• Journal of Korea Technology Innovation Society
• /
• v.17 no.4
• /
• pp.703-732
• /
• 2014

Meta-evaluation for national R&D programs should be established within the framework of whole R&D system linked with science and technology needs and objectives. The R&D program evaluation system can be understood as a circulation of input, implementation, output, and utilization. In the result of the Delphi survey, which consisted of twenty-four experts (performed in three rounds), twenty-four indices were developed. The meta-evaluation model included sub-items which were important points of view of it as follow (eight items): propriety of planning, sufficiency of information, and propriety of evaluators in evaluation input; appropriateness of method and appropriateness of procedure in evaluation implementation; credibility of output in evaluation output; and usefulness of report and application of evaluation utilization. As the application of the meta-evaluation model, the total mean was lower than 3.0 of the median value of 2.73 (5 point Likert scale). Finally, it was suggested that the feedback of evaluation results should be more enforced to R&D program improvement particularly (evaluation utilization 2.50).

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.2605-2610
• /
• 2012

Background: Studies investigating the association of 2R/3R polymorphism in the thymidylate synthase 5'-untranslated enhanced region (TSER) and colorectal cancer (CRC) risk have reported conflicting results. Thus, a meta-analysis was performed to summarize the data on the potential association. Methods: Pubmed, Embase and CBM databases were searched for all available studies. Links between the TSER 2R/3R polymorphism and CRC risk were estimated by odds ratios (ORs) with 95% confidence intervals (CIs). Results: Seven case-control studies with a total of 2723 cases and 4030 controls were included in this meta-analysis. The results showed that the 3R variant of TSER 2R/3R polymorphism contributes to CRC risk in two comparison models (OR 3R vs. 2R =1.10, 95%CI 1.02-1.18, P = 0.015; OR Homozygote comparison model = 1.22 1.04-1.43, 95%CI 1.04-1.43, P = 0.012). Subgroup analyses by ethnicity further demonstrated a contribution in Caucasians with three comparison models (OR 3R vs. 2R = 1.10, 95%CI 1.02-1.19, P = 0.015; OR Homozygote comparison model = 1.21, 95%CI 1.03-1.41, P = 0.019; OR Recessive comparison model = 1.18, 95%CI 1.05-1.33, P = 0.008). However, the association in the Asian population was still uncertain due to the limited data (all P values were more than 0.05). Conclusions: Our meta-analysis suggests that the 3R variant of Thymidylate synthase 5'-untranslated enhanced region 2R/3R polymorphism contributes to gastric cancer risk in the Caucasian population, while any association in Asian populations needs further study.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.2867-2871
• /
• 2012

Background: Multiple studies have reported associations between the PSCA rs2294008 C > T polymorphism and GC, but susceptibility has proven inconsistent. Therefore, we estimates the relationship between the rs2294008 C > T polymorphism and GC by meta-analysis. Methods: PubMed, Embase and Web of Science databases were searched and nine independent case-control studies were included in this meta-analysis. Crude ORs with 95% CIs were extracted according to the Mantal-Haenszel method and pooled to assess the strength of the association. Results: We observed that the PSCA rs2294008 C > T polymorphism was significantly correlated with GC risk when all studies were pooled into the meta-analysis. Further subgroup analysis showed the polymorphism to be linked with diffuse and noncardia GC in the allele contrast model, homozygote codominant model, dominant model, and recessive model. However, no connection was apparent for intestinal and cardia GC. In the stratified analysis by ethnicity, significant associations were observed in Asians for the recessive model. Interestingly, the relationship was particularly significant in the Chinese population. Conclusions: Our findings suggest that the PSCA rs2294008 C > T polymorphism is a risk factor for GC, especially in diffuse and noncardia GC and in Chinese.

• Journal of the Korea Society of Computer and Information
• /
• v.24 no.12
• /
• pp.85-92
• /
• 2019

Companies can identify user groups or consumption trends by collecting and analyzing opinions of many users on special subjects or their products as well as utilize them as various purposes such as predicting some specific trends or marketing strategies. Therefore current analyzing tools of social media have come into use as a means to measure the performances of social media marketing through network's statistical analysis. However these tools require expensive computing and network resources including burden of costs for building up and operating complex software platforms and much operating know-how. Hence, small companies or private business operators have difficulty in utilizing those social media data effectively. This paper proposes a framework applied into developing analysis system of social media. The framework could be set up and operate the system to extract necessary social media's data. Also to design the system, this study suggests a meta-model of proposed framework and to guarantee completeness and consistency, a formal specification of meta-model by using Z language is suggested. Finally, we could verify the clearness of framework's design by performing Z model checking of formal specification's output through Z-EVES tool.

• The KIPS Transactions:PartD
• /
• v.16D no.3
• /
• pp.381-394
• /
• 2009

As a technique to enhance reusability for the created artifacts in software modeling process, the model driven method such like MDA has been applied. Unfortunately, the hierarchical and systematic MDA based development technique using UML is poor yet. This causes the problem that the MDA modeling with high consistency and reusability based on MDA metamodel is not being realized. To solve this problem, this paper proposes a MDA (PIM/PSM) component modeling technique using 2+1 view integrated metamodel. At first, the meta-architecture view model which can represents development process view and MVC view is defined. Then, the hierarchical integrated metamodels per view are addressed separately for modeling process and MVC at metamodel level on the hierarchy of the defined meta-architecture view model. These metamodels are defined hierarchically by layering the modeling elements in PIM and PSM pattern for UML models and GUI models. Appling the proposed metamodel to an ISMS application system, it is shown as a component modeling case study based on MDA. Through this approach, we are able to perform a component model with consistency and hierarchy corresponding to development process and MVC way. Accordingly, this may improve more independence and reusability of model.

• Proceedings of the Korea Association of Crystal Growth Conference
• /
• 1997.10a
• /
• pp.1-5
• /
• 1997

The growth mechanism of AMT(Ammonium Meta-Tungstate) crystal was interpreted as two-step model. The contribution of the diffusion step increased with the increase of temperature, crystal size, and supersaturation. The crystal size distribution from a batch cooling crystallizer was predicted by the numerical solution of a mathematical model which uses the kinetics of nucleation and crystal growth. Temperature control of a batch crystallizer was studied using Learning control algorithm. The purity of AMT crystal producted in this investigation was above 99.99%.

• Journal of KIISE:Computer Systems and Theory
• /
• v.27 no.1
• /
• pp.34-43
• /
• 2000

Replicated data that is used for fault tolerant distributed system requires replica control protocol to maintain data consistency. The one of replica control protocols is quorum consensus method which accesses replicated data by getting majority approval. If site failure or communication link failure occurs and any one can't get quorum consensus, it degrades the availability of data managed by quorum consensus protocol. So it needs for ghost to replace the failed site. Because ghost is not full replica but process which has state information using meta data, it is important to simplify meta data. In order to maintain availability and simplify meta data, we propose a method to use cohort set as ghost's meta data. The proposed method makes it possible to organize meta data in 2N+logN bits and to have higher availability than quorum consensus only with cohort set and dynamic linear voting protocol. Using Markov model we calculate proposed method's availability to analyze availability and compare it with existing protocols.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.21
• /
• pp.9241-9247
• /
• 2014

Background: Rs31489 in the cleft lip and palate transmembrane1-like gene (CLPTM1L) has been identified to be associated with lung cancer through genome-wide association studies (GWAS). However, some recent replication studies yielded inconclusive results. Thus, we undertook this study to investigate the precise effect of rs31489 on lung cancer susceptibility. Materials and Methods: A hospital-based case-control study in 1,673 Chinese subjects (611 individuals with lung cancer and 1,062 controls) and a meta-analysis among 32,199 subjects (16,364 cases and 15,835 controls) were performed in this study. Results: In our case-control study, rs31489 was inversely associated with lung cancer (AC versus CC: OR=0.68, 95%CI=0.52-0.88; additive model: OR=0.68, 95%CI=0.54-0.85; dominant model: OR=0.65, 95%CI =0.51-0.84). Stratification analysis by smoking status showed a significant association and strong genetic effect in non-smokers but not in smokers. Our meta-analysis further confirmed the association, although with significant heterogeneity contributed by study design and source of controls, as shown by stratified analysis. Sensitive and cumulative analyses both indicated robust stability of our results. In addition, there was no observable publication bias in our meta-analysis. Conclusions: Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.8
• /
• pp.3285-3291
• /
• 2015

Background: Non-synonymous polymorphisms in XRCC1 hase been shown to reduce effectiveness of DNA repair and be associated with risk of certain cancers. In this study we aimed to clarify any association between XRCC1 Arg399Gln and colorectal cancer (CRC) risk by performing a meta-analysis of published case-control studies. Materials and Methods: PubMed and Google Scholar were searched to explore the association between XRCC1 and CRC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength. Publication bias was assessed by Egger's and Begg's tests. Results: Up to January 2015, 35 case control studies involving 9,114 CRC cases and 13,948 controls were included in the present meta-analysis. The results showed that the Arg399Gln polymorphism only under an allele genetic model was associated with CRC risk (A vs. G: OR 0.128, 95% CI 0.119-0.138, p<0.001). Also, this meta-analysis suggested that the XRCC1 Arg399Gln polymorphism might associated with susceptibility to CRC in Asians (A vs G: OR 0.124, 95% CI 0.112-0.138, p<0.001) and Caucasian (A vs G: OR 0.132, 95% CI 0.119-0.146, p<0.001) only under an allele genetic model. Conclusions: This meta-analysis confirms the association between XRCC1 Arg399Gln polymorphism and CRC risk and suggests that the heterogeneity is not strongly modified by ethnicity and deviation from the Hardy-Weinberg equilibrium.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.39 no.1
• /
• pp.19-26
• /
• 2015

This paper proposes a design method for improving the frequency-domain performance reliability of dynamic systems with uncertain and degrading components. Discrete frequencies are used in this method as surrogates for the frequency band of interest, and the conformance of the frequency responses to the specification at these frequencies is utilized to model the frequency-domain performance reliability. A meta-model for the frequency responses, an extreme-value event, and the set-theory are integrated to improve the computational efficiency of the reliability estimation. In addition, a sample-based approach is presented to evaluate and optimize the estimated performance reliability. A case study of a vibration absorber system showed that the proposed design method has engineering applications.