• 대한지역사회작업치료학회지
• /
• 제8권3호
• /
• pp.69-76
• /
• 2018

목적 : 본 연구는 복합운동프로그램이 수면장애 모델 쥐의 수면장애 개선과 뇌기능 기억력에 어떠한 영향을 주는지 신경생리학적 접근을 통한 과학적 근거를 제시하는데 그 목적이 있다. 연구방법 : 본 연구는 수면장애 모델 쥐 16마리에게 동물실험실에서 제작된 복합운동프로그램을 적용하여 4일간 실시하였다. 실시 후 뇌기능은 해마의 BDNF의 변화를 확인하였고 수면의 변화는 혈액 중의 멜라토닌의 농도를 확인하였다. 결과 : 첫째, 복합운동프로그램의 뇌기능에 대한 영향은 실험군에서 유의미한 증가를 보였다(p<0.01). 둘째, 복합운동프로그램의 수면장애에 대한 영향은 실험군과 대조군에서 유의미한 증가를 보였다(p<0.01) (p<0.05). 결론 : 지역사회의 노인증가율이 급속히 증가하고 있으며 노인의 수면장애는 이러한 노인들의 삶의 질에 영향을 줄 수 있다. 그리고 수면장애로 인한 이차적인 기억력 저하도 문제가 될 수 있다. 수면장애를 개선할 수 있는 방법은 여러 가지가 있겠지만 경제적, 공간적으로 부담이 되지 않는 복합운동만으로도 수면과 기억의 개선을 도모할 수 있음을 실험동물을 통하여 과학적으로 증명하였다.

• 대한통합의학회지
• /
• 제1권3호
• /
• pp.79-95
• /
• 2013

Purpose : This study aims to investigate the effect of the Snoezelen and Rehacom programs on improvement of attention and memory, and the effect of the Snoezelen program on stress reduction. Method : This study was targeted at 11 subjects in the Snoezelen experimental group, 11 subjects in the Rehacom group and 11 subjects in the non-experimental group. As the initial evaluation, all the subjects took electroencephalography. Then, the Snoezelen group and Rehacom group did Snoezelen training and Rehacom training, respectively total 12 times(for 20 minutes twice per week for six weeks), but no training was applied to the control group. Three weeks after the training, the interim was carried out, and four weeks after the training, the final evaluation was carried out. Results : Subjects' attention increased to $58.15{\pm}4.96$ from $43.75{\pm}4.69$ during the Snoezelen training, and increased to $49.85{\pm}1.91$ from $43.28{\pm}2.71$ during the Rehacom training, which means the Snoezelen training was more effective in improving attention(P<0.05). Subjects' memory increased to $56.14{\pm}1.26$ from $43.19{\pm}3.46$ during the Snoezelen training, and increased to $50.94{\pm}4.0$ from $43.07{\pm}2.58$ during the Rehacom training. This also implies that the Snoezelen training was more effective in improving memory(P<0.05). Conclusion : Though both of the Snoezelen training and Rehacom training improved attention and memory, the Snoezelen program was more effective, and it also influenced stress resistance and physical arousal.

• 생물정신의학
• /
• 제14권1호
• /
• pp.61-67
• /
• 2007

Objectives : The purpose of this study was to test stage model in Traumatic Brain Injury(TBI) patients. According to the stage model, attention deficits which is basic stage in information processing lead to memory disturbance and subsequently affect higher-order cognitive function such as memory, decision-making, abstract thinking, and judgement related to executive function. Therefore, it was hypothesized that attention affect recall(retrieval efficacy) related to executive function mostly relative to other cognitive function, in TBI patients with low executive function. Methods : Participants were referred to a TBI clinic and then was rated on K-WAIS and Executive Intelligence Test(EXIT). Participants were divided into two groups according to Executive IQ(EIQ) score, which of high function group(N=67) was more than 80(above low average) and of low function group(N=52) was under 80 (under borderline). To test the stage model, using hierarchical regression analysis, recall(retrieval efficacy) was regressed on 3 subscales(attention, verbal, visuospatial scale) after controlling for IQ according to each group. Furthermore, the mediation effect of attention between retrieval efficacy and verbal, visuospatial score was analyzed. Results : In the low function group, only attention area predicted significantly recall(retrieval efficacy), indicating that lower attention were related to lower EIQ after controlling for IQ. In the high function group, no area predicted significantly retrieval efficacy. In the low function group, verbal and visuospatial scale did not predicted significantly retrieval efficacy, indicating that there was no evidences supporting the mediation model. Conclusion : Only attention affect retrieval efficacy in TBI patients with low executive function. But, the mediation effect of attention between retrieval efficacy and verbal and visuospatial scale was not tested in the low function group. These results implied that stage model was tested partially. In treating cognitive deficit in TBI patients, it is necessary to develop cognitive rehabilitation program based on stage model. Furthermore, it is necessary to necessary to test mediation model in the future study.

• Toxicological Research
• /
• 제31권4호
• /
• pp.347-354
• /
• 2015

Excess manganese (Mn) is neurotoxic. Increased manganese stores in the brain are associated with a number of behavioral problems, including motor dysfunction, memory loss and psychiatric disorders. We previously showed that the transport and neurotoxicity of manganese after intranasal instillation of the metal are altered in Hfe-deficient mice, a mouse model of the iron overload disorder hereditary hemochromatosis (HH). However, it is not fully understood whether loss of Hfe function modifies Mn neurotoxicity after ingestion. To investigate the role of Hfe in oral Mn toxicity, we exposed Hfe-knockout ($Hfe^{-/-}$) and their control wild-type ($Hfe^{+/+}$) mice to $MnCl_2$ in drinking water (5 mg/mL) for 5 weeks. Motor coordination and spatial memory capacity were determined by the rotarod test and the Barnes maze test, respectively. Brain and liver metal levels were analyzed by inductively coupled plasma mass spectrometry. Compared with the water-drinking group, mice drinking Mn significantly increased Mn concentrations in the liver and brain of both genotypes. Mn exposure decreased iron levels in the liver, but not in the brain. Neither Mn nor Hfe deficiency altered tissue concentrations of copper or zinc. The rotarod test showed that Mn exposure decreased motor skills in $Hfe^{+/+}$ mice, but not in $Hfe^{-/-}$ mice (p = 0.023). In the Barns maze test, latency to find the target hole was not altered in Mn-exposed $Hfe^{+/+}$ compared with water-drinking $Hfe^{+/+}$ mice. However, Mn-exposed $Hfe^{-/-}$ mice spent more time to find the target hole than Mn-drinking $Hfe^{+/+}$ mice (p = 0.028). These data indicate that loss of Hfe function impairs spatial memory upon Mn exposure in drinking water. Our results suggest that individuals with hemochromatosis could be more vulnerable to memory deficits induced by Mn ingestion from our environment. The pathophysiological role of HFE in manganese neurotoxicity should be carefully examined in patients with HFE-associated hemochromatosis and other iron overload disorders.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2009년도 제38회 동계학술대회 초록집
• /
• pp.240-240
• /
• 2010

A multiple alloy metal nano-dots memory using FN tunneling was investigated in order to confirm its structural possibility for future flash memory. In this work, a multiple FePt nano-dots device with a high work function (~5.2 eV) and extremely high dot density (${\sim}\;1.2{\times}10^{13}/cm^2$) was fabricated. Its structural effect for multiple layers was evaluated and compared to one with a single layer in terms of the cell characteristics and reliability. We confirm that MOS capacitor structures with 2-4 multiple FePt nano-dot layers provide a larger threshold voltage window and better retention characteristics. Furthermore, it was also revealed that several process parameters for block oxide and inter-tunnel oxide between the nano-dot layers are very important to improve the efficiency of electron injection into multiple nano-dots. From these results, it is expected that a multiple FePt nano-dots memory using Fowler-Nordheim (FN)-tunneling could be a candidate structure for future flash memory.

• 한국수산과학회지
• /
• 제47권3호
• /
• pp.195-203
• /
• 2014

We investigated the effect low salt (2 or 4% salt) concentrations jeotgal made from Todarodes pacificus on the learning and memory impairments in scopolamine-induced (2 mg/kg, i.p.) dementia rats. Rats treated with oral BF-7 (200 mg/kg, p.o.) as a positive control and Todarodes pacificus jeotgal had significantly reduced scopolamine-induced memory deficits in the passive avoidance test. The Morris water maze test or treatment with 2% salt jeotgal made from Todarodes pacificus significantly ameliorated the scopolamine-induced memory deficits in the formation of long- and short-term memory. The acetylcholine content and acetylcholinesterase acitivity paralleled the results of the behavior experiment. There were no significant differences in the brain acetylcholine contents of the experimental groups, while the brain acetylcholine content of the group treated with 2% salt Todarodes pacificus jeotgal was higher than that of the control group. The inhibitory effect of 2% salt jeotgal made from Todarodes pacificus on the acetylcholinesterase activity in the brain was lower than that of the control group. These trends were similar to those of the gamma-aminobutyric acid content. We suggest that Todarodes pacificus jeotgal enhances learning memory and cognitive function by regulating cholinergic enzymes.

• Smart Structures and Systems
• /
• 제19권4호
• /
• pp.341-350
• /
• 2017

Based on the super elastic properties of the shape memory alloy (SMA) and the inverse piezoelectric effect of piezoelectric (PZT) ceramics, a kind of hybrid semi-active control device was designed and made, its mechanical properties test was done under different frequency and different voltage. The local search ability of genetic algorithm is poor, which would fall into the defect of prematurity easily. A kind of adaptive immune memory cloning algorithm(AIMCA) was proposed based on the simulation of clone selection and immune memory process. It can adjust the mutation probability and clone scale adaptively through the way of introducing memory cell and antibody incentive degrees. And performance indicator based on the modal controllable degree was taken as antigen-antibody affinity function, the optimization analysis of damper layout in a space truss structure was done. The structural seismic response was analyzed by applying the neural network prediction model and T-S fuzzy logic. Results show that SMA and PZT friction composite damper has a good energy dissipation capacity and stable performance, the bigger voltage, the better energy dissipation ability. Compared with genetic algorithm, the adaptive immune memory clone algorithm overcomes the problem of prematurity effectively. Besides, it has stronger global searching ability, better population diversity and faster convergence speed, makes the damper has a better arrangement position in structural dampers optimization leading to the better damping effect.

• Journal of Korean Biological Nursing Science
• /
• 제18권4호
• /
• pp.274-279
• /
• 2016

Purpose: Adolescents who experienced the alcohol consumption have gradually increased. Adolescence is a critical period of the neural plasticity in the brain. Neural plasticity is mediated by neurotrophins and has an impact on cognitive function. Environmental enrichment ameliorates the cognitive function and increases neurotrophins. Thus, we investigated the neuroprotective effect of environmental enrichment on ethanol induced cognitive impairment in adolescent rats. Methods: The ethanol groups and the controls groups were injected with ethanol (0.5g/kg) and phosphate buffered saline, respectively, through intraperitoneal from 28th day of birth for 11 days. The environmental enrichment groups were provided larger cages containing toys than the standard cage. Passive avoidance test and Y-maze test were performed to evaluate the spatial memory. Results: Environmental enrichment+ethanol group showed higher alterations than the standard environment+ethanol group in Y-maze test (p<.05). In hippocampus, The environmental enrichment+ethanol group showed significantly higher level of the number of c-fos positive celsl and density of tropomyosin receptors kinase B receptor than the standard environment+ethanol group (p<.05). Conclusion: So, we suggested that the environmental enrichment played a role as a prophylaxis for prevention of memory impairment induced by ethanol exposure in adolescence.

• 한국해양공학회:학술대회논문집
• /
• 한국해양공학회 2000년도 춘계학술대회 논문집
• /
• pp.18-22
• /
• 2000

This paper is transient motions of a very large floating structure subjected to dynamic load induced by wave. A time domain method is applied to the hydroelasticity problems for this purpose. The method is based on source-dipole and FEM scheme and on Newmark $\beta$ method to pursuit time step process taking advantage of the memory effect. The present method is appied to hydroelastic response analysis in regular waves and impact responses due to dropping aircraft.

• 생물정신의학
• /
• 제23권3호
• /
• pp.89-101
• /
• 2016

Transcranial magnetic stimulation (TMS) is a safe, noninvasive and useful technique for exploring brain function. Especially, for the study of cognition, the technique can modulate a cognitive performance if the targeted area is engaged, because TMS has an effect on cortical network. The effect of TMS can vary depending on the frequency, intensity, and timing of stimulation. In this paper, we review the studies with TMS targeting various regions for evaluation of cognitive function. Cognitive functions, such as attention, working memory, semantic decision, discrimination and social cognition can be improved or deteriorated according to TMS stimulation protocols. Furthermore, potential therapeutic applications of TMS, including therapy in a variety of illness and research into cortical localization, are discussed.