• Journal of Oriental Neuropsychiatry
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• v.23 no.2
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• pp.67-84
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• 2012

Objectives : The purpose of this study is to evaluate the effects of Yeongkyekamjo-tang on patients with menopausal disorder. Methods : We recruited 3 patients with menopausal disorder, who have been suffering from palpitation and depression. In addition, the patients had been administrated Yeongkyekamjo-tang. The patients of menopausal disorder had been estimated with Kupperman's index, Beck's Depression Inventory, The Menopause Quiz of Argosy University, visual analogue scale and Heart rate variability. We measured the Kupperman's index, Beck's Depression Inventory and The Menopause Quiz of Argosy University for every seven days. The heart rate variability was estimated twice, before and after the treatment. Results : After the treatments, symptoms of menopausal disorder were decreased. Conclusions : This study suggests that Yeongkyekamjo-tang is significantly effective on patients with menopausal disorder as well as palpitation and depression.

• Journal of the Korean Applied Science and Technology
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• v.38 no.1
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• pp.136-146
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• 2021

This study is a descriptive research to determine the degree of self-esteem, menopausal symptom, spousal support of middle-aged women and investigate the factors affecting aging anxiety. For 3 weeks from May 23 to June 13, 2020, data total of 110 people were collected using online questionnaires for late middle-aged women. As a result of date analysis, factors affecting aging anxiety in late middle-aged women were menopausal symptoms(B=17.943, p<.001), self-esteem(B=-.585, p=.001) and the explanatory power of the regression model was 41.4%. Therefore, in order to lower againg anxiety, active intervention for menopausal symptoms of late middle-aged women is required, and measures should be taken to increase self-esteem.

• Journal of Microbiology and Biotechnology
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• v.34 no.8
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• pp.1580-1591
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• 2024

Menopause is induced by spontaneous ovarian failure and leads to life quality deterioration with various irritating symptoms. Hormonal treatment can alleviate these symptoms, but long-term treatment is closely associated with breast and uterine cancer, and stroke. Therefore, developing alternative therapies with novel anti-menopausal substances and improved safety is needed. In our study, heat-killed Bifidobacterium breve HDB7040 significantly promoted MCF-7 cell proliferation in a dose-dependent manner under estrogen-free conditions, similar to 17β-estradiol. This strain also triggered ESR2 expression, but not ESR1, in MCF-7 cells. Moreover, administrating HDB7040 to ovariectomized (OVX) Sprague-Dawley (SD) female rats reduced estrogen deficiency-induced weight gain, fat mass, blood triglyceride, and total cholesterol levels. It also recovered collapsed trabecular microstructure by improving trabecular morphometric parameters (bone mineral density, bone volume per tissue volume, trabecular number, and trabecular separation) and decreasing blood alkaline phosphatase levels with no significant changes in uterine size and blood estradiol. HDB7040 also significantly regulated the expression of Tff1, Pgr, and Esr2, but not Esr1 in uteri of OVX rats. Heat-killed B. breve HDB7040 exerts an anti-menopausal effect via the specific regulation of ERβ in vitro and in vivo, suggesting its potential as a novel substance for improving and treating menopausal syndrome.

• Korean Journal of Health Education and Promotion
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• v.10 no.1
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• pp.72-86
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• 1993

The purpose of this study is to find out the menopausal symptom of middle-aged women and their self-care on it. This study also intended to awaken the relationship of the menopausal symptom and self-care and to provide basic data on the health education of middle-aged women. For this purpose, the study (1) identified respondents background variables, (2) found menopausal symptom and the state of self-care, (3) analyzed relationship between general character, menopausal symptom, and self-care, (4) analyzed the relationship of menopausal symptom and self-care for 543 random sampled women in City of Incheon. The questionnaire consisted of 25 questions on the menopausal symptom interview by Neugarton translated by Jung Hae Ran(1985) and questions of the self-care inventory by Orem reconstructed by Sung Moon Hee(1988). The data were analyzed by using frequency, percentage, t-test, X²-test, pearson's correlation coefficient with SPSS statistical package. The results of this study could be summed up as follows ; 1. The Degree of menopausal symptom were graded from 25 to 75. (x 40.85, s. d. 8. 6.) 2. The test of relationship between the individual background and the menopausal symptom revealed that there seemed to be statistically significant correlation between the sexual life, life-content, the level of education, menstruation(p<0.000). 3. In the test of relationship between the individual background and the self-care process, (1) in case of insight of symptom, there seemed to be statistically significant correlation between the self-content(r=0.1463), sexual life(r= -0.1376), menstruation(r=0.1561), and artificial abortion(r=0.1577), (p<0.001), (2) In case of self-health control, there seemed to be statistical correlation between the states of menstruation and the number of induced abortion. (3) In case of self-health decision, there seemed to be statistically significant correlation between the number of visiting hospitals or clinics and the level of education(r=0.106), the self-content(r=0.1235), induced abortion(r=0.1343) (p<0.0000). And also individual background can show the 40.21 percent of self-health maintenance. 4. The relationship between menopausal symptom and self-care has a significant meaning to the insight of symptom, self-health decision according to the groups of menopausal symptom(p<0.000), but it doesn't have any meaning to self-health control. And self-health maintenance can manifest the 19.88 percent of menopausal symptom.

• Journal of Digital Convergence
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• v.14 no.11
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• pp.597-605
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• 2016

This study aimed to examine the multiple factors to affect the health conservation in the middle aged women. The subjects were 143 middle aged women from 40 to 59 years old and the data collection period was from June 1 to 25, 2016. The data was analyzed by descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients, and stepwise multiple regression. We found a significantly positive association between health conservation and health promotion behaviors among middle-aged women. However, menopausal symptoms and wisdom were not significantly associated with health conservation. Stepwise multiple regression analysis was performed to analyze the most correlation variables were health enhancement behaviors with 12.5% and existence of spouse with 3.2%. This study provides more ensured fundamental data for the health conservation and enhancement in the middle aged women.

• Journal of Korean Academy of Nursing
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• v.49 no.4
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• pp.375-385
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• 2019

Purpose: This study aimed to develop and test a structural model for chemotherapy-related cognitive impairment of breast cancer patients based on a literature review and Hess and Insel's chemotherapy-related cognitive change model. Methods: The Participants consisted of 250 patients who were ${\geq}19$ years of age. The assessment tools included the Menopause Rating Scale, Symptom Experience Scale, Hospital Anxiety and Depression Scale, Everyday Cognition, and Functional Assessment of Cancer Therapy-Breast Cancer. Data were analyzed using the SPSS 21.0 and AMOS 21.0 programs. Results: The modified model was a good fit for the data. The model fit indices were ${\chi}^2=423.18$ (p<.001), ${\chi}^2/df=3.38$, CFI=.91, NFI=.91, TLI=.89, SRMR=.05, RMSEA=.09, and AIC=515.18. Chemotherapy-related cognitive impairment was directly influenced by menopausal symptoms (${\beta}=.38$, p=.002), depression and anxiety (${\beta}=.25$, p=.002), and symptom experiences (${\beta}=.19$, p=.012). These predictors explained 47.7% of the variance in chemotherapy-related cognitive impairment. Depression and anxiety mediated the relations among menopausal symptoms, symptom experiences, and with chemotherapy related cognitive impairment. Depression and anxiety (${\beta}=-.51$, p=.001), symptom experiences (${\beta}=-.27$, p=.001), menopausal symptoms (${\beta}=-.22$, p=.008), and chemotherapy-related cognitive impairment (${\beta}=-.15$, p=.024) had direct effects on the quality of life and these variables explained 91.3%. Conclusion: These results suggest that chemotherapy-related toxicity is highly associated with cognitive decline and quality of life in women with breast cancer. Depression and anxiety increased vulnerability to cognitive impairment after chemotherapy. Nursing intervention is needed to relieve chemotherapy-related toxicity and psychological factor as well as cognitive decline for quality of life in patients undergoing chemotherapy.

• CELLMED
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• v.13 no.14
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• pp.17.1-17.23
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• 2023

Menopause is a physiological phase experienced by all women as part of normal aging known as menopause. Per se, menopause is not a disease, but hormonal imbalance may lead to menopausal symptoms in some women. The unani physician described that in Sinn-i-Inḥiṭāṭ/ Sinn al-Yās, Burūdat (coldness) increases lead to Ihtibās al-Tamth (amenorrhea) that can occur naturally. Besides, Khilt Dam (blood) production decreases from the liver, slight production occurs, tends towards Burūdat. Therefore, at this age, Ihtibās al-Tamth is associated with Alāmāt Sinn al-Yās(menopausalsymptoms) including weight gain, loss of appetite, hirsutism, fatigue, headache, backache, arthralgia, neck pain, general myalgia, nervousness, anxiety, depression, and insomnia. The traditional Unani manuscripts are enriched with knowledge for the management of Alāmāt Sinn al-Yās. Consequently, an extensive exploration of classical texts concerning the management of Alāmāt Sinn al-Yās was undertaken. Moreover, PubMed, Scopus, Google Scholar, and other indexing databases were thoroughly explored for evidence-based approaches to managing menopausalsymptoms. The principle management as per Unani texts is to treat the cause of Alāmāt Sinn al-Yās. Unani medicines with emmenagogue, anti-inflammatory, analgesic, cardioprotective, and neuroprotective properties are beneficial for the amelioration of Alāmāt Sinn al-Yās. Unani Herbs such as Asgandh, Aslusūs, Khārkhasak, Tagar, Shuneez, Ustukhuddus, Zafran, and Majūn Najāh possess properties and are proven scientifically for their efficacy in Alāmāt Sinn al-Yās. Hence, the substantiation and preservation of traditional knowledge assume paramount importance in facilitating prospective research and proving invaluable in the modern era. Moreover, the conduct of randomized controlled trials, systematic reviews, and meta-analyses becomes imperative.

• Human Ecology Research
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• v.62 no.1
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• pp.33-45
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• 2024

This study aimed to identify the need for dietary management due to weight changes among middle-aged women in the Gwangju area during the COVID-19 pandemic. To achieve this, a survey was conducted of their eating habits, dietary and lifestyle habits, alterations in food intake, and changes in menopausal symptoms. Overall, significant differences were found between dietary and lifestyle habits (p<.01) depending on the frequency of eating out. Specifically, those who eating out two to three times a week exhibited a significant increase in negative habits such as ordering delivery food and consuming instant meals. In terms of food consumption changes, those who eating out two or three times a week displayed a relatively higher increase in the consumption of non-recommended food than those who eating out once a week. Regarding changes in menopausal symptoms, individuals who eating out two to three times a week experienced a greater increase in the severity of menopausal symptoms than those who eating out once a week. In terms of dietary and lifestyle habit changes, it was found that the more frequent the exercise, the greater the overall improvement in dietary and lifestyle habits (p<.001). Moreover, women who did not experience weight gain exhibited positive changes in their dietary and lifestyle habits compared with women who experienced weight gain. The results for food consumption changes revealed that the consumption of non-recommended foods was higher in middle-aged women who experienced weight gain, particularly the consumption of meat (p<.001) and noodles (p<.05).

• Asian Oncology Nursing
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• v.12 no.3
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• pp.221-229
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• 2012

Purpose: The purpose of this study was to identify correlates influencing cognitive impairment in breast cancer patients receiving chemotherapy. Methods: Study subjects consisted of 102 breast cancer patients who received chemotherapy. Subjects were the members of a breast cancer self-help group. Data were collected using structured self-reporting questionnaires including scales of cognitive impairment, physical status, fatigue, quality of life, emotional status, sleeping, family support, and menopausal symptoms. Statistical Package for Social Sciences was used for statistical analyses. Results: Breast cancer patients receiving chemotherapy appeared to show a high level of cognitive impairment. Among demographic characteristics, the effects of economic status and family type on cognitive impairment were found to be statistically significant. Among disease related characteristics, the effect of duration of chemotherapy on cognitive impairment was statistically significant. Menopausal symptoms were positively associated with cognitive impairment. The model including postmenopausal symptoms and caregiver type explained about 66% of variability in cognitive impairment. Conclusion: These findings highlight the importance of contextual factors in understanding cognitive impairment in breast cancer patients receiving chemotherapy and can be used to develop appropriate, effective nursing interventions.

• Journal of Microbiology and Biotechnology
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• v.31 no.9
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• pp.1281-1287
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• 2021

Clinical and preclinical studies have reported that Lactobacillus gasseri BNR17, a probiotic bacterial strain isolated from human breast milk, reduces body weight and white adipose tissue volume. In order to further explore the actions of L. gasseri BNR17, we investigated the anti-menopausal effects of L. gasseri BNR17 in an ovariectomized (OVX) rat model. The serum alanine aminotransferase levels of the rats in the OVX-BNR17 group were lower than those of the rats in the OVX-vehicle only (OVX-Veh) group. Upon administration of L. gasseri BNR17 after ovariectomy, calcitonin and Serotonin 2A levels increased significantly, whereas serum osteocalcin levels showed a decreasing tendency. Compared to the rats in the OVX-Veh group, those in the OVX-BNR17 group showed lower urine deoxypyridinoline levels, lower pain sensitivity, and improved vaginal cornification. Furthermore, L. gasseri BNR17 administration increased bone mineral density in the rats with OVX-induced femoral bone loss. These results suggest that L. gasseri BNR17 administration could alleviate menopausal symptoms, indicating that this bacterium could be a good functional probiotic for managing the health of older women.