• Journal of Audiology & Otology
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• v.24 no.2
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• pp.53-60
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• 2020

Several novel animal models that represent the pathophysiological process of endolymphatic hydrops (ELH) of Meniere's disease (MD) have been developed. Animal models are important to identify and characterize the pathophysiology of ELH and to corroborate molecular and genetic findings in humans. This review of the current animal models will be useful in understanding the pathophysiology of and developing proper treatments for MD. Surgical animal models will be replaced by medication-induced animal models. Study models previously developed in guinea pigs will be developed in several smaller animals for ease of conducting molecular analysis. In this review, we provided updated resources including our previous studies regarding the current and desirable animal models for MD.

• The Journal of the Society of Stroke on Korean Medicine
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• v.9 no.1
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• pp.40-45
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• 2008

Meniere's disease is characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating hearing loss, tinnitus, and aural pressure. The primary histopathological correlate is endolymphatic hydrops, but its etiology is still disputed. Several medical therapies have been offered to patients with this disease since 1961 that the first report had been given by Prosper Meniere. Some will be helpful for relieving the symptoms but there is still no absolutely effective treatment to cure the disease. One male patient with Meniere's disease was hospitalized in Kyung-Hee medical center, and we treated him with oriental medical therapies. The treatment was effective to relieve his symptoms, and they had been successfully controlled until he was discharged from hospital. The result suggests that the oriental medical therapy is safe and helpful to patients with Meniere's disease, so we reported this case.

• 대한상한금궤의학회지
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• v.13 no.1
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• pp.99-110
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• 2021

Objective: This study aimed to report the effect of Oryeong-san on Menière's disease. Methods : A 48-year-old female complained of Menière's disease and daily frequent headache. Based on the Shanghanlun disease pattern identification diagnostic system, the patient was treated with Oryeong-san. The result was evaluated by the Dizziness Handicap Inventory (DHI) and a numerical rating score. Results : After administration of Oryeong-san for 46 days, the DHI score decreased from 42 to 4. The average number of dizzy spells decreased from 6 to 0. Conclusions : Some cases of Menière's disease can be treated by Oryeong-san.

• Korean journal of aerospace and environmental medicine
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• v.31 no.2
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• pp.51-53
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• 2021

Aviation medical examiners should always keep two principles in mind when evaluating patients with vertigo: Does this disease render him or her incapacitated? And does this disease recur? Meniere's disease accompanies vertigo and hearing symptoms such as hearing loss and tinnitus and is particularly important because it can render the patient incapacitated and has recurrent consequences. In this case, we intended to investigate the course of a patient who was evaluated with symptoms of dizziness and tinnitus and to review the patient's judgment result according to the principles of aeromedical evaluation.

• Korean journal of aerospace and environmental medicine
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• v.31 no.1
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• pp.9-12
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• 2021

Aircraft accidents caused by dizziness of aviation workers are so common that they account for 5% to 10% of the total, and in most cases, have fatal consequences. Therefore, it is essential to diagnose and treat the dizziness of aviation workers properly. Common diseases caused by abnormal vestibular function include benign paroxysmal positional vertigo, Meniere's disease, and vestibular neuritis. In this paper, we first proposed an overview of these diseases' pathophysiology, diagnosis, and treatment. Also, we evaluated the importance of these diseases in aerospace medicine and presented aerospace medical dispositions for aviation medical examiners.

• Journal of Medicine and Life Science
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• v.16 no.3
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• pp.64-75
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• 2019

Vertigo and dizziness are common symptoms with various etiologies and pathogeneses. Vertigo is an illusion of motion due to disease of the vestibular system, usually a sense of rotation. Dizziness, a term that represents a wide range of non-vertigo symptoms, is commonly associated with non-vestibular disorders including old age, cardiac syncope, orthostatic hypotension, metabolic disease, anxiety, and drugs. Vertigo should be determined whether the cause is central or peripheral. Peripheral vertigo is usually benign but central vertigo is serious and often require urgent treatment. The careful history and detailed physical examinations(pattern of nystagmus, ocular tilt reaction, head impulse test and positional tests such as Dix-Hallpike maneuver) provide important clues to the diagnosis of vertigo. Most of patients have benign peripheral vestibular disorders - vestibular neuritis, benign paroxysmal positional vertigo (BPPV), and Meniere's disease. BPPV is a leading cause of peripheral vertigo and can easily be cured with a canalith repositioning maneuver. In this review, a focus is on the differential diagnosis of common vestibular disorders with peripheral and central causes.

• Journal of Web Engineering
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• v.14 no.22
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• pp.4885-4900
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• 2022

A high rate of Meniere's disease (MD) in patients with osteoporosis has been suggested. This research intended to estimate the bidirectional association of MD with osteoporosis. The ≥40-year-old population in the Korean National Health Insurance Service-Health Screening Cohort 2002-2019 was examined. In study I, 9529 patients with MD and 38,116 control I participants were analyzed for a previous history of osteoporosis. In study II, 65,858 patients with osteoporosis and 65,858 control II participants were analyzed for a previous history of MD. Stratified Cox proportional hazard models were applied to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) of MD for osteoporosis in study I and of osteoporosis for MD in study II. The rate of a prior history of osteoporosis was 13.3% for the MD group and 11.3% for the control I group. The patients with MD had a 1.12 times higher HR for previous osteoporosis (95% CI = 1.04-1.20). In study II, the rate or a prior history of MD was 3.7% for patients with osteoporosis and 2.0% for the control II group. The patients with osteoporosis had a 1.50 times higher HR for previous MD (95% CI = 1.40-1.61). Most subgroups according to age, sex, and comorbid conditions demonstrated consistent bidirectional associations between MD and osteoporosis. Adult patients with MD had a greater risk of osteoporosis. In addition, adult patients with osteoporosis also showed a higher risk of MD.

• Annals of Clinical Neurophysiology
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• v.7 no.1
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• pp.1-6
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• 2005

Loud click or tone burst sound can activate vestibular receptor and evoke reflex changes in tonic electromyographic activity within the stenocleidomastoid muscles. This reflex is assumed to originate in the saccule, the afferent pathways being the inferior vestibular nerve, and the efferent pathways the vestibulospinal tract. Averaging these muscular responses allows vestibular evoked myogenic potentials (VEMP) to be obtained. The earliest response ipsilateral to a loud click, p13n23, is dependent upon vestibular activation, specifically saccular afferents. These new techniques are beginning to be applied clinically in the patient of vestibular neuritis, Meniere's disease, acoustic neuromas, Tullio phenomenon, etc. VEMP recording will provide both a straightforward non-invasive exploration of each vestibule independently and an attractive method by which to explore otolithic receptors and vestibulospinal pathways.

• Annals of Clinical Neurophysiology
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• v.9 no.1
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• pp.1-4
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• 2007

Vertigo is an illusion of rotation, which results from an imbalance within the vestibular system. This review focuses on two common presentations of spontaneous vertigo: acute prolonged spontaneous vertigo and recurrent spontaneous vertigo. Common causes of acute prolonged spontaneous vertigo include vestibular neuritis, labyrinthitis, and brainstem or cerebellar stroke. The history and detailed neurological/neurotological examinations usually provide the key information for distinguishing between peripheral and central causes of vertigo. Brain MRI is indicated in any patient with acute vertigo accompanied by abnormal neurological signs, profound imbalance, severe headache, and central patterns of nystagmus. Recurrent spontaneous vertigo occurs when there is a sudden, temporary, and largely reversible impairment of resting neural activity of one labyrinth or its central connections, with subsequent recovery to normal or near-normal function. Meniere's disease, migrainous vertigo, and vertebrobasilar insufficiency (VBI) are common causes. The duration of the vertigo attack is a key piece of information in recurrent spontaneous vertigo. Vertigo of vascular origin, such as VBI, typically lasts for several minutes, whereas recurrent vertigo due to peripheral inner-ear abnormalities lasts for hours. Screening neurotological evaluations, and blood tests for autoimmune and otosyphilis are useful in assessment of recurrent spontaneous vertigo that are likely to be peripheral in origin.

• Journal of Society of Preventive Korean Medicine
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• v.28 no.1
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• pp.89-107
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• 2024

Objectives : To investigate the clinical usage of Banhabaekchulcheonmatang (BBCT), this study reviewed clinical studies conducted in Korea. Method : Literature search was performed on four Korean database; OASIS, RISS, KTKP and NDSL. Studies published before July 2023 were categorized and analyzed according to the target disease. Results : Fifty-four studies including 36 single case reports and 18 case series were included in this review and the total number of case patients was 79. There were 24 patients with peripheral vertigo such as benign paraoxysmal positional vertigo and Meniere's disease, 17 with central vertigo such as cerebellar infarction, 15 with vertigo accompanied by digestive symptoms, 13 with headache, and 10 with other diseases. Vertigo treatment accounted for more than 70% of the total case and there was no cases of hypertension and dementia. The BBCT formulation used was decoction in 69 patients (87.3%), powder in 7 patients (8.9%), and combination of decoction and powder in 3 patients (3.8%). Conclusion : Clinical research should be accumulated to expand the use of BBCT in the treatment of hypertension and dementia. In order to increase the use of insurance-covered extract preparation, it is necessary to make an effort to include the various diseases actually treated with BBCT in the indications.