• 산업공학
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• 제17권4호
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• pp.407-413
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• 2004

Recently, many enterprises are adopting EAI (Enterprise Application Integration) technologies for integrating heterogeneous enterprise information systems. Among EAI levels, data-level integration is relatively straightforward and most popular. However, most commercial solutions provide complex functionalities and are expensive for implementing the data integration tasks at the small & medium enterprises. Also, they have their own proprietary architectures and have a restricted interoperability. Proposed in this paper is the development of a data integration middleware for facilitating data exchanges between the heterogeneous information systems. The main feature of this middleware is a explicit mapping of meta data about the relationships between source and target data. Based on this explicit mapping, users who do not have expertise in information technology at the small & medium enterprises can easily execute data exchange tasks among various information systems.

• International Journal of Knowledge Content Development & Technology
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• 제13권1호
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• pp.75-100
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• 2023

With research data generation on the rise, Institutional Repositories (IR) are one of the tools to manage it. However, the variety of data practices across institutions, domains, communities, etc., often requires dedicated studies in order to identify the research data management (RDM) require- ments and mapping them to IR features to support them. In this study, we investigated the data practices for a few national universities in North Macedonia, including 110 participants from different departments. The methodology we adopted to this end enabled us to derive some of the key RDM requirements for a variety of data-related activities. Finally, we mapped these requirements to 6 features that our participants asked for in an IR solution: (1) create (meta)data and documentation, (2) distribute, share, and promote data, (3) provide access control, (4) store, (5) backup, and (6) archive. This list of IR features could prove useful for any university that has not yet established an IR solution.

• Journal of Acupuncture Research
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• 제28권6호
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• pp.1-17
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• 2011

Objectives : This study aimed to review randomized controlled trials of acupuncture performed in South Korea that used sham acupuncture as a control group. Methods : The following databases were searched through the end of September 2011: Koreanstudies information service system (KISS), Korean medical database (KMbase), national discovery OR science leaders (NDSL), oriental medicine advance searching integrated system (OASIS), and research information service system (RISS). The following search terms were used: acupuncture AND (sham or placebo). The reference lists of searched articles and Korea institute of oriental medicine (KIOM) reports(2005~2009) were identified. The following data were extracted: year/first author, disease, number of participants, blinding, intervention, outcome, and result. Where appropriate, we performed meta-analysis. The methodological quality was assessed according to the Jadad scale and 'risk of bias' by Cochrane Handbook procedure. Results : Twenty-nine studies were included in this review. In eighteen studies, penetrating sham controls were used as the control intervention, whereas the remaining eleven studies adopted non-penetrating sham controls such as the Park Sham Device or blunt auricular acupuncture. Nine studies showed statistically significant difference in outcomes. Twelve studies concerning insomnia after stroke, chronic tension-type headache, idiopathic Parkinson's disease, Hwa-Byung, and smoking cessation were included in meta-analysis. A meta-analysis of insomnia after stroke only found significant difference(MD -4.31, 95% Cl -6.19 to -2.42, $p$<0.00001). In general, all of the studies showed low methodological quality(Jadad score: mean 2.1). Risk of bias by Cochrane Handbook procedure varied. Conclusions : The results of this study could not suggest conclusive evidence that acupuncture is more effective than sham acupuncture in several diseases. In the future, more studies with rigorous acupuncture trials using sham controls should be conducted.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8051-8055
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• 2014

Background: A common genetic variant rs3757318, located in intron of C6orf97, was firstly identified to be associated with breast cancer (BC) risk by a genome-wide association (GWA) study. However, subsequent validation studies with different ethnicities have yielded conflicting results. Materials and Methods: We performed a meta-analysis to synthesize all available data for evaluating the precise effect of this variant on BC susceptibility. Results: A total of 8 articles containing 11 studies with 62,891 cases and 65,635 controls were included in this meta-analysis. When compared to the G allele, the rs3757318-A allele was significantly associated with BC risk with the pooled OR of 1.21 (95% CI=1.15 - 1.29, P<0.001) but with obvious between-study heterogeneity (P=0.040). Stratified analysis suggested that diversity of ethnicity along with control source may explain part of the heterogeneity. Similarly, significant associations were also identified in heterozygote, homozygote, dominant and recessive genetic models. Sensitivity and publication bias analyses indicated robust stability of our results. Conclusions: Our present meta-analysis demonstrated that the variant rs3757318 is associated with increased BC risk. Nevertheless, further studies are needed to clarify the underlying biological mechanisms.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4449-4454
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• 2014

Aim: Helicobacter pylori (H. pylori) have been considered as a risk factor for many cancers. We conducted this meta-analysis to clarify the association between H. pylori infection and the risk of pancreatic cancer. Methods: We searched the Medicine/Pubmed and Embase databases, studies about the association between H. pylori infection and pancreatic cancer published up to Jan.2014 were included. Finally, a total of 9 studies were used for this a meta-analysis. The odds ratios (ORs) and 95% confidence interval (95%CI) of H. pylori infection on pancreatic cancer with respect to control groups were evaluated. Two authors independently assessed the methodological quality and extracted data. This meta-analysis was conducted using software, state (version 12.0) to investigate heterogeneity among individual studies and to summarize the studies. Using the fixed-effects or random-effects model, depending on the absence or presence of significant heterogeneity. Sensitivity analysis was performed to assess the influence of each individual study on the pooled ORs by omitting a single study each time. Publication bias was evaluated by funnel plot, using Egger's and Begg's tests. Results: There was no significant association between H. pylori infection and pancreatic cancer risk in the summary ORs,(OR=1.06, 95%CI: 0.74-1.37) through the random-effect method, but heterogeneity among studies was significant ($I^2$=58.9%), so we put the studies into two subgraphs (eastern and western). The results about western (OR=1.14 95%CI:0.89, 1.40) showed heterogeneity among the western countries of $I^2$=6.6%, with no significant association between Hp+ and pancreatic cancer, but the eastern countries (OR=0.62, 95%CI:0.49, 0.76), $I^2$=0, suggested that decreasing pancreas-cancer risk in subjects with Hp+ infection. Simultaneously, 7 studies examined CagA+ strains was (OR=0.84 95%CI:0.63, 1.04), $I^2$=36% with the random-effect method, subgraphs indicated that CagA+ could decrease the risk of pancreatic cancer in the eastern subjects (OR=0.66, 95%CI:0.52-0.80), but the association was not statistically significant in the western subjects (OR=0.95, 95%CI:0.73, 1.16). Conclusion: Hp+ and CagA+ infection are associated with a decreased risk of pancreatic cancer in eastern populations but have no significant associations in western countries.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4689-4695
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• 2014

Background: A great number of studies have shown that cytochrome P450 1A1 (CYP1A1) genetic polymorphisms, CYP1A1 Msp I and CYP1A1 Ile/Val, might be risk factors for digestive tract cancers, including esophageal cancer (EC), gastric cancer (GC), hepatic carcinoma (HC), as well as colorectal cancer (CC), but the results are controversial. In this study, a meta-analysis of this literature aimed to clarify associations of CYP1A1 genetic polymorphisms with digestive tract cancers susceptibility in Chinese populations. Materials and Methods: Eligible case-control studies published until December 2013 were retrieved by systematic literature searches from PubMed, Embase, CBM, CNKI and other Chinese databases by two investigators independently. The associated literature was acquired through deliberate search and selection based on established inclusion criteria. Fixed-effects or random-effects models were used to estimate odds ratios (ORs and 95%CIs). The meta-analysis was conducted using Review Manager 5.2 and Stata 12.0 softwares with stability evaluated by both stratified and sensitivity analyses. Moreover, sensitivity analysis and publication bias diagnostics confirmed the reliability and stability. Results: Eighteen case-control studies with 1,747 cases and 2,923 controls were selected for CYP1A1 MspI polymorphisms, and twenty case-control studies with 3, 790 cases and 4, 907 controls for the CYP1A1 Ile/Val polymorphisms. Correlation associations between CYP1A1 Ile/Val polymorphisms and digestive tract cancers susceptibility were observed in four genetic models in the meta-analysis (GG vs AA:OR= 2.03, 95%CI =1.52- 2.72; AG vs AA: OR=1.26, 95%CI =1.07-1.48; [GG+AG vs AA] :OR =1.42, 95%CI=1.20-1.68, [GG vs AA+AG]:OR=1.80, 95%CI =1.40-2.31). There was no association between CYP1A1 Msp I polymorphisms and digestive tract cancers risk. Subgroup analysis for tumor type showed a significant association of CYP1A1 Ile/Val genetic polymorphisms with EC in China. However, available data collected by the study failed to reveal remarkable associations of GC or HC with CYP1A1 Ile/Val genetic polymorphisms and EC, GC or CC with CYP1A1 MspI genetic polymorphisms. Conclusions: Our results indicated that CYP1A1 Ile/Val genetic polymorphisms, but not CYP1A1 Msp I polymorphisms, are associated with an increased digestive tract cancers risk in Chinese populations. Additional well-designed studies, with larger sample size, focusing on different ethnicities and cancer types are now warranted to validate this finding.

• 한국산학기술학회논문지
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• 제18권1호
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• pp.649-662
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• 2017

1980년대 이후 우리나라 대학 수와 학생 수는 비약적으로 증가해 왔으나, 급격한 양적인 팽창에 비해 질적인 성장부진은 많은 비판을 받아왔다. 앞으로 2025년까지 학령인구는 급속하게 감소하여 2014년 현재 대입정원 대비 절반 수준이 될 것으로 예상되고 있다. 이로 인해 지방 소재 대학, 전문대학부터 타격을 입게 되면서 전반적인 고등교육 생태계의 황폐화를 초래할 우려가 제기된다. 이에 대해 선제적으로 대응하고자 대학 이해관계자들의 논란 속에서 정원감축을 포함하는 대학 구조개혁을 위해 1주기 대학 구조개혁평가가 실시되었다. 평가결과 하위 등급을 받은 대학들이 거세게 반발하는 등 평가결과를 두고 내홍을 겪고 있는데, 이는 대학 구조개혁평가 평가지표를 포함하는 평가 프로세스에 대한 신뢰도를 문제 삼는 경우로 평가시스템에 대한 불신을 기초로 하고 있다. 2주기, 3주기 대학 구조개혁평가를 앞두고 있는 상황에서 대학 구조개혁평가의 질을 제고하고, 문제점을 진단, 개선하기 위하여 메타평가가 요구된다. 대학 구조개혁평가의 메타평가를 위해서는 평가준거의 개발이 선결되어야 하는데, 기존 교육학적인 연구에 인적자원개발 접근을 더한 학제적 연구가 필요하게 되었다. 본 연구에서는 대학 사회에서 초미의 관심사가 되고 있는 대학 구조개혁평가를 종합적으로 진단, 평가할 수 있는 메타평가 준거를 개발하고, 인적자원개발 관점에서 학제적 접근을 시도하였다. 문헌연구, 전문가좌담회, 설문조사를 통해 대학 구조개혁평가 메타평가 준거로서 총 5개 평가영역, 21개 평가부문, 42개 평가준거로 구성된 ERPOU 모형이 개발되었다. 향후 대학 구조개혁평가를 비롯한 대학평가에 대한 메타평가 연구에 경영학을 비롯한 연구가 촉발되고, 활성화되기를 기대한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8637-8644
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• 2016

Background: Malignant serous effusions (MSE) are one complication in patients with advanced cancer. Endostar is a new anti-tumor drug targeting vessels which exerts potent inhibition of neovascularization. This study aimed to systematically evaluate the efficacy and safety of intraperitoneal perfusion therapy of Endostar combined with platinum chemotherapy for malignant serous effusions (MSE). Materials and Methods: Randomized controlled trials (RCTs) on intraperitoneal perfusion therapy of Endostar combined with platinum chemotherapy for malignant serous effusions were searched in the electronic data of PubMed, EMBASE, Web of Science, CNKI, VIP, CBM and WanFang. The quality of RCTs was evaluated by two independent researchers and a meta-analysis was performed using RevMan 5.3 software. Results: The total of 25 RCTs included in the meta-analysis covered 1,253 patients, and all literature quality was evaluated as "B" grade. The meta-analysis showed that Endostar combined with platinum had an advantage over platinum alone in terms of response rate of effusions (76% vs 48%, RR=1.63, 95%CI: 1.50-1.78, P<0.00001) and improvement rate in quality of life (69% vs 44%, RR=1.57, 95%CI: 1.42-1.74, P<0.00001). As for safety, there was no significant difference between the two groups in the incidences of nausea and vomiting (35% vs 34%, RR=1.01, 95%CI: 0.87-1.18, P=0.88), leucopenia (38% vs 38%, RR=1, 95%CI: 0.87-1.15, P=0.99), and renal impairment (18% vs 20%, RR=0.86, 95%CI: 0.43-1.74, P=0.68). Conclusions: Endostar combined with platinum by intraperitoneal perfusion is effective for malignant serous effusions, and patient quality of life is significantly improved without the incidence of adverse reactions being obviously increased.

• 한국환경보건학회지
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• 제32권4호
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• pp.304-315
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• 2006

This study is performed to reexamine the association between ambient air pollution and daily mortality in seven major cities of Korea using a method of meta-analysis with the data filed for the period 1998-2001. These cities account for half of the Korean population (about 23 million). The observed concentrations of carbon monoxide (CO, mean=1.08 ppm), ozone ($O_3$, mean=33.97 ppb), particulate matter less than 10 ${\mu}m$ ($PM_{10},\;mean=57.11\;{\mu}g/m^3$), nitrogen dioxide ($NO_2$, mean=25.09 ppb), and sulfur dioxide ($SO_2$, mean=9.14 ppb) during the study period were at levels below Korea's current ambient air quality standards. Generalized additive models were applied to allow for the highly flexible fitting of seasonal and long-term time trends in air pollution as well as nonlinear associations with weather variables, such as air temperature and relative humidity. Also, we calculated a weighted mean as a meta-analysis summary of the estimates and its standard error. In city-specific analyses, an increase of $41.17{\mu}g/m^3(IQR)\;of\;PM_{10}$ corresponded to $1{\sim}12%$ more deaths, given constant weather conditions. Like most of air pollution epidemiologic studies, this meta-analysis cannot avoid fleeing from measurement misclassification since no personal measurement was taken. However, we can expect that a measurement bias be reduced in district-specific estimate since a monitoring station is better representative of air quality of the matched district. Significant heterogeneity was found for the effect of all pollutants. The estimated relative risks from meta-like analysis increased compared to those relative risks from pooled analysis. The similar results to those from the previous studies indicated existence of health effect of air pollution at current levels in many industrialized countries, including Korea.

• 한국보육지원학회지
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• 제8권1호
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• pp.25-44
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• 2012

본 연구는 지난 10년간의 보육교사 이직의도와 관련된 선행연구를 바탕으로 이직의도를 억제하는 변인들의 효과크기를 메타분석을 통해 검증하였고 메타회귀분석을 통해 조사시기와 조사지역에 따른 변화추이를 검증하였다. 연구대상으로는 분석을 위해 효과크기 변환이 가능한 논문 33편을 선정하였다. 연구결과 이직의도와 관련된 억제변인군의 효과크기는 조직외면적, 직무, 조직내면적변인군 순으로 나타났고, 세변인군 모두 중간효과크기를 가지고 있는 것으로 나타났다. 조직외면적변인군의 하위변인은 근로시간의 효과크기가 가장 큰 것으로 나타났으며, 직무변인군의 하위변인은 교사효능감과 직무만족이 큰 효과크기를 가진 것으로 나타났다. 또한 조직내면적변인군의 하위변인은 대인관계와 원장과의 관계의 관계가 큰 효과크기를 가진 것으로 나타났다. 조사대상, 조사년도에 따른 이직의도 억제와 관련된 변인의 메타회귀분석 결과 모든 연구 개념들이 통계적으로 유의미한 차이가 없는 것으로 나타났다. 그러나 변인들에 대한 상관분석 결과, 복지후생은 수도권외지역보다 수도권지역일 수록 효과크기가 큰 것으로 나타났다.