• 제목/요약/키워드: MetaHuman

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Factors Influencing the Adoption of Cloud Computing in Healthcare Organizations: A Systematic Review

  • Qiu, Hong;Shen, Beimin;Wang, Yuhao;Mei, Yu;Gu, Wenjie
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제16권12호
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    • pp.3960-3975
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    • 2022
  • To analyze and compare the most influencing factors on cloud computing adoption (CCA) in the healthcare organization, a systematic review and meta-analyses of studies was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane collaboration recommendations. A search of PubMed, ScienceDirect, Springer, Wiley Online, and Taylor & Francis Online digital libraries (From inception to January 19, 2022) was performed. A total of 17 studies met the defined studies' inclusion and exclusion criteria. Statistical significance difference favoring most influencing factors on CCA were (MD 0.76, 95% CI -1.48 - 3.01, p <0.00001, I2 = 90%), (MD 1.40, 95% CI -4.76 - 7.55, p < 0.00007, I2 = 97%) (MD 0.17, 95% CI -2.69 - 3.03, p<0.00001, I2 = 96%) for technology vs. organizational, technology vs. environmental and business vs. human factors, respectively. Organizational and environmental factors had greater impacts on CCA compared with technological factors. Moreover, business factors were more influential than the human factors.

Distributions of the GSTM1 and GSTT1 Null Genotypes Worldwide are Characterized by Latitudinal Clines

  • Saitou, Marie;Ishida, Takafumi
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권1호
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    • pp.355-361
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    • 2015
  • Background: Deletion types of genetic variants of glutathione S-transferase (GST) M1 and T1, the GSTM1 null and GSTT1 null which are risk factors for certain cancers, have been ubiquitously found in human populations but their worldwide distribution pattern is unclear. Materials and Methods: To perform a meta-analysis, a systematic search for the literature on GSTM1 and GSTT1 null genotypes was done to identify 63 reports for 81 human populations. Relationships between the GSTM1 and GSTT1 null genotype frequencies and the absolute latitude of 81 populations were tested by Spearman's rank correlation coefficient. Results: A significant positive correlation was detected between the GSTM1 null genotype frequency and the absolute latitude (r=0.28, p-value <0.05), whereas the GSTT1 null genotype frequency and absolute latitude showed a significant negative correlation (r= -0.41 p-value <0.01). There was no correlation between the frequencies of GSTM1 and GSTT1 null genotype in each population (r= -0.029, p-value=0.80). Conclusions: Latitudinal clines of the distribution of the GSTM1 and GSTT1 null genotypes may be attributed to the result of gene-environmental adaptation. No functional compensation between GSTM1 and GSTT1 was suggested by the lack of correlation between the null frequencies for GSTM1 and GSTT1.

안전중시 시스템의 모델기반 설계에서 메타모델을 활용한 기능 고장의 탐지 및 안전 요구사항 검증 (Detection of Functional Failure and Verification of Safety Requirements Using Meta-Models in the Model-Based Design of Safety-Critical Systems)

  • 김영현;이재천
    • 한국산학기술학회논문지
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    • 제17권9호
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    • pp.308-313
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    • 2016
  • 사용자의 요구사항 증대와 기술의 발전으로 인해 현대 시스템은 계속해서 복잡해지고 있어 시스템 설계 오류 및 고장 등으로 인한 시스템 운용 중의 사고도 빈번해지고 있다. 특히 사고로 인한 인적 및 물적 피해가 심각할 수 있는 시스템을 안전중시 시스템이라고 부른다. 이러한 시스템에 대해서는 안전성을 확보하기 위한 특별한 노력이 필요한데 이에 부응하여 본 논문에서는 개발 초기 단계부터 안전성을 반영하면서 시스템 설계를 수행할 수 있는 방법을 연구하였다. 특히 안전 메타모델을 활용해서 기능의 고장 탐지를 수행할 수 있는 시스템 설계 방법을 제시하였다. 구체적으로 국제 안전 표준들을 참고하여 안전 데이터를 추출하고, 시스템 모델링 표준 언어인 SysML을 이용하여 안전 데이터 메타모델을 생성한 후, 시스템 설계에서 안전 데이터 메타모델을 효과적으로 활용하는 모델 기반 안전 시스템 설계 방법을 제시하였고, 이를 기반으로 안전요구사항 생성 및 시뮬레이션 방법에 관하여 논의하였다. 마지막으로 사례연구로서 자동차 시스템 설계에서 SysML 기반 모델링 및 시뮬레이션을 통해 기능 고장의 탐지나 안전 요구사항의 검증이 가능한 것을 보여 주었다. 본 연구에서 안전 데이터에 대한 메타모델의 활용을 통해 안전 데이터 및 정보의 구성 및 관리를 효율적으로 수행할 수 있는 것과, 메타모델 기반 시스템 설계와 시뮬레이션을 활용하여 설계 오류를 줄임으로써 요구사항에 맞는 시스템 설계를 할 수 있음을 제시하였다.

Lack of Prognostic Value of Human Epidermal Growth Factor- Like Receptor 2 Status in Inflammatory Breast Cancer (IBC): a Meta-analysis

  • Li, Xiu-Juan;Zha, Quan-Bin;Xu, Xin-Yu;Xia, Lei;Zhang, Zhe;Ren, Zhao-Jun;Tang, Jin-Hai
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권22호
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    • pp.9615-9619
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    • 2014
  • Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer which is more likely to be her-2/neu amplified. While the her-2/neu status has been utilised to predict prognosis, the published data are inconsistent. The present meta-analysis was conducted to determine whether the her-2/neu status predicts outcomes. Papers were selected from the PubMed database based on defined inclusion and exclusion criteria. Parameters such as total patients, follow-up time and outcome statistics (i.e. overall survival (OS), relapse-free survival (RFS) were collected. The analysis included 6 studies with 2,838 IBC patients. The summary hazards ratio (HR) estimating the association of OS with HER-2-positive disease was 0.96 (95% confidence interval (95%CI: 0.85-1.10)), with similar findings for RFS (HR=0.81, 95%CI: 0.61-1.09). No obvious statistical heterogeneity was detected. This meta-analysis suggests that HER-2-positive status is not an independent adverse prognostic factor for survival among IBC patient cases.

대학 구조개혁평가에 대한 메타평가 준거 개발 연구 : 인적자원개발 관점의 적용 (The Research of Developing Meta-Evaluation Standards of the University Reform Evaluation : in respect of evaluation human resource development)

  • 이태희;김종인
    • 한국산학기술학회논문지
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    • 제18권1호
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    • pp.649-662
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    • 2017
  • 1980년대 이후 우리나라 대학 수와 학생 수는 비약적으로 증가해 왔으나, 급격한 양적인 팽창에 비해 질적인 성장부진은 많은 비판을 받아왔다. 앞으로 2025년까지 학령인구는 급속하게 감소하여 2014년 현재 대입정원 대비 절반 수준이 될 것으로 예상되고 있다. 이로 인해 지방 소재 대학, 전문대학부터 타격을 입게 되면서 전반적인 고등교육 생태계의 황폐화를 초래할 우려가 제기된다. 이에 대해 선제적으로 대응하고자 대학 이해관계자들의 논란 속에서 정원감축을 포함하는 대학 구조개혁을 위해 1주기 대학 구조개혁평가가 실시되었다. 평가결과 하위 등급을 받은 대학들이 거세게 반발하는 등 평가결과를 두고 내홍을 겪고 있는데, 이는 대학 구조개혁평가 평가지표를 포함하는 평가 프로세스에 대한 신뢰도를 문제 삼는 경우로 평가시스템에 대한 불신을 기초로 하고 있다. 2주기, 3주기 대학 구조개혁평가를 앞두고 있는 상황에서 대학 구조개혁평가의 질을 제고하고, 문제점을 진단, 개선하기 위하여 메타평가가 요구된다. 대학 구조개혁평가의 메타평가를 위해서는 평가준거의 개발이 선결되어야 하는데, 기존 교육학적인 연구에 인적자원개발 접근을 더한 학제적 연구가 필요하게 되었다. 본 연구에서는 대학 사회에서 초미의 관심사가 되고 있는 대학 구조개혁평가를 종합적으로 진단, 평가할 수 있는 메타평가 준거를 개발하고, 인적자원개발 관점에서 학제적 접근을 시도하였다. 문헌연구, 전문가좌담회, 설문조사를 통해 대학 구조개혁평가 메타평가 준거로서 총 5개 평가영역, 21개 평가부문, 42개 평가준거로 구성된 ERPOU 모형이 개발되었다. 향후 대학 구조개혁평가를 비롯한 대학평가에 대한 메타평가 연구에 경영학을 비롯한 연구가 촉발되고, 활성화되기를 기대한다.

Mercury exposure is associated with obesity: a systematic review and meta-analysis

  • Jimin Jeon;Kyong Park
    • 대한지역사회영양학회지
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    • 제28권3호
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    • pp.192-205
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    • 2023
  • Objectives: Previous studies have evaluated the association between mercury exposure and obesity but have yielded mixed conclusions. The aim of this study was to systematically review and summarize scientific evidence regarding the association between mercury exposure and obesity in the human population. Methods: We conducted a systematic search of PubMed, Web of Science, Scopus, and Science Direct for articles related to mercury exposure and obesity. Meta-analyses of the highest and lowest categories of mercury levels were evaluated using a random effects model. Begg's test was used to detect publication bias. Results: A total of 9 articles were included. The pooled random effects odds ratio (OR) for mercury exposure and obesity of all 9 studies was 1.66 (95% confidence interval [CI]: 1.16-2.38). This positive association was evident in adults (OR: 1.61, 95% CI: 1.02-2.54) and among studies with Asian populations (OR: 2.00, 95% CI: 1.53-2.59), but not among those with North America/African populations (OR: 0.90, 95% CI: 0.50-1.65). Conclusions: The present meta-analysis identified a positive association between mercury exposure and obesity. These findings suggest that toxic environmental metals such as mercury may be an important risk factor for obesity along with dietary habits and lifestyles.

Soccer league optimization-based championship algorithm (SLOCA): A fast novel meta-heuristic technique for optimization problems

  • Ghasemi, Mohammad R.;Ghasri, Mehdi;Salarnia, Abdolhamid
    • Advances in Computational Design
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    • 제7권4호
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    • pp.297-319
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    • 2022
  • Due to their natural and social revelation, also their ease and flexibility, human collective behavior and teamwork sports are inspired to introduce optimization algorithms to solve various engineering and scientific problems. Nowadays, meta-heuristic algorithms are becoming some striking methods for solving complex real-world problems. In that respect in the present study, the authors propose a novel meta-innovative algorithm based on soccer teamwork sport, suitable for optimization problems. The method may be referred to as the Soccer League Optimization-based Championship Algorithm, inspired by the Soccer league. This method consists of two main steps, including: 1. Qualifying competitions and 2. Main competitions. To evaluate the robustness of the proposed method, six different benchmark mathematical functions, and two engineering design problem was performed for optimization to assess its efficiency in achieving optimal solutions to various problems. The results show that the proposed algorithm may well explore better performance than some well-known algorithms in various aspects such as consistency through runs and a fast and steep convergence in all problems towards the global optimal fitness value.

Lack of Association Between LIG4 Gene Polymorphisms and the Risk of Breast Cancer: A HuGE Review and Meta-analysis

  • Zhou, Li-Ping;Luan, Hong;Dong, Xi-Hua;Jin, Guo-Jiang;Man, Dong-Liang;Shang, Hong
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권7호
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    • pp.3417-3422
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    • 2012
  • Objective: Non-homologous end joining (NHEJ) is one of the pathways of repair of DNA double-strand breaks. A number of genes involved in NHEJ have been implicated as breast cancer susceptibility genes such as LIG4. However, some studies have generated conflicting results. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to investigate association between LIG4 gene polymorphisms in the NHEJ pathway and breast cancer risk. Methods: Studies focusing on the relationship between LIG4 gene polymorphisms and susceptibility to breast cancer were selected from the Pubmed, Cochrane library, Embase, Web of Science, Springerlink, CNKI and CBM databases. Data were extracted by two independent reviewers and the meta-analysis was performed with Review Manager Version 5.1.6 and STATA Version 12.0 software, calculating odds ratios (ORs) with 95% confidence intervals (95%CIs). Results: According to the inclusion criteria, we final included seven studies with a total of 10,321 breast cancer cases and 10,160 healthy controls in the meta-analysis. The results showed no association between LIG4 gene polymorphisms (rs1805386 T>C, rs1805389 C>T, rs1805388 C>T and rs2232641 A>G) and breast cancer risk, suggesting that the mutant situation of these SNPs neither increased nor decreased the risk for breast cancer. In the subgroup analysis by Hardy-Weinberg equilibrium (HWE) and ethnicity, we also found no associations between the variants of LIG4 gene and breast cancer risk among HWE, non-HWE, Caucasians, Asians and Africans. Conclusion: This meta-analysis suggests that there is a lack of any association between LIG4 gene polymorphisms and the risk of breast cancer.

Menopausal Status Modifies Breast Cancer Risk Associated with ESR1 PvuII and XbaI Polymorphisms in Asian Women: a HuGE Review and Meta-analysis

  • Li, Li-Wen;Xu, Lei
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권10호
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    • pp.5105-5111
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    • 2012
  • Background: Published data on the association between single nucleotide polymorphisms (SNPs) in the ESR1 gene and breast cancer susceptibility are inconclusive or controversial. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to derive a more precise estimation of this relationship. Methods: A literature search of Pubmed, Embase, Web of science and CBM databases was conducted from inception through September 1th, 2012. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Results: A total of five studies including 1,678 breast cancer cases and 1,678 general population controls in Asian populations were involved in this meta-analysis. When all the eligible studies were pooled into the meta-analysis, the higher transcriptional activity variant allele T of ESR1 PvuII (C>T) (rs2234693) in pre-menopausal breast cancer women showed a significant relation to increased risk (OR = 1.13, 95%CI: 1.01-1.28, P = 0.040) in contrast to their post-menopausal counterparts which showed non-significant increased risk (OR = 1.01, 95%CI: 0.87-1.18, P = 0.858). Nevertheless, no significant association between ESR1 XbaI (A>G) (rs9340799) polymorphism and the risk of breast cancer was observed in pre-menopausal and post-menopausal individuals. Conclusion: Based on a homogeneous Asian population, results from the current meta-analysis indicates that the ESR1 PvuII (C>T) polymorphism places pre-menopausal breast cancer women at risk for breast cancer, while ESR1 XbaI (A>G) polymorphism is not likely to predict the risk of breast cancer.

Association Between p53 codon 72 Polymorphism and Cervical Cancer Risk Among Asians: a Huge Review and Meta-analysis

  • Zhou, Xin;Gu, Yang;Zhang, Shu-Lan
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권10호
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    • pp.4909-4914
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    • 2012
  • Objective: The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to derive a more precise estimation of the association between p53 codon 72 polymorphism (Arg72Pro, rs1042522 G>C) and cervical cancer risk among Asians. Methods: A literature search of Pubmed, Embase, Web of Science and CBM databases from inception through June 2012 was conducted. The meta-analysis was performed using STATA 12.0 software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. Twenty-eight case-control studies were included with a total of 3,580 cervical cancer cases and 3,827 healthy controls. When all the eligible studies were pooled into the meta-analysis, the results showed that the Pro/Pro genotype was associated with increased risk of cervical cancer under the heterozygous model (Pro/Pro vs. Arg/Pro: OR = 1.25, 95%CI: 1.02-1.53, P= 0.005). However, no statistically significant associations were found under four other genetic models (Pro vs. Arg: OR = 0.97, 95%CI: 0.85-1.10, P= 0.624; Pro/Pro + Arg/Pro vs. Arg/Arg: OR = 0.84, 95%CI: 0.70-1.01, P= 0.058; Pro/Pro vs. Arg/Arg + Arg/Pro: OR = 1.13, 95%CI: 0.92-1.39, P= 0.242; Pro/Pro vs. Arg/Arg: OR = 0.97, 95%CI: 0.76-1.22, P= 0.765; respectively). In the subgroup analysis based on country, the Pro/Pro genotype and Pro carrier showed significant associations with increased risk of cervical cancer among Indian populations, but not among Chinese, Japanese and Korean populations. Conclusion: Results from the current meta-analysis suggests that p53 codon 72 polymorphism might be associated with increased risk of cervical cancer, especially among Indians.