• 한국노년학
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• 제38권3호
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• pp.435-452
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• 2018

본 연구는 체계적 리뷰 및 메타분석 방법을 활용하여 한국에서 발행된 노인 자원봉사활동에 대한 다양한 연구 결과를 체계적으로 수집하여 노인의 심리사회적 건강에 미치는 자원봉사활동의 효과를 계량적이고 종합적인 결과로 제시하는 데 그 목적이 있다. 6개의 데이터베이스와 3개의 홈페이지에서 발견한 연구 중 포함조건을 충족한 총 47편의 연구가 분석에 활용되었고, 추출된 데이터의 수는 53개였다. R 프로그램을 활용하여 평균 효과 크기를 산출한 결과, 생활만족도에 대한 노인 자원봉사활동의 평균 효과 크기는 r=0.340이었으며, 우울은 r=-0.310이었다. 이러한 결과는 노인의 심리사회적 건강을 위해 자원봉사활동이 효과적임을 보여주며, 정책과 실천영역에서 자원봉사활동 제공의 근거가 된다.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.361-375
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• 2018

We aimed to compare the efficacy and safety of long-acting injectable (LAI) and oral second-generation antipsychotics (SGAs) in treating schizophrenia by performing a systematic review and meta-analysis. MEDLINE, EMBASE, PsycINFO, CINAHL, and the Cochrane Library, as well as five Korean databases, were systemically searched to identify studies published from 2000 to 16 April 2015, which compared the efficacy and safety of LAI and oral SGAs. Using data from randomized controlled trials (RCTs), meta-analyses were conducted. In addition, the GRADE (the Grading of Recommendations, Assessment, Development and Evaluation) approach was applied to explicitly assess the quality of the evidence. A total of 30 studies including 17 RCTs and 13 observational studies were selected. The group treated with LAI SGAs was characterized by significantly lower relapse rates, longer times to relapse and fewer hospital days, but also by a higher occurrence of extrapyramidal syndrome and prolactin-related symptoms than that in the group treated with oral SGAs. Our findings demonstrate that there is moderate to high level of evidence suggesting that in the treatment of schizophrenia, LAI SGAs have higher efficacy and are associated with higher rates of extrapyramidal syndrome and prolactin-related symptoms. Additionally, the use of LAI SGAs should be combined with appropriate measures to reduce dopamine $D_2$ antagonism-related symptoms.

• 한국콘텐츠학회논문지
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• 제19권9호
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• pp.338-347
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• 2019

본 연구에서는 노인의 삶의 질 향상을 위한 정책과 실천적 제언을 제공하려는 목적으로 노인의 심리 정서적 변인과 노인의 삶의 질에 대한 메타분석을 실시하였다. 총 65편의 학술지 논문을 선정해 위험요인과 보호요인으로 구분하여 메타분석을 진행한 결과, 심리 정서적 변인의 위험요인은 우울, 고독, 외로움, 불안, 스트레스 순으로 중간효과크기가 나타났으며 자살생각과 죽음불안은 작은 효과크기를 보였다. 보호요인으로는 자아존중감이 가장 큰 효과크기를 보였고 자아효능감, 자아통제 순으로 효과크기가 나타났다. 본 연구를 통해서 우울이 노인의 삶의 질에 중요한 영향요인이 되고 있음을 확인할 수 있었으며 노인의 삶의 질 향상을 위해서 우울을 조기발견하고 개입할 수 있는 게이트키퍼의 활용과 찾아가는 상담서비스의 확대가 필요하며 자살생각이나 죽음불안을 경감시키기 위해 죽음준비교육을 일반화시키고 자아존중감을 높이기 위해 노인에게 적합한 일자리를 창출하고 재능기부 및 자원봉사활동 참여 기회의 확대를 제언하였다.

• 한국콘텐츠학회논문지
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• 제19권3호
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• pp.649-658
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• 2019

본 연구의 목적은 국내에서 수행된 산후우울 중재프로그램의 현황을 파악하고 효과를 알아보기 위함이다. 2018년 11월까지 보고된 국내 학술지 논문 중, 13편의 실험연구를 선별하여 최종 분석에 사용하였다. 연구대상자의 평균 연령은 26.9~34.4세로, 산모 또는 산모와 배우자를 대상으로 하였다. 표본크기는 실험군 6~39명 (평균 20.4), 대조군 5~40명 (평균 20.0)이었고, 중재프로그램의 구성은 0.5~12주/2~14회기/1회 당10~120분으로 이루어졌다. 모든 연구의 설계는 비동등성 대조군전후실험설계였다. 주요 종속변수인 산후우울, 피로도, 모성역할자신감은 메타분석 결과 모두 통계적으로 유의미한 중간 수준 이상의 효과크기를 가지는 것으로 확인되었다. 본 연구는 국내에서 산후우울을 중재하기 사용되는 다양한 실험연구들의 구성과 효과를 확인하였다. 이는 최적의 산후우울 중재프로그램을 구성하기 위한 구체적인 근거기반자료로 활용될 수 있을 것이다.

• 한국게임학회 논문지
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• 제19권2호
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• pp.33-44
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• 2019

본 연구는 게임놀이치료 프로그램으로 발표된 국내 학위와 학술지 논문 중 아동을 대상으로 한 연구논문 32편(2004~2017년)을 최종 선정하여 그 효과성에 대한 메타 분석을 실시하였다. 그 결과 전체 효과 크기는 0.971로 큰 효과크기를 보였다. 변인별 효과크기로 대상별은 장애아동이, 연령별로는 3~5세가, 종속변인으로는 심리적변이 가장 큰 효과 크기를 보고 진행 절차별 효과 크기로 구성원 수는 11~15명, 총 회기는 16회기 이상, 주당 회기 수는 기타, 회기 당 소요시간은 61~90분이 가장 큰 효과 크기를 보였다. 게임놀이치료 프로그램에 대하여 총체적이고 객관적으로 분석한 최초의 연구라는 점에서 그 의의가 크며 임상현장에서 게임놀이치료 프로그램을 실시할 때 치료를 설계하는데 기초적인 자료로 활용될 수 있을 것을 기대한다.

• The Korean Journal of Pain
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• 제34권3호
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• pp.271-287
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• 2021

Background: Postoperative pain management is crucial for patients undergoing total knee arthroplasty (TKA). There have been many recent clinical trials on post-TKA peripheral nerve block; however, they have reported inconsistent findings. In this meta-analysis, we aimed to comprehensively analyze studies on post-TKA analgesia to provide evidence-based clinical suggestions. Methods: We performed a computer-based query of PubMed, Embase, the Cochrane Library, and the Web of Science to retrieve related articles using neurothe following search terms: nerve block, nerve blockade, chemodenervation, chemical neurolysis, peridural block, epidural anesthesia, extradural anesthesia, total knee arthroplasty, total knee replacement, partial knee replacement, and others. After quality evaluation and data extraction, we analyzed the complications, visual analogue scale (VAS) score, patient satisfaction, perioperative opioid dosage, and rehabilitation indices. Evidence was rated using the Grading of Recommendations Assessment, Development, and Evaluation approach. Results: We included 16 randomized controlled trials involving 981 patients (511 receiving peripheral nerve block and 470 receiving epidural block) in the final analysis. Compared with an epidural block, a peripheral nerve block significantly reduced complications. There were no significant between-group differences in the postoperative VAS score, patient satisfaction, perioperative opioid dosage, and rehabilitation indices. Conclusions: Our findings demonstrate that the peripheral nerve block is superior to the epidural block in reducing complications without compromising the analgesic effect and patient satisfaction. Therefore, a peripheral nerve block is a safe and effective postoperative analgesic method with encouraging clinical prospects.

• The Korean Journal of Pain
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• 제35권1호
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• pp.43-58
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• 2022

Background: Current therapies are quite unsuccessful in the management of neuropathic pain. Therefore, considering the inhibitory characteristics of GABA mediators, the present systematic review and meta-analysis aimed to determine the efficacy of GABAergic neural precursor cells on neuropathic pain management. Methods: Search was conducted on Medline, Embase, Scopus, and Web of Science databases. A search strategy was designed based on the keywords related to GABAergic cells combined with neuropathic pain. The outcomes were allodynia and hyperalgesia. The results were reported as a pooled standardized mean difference (SMD) with a 95% confidence interval (95% CI). Results: Data of 13 studies were analyzed in the present meta-analysis. The results showed that administration of GABAergic cells improved allodynia (SMD = 1.79; 95% CI: 0.87, 271; P < 0.001) and hyperalgesia (SMD = 1.29; 95% CI: 0.26, 2.32; P = 0.019). Moreover, the analyses demonstrated that the efficacy of GABAergic cells in the management of allodynia and hyperalgesia is only observed in rats. Also, only genetically modified cells are effective in improving both of allodynia, and hyperalgesia. Conclusions: A moderate level of pre-clinical evidence showed that transplantation of genetically-modified GABAergic cells is effective in the management of neuropathic pain. However, it seems that the transplantation efficacy of these cells is only statistically significant in improving pain symptoms in rats. Hence, caution should be exercised regarding the generalizability and the translation of the findings from rats and mice studies to large animal studies and clinical trials.

• Journal of Periodontal and Implant Science
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• 제52권4호
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• pp.261-281
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• 2022

Purpose: Short implants are a potential alternative to long implants for use with bone augmentation in atrophic jaws. This meta-analysis investigated the survival rate and marginal bone level (MBL) of surface-modified short vs. long implants. Methods: Electronic and manual searches were performed for articles published between January 2010 and June 2021. Twenty-two randomized controlled trials (RCTs) comparing surface-modified short and long implants that reported the survival rate with at least 1 year of follow-up were selected. Two reviewers independently extracted the data, and the risk of bias and quality of evidence were evaluated. A quantitative meta-analysis was performed regarding survival rate and MBL. Results: The failure rates of surface-modified short and long implants differed significantly (risk ratio, 2.28; 95% confidence interval [CI], 1.46, 3.57; P<0.000). Long implants exhibited a higher survival rate than short implants (mean follow-up, 1-10 years). A significant difference was observed in mean MBL (mean difference=-0.43, 95% CI, -0.63, -0.23; P<0.000), favoring the short implants. Regarding the impact of surface treatment in short and long implants, for hydrophilic sandblasted acid-etched (P=0.020) and titanium oxide fluoride-modified (P=0.050) surfaces, the survival rate differed significantly between short and long implants. The MBL differences for novel nanostructured calcium-incorporated, hydrophilic sandblasted acid-etched, and dual acid-etched with nanometer-scale calcium phosphate crystal surfaces (P=0.050, P=0.020, and P<0.000, respectively) differed significantly for short vs. long implants. Conclusions: Short surface-modified implants are a potential alternative to longer implants in atrophic ridges. Long fluoride-modified and hydrophilic sandblasted acid-etched implants have higher survival rates than short implants. Short implants with novel nanostructured calcium-incorporated titanium surfaces, hydrophilic sandblasted acid-etched surfaces, and dual acid-etched surfaces with nanometer-scale calcium phosphate crystals showed less marginal bone loss than longer implants. Due to high heterogeneity, the MBL results should be interpreted cautiously, and better-designed RCTs should be assessed in the future.

• 동의신경정신과학회지
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• 제33권4호
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• pp.401-424
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• 2022

Objectives: As effective treatments for dementia are lacking in Western medicine, complementary and alternative medicine (CAM) is considered a useful option. While the quality of life (QoL) is a vital outcome for patients with dementia, the QoL of patients receiving CAM for dementia remains ambiguous. This study aimed to determine the effect of CAM on QoL outcomes in dementia patients. Methods: A search was performed using the keywords "dementia," "Alzheimer's," "cognitive impairment," "Chinese," "Korean," "oriental," "herbal," "acupuncture," and "quality of life". All quantitative data were synthesized using R version 4.1.1. Results: Twenty-five randomized controlled trials (RCTs), 16 pre-post trials, and two cohort studies were selected for the systematic review. QoL in Alzheimer's disease (QOL-AD) (n=11, 25.6%) and geriatric QoL in dementia (GQOL-D, n=9, 20.9%) were the most utilized QoL instruments. Significant benefits in QoL were observed after receiving mind, body, combined mind and body, nursing, oriental medicine, and acupuncture therapies. In the meta-analysis, the combined effect was shown to significantly increase QOL-AD compared to before CAM interventions (standardized mean difference, SMD: 0.507; 95% confidence interval (CI), 0.191~0.824; p<0.01). The overall synthesized estimates in the GQOL-D showed a significantly improved QoL (SMD: 0.537, 95% CI: 0.238~0.837 p<0.01; one group; SMD: 1.465, 95% CI: 0.934~1.996, p<0.01). The seven studies assessing the cost-effectiveness of CAM reported uncertain outcomes. Conclusions: This study showed that CAM interventions benefited patients with dementia by improving their QoL. While additional standardized research is required, CAMs are suggested as effective clinical management for patients with dementia. They are also suggested as complementing therapies for these patients.

• 시스템엔지니어링학술지
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• 제18권2호
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• pp.75-93
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• 2022

Machine learning (ML) data-driven meta-model is proposed as a surrogate model to reduce the excessive computational cost of the physics-based model and facilitate the real-time prediction of a nuclear power plant's transient response. To forecast the transient response three machine learning (ML) meta-models based on recurrent neural networks (RNNs); specifically, Long Short Term Memory (LSTM), Gated Recurrent Unit (GRU), and a sequence combination of Convolutional Neural Network (CNN) and LSTM are developed. The chosen accident scenario is a control element assembly withdrawal at power concurrent with the Loss Of Offsite Power (LOOP). The transient response was obtained using the best estimate thermal hydraulics code, MARS-KS, and cross-validated against the Design and control document (DCD). DAKOTA software is loosely coupled with MARS-KS code via a python interface to perform the Best Estimate Plus Uncertainty Quantification (BEPU) analysis and generate a time series database of the system response to train, test and validate the ML meta-models. Key uncertain parameters identified as required by the CASU methodology were propagated using the non-parametric Monte-Carlo (MC) random propagation and Latin Hypercube Sampling technique until a statistically significant database (181 samples) as required by Wilk's fifth order is achieved with 95% probability and 95% confidence level. The three ML RNN models were built and optimized with the help of the Talos tool and demonstrated excellent performance in forecasting the most probable NPP transient response. This research was guided by the Systems Engineering (SE) approach for the systematic and efficient planning and execution of the research.