• Journal of Life Science
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• v.30 no.8
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• pp.708-712
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• 2020

Vacuolar protein sorting (VPS) 26b is a newly discovered member of the retromer complex; it is encoded by a single-copy gene located on mouse chromosome 9, and the complex has been reported as being composed of proteins VPS26, VPS29, and VPS35. We have previously shown that mice lacking VPS26b exhibited no significant body size or health issues. Although retromer components are widely expressed in mouse tissue, their roles have not yet been completely elucidated. The current study investigates whether the VPS26b-associated retromer complex can be used as a neurodegeneration model. Previously, we observed a significant reduction in VPS35 and VPS29 in the brain cells of in VPS26b-deficient mice as well as an absence of the VPS26b-VPS29-VPS35 retromer complex despite the normal presence of VPS26a-VPS29-VPS35. Recent studies have suggested that low levels of VPS35 can lead to Alzheimer's disease-like phenotypes including cognitive memory deficits. In this study, we successfully demonstrate an association between the absence of the VPS26b-VPS29-VPS35 retromer complex, reduced cell density in the CA3 region of the hippocampus, and learning disability in VPS26b knock-out mice. The results also indicate that the VPS26b-associated retromer complex affects neurodegenerative disorders and learning processes.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.40 no.6
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• pp.84-89
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• 2003

In this paper, we real-time implemented to the TMS320C5416 the vocoder of variable bit rate applied the SOLA-B algorithm by Henja to the ITU-T G.729A vocoder of 8kbps transmission rate. This proposed method using the SOLA-B algorithm is that it is reduced the duration of the speech in encoding and is played at the speed of normal by extending the duration of the speech in decoding. At this time, we bandied that the interval of cross correlation function if skipped every 3 sample for decreasing the computational amount of SOLA-B algorithm. The real-time implemented vocoder of C.729A and SOLA-B algorithm is represented the complexity of maximum that is 10.2MIPS in encoder and 2.8MIPS in decoder of 8kbps transmission rate. Also, it is represented the complexity of maximum that is 18.5MIPS in encoder and 13.1MIPS in decoder of 6kbps, it is 18.5MIPS in encoder and 13.1MIPS in decoder of 4kbps. The used memory is about program ROM 9.7kwords, table ROM 4.5kwords, RAM 5.1 kwords. The waveform of output is showed by the result of C simulator and Bit Exact. Also, for evaluation of speech quality of the vocoder of real-time implemented variable bit rate, it is estimated the MOS score of 3.69 in 4kbps.

• Applied Chemistry for Engineering
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• v.29 no.2
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• pp.215-224
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• 2018

Influences of the magnetic field on 5, 10 and 15 wt% (1.5, 3 and 4.5 M) HCl solution behaviour, which has widespread applications in petroleum well acidizing, were investigated in various conditions. Differences in the pH of magnetized hydrochloric acid compared to that of normal hydrochloric acid were measured. Taguchi design of experimental (DoE) method were used to model effects of the magnetic field intensity, concentration, velocity and temperature of acid in addition to the elapsed time. The experimental results showed that the magnetic field decreases [$H^+$] concentration of hydrochloric acid up to 42% after magnetization. Increasing the magnetic field intensity (with 28% contribution), concentration (with 42% contribution), and velocity of acid increases the effect of magnetic treatment. The results also demonstrated that the acid magnetization was-not influenced by the fluid velocity and heating. It was also displayed that the acid preserves its magnetic memory during time. The optimum combination of factors with respect to the highest change of [$H^+$] concentration was obtained as an acid concentration of 10% and an applied magnetic field of 4,300 Gauss. Due to the reduction of HCl reaction rate under the magnetization process, it can be proposed that the magnetized HCl is a cost effective and reliable alternative retarder in the matrix acidizing of hydrocarbon (crude oil and natural gas) wells.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.9
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• pp.46-51
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• 2013

In this paper, the optimum placement and shape of UHF antenna on the unmanned aerial vehicle (UAV) are analyzed by using the electromagnetic (EM) simulation on the various locations. The FEKO was used for the EM-simulation. In order to reduce the complexity of simulation and minimize the runtime and memory usage, the composite aircraft structure is simplified as the PEC model excluding the radome structure. The simulation was performed on the wing and ventral fin of UAV, and the antenna shape used the monopole, dipole, and bent monopole antennas. When the monopole antenna is mounted under the wing, two antennas need to be mounted under the right and left wings, and those antennas have to be switched as the direction of UAV wing to the line of sight (LOS) data-link (DL) ground antenna. In the case of mounting under the ventral fin, one antenna can be used regardless of the direction of UAV wing to the LOS DL ground antenna. Also, the antenna gain is improved by the blockage reduction. The antenna gain is further improved by using the bent monopole antenna. The optimum solution of UHF antenna placement and shape on UAV is to mount the bent monopole antenna under the ventral fin.

• KIISE Transactions on Computing Practices
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• v.21 no.2
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• pp.126-131
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• 2015

As flash-based storage systems have been actively employed in large-scale servers and data centers, reliability has become an indispensable element. One promising technique for enhancing reliability is static wear-leveling, which distributes erase operations evenly among blocks so that the lifespan of storage systems can be prolonged. However, increasing the capacity makes the processing overhead of this technique non-trivial, mainly due to searching for blocks whose erase count would be minimum (or maximum) among all blocks. To reduce this overhead, we introduce a new randomized block selection method in static wear-leveling. Specifically, without exhaustive search, it chooses n blocks randomly and selects the maximal/minimal erased blocks among the chosen set. Our experimental results revealed that, when n is 2, the wear-leveling effects can be obtained, while for n beyond 4, the effect is close to that obtained from traditional static wear-leveling. For quantitative evaluation of the processing overhead, the scheme was actually implemented on an FPGA board, and overhead reduction of more than 3 times was observed. This implies that the proposed scheme performs as effectively as the traditional static wear-leveling while reducing overhead.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.31 no.4
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• pp.269-275
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• 2013

Recently, importance of pedestrian road network is getting emphasized as it is possible to provide mobile device users with both route guidance services and surrounding spatial information. However, it costs a tremendous amount of budget for generating and renovating pedestrian road network nationally, which hinder further advances of these services. Hence, algorithms extracting pedestrian road network automatically based on raster data are needed. On the other hand, road dataset generated from raster data usually has unnecessary vertices which lead to maintenance disutility such as excessive turns and increase in data memory. Therefore, this study proposed a method of selecting a proper threshold automatically for separate road entity using not only Douglas-Peucker algorithm but also road attribute data of digital map in order to remove redundant vertices, which maximizes line simplification efficiency and minimizes distortion of shape of roads simultaneously. As a result of the test, proposed method was suitable for automatic line simplification in terms of reduction ratio of vertices and accuracy of position.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.6C
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• pp.614-622
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• 2006

In this paper, we propose an efficient packetization method to reduce the packetization overhead. For the purpose, we firstly verify the relationship between packet length and packet loss rate. The empirical results show that as the packet length is larger than the path MTU, the packet loss rate is drastically increased, producing poor visual quality at the receiver side. However, as the length of the packet is reduced, we should transmit more packets per frame and the packetization overhead will be increased. This increase in the packetization overhead reduces the number of bits allocated to the video data, resulting in the low visual quality. Therefore, each packet should be packetized to have the packet length close to the path MTU. In this paper, we show that the this process of the packetization with the constraint on the packet length is very similar to the dynamic storage allocation in the operating system. We had thoroughly surveyed the dynamic storage allocation methods used in the recent operating systems and propose to use the allocation methods for the video packetization. We empirically show that the proposed method can reduce the packetization overhead upto 28.3%, compared with the conventional sequential packetization method which have been widely used in Internet video transmission.

• Proceedings of the Ginseng society Conference
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• 1984.09a
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• pp.97-105
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• 1984

Effect of water extract of red ginseng (Panax ginseng C.A. Meyer) from Nagano prefecture on (1) forced exercise in mice using rope climbing test, (2) extinction of memory in hanging stressed mice and rectal temperature during the exposure to hanging stress, (3) sex and learning behavior of chronic hanging stressed mice, (4) sex cycle in the adult female mice using chronic hanging stress, and (5) motor coordination and one trial passive avoidance response in $40\%$ alcohol administered mice using rotar-rod and step-through tests, were studied. Drugs tested were given orally. (1) When it was given before the forced exercise, it potentiated the performance of the forced exercise. When it was given just after the forced exercise once a day for 2 weeks, it protected the mice against the reduction of the performance on the forced exercise. (2) When it was given just after the stress once a day for 4 days, it delayed the extinction of passive avoidance response in both step through and stepdown tests, and protected the stressed mice against the decrease in rectal temperature slightly. (3) It protected the stressed mice against the decrease of sex behaviour and the increase in the failure of performance of passive avoidance response, and delayed the extinction of passive avoidanc

• Journal of the Computational Structural Engineering Institute of Korea
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• v.13 no.2
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• pp.245-256
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• 2000

A moment-curvature relationship to simulate the behavior of reinforced concrete beam under cyclic loading is introduced. Unlike previous moment-curvature models and the layered section approach, the proposed model takes into consideration the bond-slip effect by using monotonic moment-curvature relationship constructed on the basis of the bond-slip relation and corresponding equilibrium equation at each nodal point. In addition, the use of curved unloading and reloading branches inferred from the stress-strain relation of steel gives more exact numerical result. The advantages of the proposed model, comparing to layered section approach, may be on the reduction in calculation time and memory space in case of its application to large structures. The modification of the moment-curvature relation to reflect the fixed-end rotation and pinching effect is also introduced. Finally, correlation studies between analytical results and experimental studies are conducted to establish the validity of the proposed model.

• Korean Journal of Materials Research
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• v.10 no.12
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• pp.812-818
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• 2000

We studied the effects of Ge preamorphization (PAM) on 0.25$\mu\textrm{m}$ Ti-salicide junctions using comparative study with As PAM. For each PAM schemes, ion implantations are performed at a dose of 2E14 ion/$\textrm{cm}^2$ and at 20keV energy using $^{75}$ /As+and GeF4 ion sources. Ge PAM showed better sheet resistance and within- wafer uniformity than those of As PAM at 0.257m line width of n +/p-well junctions. This attributes to enhanced C54-silicidation reaction and strong (040) preferred orientation of the C54-silicide due to minimized As presence at n+ junctions. At p+ junctions, comparable performance was obtained in Rs reduction at fine lines from both As and Ge PAM schemes. Junction leakage current (JLC) revels are below ~1E-14 A/$\mu\textrm{m}^{2}$ at area patterns for all process conditions, whereas no degradation in JLC is shown under Ge PAM condition even at edge- intensive patterns. Smooth $TiSi_2$ interface is observed by cross- section TEM (X- TEM), which supports minimized silicide agglomeration due to Ge PAM and low level of JLC. Both junction break- down voltage (JBV) and contact resistances are satisfactory at all process conditions.