• Journal of Korean Academy of Nursing
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• v.41 no.6
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• pp.788-794
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• 2011

Purpose: Reduced heart rate variability significantly increases cardiovascular mortality. Metabolic syndrome increases the cardiac autonomic dysfunction. Recently, increasing cardiovascular mortality has been reported in patients with schizophrenia. This study was done to compare heart rate variability between adults with and without schizophrenia and to compare the relationship of heart rate variability to metabolic syndrome in hospitalized patients with schizophrenia. Methods: This was a descriptive and correlational study in which 719 adults without schizophrenia and 308 adults with schizophrenia took part between May and June 2008. We measured the following: five-minute heart rate variability; high-frequency, low-frequency, the ratio of low-frequency to high-frequency, and the Standard Deviation of all the normal RR intervals. Data was also collected on metabolic syndrome, abdominal obesity, triglycerides, HDL cholesterol, blood pressure and fasting glucose. Results: The Standard Deviation of all the normal RR intervals values of heart rate variability indices were $1.53{\pm}0.18$. The low-frequency and high-frequency values of heart rate variability indices were significantly higher in hospitalized patients with schizophrenia ($3.89{\pm}1.36$; $3.80{\pm}1.20$) than those in the healthy participants ($2.20{\pm}0.46$; $2.10{\pm}0.46$). There were no significant differences between the schizophrenic patients with and without metabolic syndrome. Conclusion: The results of this study indicate that schizophrenia patients have significantly lower cardiac autonomic control, but they have significantly higher low-frequency and high-frequency values than those of healthy adults. Use of antipsychotic drug may affect the autonomic nervous system in schizophrenic patients. Metabolic syndrome was not associated with cardiac autonomic control in schizophrenia patients.

• Journal of Korean Biological Nursing Science
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• v.17 no.1
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• pp.11-18
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• 2015

Purpose: The purpose of this study was to analyze the prevalence, risk factors of metabolic syndrome, and lifestyle in religious women by age and metabolic syndrome status between the metabolic syndrome group and the normal group. Methods: As the subjects for this study, 125 religious women in the city of D, H, S, Y, participated in this study. The diagnostic criterion of metabolic syndrome used was the National Cholesterol Education Program Adult Treatment Panel III. Results: The prevalence of metabolic syndrome was higher as the religious women got older. The metabolic syndrome group in their forties showed higher waist circumference, triglycerides, and lower HDL-cholesterol than the normal group. Among those in their fifties, the metabolic syndrome group had higher waist circumference, fasting glucose, triglyceride and lower HDL-cholesterol than the normal group. In their sixties, the metabolic syndrome group had higher fasting glucose, triglyceride and systolic blood pressure than the normal group. Conclusion: The metabolic syndrome group in their forties showed that their practice rate of 'trying to avoid stresses at work', 'taking prescription medicines' was low. For those in their fifties, the practice rate of 'reducing overeating' and 'choice of low fat meats' was low. Finally, in the group of those in their sixties, 'reducing fried foods' was low.

• Korean Journal of Biological Psychiatry
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• v.15 no.3
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• pp.186-193
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• 2008

Objectives : The authors tried to investigate the characteristics of Heart Rate Variability(HRV) among the subjects with metabolic syndrome for testing the possibility of clinical application of HRV in evaluating metabolic syndrome. Methods : We examined the difference of the means of HRV between 122 subjects of metabolic syndrome and 1057 healthy controls using T-test, and the change of means in HRV according to increasing risk factors of metabolic syndrome. Using multiple regression analysis, we examined the association of HRV with the risk factors of metabolic syndrome. Results : The HRV indices including SDNN(Standard Deviation of all normal NN intervals), RMSSD(the square Root of the Mean Squared Differences of successive all normal NN interval), TP(Total Power), LF(Low Freuency), and HF(High Frequency) were significantly lower in the metabolic syndrome group than in the normal control group, and the means of all HRV indices except LF/HF were decreased consistently according to increasing risk factors of metabolic syndrome. The fasting glucose, triglyceride, and waist circumference were dependent factors that contributed significantly to the change of HRV. Conclusion : These findings suggest metabolic syndrome adversely affects cardiac autonomic system and HRV could be a useful method for evaluating metabolic syndrome.

• Environmental Analysis Health and Toxicology
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• v.12 no.3_4
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• pp.43-54
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• 1997

Species, doses and routes extrapolation can be sucessfully carried out by using a physiologically-based pharmacokinetic (PBPK) approach. And PBPK approach to assess risk of hazardous chemicals is reasonable whatever the exposure scenarios are happened. Both partitioning coefficients of chemical between tissue and blood and enzymatic metabolic rate constants are key parameters to build up the PBPK model. In this study, we tried to estimate in vitro metabolic rate constants using a special apparatus instead to measure the in vivo constants which are used to PBPK simulation since the in vitro tests are less expensive and more convenient than in vivo tests. For the purpose, we designed and tested the new system to measure continuously the headspace concentration of VOC. The newly designed system is composed with a diffusion chamber which generates gaseous substrate, a reaction vessel with a recirculating pump to establish a closed system, an autbmatic sampler from a gas phase, a gas chromatography to analyze the headspace. In addition, a cold water condenser is attached between the reaction vessel and pump to reduce the content of gaseous moisture which interferes with chemical analysis. To validate the newly developed methodology, in vitro metabolic rate constants of trichloroethylene (TCE) as a prototype VOC were estimated by simulating observed results with an ACSL program. The simulated results are consistent to those estimated by the other research groups. This finding suggests that our newly designed closed system may be a useful apparatus to estimate in vitro metabolic rate constants for VOC.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.1
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• pp.83-89
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• 2010

If an appliance perceives the location or health condition of a resident in the smart home, it can provide more intelligent service actively. That is, while the conventional appliance is operated by manual input of a resident, the location-based human adaptive appliance detects the resident's information such as location, activity pattern, or health condition by itself and provides the most suitable living condition for the resident autonomously. This paper presents the real-time location-based metabolic rate estimation method that measures the amount of physical activity (metabolic rate) for location-based human adaptive air-conditioner. And, the feasibility of the algorithm is evaluated experimentally on a test bed using the pyroelectric infrared sensor-based indoor location aware system (PILAS) that is a non-terminal-based location-aware system.

• Animal cells and systems
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• v.2 no.1
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• pp.49-53
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• 1998

The winter-resident Korean bats, Murina leucogaster ognevi, show a circadian cycle of thermoregulation and locomotion in summer, as do other bat species in temperate regions. They are most active between dusk and dawn with body temperature (Tb) of 35-4OC, and are usually torpid in their roost sites for the rest of day with their Tb close to ambient temperature (Ta) of around 15C. The present study was conducted to determine thermogenic and thermolabile properties of the heterothermic bats that would influence their daily feeding activities and ultimately, their energy conservation strategy. Testing on active male Murina, resting metabolic rate (RMR, gauged by oxygen consumption rate) at the lower limit of thermoneutral zone (31C) was 2.0 L kq-1 h-1. The regression slope of RMR below the thermoneutral zone (an index of metabolic thermal sensitivity) was -0.38 L $kg^{-l} h^{-1} C^{-1}$. The metabolic rate at the roost Ta (15C) was 4.5 times the lowest RMR in the active state but becomes nearly zero in the torpid state. This implies that by being torpid during daytime (between dawn and dusk), the individual bats would save about 4.7 kcal each day in mid-summer. Interspecific comparisons of thermal metabolic response over a mass scale suggest that the smaller bats show a relatively higher metabolic rate in thermoneutral zone and a greater thermal sensitivity of metabolism, which follows the general principle seen in homeothermic metabolism. Thermolabile features in metabolic responses seem to be fairly common for these bats in conditions other than a fully active state. Types of thermolabile responses and their energetic significance are discussed.

• Genomics & Informatics
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• v.11 no.4
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• pp.263-271
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• 2013

We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. A variation of KLF5 (rs3782933) was genotyped in 62 Korean children. Using multiple linear regression analysis, we developed a model to predict BMR in children. We divided them into several groups; normal versus overweight by body mass index (BMI) and low BMR versus high BMR by BMR. There were no differences in the distributions of alleles and genotypes between each group. The genetic variation of KLF5 gene showed a significant correlation with several clinical factors, such as BMR, muscle, low-density lipoprotein cholesterol, and insulin. Children with the TT had significantly higher BMR than those with CC (p=0.030). The highest muscle was observed in the children with TT compared with CC (p=0.032). The insulin and C-peptide values were higher in children with TT than those with CC (p=0.029 vs. p=0.004, respectively). In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p=0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust $r^2$=1.000, p < 0.001, respectively). We identified a novel association between TT of KLF5 rs3782933 and BMR in Korean children. We could make better use of the variation within KLF5 in a future clinical intervention study of obesity.

• KIEAE Journal
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• v.17 no.5
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• pp.95-100
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• 2017

Purpose: The purpose of this study is to investigate the prior art based on deep learning to objectively calculate the metabolic rate which is the subjective factor for the PMV optimum control and to make a plan for future research based on this study. Methods: For this purpose, the theoretical and technical review and applicability analysis were conducted through various documents and data both in domestic and foreign. Results: As a result of the prior art research, the machine learning model of artificial neural network and deep learning has been used in various fields such as speech recognition, scene recognition, and image restoration. As a representative case, OpenCV Background Subtraction is a technique to separate backgrounds from objects or people. PASCAL VOC and ILSVRC are surveyed as representative technologies that can recognize people, objects, and backgrounds. Based on the results of previous researches on deep learning based on metabolic rate for occupational metabolic rate, it was found out that basic technology applicable to occupational metabolic rate calculation technology to be developed in future researches. It is considered that the study on the development of the activity quantity calculation model with high accuracy will be done.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.1
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• pp.91-98
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• 2005

In order to investigate central metabolic changes in Beijerinckia indica, cells were grown on different carbon sources and intracellular flux distributions were studied under varying concentrations of nitrogen. Metabolic fluxes were estimated by combining material balances with extracellular substrate uptake rate, biomass formation rate, and exopolysaccharide (EPS) accumulation rate. Thirty-one metabolic reactions and 30 intracellular metabolites were considered for the flux analysis. The results revealed that most of the carbon source was directed into the Entner-Doudoroff pathway, followed by the recycling of triose-3-phosphate back to Hexose­6-phosphate. The pentose phosphate pathway was operated at a minimal level to supply the precursors for biomass formation. The different metabolic behaviors under varying nitrogen concentrations were observed with flux analysis.

• Journal of Life Science
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• v.20 no.8
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• pp.1261-1267
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• 2010

The aim of this study was to investigate the combined effects of aerobic training and diacylglycerol ingestion on lipid profiles and resting metabolic rate changes in obese men. The subjects were divided into 3 groups: the Diacylglycerol group (D, n=6), aerobic training group (E, n=6), and diacylglycerol ingestion and aerobic training group (DE, n=6). Diacylglycerol was ingested and aerobic exercise training performed for 12 weeks. The information from the research was calculated through a Windows SPSS/PC+ Ver. 12.0K statistics package to standardize the means and deviations for each group. Then, two-way repeated measures ANOVA was used to evaluate the research hypothesis. Percent body fat, blood lipid profiles and resting metabolic rate changes were tested to evaluate the combined effect of aerobic exercise training and diacylglycerol ingestion. The results of this study were as follows; DG ingestion was shown to have a positive effect on body weight and body fat, while having a negative effect on resting metabolic rate changes. However, aerobic training was shown to have a positive effect on all factors including body weight, body fat, and resting metabolic rate. In conclusion, DG ingestion and exercise training were not shown to have synergistic effects on resting metabolic rate changes, percent body fat and lipid profiles, while aerobic exercise training was shown to have a positive effect on resting metabolic rate changes, percent body fat, and lipid profiles. To investigate the therapeutic effect of DG ingestion and aerobic exercise for obese men, analysis of catecholamine, cAMP, HSL, or insulin sensitivity should be considered.