotion of obese adults' health, and it suggests that it is necessary to develop a program for the promotion of obese adults' health based on these results.