• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7085-7090
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• 2013

Objective: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of microRNA-155 are inconclusive. The aim of the present analysis was therefore to evaluate the role of miR-155 in prognosis for patients with a variety of carcinomas. Methods: Relevant studies were identified by searching PubMed and EMBASE. Data were extracted from studies comparing overall survival (OS), recurrence-free survival (RFS) or cancer-specific survival (CSS) in patients with carcinoma with higher miR-155 expression and those with lower levels. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) of miR-155 for clinical outcome were calculated. Results: A total of 15 studies were included. The pooled hazard ratio (HR) for OS of higher miR-155 expression in cancerous tissue was 1.89 (95% CI: 1.20-2.99, P=0.006), which could markedly predict poorer survival in general cancer. For RFS/CSS, elevated miR-155 was also associated with poor prognosis of cancer (HR=1.50, 95% CI: 1.10-2.05, P=0.01). On subgroup analysis, the pooled HR for OS in non-small cell lung cancer (NSCLC) was 2.09 (95% CI: 0.68-6.41, P > 0.05), but for RFS/CSS was 1.28 (95% CI: 1.05-1.55, P=0.015), with statistical significance; the pooled HRs for OS and RFS/CSS in digestive system neoplasms were 3.04 (95% CI: 1.48-6.24, P=0.003) and 2.61 (95% CI: 1.98-3.42, P<0.05), respectively. Conclusions: The results indicated that the miR-155 expression level plays a prognostic role in patients with cancer, especially NSCLCs and digestive system carcinomas.

• 대한간호학회지
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• 제22권4호
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• pp.526-551
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• 1992

The purpose of this study was to identify the commonalities of various nursing interventions and effective intervention methods in each intervention through analysis and synthesis of many accumulated research papers. The study analyzed the effects of various nursing interventions on anxiety and /or stress. For this purpose, 64 experimental studies with randomized or nonequivalent control group pre-test-posttest design were selected from journals of medical and nursing schools, the Korean Nurse, the Korean Nurses' Academic Society Journal, the Cetnral Journal of Medicine, the New Medical Journal, the Nurse Monthly, and from theses and dissertations conducted from 1970 to 1991. The selected studies nor classified according to three characteristics : 1) the research samuel, 2) types and methods of nursing interventions, and 3) statistical tests. The following analysis was done : 1) Confirmation of the accuracy of data drawn from each study by paired review, 2) Estimation of the homogenity of pre-test scores of the dependent variable between control and experimental groups warranted the effect size of post-scores, 3) If the homogenity of pre-test scores did not warrant, the change scores from pre-test to post-test were used to estimate the effect size, 4) Use of the effect size of each study among homogenious studies was tested for each intervention method, such as relaxation, information, and touch and /or support. Finally, for the studies not showing homogenity, an ANOVA test was used to identify patterns for each intervention. Some findings are summarized as follow : The effect sizes for relaxation and information were greater than those for touch and /or supportive technique. Studies using random assignment had greater effect sizes than nonrandomized sample studies using the same intervention. For healthy people, group education was more effective than individual teaching. However, for patients, relaxation and touch and /or supportive techniques given on individual basis were more effective than when given in a group situation. Measuring anxiety and stress by biological indicators was less effective than by self-report. Budzynski's relaxation method was the most effective. The more frequently the techniques applied, the larger the effect size. On the bases of these findings, the following recommendations were made : 1. A combination of information, relaxtion, and touch-supportive techniques should be used for greater effect in reducing the level of anxiety and /or stress. 2. Information is the first choice of intervention to reduce the level of anxiety and /or stress of healthy People : other interventions may be added depending on the conditions of the subjects.

• 한국환경보건학회지
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• 제43권6호
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• pp.478-490
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• 2017

Objectives: The association of air pollution levels and land-use types with changes in the prevalence of allergic diseases (allergic conjunctivitis, allergic rhinitis, asthma, and atopic dermatitis) was investigated for seven metropolitan cities in Korea Methods: Data on daily hospital visits and admissions (of those under 19 years old) for 2003-2012 were obtained from the National Health Insurance Cooperation. Meteorological data on daily mean temperature, humidity, and air pressure were obtained from the Korea Meteorological Administration. Daily mean or maximum concentration data for five pollutants ($PM_{10}$, $O_3$, $NO_2$, $SO_2$, and CO) as measured at air quality monitoring sites operated by the Ministry of Environment were used. We estimated excess risk and 95% confidence intervals for the increasing interquatile range (IQR) of each air pollutant using Generalized Additive Models (GAM) appropriate for time series analysis. Results: In this study, we observed a significant association between the IQR increases of air pollutants and the prevalence risk of allergic diseases (allergic conjunctivitis, allergic rhinitis, asthma, and atopic dermatitis) in all metropolitan cities after adjusting for temperature, humidity, and air pressure at sea level. Among the air pollutants, $NO_2$ and $PM_{10}$ were associated with the prevalence of asthma, and $O_3$ was associated with only allergic conjunctivitis in regression analysis. However, in GAM analysis considering land-use, $O_3$ and $SO_2$ were associated with allergic conjunctivitis, PM10, O3, NO2, and CO were associated with allergic rhinitis, and $PM_{10}$, $O_3$ and $NO_2$ were associated with asthma in industrial area. Conclusion: This study found a significant association between air pollution and the prevalence of allergic related diseases in industrial areas. More detailed research considering mixed traffic-related air pollution (TRAP) and conducting meta-analyses combining data of the all cities is required.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6033-6038
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• 2015

Background: Experience of lung cancer includes negative impacts on both physical and psychological health. Pain is one of the negative experiences of lung cancer. Cognitive behavioral therapy techniques are often recommended as treatments for lung cancer pain. The objective of this review was to synthesize the evidence on the effectiveness of cognitive behavioral therapy techniques in treating lung cancer pain. This review considered studies that included lung cancer patients who were required to 1) be at least 18 years old; 2) speak and read English or Thai; 3) have a life expectancy of at least two months; 4) experience daily cancer pain requiring an opioid medication; 5) have a positive response to opioid medication; 6) have "average or usual" pain between 4 and 7 on a scale of 0-10 for the day before the clinic visit or for a typical day; and 7) able to participate in a pain evaluation and treatment program. This review considered studies to examine interventions for use in treatment of pain in lung cancer patients, including: biofeedback, cognitive/attentional distraction, imagery, hypnosis, and meditation. Any randomized controlled trials (RCTs) that examined cognitive behavioral therapy techniques for pain specifically in lung cancer patients were included. In the absence of RCTs, quasi-experimental designs were reviewed for possible conclusion in a narrative summary. Outcome measures were pain intensity before and after cognitive behavioural therapy techniques. The search strategy aimed to find both published and unpublished literature. A three-step search was utilised by using identified keywords and text term. An initial limited search of MEDLINE and CINAHL was undertaken followed by analysis of the text words contained in the title and abstract, and of the index terms used to describe the article. A second search using all the identified keywords and index terms was then undertaken across all included databases. Thirdly, the reference list of all identified reports and articles were searched for additional studies. Searches were conducted during January 1991- March 2014 limited to English and Thai languages with no date restriction. Materials and Methods: All studies that met the inclusion criteria were assessed for methodological quality by three reviewers using a standardized critical appraisal tool from the Joanna Briggs Institute (JBI). Three reviewers extracted data independently, using a standardized data extraction tool from the Joanna Briggs Institute (JBI). Ideally for quantitative data meta-analysis was to be conducted where all results were subject to double data entry. Odds ratios (for categorical data) and weighted mean differences (for continuous data) and their 95% confidence intervals were to be calculated for analysis and heterogeneity was to be assessed using the standard Chi-square. Where statistical pooling was not possible the finding were be presented in narrative form. Results: There were no studies located that met the inclusion requirements of this review. There were also no text and opinion pieces that were specific to cognitive behavioral therapy techniques pain and lung cancer patients.Conclusions: There is currently no evidence available to determine the effectiveness of cognitive behavioural therapy techniques for pain in lung cancer patients.

• 한국정보과학회논문지:소프트웨어및응용
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• 제34권3호
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• pp.196-211
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• 2007

제품 계열 공학에서 제품의 공통성 및 가변성 분석을 결정짓게 하는 기준인 휘처 (feature) 분석에 대한 기존 연구는 개발자의 직관이나 도메인 전문가의 경험에 근간으로 분석 기준이 객관적이지 못하며, 비정형적인 휘처 분석으로 인한 이해 당사자 (stakeholder)의 공통된 휘처의 이해 부족 및 불명확한 휘처를 추출하는 문제점이 있었고, 기 개발된 소프트웨어에서 사용된 휘처의 재사용 개념이 부족했었다. 본 논문에서는 특정 도메인의 휘처 모델을 온톨로지로 변환하여 의미 기반 유사성 분석 기준에 의해 휘처의 공통성과 가변성을 추출하는 기법을 제시한다. 이를 위해, 먼저 공통된 휘처 중심의 메타 휘처 모델 기반으로 휘처의 속성을 정립하고, 메타 모텔에 준거하여 휘처 모델을 생성하여 온톨로지로 변환 후, 휘처 온톨로지 리포지토리 (Repository)에 저장한다. 이후， 동일 제품 계열 도메인의 휘처 모델 구축 시, 기 존 생성 모델과 온톨로지의 의미 기반 유사성 비교 분석 기법을 통해 휘처의 공통성과 가변성을 추출하는 것이다 또한 유사성 비교 알고리즘을 툴로 구현하였으며, 전자 결재 시스템 도메인의 실험 및 평가를 통 해 효과성을 보인다. 본 기법을 통해 메타 휘처 모델의 구문적 정립으로 이해성과 정확성을 제고시켜 고품질의 휘처 모델을 구축할 수 있으며， 온톨로지의 의미 기반 매핑으로 휘처의 공통성 및 가변성 추출을 정형화할 수 있고, 재사용성을 향상시킬 수 있다.

• 말소리와 음성과학
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• 제12권1호
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• pp.51-63
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• 2020

음운인식은 음운론 영역의 상위언어인식 능력으로, 읽기 및 어휘력 등의 언어능력을 예측하는 것으로 알려져 있다. 본 연구는 음운인식 능력과 기타 음운처리 능력, 그리고 언어능력 간의 관계를 일반아동 집단과 언어발달지연 아동 집단 간 비교를 통해 살펴보고자 하였다. 4~6세의 언어발달지연 아동(n=15)과 일반아동(n=18)을 대상으로 음운인식 능력을 평가하기 위하여 음절수세기, 음절탈락, 음절변별 과제를 실시하였다. 또한 비단어 따라말하기, 숫자 거꾸로 회상하기의 두 가지 음운처리 과제와 수용 및 표현어휘력, 문법성판단 과제와의 상관관계를 분석하고, 언어능력을 예측하는 음운인식 하위과제가 무엇인지 검토하였다. 음운인식 하위과제 중 음절수세기를 제외한 음절탈락, 음절변별 과제 수행력의 집단 간 차이가 유의하였다. 또한 일반아동 집단은 음절탈락과 숫자 거꾸로 회상하기, 음절변별과 수용어휘력 과제 수행력 간 상관관계가 유의하였으며, 언어발달지연 아동 집단은 음절수세기 과제와 숫자 거꾸로 회상하기, 수용어휘력, 표현어휘력, 문법성판단 과제의 수행력 간 상관관계가 유의하였다. 그리고 단계적 중다회귀분석 결과 일반아동 집단은 음절변별 과제가 수용어휘력 및 문법성판단 과제 수행력을 유의하게 예측하는 것으로 나타났으며, 언어발달지연 아동 집단은 음절수세기 과제가 수용어휘력, 표현어휘력, 문법성판단 과제 수행력을 유의하게 예측하는 것으로 나타났다. 언어발달지연 아동 집단은 일반아동 집단에 비해 음절수세기를 제외한 나머지 음절 수준의 음운인식 과제의 수행력이 저조하였으며, 이러한 특징이 상관관계 분석 및 회귀분석 결과에도 반영되었다. 또한 각 집단에서 음운인식 과제 수행력이 언어능력을 유의하게 예측하는 것으로 나타난 결과는 음운론 영역의 상위언어인식 능력의 중요성을 시사한다.

• 치위생과학회지
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• 제12권3호
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• pp.259-269
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• 2012

"구강보건교육학 및 실습" 교과목에서 제시된 학습목표는 '교육일반', '구강보건교육의 실제', '대상 및 장소별 구강보건교육'으로 분류하였고 최종 분석한 결과는 다음과 같다. 첫째, '교육일반' 영역에서는 19개의 학습목표 중 사실적 지식과 개념적 지식이 대부분 이었고, 절차적 지식은 10.6%였으며, 메타인지적 지식에 해당하는 수업목표는 없었다. 둘째, '구강보건교육의 실제'에서는 34개의 학습목표 중 사실적 지식과 개념적 지식이 약 76%였고, 나머지는 절차적 지식이었으며, 메타인지 지식범주에 해당하는 수업목표는 없었다. 셋째, '대상 및 장소별 구강보건교육'에서는 18개의 학습목표 중 다른 영역들과는 달리 절차적 지식이 가장 많았고, 그 다음이 사실적 지식의 학습목표였다. 지식차원의 하위유형은 구체적 사실과 요소에 관한 지식과 교과의 특수한 기법과 방법에 대한 지식범주가 가장 많았고, 다음으로는 원리와 일반화에 대한 지식과 교과의 특수한 기능과 알고리즘에 대한 지식 순이었다.

• 정보관리학회지
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• 제22권1호
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• pp.47-64
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• 2005

디지털 자료에의 장기적인 접근을 보장하기 위해서는 체계적인 디지털 보존이 이루어져야 하며, 디지털 보존에 대한 지속적인 예산 지원에는 비용요소에 대한 구체적인 파악이 선행되어야 한다. 본 연구는 기존 관련연구를 토대로 디지털 보존의 필수 비용요소들을 추출하였으며, 이를 보존과의 관련성 정도에 따라 직접보존비용과 간접보존비용으로 범주화하였다. 디지털화 사업이 대규모로 진행되고 있는 국내 도서관을 사례분석 대상으로 선정하여 디지털 보존현황을 분석하고 보존비용을 추정하였다. 사례분석 결과, 기본적인 디지털 보존은 이루어지고 있으나 디지털 자료에의 장기적인 접근을 보장하기 위한 보다 포괄적이고 체계적인 보존기능이 미흡한 것으로 나타났다. 현재 사례분석 대상 도서관에서 수행되고 있는 디지털 보존을 토대로 분석했을 때, 도서관 A와 B에서는 각각 원문DB 구축비용의 $11.8\%$와 $8.6\%$에 달하는 디지털 보존비용이 매년 투입되어야 하는 것으로 추정되었다. 그러나 본 연구의 결과는 매우 보수적인 추정치라고 할 수 있다. 이는 대상 도서관의 경우 디지털 서고의 구축과 메타데이터 생성 등의 보존기능이 수행되지 않고 있어 이에 소요되는 비용이 추정에서 배제되었기 때문이다. 본 연구는 디지털 보존이 디지털 자료의 생산 단계부터 접근까지의 모든 활동에 직${\cdot}$간접으로 관련되어 있는 종합적인 활동이며, 디지털화 사업을 착수하는 단계에서부터 반드시 고려되어야 하는 사업임을 입증해 주고 있다.

• Journal of Korean Dental Science
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• 제12권1호
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• pp.13-19
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• 2019

Purpose: The aim of this study was to compare the flexural strength of provisional fixed dental prostheses which was three-dimensional (3D) printed by several build directions. Materials and Methods: A metal jig with two abutment teeth and pontic space in the middle was fabricated. This jig was scanned with a desktop scanner and provisional restoration was designed on dental computer-aided design program. On the preprocessing software, the build angles of the restorations were arranged at $0^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$, and $90^{\circ}$ and support was added and resultant structure was sliced to a thickness of $100{\mu}m$. Processed restorations were printed with digital light processing type 3D printer using poly methyl meta acrylate-based resin. After washing and post-curing, compressive loading was applied at a speed of 1 mm/min on a metal jig fixed to a universal testing machine. The maximum pressure at which fracture occurred was measured. For the statistical analysis, build direction was set as the independent variable and fracture strength as the dependent variable. One-way analysis of variance and Tukey's post hoc analysis was conducted to compare fracture strength among groups (${\alpha}=0.05$). Result: The mean flexural strength of provisional restoration 3D printed with the build direction of $0^{\circ}$ was $1,053{\pm}168N$; it was $1,183{\pm}188N$ at $30^{\circ}$, $1,178{\pm}81N$ at $45^{\circ}$, $1,166{\pm}133N$ at $60^{\circ}$, and $949{\pm}170N$ at $90^{\circ}$. The group with a build direction of $90^{\circ}$ showed significantly lower flexural strength than other groups (P<0.05). The flexural strength was significantly higher when the build direction was $30^{\circ}$ than when it was $90^{\circ}$ (P<0.01). Conclusion: Among the build directions $0^{\circ}$, $30^{\circ}$, $45^{\circ}$, $60^{\circ}$, and $90^{\circ}$ set for 3D printing of fixed dental prosthesis, an orientation of $30^{\circ}$ is recommended as an effective build direction for 3D printing.

• 근관절건강학회지
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• 제29권1호
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• pp.69-80
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• 2022

Purpose: To identify research trends in the Journal of Muscle and Joint Health. Methods: In total, 315 studies published between 2008 and 2020 in the Journal of Muscle and Joint Health were reviewed using analysis criteria developed by the authors Results: Most participants were adults or older adults, they mostly had arthritis. The types of research design were descriptive research (46.4%), quasi-experimental design (21.9%), randomized controlled trial (1.9%), and qualitative research (4.1%). The occupation of most authors was professor in universities (61.0%). Data were collected mostly in hospitals (41.6%) or communities (24.4%) using a questionnaire (52.4%). Written consent was obtained at 75.6% and 47.9% of studies were approved by the Institutional Review Board (IRB). The instruments measuring physical concepts such as pain, flexibility, sense of balance and fatigue were mostly used. The most common interventions in experimental studies were physical interventions, with the main being exercise. Key words were categorized into four nursing meta-paradigms: human, health, environment and nursing. The most frequently reported key words were included in the health domain. The most frequently used key words were physical intervention, older patient, osteoarthritis, pain and depression. Conclusion: The results suggest that more research studies targeting various age groups related to muscle and joint health are required. Additionally there is a need to increase the number of qualitative studies, randomized experimental studies, and systematic review studies. It is necessary to pay attention to compliance with research ethics publication regulations.