• 한국임상보건과학회지
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• 제4권4호
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• pp.742-755
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• 2016

Pupose. This study aimed to analyze the relationship between metabolic syndrome and glaucoma in a middle-aged men over the age of 40's by using the data from the 5th Korean National Health and Nutrition Examination Survey(2010~2012). Methods. The subjects for the analysis were comprised of 410 patients who were at least 40 years or more with metabolic syndrome and glaucoma. The comparison between the metabolic syndrome and glaucoma according to the health demographic characteristics, health behavior and health conditions was analyzed with ${\chi}^2$-test. The complex samples logistic regression analysis was used to calculate the odds ratio of glaucoma according to the health demographic characteristics, health behavior and health conditions and the combination of the comprising factors of the metabolic syndrome. Results. The prevalence of glaucoma among the subjects with metabolic syndrome and glaucoma was significantly higher in the case of females, as their age increased, educational level decreased, income level decreased, who are non-smokers, non-drinkers, with exercising habits of less than 3 days a week (p<0.001). However, the glaucoma OR was significantly high in case of increasing age, with exercising habits of less than 3 days a week, and hypertension (p<0.01), while the OR was significantly low in case of the drinking group (p<0.05). The results of analyzing the odds ratio for the occurrence of glaucoma with the components of metabolic syndrome showed that the OR for glaucoma is significantly low (OR 0.63) in case of concurrently high fasting blood glucose, high triglycerides and low HDL cholesterol levels (p=0.05). Conclusions. Therefore the thorough management of metabolic syndrome and components is needed to prevent glaucoma.

• 대한지역사회영양학회지
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• 제22권1호
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• pp.63-73
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• 2017

Objectives: This study was conducted to survey the related factors of metabolic syndrome of Chinese workers aged 20 years and above. Methods: The study was conducted at three locations in Shandong, China, currently working and took the physical examination (PE) within one year in the area as target participants. Personal characteristics, physical and biochemical results based on the PE, lifestyle habits, and food intake of the participants were used to analyze the relationship with metabolic syndrome. Results: Results showed that overall, thirty-one subjects (22.5%) had metabolic syndrome, twenty males (32.7%) and eleven females (14.2%). Metabolic syndrome was related to age, gender, educational level and occupational type with more risk in male (P < 0.05), people of older age (P < 0.001), low educational level (P < 0.05) and non-office workers (P < 0.01). According to the life style scores, lifestyle evaluation showed specifically alcohol consumption and smoking (P < 0.001) and stress management (P < 0.05) as important factors that were associated with the metabolic syndrome. High calorie (P < 0.01) and carbohydrate (P < 0.01) intakes were observed on male participants with metabolic syndrome in comparison to the non-metabolic syndrome but no significant difference on female participants. Conclusions: This results of this study can be used as significant supporting data to prevent and control metabolic syndrome in Chinese workers.

• 혜화의학회지
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• 제23권1호
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• pp.149-156
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• 2014

A 30 year old female patient suffering from metabolic syndrome, who was diagnosed with hyperglycemia, dyslipidemia and diabetes 2 years ago, was treated with Traditional Korean Medicine including acupuncture, herbal medicine and tuina for one month. After the treatments, her fasting blood sugar level was remarkably decreased (from $304mg/d{\ell}$ to $74mg/d{\ell}$). And the levels of blood lipids were decreased as well ; the level of TG was decreased from $330mg/d{\ell}$ to $90mg/d{\ell}$, the level of total cholesterol was decreased from $217mg/d{\ell}$ to $111mg/d{\ell}$, the level of LDL was decreased from $119mg/d{\ell}$ to $53mg/d{\ell}$). The waist circumference was also decreased from 96 cm to 90.5 cm. Korean Medical therapies may bring a new clue for the treatment of metabolic syndrome with diabetes.

• 근관절건강학회지
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• 제25권2호
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• pp.75-83
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• 2018

Purpose: The purpose of this study is to investigate the effects of an 8-week aquatic exercise program on risk factors of metabolic syndrome and stress in women. Methods: This study employed a non-equivalent control group pretest-posttest design. A total of 35 patients were recruited through a community health center. The data were analyzed with the SPSS 22.0 version program, and the outcome variables were risk factors of metabolic syndrome including abdominal circumference, triglyceride, high density lipoprotein cholesterol, blood pressure, fasting blood glucose, and the level of stress. Results: There was no statistically significant differences in abdominal circumference, triglyceride, high density lipoprotein cholesterol, and blood pressure difference (post-pre) between the experimental and control group. However, there was a significant difference in the stress level. Conclusion: This study result support the beneficial effect of stress management in women on risk reduction for metabolic syndrome. Health professionals consider to develop strategy of the aquatic exercise program to reduce factors of metabolic syndrome.

• Journal of Preventive Medicine and Public Health
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• 제42권3호
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• pp.160-164
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• 2009

Objectives : The objective of this study was to determine the relationship between past smoking and the risk factors for metabolic syndrome. Methods : From January 2007 to December 2007, a total of 3,916 over thirty years old male health screen examinees were divided into the nonsmoking, smoking, ex-smoking groups. The diagnosis of metabolic syndrome was based on the criteria of the NCEP ATP III(Executive Summary of The Third Report of The National Cholesterol Education Program). Metabolic syndrome was defined as the presence of three or more of the following: a blood pressure $\geq$ 130/85 mmHg, a fasting glucose level $\geq$ 110 mg/dL, a HDL-C (High Density Lipoprotein Cholesterol) level < 40 mg/dL, a triglyceride level $\geq$ 150 mg/dL and, a waist circumference men $\geq$ 102 cm, but a waist to hip ratio > 0.90 was used as a surrogate for the waist circumference. Results : After adjustment for age, alcohol consumption and, exercise in the smokers, for the ex-smokers compared with the nonsmokers, the odds ratio (OR) of a lower HDL cholesterol level (<40 mg/dL) was 1.29 (95% CI=1.03-1.61) in the smokers, the ORs of a higher triglyceride level were 1.35 (95% CI=1.09-1.66) in the ex-smokers and, 2.12 (95% CI=1.75-2.57) in the smokers, and the OR of a waist to hip ratio was 1.25 (95% CI=1.03-1.52) in the ex-smokers. When there were over three components of metabolic syndrome in the ex-smokers and smokers as compared with the nonsmokers, the odds ratio against the risk of metabolic syndrome were 2.39 (95% CI=1.00-6.63) and 2.37 (95% CI=1.02-6.46), respectively. Conclusions : The present study suggested that there is an association of smoking with metabolic syndrome in men.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2000년도 International Symposium on Bioinformatics
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• pp.13-16
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• 2000

Microorganisms have been widely employed for the production of useful bioproducts including primary metabolites such as ethanol, succinic acid, acetone and butanol, secondary metabolites represented by antibiotics, proteins, polysaccharides, lipids and many others. Since these products can be obtained in small quantities under natural condition, mutation and selection processes have been employed for the improvement of strains. Recently, metabolic engineering strategies have been employed for more efficient production of these bioproducts. Metabolic engineering can be defined as purposeful modification of cellular metabolic pathways by introducing new pathways, deleting or modifying the existing pathways for the enhanced production of a desired product or modified/new product, degradation of xenobiotics, and utilization of inexpensive raw materials. Metabolic flux analysis and metabolic control analysis along with recombinant DNA techniques are three important components in designing optimized metabolic pathways, This powerful technology is being further improved by the genomics, proteomics, metabolomics and bioinformatics. Complete genome sequences are providing us with the possibility of addressing complex biological questions including metabolic control, regulation and flux. In silico analysis of microbial metabolic pathways is possible from the completed genome sequences. Transcriptome analysis by employing ONA chip allows us to examine the global pattern of gene expression at mRNA level. Two dimensional gel electrophoresis of cellular proteins can be used to examine the global proteome content, which provides us with the information on gene expression at protein level. Bioinformatics can help us to understand the results obtained with these new techniques, and further provides us with a wide range of information contained in the genome sequences. The strategies taken in our lab for the production of pharmaceutical proteins, polyhydroxyalkanoate (a family of completely biodegradable polymer), succinic acid and me chemicals by employing metabolic engineering powered by genomics, proteomics, metabolomics and bioinformatics will be presented.

• The Korean Journal of Physiology
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• 제11권1호
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• pp.37-44
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• 1977

In the previous study of the release, excretion, and plasma concentration of aldosterone in normal Koreans, the author found that urinary aldosterone excretion and aldosterone secretion rate of the Korean who usually take high amount of salt are significantly lower, in compared to Americans, although the plasma concentration is only tended to be low. The control of plasma aldosterone level depends on the secretion rate and the metabolic clearance of the hormone. In this experiments, the metabolic clearance rate of aldosterone was determined in normotensive korean and the effects of adrenal stimulations on the rates were also studied in the same subjects. The metabolic clearance rate of the normal Korean was not significantly different from those of the American, and shown a little increase in response to sodium restriction. These results indicate that the decrease in secretion rate rather than the increase in metabolic clearance Tate is the major factor maintaining lower plasma aldosterone level. After furosemide diuresis, on the contrary, the removal of aldosterone showed significant the decrease despite slight increase of secretion rate. This suggest that the reduction in metabolic clearance rate of the hormone during volume depletion found to be major cause of high plasma concentration. Additional potassium supply produced detectable decrease of metabolic clearance rate, but the changes were smaller than that of secretion rate, which suggested that the higher secretion rate could account for elevated plasma concentration of aldosterone rather than metabolic clearance. Above results also support author's previous evidences that the normal Korean who already adapted to a high sodium diet have ability to produce adequate aldosterone activity without producing detectable changes on the metabolic clearance rate under the condition of sodium restriction with approp riate potassium intake.

• Journal of Microbiology and Biotechnology
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• 제16권6호
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• pp.832-848
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• 2006

Systems biology has recently become an important research paradigm that is anticipated to decipher the metabolic, regulatory, and signaling networks of complex living organisms on the whole organism level. Thus, various research outputs are being generated, along with the development of many tools and resources for systems biology research. Accordingly, this review provides a comprehensive summary of the current resources and tools for systems biology research that will hopefully be helpful to researchers involved in this field. The resources are categorized into the following five groups: genome information and analysis, transcriptome and proteome databases, metabolic profiling and metabolic control analysis, metabolic and regulatory information, and software for computational systems biology. A summary table and some future perspectives are also provided.

• 한방비만학회지
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• 제11권2호
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• pp.1-14
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• 2011

Objectives: Some papers have raised a lot of concerns about relation among the prevalence of metabolic syndrome, serum ferritin and metabolic syndrome. Accordingly, we researched relation between the prevalence of metabolic syndrome and iron state. Methods: A group of 1304 test subjects were gathered in university student medical examination in Sungnam metropolitan city. BIA for body position, body size and blood test were estimated. Results & conclusions: The study represents an adult population of young people in their twenties. Therefore there is so little level for prevalence of metabolic syndrome than have ever known things. And actually, metabolic syndrome was closely connected with so high iron state.

• 대한임상검사과학회지
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• 제46권2호
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• pp.68-74
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• 2014

The purpose of this study is to provide an academic basis regarding the necessity of managing depression and stress among metabolic syndrome patients by understanding 5 components of metabolic syndrome, perceived stress, and degree of depression, and by investigating their association using the national nutrition survey reference. This study was conducted by using mental health surveys and health screening test data of the 5th (2010~2012) primitive data of the national health and nutrition survey. A total of 19,599 respondents over 19 years of age were selected for the final analysis. The level of depression and stress was set as the dependent variable to identify its connection with 5 components of the metabolic syndrome. For the stress recognition, none of the metabolic syndrome components showed a significant correlation. For experiencing the depression symptom, the fasting glucose among the factors showed a significant correlation (p<0.05) among the metabolic syndrome factors. When it falls within the criteria of fasting glucose of metabolic syndrome, it has a great probability of falling under the group who experienced greater depression symptoms. As a result of the analysis by controlling cardiovascular and cerebrovascular disease which is tightly related with metabolic syndrome and depression, this study observed that glucose out of 5 metabolic syndrome components is related with depression.