• Clinical and Experimental Pediatrics
• /
• v.62 no.6
• /
• pp.206-212
• /
• 2019

Purpose: The present study aimed to determine the prevalence of childhood obesity and overweight in Iranian children under 5 years of age using a systematic review and meta-analysis. Methods: We searched MEDLINE (PubMed), Web of Science, Google Scholar, Scopus, CINHAL, and the Iranian databases, including Scientific Information Database (www.sid.ir), Iranian Research Institute for Information Science and Technology (Irandoc.ac.ir), Iranmedex (www.iranmedex.com), and Magiran (www.magiran.com), for all articles published between January 1989 and August 2017. Sources of heterogeneity were determined using subgroup analysis and meta-regression. Results: Six articles were ultimately included in the meta-analysis to estimate the pooled prevalence, based on which the prevalence of obesity and overweight were estimated to be 8% (95% confidence interval [CI], 6%-10%) and 9% (95% CI, 7%-11%), respectively. The results of the subgroup analysis showed that the prevalence of obesity in boys and girls was 9% (95% CI, 6%-13%) and 7% (95% CI, 4-10%), respectively, and the prevalence of overweight in boys and girls was 10% (95% CI, 5%-15%) and 9% (95% CI, 5%-13%), respectively. Conclusion: Despite high heterogeneity among the results of the articles included in the meta-analysis, the prevalence of obesity and overweight is higher in Iranian children under 5 years of age. Therefore, parents and the health system must pay more attention to the lifestyle, nutritional habits, and physical activity of these children.

• Journal of Korean Academy of Nursing
• /
• v.51 no.4
• /
• pp.414-429
• /
• 2021

Purpose: This systematic review and meta-analysis analyzed the effects of 2% chlorhexidine bathing on the incidence of hospital-acquired infection (HAI) and multidrug-resistant organisms (MDRO) in adult intensive care units. Methods: PubMed, CINAHL, Cochrane library, and RISS database were systematically searched, and 12 randomized studies were included in the analysis. Comprehensive Meta-Analysis version 3.0 was used to calculate the effect size using the odds ratio (OR) and a 95% confidence interval (CI). Subgroup analysis was performed according to the specific infection and intervention types. Results: In general, 2% chlorhexidine bathing has a significant effect on the incidence of HAI (OR, 0.59; 95% CI, 0.40~0.86) and MDRO (OR, 0.52; 95% CI, 0.34~0.79). Subgroup analyses show 2% chlorhexidine bathing is effective in bloodstream infections (OR, 0.51; 95% CI, 0.39~0.66) but not for urinary tract infections, ventilator-associated pneumonia infections, and Clostridium difficile infections. Moreover, 2% chlorhexidine bathing alone or its combination with other interventions has a significant effect on the incidence of HAI and MDRO (OR, 0.59; 95% CI, 0.38~0.92). Conclusion: This meta-analysis reveals that 2% chlorhexidine bathing significantly reduces the incidence of HAI and MDRO in intensive care units. The effect of 2% chlorhexidine bathing on pediatric patients or patients at general wards should be further assessed as a cost-effective intervention for infection control.

• Journal of The Korean Society of Integrative Medicine
• /
• v.10 no.3
• /
• pp.37-52
• /
• 2022

Purpose : The purpose of this meta-analysis was to evaluate the effects of electrical stimulation on patients with non-specific low back pain. Methods : Domestic databases were gathered from studies that conducted clinical trials associated with electrical stimulation and its impact on pain of non-specific low back patients. A total of 681 studies were identified, with 12 studies satisfying the inclusion data. The studies consisted of patient, intervention, comparison, outcome, and study design (PICO-SD). The search outcomes were items associated with low back pain. Cochrane risk of bias 2 (RoB 2) was used to evaluate the quality of 12 randomized controlled trials. Effect sizes (Hedges's g) in this study were computed as the corrected standard mean difference (SMD). A random-effect model was used to analyze the effect size because of the high heterogeneity among the studies. Egger's regression and 'trim-and-fill' tests were carried out to analyze the publication bias. Cumulative meta-analysis and sensitivity analysis were conducted to analyze the effect according to the sample size and the consistency of the effect size. Results : The following factors had a large overall effect size (Hedges's g=1.28, 95 % CI=.20~2.36) involving electrical stimulation on non-specific low back pain. The subgroup analysis all showed a statistical difference in the types of study design, electrical stimulation, and assessment tool. No statistically significant difference was found in the meta-regression analysis. Publican bias was found in the data. Conclusion : The findings in this study indicate that electrical stimulation interventions have a positive effect on patients with non-specific low back pain. However, due to the low quality of studies and publication bias, the results of our study should be interpreted cautiously.

• Journal of the Korean Applied Science and Technology
• /
• v.40 no.1
• /
• pp.123-134
• /
• 2023

This study presents a meta-analysis research to test the improve effects of obesity and blood lipids on Salicronia herbacea L. (S. herbacea) intake in rats. Individual research materials were selected from database such as PubMed, Embase, RISS, DBpia, and NDSL. The Review Manager 5.3 version was used to estimate effect size through meta-analysis. A total of 9 studies were finally included. Body weight gains were decreased in S. herbacea-treated groups as compared to the high fat diet groups. But, no significant effect was observed on FER, liver index, and total cholesterol. In addition, the effect size of triglyceride was reduced, whereas high density lipoprotein (HDL)-cholesterol was increased in S. herbacea-treated group. In this meta-analysis, the results indicated that S. herbacea have a strong effect on anti-obesity through the blood lipids improvement.

• The korean journal of orthodontics
• /
• v.53 no.6
• /
• pp.374-392
• /
• 2023

Objective: Assess and evaluate the different indicators of oral health-related quality of life (OHRQoL) among patients treated with clear aligners (CAs) versus those treated with conventional fixed orthodontics (FAs). Methods: An electronic search was performed on the database is Web of Science, Scopus, and Embase databases. Randomized and non-randomized control trials, cross-sectional, prospective cohort and retrospective trials were included. Quality was assessed with risk of bias tool and risk of bias in non-randomised studies. Meta-analyses were performed with random effects models, estimating the standardized and non-standardized mean differences, odds ratio and risk ratio as the measure of effect. The effect on time was determined using a meta-regression model. Results: Thirty one articles were included in the qualitative synthesis and 17 in the meta-analysis. CAs had a significantly lower negative impact on QoL, with an "important" effect size, while the influence of time was not significant. Periodontal indicators plaque index (PI), gingival index (GI), probing depth (PD), and bleeding on probing show significantly better values in patients treated with CAs, with moderate to large effect sizes. PI and GI have a significant tendency to improve over time. In microbiological indicators, CAs present a lower biofilm mass without differences in the percentage of patients with high counts of Streptococcus mutans and Lactobacilli bacteria. The risk of white spot lesion onset is ten times lower in carriers of CAs. Conclusions: Patients wearing CAs show better periodontal indicators, less risk of white spot development, less biofilm mass and a better QoL than patients with FAs.

• The Journal of Internal Korean Medicine
• /
• v.45 no.4
• /
• pp.549-567
• /
• 2024

Objectives: This study was aimed at evaluating the effectiveness and safety of Danggui buxue decoction (DBD) for iron deficiency anemia (IDA) by systematic review and meta-analysis of the randomized controlled trials (RCTs). Methods: Randomized controlled trials on the treatment of DBD for IDA patients were selected from among the literature published from the beginning of each database to May 30, 2023 in nine domestic and foreign databases (PubMed, EMBASE, Cochrane, Chinese Academic Journals (CAJ), CiNii Research, J-STAGE, Oriental Medicine Advanced Searching Integrated System (OASIS), Research Information Sharing Service (RISS), and ScienceON). The quality of the literature was evaluated using the Cochrane ROB tool 2.0 (ROB2) and GRADE method. The meta-analysis was conducted using RevMan5.4. Results: A total of 636 patients with IDA were finally selected from the 7 RCTs. The meta-analysis showed that the treatment groups that underwent both DBD and conventional treatment were statistically higher than the control groups that performed only conventional treatment in all indicators that showed effectiveness of DBD such as red blood cell (mean difference (MD) 0.38×10¹²/L, 95% CI: 0.16-0.60), hemoglobin (MD 12.45 g/L, 95% CI: 10.27-14.63), serum ferritin (MD 3.50 ㎍/L, 95% CI: 1.71-5.29), and total effective rate (relative risk (RR) 1.13, 95% CI: 1.05-1.21). The incidence of adverse events was 0.39 times lower in the DBD group than in the conventional group (RR 0.39, 95% CI: 0.22-0.70). Conclusion: This study demonstrated the effectiveness and safety of DBD with conventional treatment and further provided a basis for administering DBD to patients with IDA in clinical treatment.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.9
• /
• pp.4417-4421
• /
• 2012

Objective: The results from studies on associations of the glutathione S-transferase T1 (GSTT1) gene polymorphism and hepatocellular carcinoma (HCC) risk in Chinese populations are still conflicting. This meta-analysis was performed to evaluate the relationship in detail. Methods: Eligible reports were recruited into this meta-analysis from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database). Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Results: Eighteen investigations were identified for the analysis of association between polymorphic deletion of GSTT1 and HCC, consisting of 2,693 patients with HCC and 4,696 controls. Null genotype of GSTT1 was associated with HCC susceptibility in Chinese (OR=1.53, 95%CI: 1.28-1.82; P<0.00001). Conclusion: The GSTT1 null genotype is associated with HCC susceptibility in Chinese.

• Journal of the Korean Society for information Management
• /
• v.16 no.1
• /
• pp.157-174
• /
• 1999

This investigation used meta-analysis to examine the quality of data of domestic ST(Science & Technical) databases. Analyses measured the quality of data itself, determined whether these databases have any critical errors in terms of accuracy, completeness, and consistency by conducting the data retrieval experiments. The purpose of this study was to diagnose the science & technical databases and to find out the problems of them and also to provide possible suggestions for their improvements. The researcher concluded the results by mentioning the three research questions.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.1
• /
• pp.457-461
• /
• 2013

Prostate cancer is a leading cause of death in male populations across the globe. With the advent of gene expression arrays, many microarray studies have been conducted in prostate cancer, but the results have varied across different studies. To better understand the genetic and biologic mechanisms of prostate cancer, we conducted a meta-analysis of two studies on prostate cancer. Eight key genes were identified to be differentially expressed with progression. After gene co-expression analysis based on data from the GEO database, we obtained a co-expressed gene list which included 725 genes. Gene Ontology analysis revealed that these genes are involved in actin filament-based processes, locomotion and cell morphogenesis. Further analysis of the gene list should provide important clues for developing new prognostic markers and therapeutic targets.

• Journal of Korean Medicine Rehabilitation
• /
• v.26 no.4
• /
• pp.37-44
• /
• 2016

Objectives To determine the effectiveness of Chuna manual therapy combined acupuncture for trigeminal neuralgia. Methods We searched 6 electronic databases (Pubmed, CAJ, Oasis, RISS, DBPIA, KoreanTK) and 2 journals up to August 2016. We included randomized controlled trials (RCTs) using Chuna manual therapy combined acupuncture for trigeminal neuralgia. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results 3 RCT studies were eligible in our review. The meta-analysis of 3 studies showed favorable results for the use of Chuna manual therapy combined acupuncture. High risk of bias were observed in all studies. Conclusions Although there are favorable results with meta-analysis, our systematic review are highly dependent on the single source of Chinese electrical database, CAJ. Now limited evidence is available to support Chuna manual therapy combined acupuncture for trigeminal neuralgia and further well-designed RCTs should be encouraged.