• 대한전기학회논문지:시스템및제어부문D
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• 제51권8호
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• pp.344-351
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• 2002

The proposed immune algorithm has an uncomplicated structure and memory-cell mechanism as the optimization algorithm which imitates the principle of humoral immune response. We use the proposed algorithm to solve parameter optimization problems. Up to now, the applications of immune algorithm have been optimization problems with non-varying system parameters. Therefore the usefulness of memory-cell mechanism in immune algorithm is without. This paper proposes the immune algorithm using a memory-cell mechanism which can be the application of system with nonlinear varying parameters. To verified performance of the proposed immune algorithm, the speed control of nonlinear DC motor are performed. The results of Computer simulations represent that the proposed immune algorithm shows a fast convergence speed and a good control performances under the varying system parameters.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2002년도 춘계학술대회 및 임시총회
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• pp.175-178
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• 2002

The proposed immune algorithm has an uncomplicated structure and memory-cell mechanism as the optimization algorithm which imitates the principle of humoral immune response, and has been used as methods to solve parameter optimization problems. Up to now, the applications of immune algorithm have been optimization problems with non-varying system parameters. Therefore, the effect of memory-cell mechanism, which is a merit of immune algorithm, is without. this paper proposes the immune algorithm using a memory-cell mechanism which can be the application of system with nonlinear varying parameters. To verified performance of the proposed immune algorithm, the speed control of nonlinear DC motor are performed. Computer simulation studies show that the proposed immune algorithm has a fast convergence speed and a good control performances under the varying system parameters.

• 한국지능시스템학회논문지
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• 제12권4호
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• pp.353-360
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• 2002

PID 제어기의 자동 동조 방법이 제어분야에서 많은 연구가 되어 왔으며, 제안된 제어기 또한 PID 제어기 자동동조에 관한 연구이다. 제안된 면역 알고리즘은 인간의 면역 체계를 모방한 최적화 알고리즘으로 기억 세포 메카니즘과 다른 면역 알고리즘에 비하여 덜 복잡한 구조를 가지고 있다. 이렇게 제안된 면역 알고리즘을 PID 제어기의 파라메터를 최적화하는데 사용하고자 한다. 현재까지 면역 알고리즘은 주로 시스템 파라메터의 변동이 없는 최적화 문제에 적용되어왔다. 그러므로 면역 알고리즘에서의 기억세포 메카니즘에 대한 유용성이 없으며, 또한 그에 대한 연구가 미진한 상태이다. 본 연구에서는 비선형 가변 시스템에 기억세포를 사용한 면역 알고리즘을 적용하고자 한다. 제안된 면역 알고리즘의 성능 평가를 위하여 비선형 직류 모터의 속도 제어에 적용하고, 그 결과를 컴퓨터 모의실험을 통하여 제안된 면역 알고리즘이 가변 시스템 파리메에 대하여 빠른 수렴 성능과 좋은 제어 성능을 보임을 보이고자 한다.

• 반도체디스플레이기술학회지
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• 제5권1호
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• pp.17-20
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• 2006

This paper presents of a new type of memory cell that could potentially replace both DRAM and flash memory. The proposed device cell operates by sensing the state of about 1,000 electrons trapped between unique insulating barriers in the channel region of the upper transistor. These electrons are controlled by a side gate on the transistor, and their state in turn controls the gate of the larger transistor, providing signal gain within the memory cell. It becomes faster and more reliable memory with lower operation voltage. Moreover, the use of a multiple tunnel junction (MTJ) fur the vertical transistor can significantly improve the data retention and operation speed.

• 전자공학회논문지D
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• 제36D권10호
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• pp.1-8
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• 1999

본 논문은 두께가 각각 다른 습식 산호막의 정전류 스트레스에 따른 SILC를 측정하여 SILC의 전도 mechanism 및 발생원인을 조사하였다. $N_2O$ 어닐링한 산화막의 SILC 특성도 조사하였다. 또한, 60A 두께의 $N_2O$ 어닐링한 터널링 산호막을 갖는 ,flash memory cell을 $0.25{\mu}m$ 설계규칙에 따라 제작하여 그 특성을 측정하였다. 그 결과, SILC의 발생 원인은 전기적 스트레스 인가에 따른 산호막내에 생성된 트랩 때문이며, SILC의 전도 mechanism은 전기장 세기가 8MV/cm 이하일 때 산호막 트랩을 경유한 modified F-N 터널링이 8MV/cm 이상일 때 전형적인 F-N터널링이 주도적임을 알 수 있었다. 60A의 $N_2O$ 어닐링한 산화막은 SILC에 대한 내성 측면에서 큰 개선 효과가 있음을 알 수 있었다. 또한 이 막을 flash memory cell의 터널링 산호막으로 이용할 경우, $10^6$회의 endurance와 10년 이상의 드레인 disturb가 보장되고 8V-프로그래밍이 가능한 특성을 얻을 수 있었다.

• 대한전자공학회논문지TC
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• 제47권7호
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• pp.1-7
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• 2010

본 논문에서는 16레벨셀 낸드 플래시 메모리 채널에 최대 유사도 검출 방법을 이용하여 데이터를 검출하기 위해 트렐리스의 정답 값을 추정하는 기법에 대해 연구 하였다. 이 기법은 최대유사도 검출기를 사용할 수 있게 되어 성능향상에 도움을 준다. 플래시 메모리는 커플링 효과 때문에 메모리가 있는 채널 모델링이므로, 이미 알고 있는 데이터 열을 훈련 과정을 통해 트렐리스의 정답 값을 추정하여, 이 값을 토대로 최대 유사도 검출한다. 본 실험을 통해 문턱 전압을 이용한 데이터 검출 방법보다 제안한 기법을 이용한 최대 유사도 검출기의 성능이 좋은 것을 보였다.

• 한국한의학연구원논문집
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• 제8권1호
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• pp.109-126
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• 2002

The herbal extract (YMT_02) is a modified herbal extracts from Yukmijihwangtang (YMJ) to promote memory-enhancing. The YMJ extracts has been widely used as an anti-aging herbal medicine for hundred years in Asian countries. The purpose of this study is to; 1) quantitatively evaluate the memory-enhancing effect of YMT_02 by hehavior task, 2) identify candidate genes responsible for enhancing memory by cDNA microarray and 3) assess the anti-oxidant effect of YMT_02 on PC12 cell. Memory retention abilities are addressed by passive avoidance task with Sprague-Dawley (SD) male rat. Before the training session, the rats are subdivided into four groups and administrated with YMT_02, Ginkgo biloba, Soya lecithin and normal saline for 10 days. The retention test was performed. 24 hours after the training session. The retention time of the YMT_02 group was significantly (p<0.05) delayed $({\sim}100%)$, whereas Ginkgo biloba and Soya lecithin treatment delayed 20% and 10% respectively. The hippocampi of YMT_02 and control group were dissected and mRNA was further purified. After synthesizing cDNA using oligo-dT primer, the cDNA were applied and mRNA was further purified. After synthesizing cDNA using oligo-dT primer, the cDNA were applied to Incyte rat GEMTM 2 cDNA microarray. The microarray results show that prealbumin(transthyretin), phosphotidy lethanolamine N-methyltransferase, and PEP-19 are expressed abundantly in the YMT_02 treated group. Especially, PEP-19 is a neuron-specific protein, which inhibits apoptotic processes in neuronal cell. On the other hand, transcripts of RAB15, glutamate receptor subunit 2 and CDK 108 are abundant in control group. Besides, neuronal genes involved in neuronal death or neurodegeneration such as neuronal-pentraxin and spectrin are abundantly expressed in control group. Additionally, the YMT_02 shows an anti oxidative effect in the PC12 cell. The list of differentially expressed genes may implicate further insight on the action and mechanism behind the memory-enhancing effect of herbal extracts YMT_02, for example, anti-apoptotic, anti-oxidative, and neuroprotective effects.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.175-175
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• 2017

To understand molecular mechanisms underlying adaptation of plant cells to saline stress and stress memory, we developed Arabidopsis callus suspension-cultured cells adapted to high salt. Adapted cells to high salt exhibited enhanced tolerance compared to control cells. Moreover, the salt tolerance of adapted cells was stably maintained even after the stress is relieved, indicating that the acquired salt tolerance of adapted cells was memorized. In order to characterize metabolic responses of plant cells during adaptation to high salt stress as well as stress memory, we compared metabolic profiles of salt-adapted and stress-memorized cells with control cells by using NMR spectroscopy. A principle component analysis showed clear metabolic discrimination among control, salt-adapted and stress-memorized cells. Compared with control cells, metabolites related to shikimate metabolism such as tyrosine, and flavonol glycosides, which are related to protective mechanism of plant against stresses were largely up-regulated in adapted cell lines. Moreover, coniferin, a precursor of lignin, was more abundant in salt-adapted cells than control cells. Cell morphology analysis using transmission electron microscopy indicated that cell wall thickness of salt-adapted cells was significantly induced compared to control cells. Consistently, salt adapted cells contained more lignin in their cell walls compared to control cells. The results provide new insight into mechanisms of plant adaptation to saline stress as well as stress memory in metabolic level.

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.55-64
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• 2017

Progressive memory impairment such as that associated with depression, stroke, and Alzheimer's disease (AD) can interfere with daily life. In particular, AD, which is a progressive neurodegenerative disorder, prominently features a memory and learning impairment that is related to changes in acetylcholine and abnormal ${\beta}$-amyloid ($A{\beta}$) deposition in the brain. In the present study, we investigated the effects of dehydroevodiamine HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a $A{\beta}_{1-42}$-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats. Moreover, DHED significantly improved learning and memory in the $A{\beta}_{1-42}$-infused rat model. Furthermore, the mechanism of these behavioral effects of DHED was investigated using a cell viability assay, reactive oxygen species (ROS) measurement, and intracellular calcium measurement in primary cortical neurons. DHED reduced neurotoxicity and the production of $A{\beta}$-induced ROS in primary cortical neurons. In addition, similar to the effect of MK801, DHED decreased intracellular calcium levels in primary cortical neurons. Our results suggest that DHED has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms.

• 한국전자통신학회논문지
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• 제8권1호
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• pp.105-111
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• 2013

선형적인 읽기와 쓰기 특성을 가지고 있는 승자전취메커니즘 방식의 아날로그 메모리를 구현하였다. 메모리의 읽기 동작은 연상메모리의 최적 함수 선택을 위하여 절대값 회로와 승자전취메커니즘 회로가 이용된다. 본 연구에서는 병렬의 고속 쓰기와 읽기 동작뿐만 아니라 고집적을 가능하게 하는 시스템 구성이 실현된다. 복수의 메모리 셀의 구현이 더 높은 집적도와 고속의 쓰기 읽기를 위하여 구현된다. 실시간 인식을 위하여 본 연구에서 사용된 함수는 이상적이며 메커니즘의 시뮬레이션을 위하여 MOSIS의 $1.2{\mu}$ 더블폴리 CMOS 공정 파라미터를 사용하였다.