• 한국보건간호학회지
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• 제32권2호
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• pp.194-207
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• 2018

Purpose: The purpose of this study was to identify the trends regarding diet and exercise intervention studies for Korean obese children between 2010 and 2017. Methods: This study was synthesized and reviewed systematically by meta-analysis. In addition, a total of thirty nine studies were investigated. The random effect model was used for meta-analysis. Results: Most studies used single interventions and that their theoretical frameworks still required improvement. In addition, on-line education programs still need to increase their number over that of off-line ones. Regarding the dependent variables for understandings the influences obesity may have on Korean children, most studies took advantage of biological indicators. In terms of the effects of obesity management programs, multiple interventions have gained a competitive edge over single ones for Korean obese children's diet and exercise. In a similar vein, healthy eating habits and adequate physical activities would have more positive effects on Korean children' obesity management programs. Conclusion: Further various studies will be needed for the early detection and prevention of obese children through varied interventions and qualitative improvement of studies.

• Genomics & Informatics
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• 제14권4호
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• pp.173-180
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• 2016

The meta-analysis has become a widely used tool for many applications in bioinformatics, including genome-wide association studies. A commonly used approach for meta-analysis is the fixed effects model approach, for which there are two popular methods: the inverse variance-weighted average method and weighted sum of z-scores method. Although previous studies have shown that the two methods perform similarly, their characteristics and their relationship have not been thoroughly investigated. In this paper, we investigate the optimal characteristics of the two methods and show the connection between the two methods. We demonstrate that the each method is optimized for a unique goal, which gives us insight into the optimal weights for the weighted sum of z-scores method. We examine the connection between the two methods both analytically and empirically and show that their resulting statistics become equivalent under certain assumptions. Finally, we apply both methods to the Wellcome Trust Case Control Consortium data and demonstrate that the two methods can give distinct results in certain study designs.

• 한국콘텐츠학회논문지
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• 제17권8호
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• pp.241-249
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• 2017

본 연구는 인공호흡기 적용 환자들의 구강간호에 있어 클로르헥시딘의 적용에 대한 효과성을 분석하고, 이를 토대로 임상에서 실질적으로 구강간호 시행에 있어 명확한 근거를 제시 하고자 시도 되었다. 주요 검색어는 Ventilator associated pneumonia AND (Oral care OR Dental care OR Chlorhexidine*)으로 검색원으로는 국내 RISS, Koreamed, KISS와 국외 MEDLINE, Cochrane Central, CINAHL, Pub Med를 활용하여 2017년 5월까지의 문헌을 대상으로 검색하였다. 총 19편의 연구가 최종 선정되었고, Revman 5.3 프로그램으로 분석 하였으며, RoB (The Cochrane's Risk of Bias)도구를 이용해 문헌의 질을 평가하였다. 연구결과 중환자의 인공호흡기 관련 폐렴 예방에 있어 클로르헥시딘의 적용은 통계적으로 유의한 효과가 있었음이 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10293-10298
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• 2015

Background: Previous epidemiologic studies on the association between energy intake and endometrial cancer risk have only generated contradictory results. The role of energy intake in endometrial carcinogenesis thus remains unclear. To quantitatively assess the potential association between energy intake and endometrial cancer, a meta-analysis of case-control and cohort studies was here conducted. Materials and Methods: Eligible studies were retrieved via both computerized searches and review of references. Fixed-or random-effect models were used to summarize the estimates of OR with 95%CIs. Stratified analyses on study design, region and macronutrients' calorie were performed. Results: Sixteen studies met the inclusion criteria of the meta-analysis. No association between total energy intake and endometrial cancer was observed in either overall group (OR=1.11, 95%CI 0.92-1.30) or subgroups stratified by study design and region. In the specific macronutrients' calorie analysis, higher fat energy intake was found to be associated with increased endometrial risk (OR=1.72, 95%CI 1.12-2.32) while energy from carbohydrate and protein was not related to endometrial cancer risk. Conclusions: Our analysis did not support that total energy intake is related to endometrial cancer risk, in contrast to fat energy.

• 한국도서관정보학회지
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• 제33권2호
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• pp.109-137
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• 2002

해양 전자정보자원 메타 데이터베이스 시스템 설계 및 구현을 위해 국내외 관련 연구를 조사하고 분석하였다. 연구대상은 해양분야 웹 자원에서 해양조사자료가지를 범위로 하였다. 본 연구의 목적은 네트워크 자원의 기술에 적합한 더블린코어를 기반으로 효율적인 해양분야 전자정보자원 정보검색서비스를 제공하는데 있다. 본 논문에서는 해양분야 전자정보원 조사, 메타데이터 기술요소 분석, 베타데이터 분류체계, 시스템 구성 및 검색 구현방안의 연구를 수행하였다.

• 한국임상약학회지
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• 제25권3호
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• pp.131-137
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• 2015

Background: The protective effect of metformin against breast cancer is inconclusive. Objective: To evaluate the effect of metformin on breast cancer risk and mortality in patients with type 2 diabetes. Method: A comprehensive literature search was performed for pertinent articles published prior to June 30, 2014, using PubMed and EMBASE. Study heterogeneity was estimated with $I^2$ statistic. The data from the included studies were pooled and weighted by random-effects model. The quality of each included study was assessed on the basis of the 9-star Newcastle-Ottawa Scale and publication bias was evaluated by visual inspection of a funnel plot. Results: Ten studies were included in the meta-analysis of the association of metformin and breast cancer risk. By synthesizing the data from the studies, the pooled odds ratio (OR) was 0.72 (95% CI: 0.59, 0.87) (p = 0.0005). Three cohort studies were included for meta-analysis of the association between metformin and breast cancer-related mortality. Metformin was associated with a significant decrease in mortality (Risk ratio: 0.68; 95% CI: 0.51, 0.90, p = 0.007). Conclusion: The present meta-analysis suggests that metformin appears to be associated with a lower risk of breast cancer incidence and mortality in patients with type 2 diabetes.

• 가정∙방문간호학회지
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• 제26권3호
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• pp.265-277
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• 2019

Purpose: This study was performed to explore research trends in the intention to stay of hospital nurses and provide basic data to establish nursing management strategies to increase the intention to stay. Methods: Articles published between 2009 and 2018 were searched. The search terminologies were "intention to stay," "nurse", and "hospital". In the first search, 381 articles were extracted from academic databases. Thirty articles were used in the systematic review, and 29 articles were used in the correlation meta-analysis. Results: Thirty-two variables were explored in relation to the intention to stay. In the correlation analysis, job satisfaction and work environment showed statistically significant positive correlations in many studies. In the correlation meta-analysis, 7 variables including organizational commitment showed statistically significant effect sizes. Conclusion: We suggest that structural equation model analysis to identify causal relations among influencing variables of the intention to stay of hospital nurses may be conducted. This study can be used as a guideline to develop intention-to-stay enhancement programs for hospital nurses.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7871-7874
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• 2015

Background: There is no consensus regarding the selection of treatment options for hepatocellular carcinoma (HCC) after initial transarterial chemoembolization (TACE). This meta-analysis aimed to explore the survival benefit of hepatic resection after initial TACE for the treatment of HCC. Materials and Methods: We searched three major databases to identify all relevant papers comparing the outcomes of hepatic resection after initial TACE versus TACE alone for the treatment of HCC. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were calculated to evaluate the survival benefit of hepatic resection after initial TACE over TACE alone. Results: Three of 2037 initially identified papers were included. All of them were cohort studies from Asia. There was a significantly better overall survival (OS) in patients undergoing hepatic resection after initial TACE than in those undergoing TACE alone (HR=0.63, 95%CI=0.52-0.76, P<0.00001). The heterogeneity among studies was not statistically significant (P=0.96; I2=0%). Conclusions: Hepatic resection could improve the OS of HCC patients treated with initial TACE. Further randomized controlled trials should be necessary to identify the target population for the sequential use of hepatic resection after initial TACE and to compare the outcomes between patients undergoing hepatic resection after initial TACE session versus those undergoing TACE alone.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.4097-4100
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• 2012

Background/Aims: Diabetes mellitus (DM) is widely considered to be associated with risk of cancer, but studies investigating the association between DM and prostate cancer in Asian countries have reported inconsistent findings. We examined this association by conducting a detailed meta-analysis of studies published on the subject. Methods: Cohort or case-control studies were identified by searching Pubmed, Embase and Wanfang databases through May 30, 2012. Pooled relative risk (RR) with its corresponding 95% confidence interval (95% CI) were calculated using the random-effects model. Subgroup analyses were performed by the study type. Results: Finally, we identified 7 studies (four cohort studies and three case-control studies) with a total of 1,751,274 subjects from Asians. DM was associated with an increased risk of prostate cancer in Asians (unadjusted RR= 2.82, 95% CI 1.73.4.58, P < 0.001; adjusted RR= 1.31, 95% CI 1.12.1.54, P = 0.001). Subgroup analyses by study design further confirmed an obvious association. Conclusion: Findings from this meta-analysis strongly support that diabetes is associated with an increased risk of prostate cancer in Asians.

• 한국컴퓨터정보학회논문지
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• 제23권3호
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• pp.71-77
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• 2018

The purpose of this study was to investigate the effectiveness of elastic band resistance training for muscle strength among community-dwelling older adults. The systematic review and meta-analysis was conducted by following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). Data were pooled using fixed effect models. Sit to stand, arm curl, and grip strength were analyzed for main effects. Heterogeneity between studies was assessed using the I2 statistics and publication bias was evaluated by funnel plots. Twelves studies were included representing 611 participants. Elastic band resistance training was effective for lower (d=3.89, 95% CI: 3.03, 4.75) and upper extremity muscle strength (d=4.08, 95% CI: 2.94, 5.23). Heterogeneity was moderate and no significant publication bias was detected. Based on these findings, there is clear evidence that elastic band resistance training has significant positive effects on muscle strength among community-dwelling older adults. Further study will be needed to perform subgroup analysis using number of sessions and exercise intensity as predictors.