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Comparison of Echocardiogram and Clinical Profile between Metabolically Healthy Obese (MHO) and Non Metabolically Healthy Obese (Non-MHO) Subjects  

Hong, Seung-Bok (Department of Clinical Laboratory Sciences, Juseong University)
Shin, Kyung-A (Department of Laboratory Medicine Bundang Jesaeng Hospital)
Choi, Wan-Soo (Department of Clinical Laboratory Science, Dong-eui Institute of Technology)
Publication Information
Biomedical Science Letters / v.18, no.3, 2012 , pp. 260-267 More about this Journal
Abstract
Obesity is associated with cardiovascular risk factors, such as dyslipidemia, hypertension and diabetes. However the presence of the obesity related deranged metabolic profiles varies widely among obese individuals. These individuals, known as 'metabolically healthy obese phenotype (MHO)', despite having excessive body fatness, display favorable metabolic profiles characterized by insulin sensitivity, no hypertension, as well as less dyslipidemia, less inflammation. The purpose of this study was to compare cardiac characterization and clinical profile of MHO and Non-MHO (nonmetabolically healthy obese) subjects in men. We measured treadmill exercise capacity (METs) and maximum blood pressure (BP) in 210 subjects through a medical checkup at J General Hospital. Metabolic syndrome was defined according to the modified Adult Treatment Panel III definition criteria. Both MHO and Non-MHO subjects showed statistically significant changes in the left ventricular mass index (P<.001, P<.01, respectively), A-velocity (P<.01, P<.001, respectively), E/A ratio (P<.01, P<.001, respectively), E'-velocity (P<.001, P<.001, respectively), HOMA-IR (P<.01, P<.001, respectively) and maximum systolic BP (P<.01, respectively) compared with the MH-NO (metabolically healthy non obese) subjects. In conclusion, MHO participants were at increased risk of cardiovascular disease and partly metabolic disorder.
Keywords
Metabolically Healthy Obese (MHO); Iinsulin sensitivity; Echocardiogram; Clinical profile;
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