• 생약학회지
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• 제26권3호
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• pp.273-275
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• 1995

Two phenolic amides were isolated from the stem of Cocculus diversifolius (Menispermaceae) and identified as N-trans-feruloyl tyramine and N-trans-feruloyl 3-methyldopamine by spectroscopic methods.

• Archives of Pharmacal Research
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• 제11권1호
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• pp.14-32
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• 1988

• 식물분류학회지
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• 제46권3호
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• pp.288-294
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• 2016

Stephania subpeltata (방기과)의 베트남 분포를 처음으로 보고한다. 본 종은 형태적으로 S. japonica와 유사하지만 엽신이 방패모양에 가까운 난상삼각상 또는 넓은 삼각상이며, 엽병이 조금 더 짧고, 잎맥의 수가 적으며, 작은 화경에 산형모양의 취산화서가 달리지만 드물게는 복취산화서를 가지며, 꽃이 자색이고 내과피에 돌출된 열의 수가 적어 뚜렷하게 구별된다. 본 종의 분류학적 기재, 상세 분포 및 생태학적 정보와 함께 베트남에 분포하는 함박이속(Stephania) 식물의 종검색표를 제시하였다.

• 한국자원식물학회지
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• 제6권1호
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• pp.45-51
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• 1993

Many plants collected at Japan, China, Korea, Imdonesia and South America were applied to antitumor and / or cytotoxic screening tests against Sarcoma 180 ascites in mice and / or V-79, KB, P388 cultured cells. On the course of these screening tests, alcoholic extracts of Forsythia viridissima (Oleaceae), Eurycoma longifolia(Simaroubaceae), Rubia cordifolia and R. akane(Rubiaceae), Cissampelos pareira and Abuta concolor (Menispermaceae), Nardostachys chinensis (Valerianacese), Mansoa alliaceae (Bignoniaceae), Casearia sylvestris (Flacourtiacear), Maytenus ilicifolia (Celastraceae), Hedychium coronarium (Zingiberaceae), Croton palanostigma(Euphorbiaceae), Cocculus trilobus(Menispermaceae), Ginkgo biloba(Ginkgoaceae), Alpinia galanga and Cucculus zanthorrhiza(Zingiberaceae), Evodia rutaecarpa(Rutaceae), and Periploca sepium(Asclepiadaceae) showed significant activity and their active principles were clarified. In this paper, a few antitumor substances in above plants are introduced.

• Bulletin of the Korean Chemical Society
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• 제33권10호
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• pp.3455-3457
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• 2012

• Natural Product Sciences
• /
• 제6권1호
• /
• pp.44-48
• /
• 2000

Tiliacora racemosa Colebr. belongs to the family Menispermaceae, the biggest storehouse of diphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods $(UV,\;IR,\;^1H-NMR,\;Mass)$. Tiliacorine possesses neuromuscular blocking activity. It produces a dose dependent hypotensive effect in rats and cats, and this effect is blocked by atropine.

• Natural Product Sciences
• /
• 제6권3호
• /
• pp.126-130
• /
• 2000

Tiliacora racemosa Colebr. belonging to the family Menispermaceae, is the biggest storehouse of diphenyl bisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods (UV, IR, $^1H-NMR$, MS). Haematological study with tiliacorine proved that there was no abnormal haematological results in comparison with the normal values. Chronic toxicity study with tiliacorine revealed that the alkaloid is devoid of any hepatotoxic and nephrotoxic action.

• Natural Product Sciences
• /
• 제7권3호
• /
• pp.83-86
• /
• 2001

Two new bisbenzylisoquinoline alkaloids tiliacosine (1) and tiliasine (2) were isolated from the leaves of Tiliacora racemosa Colebr.. The structures of these alkaloids were established on the basis of spectral evidence and by the correlation of their $^1H-NMR$ spectral data with those of the congeners N-methyltiliamosine (3), tiliamosine (4) and tiliacorine (5).

• Natural Product Sciences
• /
• 제5권3호
• /
• pp.142-147
• /
• 1999

Tiliacora racemosa Colebr. belonging to the family Menispermaceae is the biggest store-house of diphenyl bisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the root of T. racemosa by the application of modern separation techniques yielded a DBBI alkaloid which was identified as tiliacorine using sophisticated spectroscopic methods (UV, IR, $1^H-NMR$, Mass). Tiliacorine potentiated the sleeping time induced by standard hypnotics viz. chlorpromazine (CPZ), pentobarbitone (PB) and diazepam (DZ) in a dose dependent manner. Tiliacorine potentiated the analgesic action of standard analgesic agents viz., morphine and meperidine. It was also found to possess anti convulsive activity in the strychnine induced convulsion model.

• Archives of Pharmacal Research
• /
• 제29권8호
• /
• pp.627-632
• /
• 2006

Chromatographic separation of the MeOH extract from the stems and rhizomes of Sinomemium acutum led to the isolation of nine alkaloids and a lignan. Their structures were determined to be dauriporphine (1), bianfugecine (2), dauriporphinoline (3), menisporphine (4), (-)-syringaresinol (5), N-feruloyltyramine (6), acutumine (7), dauricumine (8), sinomenine (9), and magnoflorine (10) by spectroscopic means. These compounds were examined for their P-gp mediated MDR reversal activity in human cancer cells. Compound 1 showed the most potent P-gp MDR inhibition activity with an $ED_{50}$ value $0.03\;{\mu}g/mL$ and $0.00010\;{\mu}g/mL$ in the MESSA/DX5 and HCT15 cells, respectively.