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http://dx.doi.org/10.7314/APJCP.2013.14.1.457

Meta-analysis of Gene Expression Data Identifies Causal Genes for Prostate Cancer  

Wang, Xiang-Yang (Department of Urology, Henan Provincial People's Hospital)
Hao, Jian-Wei (Department of Urology, Henan Provincial People's Hospital)
Zhou, Rui-Jin (Department of Urology, Henan Provincial People's Hospital)
Zhang, Xiang-Sheng (Department of Urology, Henan Provincial People's Hospital)
Yan, Tian-Zhong (Department of Urology, Henan Provincial People's Hospital)
Ding, De-Gang (Department of Urology, Henan Provincial People's Hospital)
Shan, Lei (Department of Urology, Henan Provincial People's Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.1, 2013 , pp. 457-461 More about this Journal
Abstract
Prostate cancer is a leading cause of death in male populations across the globe. With the advent of gene expression arrays, many microarray studies have been conducted in prostate cancer, but the results have varied across different studies. To better understand the genetic and biologic mechanisms of prostate cancer, we conducted a meta-analysis of two studies on prostate cancer. Eight key genes were identified to be differentially expressed with progression. After gene co-expression analysis based on data from the GEO database, we obtained a co-expressed gene list which included 725 genes. Gene Ontology analysis revealed that these genes are involved in actin filament-based processes, locomotion and cell morphogenesis. Further analysis of the gene list should provide important clues for developing new prognostic markers and therapeutic targets.
Keywords
Prostate cancer; meta-analysis; gene expression data; co-expression; protein interaction;
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