• Journal of Life Science
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• v.34 no.3
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• pp.208-213
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• 2024

Depression is one of the greatest health concerns in the world. Symptoms include emotion disorders, loss of appetite, reduction in interest, and insomnia. The prevalence of depression is increasing rapidly around the world and in South Korea. Elderly people are vulnerable to depression, resulting in serious socioeconomic problems. Depression in the elderly can cause sleep disorders, cognitive impairment, memory impairment, and many other diseases. Additionally, depression can cause frailty, which is associated with increased falls, chronic diseases, and mortality. Therefore, this study empirically analyzed sleep disorders in relation to depression, the link between exercise and the hippocampus in mitigating depression, and physical activity and exercise in the management of depression for successful aging.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.9
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• pp.597-604
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• 2016

A parallel algorithm of bi-conjugate gradient method was developed based on CUDA for parallel computation of the incompressible Navier-Stokes equations. The governing equations were discretized using splitting P2P1 finite element method. Asymmetric stenotic flow problem was solved to validate the proposed algorithm, and then the parallel performance of the GPU was examined by measuring the elapsed times. Further, the GPU performance for sparse matrix-vector multiplication was also investigated with a matrix of fluid-structure interaction problem. A kernel was generated to simultaneously compute the inner product of each row of sparse matrix and a vector. In addition, the kernel was optimized to improve the performance by using both parallel reduction and memory coalescing. In the kernel construction, the effect of warp on the parallel performance of the present CUDA was also examined. The present GPU computation was more than 7 times faster than the single CPU by double precision.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.41 no.1
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• pp.9-18
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• 2004

This paper presents an efficient image compression method for memory reduction in multimedia processor which can be simply implemented in hardware and provides high performance. The multimedia processor, which includes processing of high-resolution images and videos, requires large memories: they are external frame memories to store frames and internal line memories for implementing some linear filters. If we can reduce those memories by adopting a simple compression method in multimedia processor, it will strengthen its cost competitiveness. There exist many standards for efficiently compressing images and videos. However, those standards are too complex for our purpose and most of them are 2-D block-based methods, which do not support raster scanned input and output. In this paper, we propose a low-complexity compression method which has good performance, can be implemented with simple hardware logic, and supports raster scan. We have adopted 1${\times}$8 Hadamard transform for simple implementation in hardware and compression efficiency. After analyzing the coefficients, we applied an adaptive thresholding and quantization. We provide some simulation results to analyze its performance and compare with the existing methods. We also provide its hardware implementation results and discuss about cost reduction effects when applied in implementing a multimedia processor.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.49 no.4
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• pp.17-22
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• 2012

Convolution filtering methods have been widely applied to various digital signal processing fields for image blurring, sharpening, edge detection, and noise reduction, etc. According to their application purpose, the filter mask size or shape and the mask value are selected in advance, and the designed filter is applied to input image for the convolution processing. In this paper, we proposed an image processing acceleration method for the convolution processing by using two-dimensional Look-up table (LUT) and overlap-region buffering technique. First, based on the fixed convolution mask value, the multiplication operation between 8 or 10 bit pixel values of the input image and the filter mask values is performed a priori, and the results memorized in LUT are referred during the convolution process. Second, based on symmetric structural characteristics of the convolution filters, inherent duplicated operation region is analysed, and the saved operation results in one step before in the predefined memory buffer is recalled and reused in current operation step. Through this buffering, unnecessary repeated filter operation on the same regions is minimized in sequential manner. As the proposed algorithms minimize the computational amount needed for the convolution operation, they work well under the operation environments utilizing embedded systems with limited computational resources or the environments of utilizing general personnel computers. A series of experiments under various situations verifies the effectiveness and usefulness of the proposed methods.

• Journal of the Korean Society of Radiology
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• v.8 no.5
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• pp.231-240
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• 2014

The purpose of this study were to analyze that the Seoul neuropsychological screening battery (SNSB) for the evaluating cognitive assessment of the Parkinson's disease patients with mild cognitive impairment (PD-MCI) and the changes of the cerebral ventricle volume in the brain magnetic resonance imaging (MRI), and we has been bring forward the guideline to determine the diagnostic criteria for the PD-MCI. To achieve this, we was diagnosed with Parkinson's disease patients (PD-MCI group: 34 patients; Parkinson's disease with normal cognition, PD-NC group: 34 patients) to perform the SNSB test for the attention, language, memory, visuospatial, and frontal/executive functions and the brain MRI. Additionally, to compared the change of the cerebral ventricle volume, we performed the brain MRI for the 32 normal control (NC) group. The volumetric analysis for a specific cerebral ventricle performed by using Freesurfer Ver. 5.1 (Massachusetts general Hospital, Boston MA, USA). As a results, compared to the PD-NC group, the PD-MCI group were statistically significant reduction in the ability to perform the memory and the visuospatial function (p<0.05). The volumetric changes for a specific cerebral ventricle were statistically significant variation in the left and right lateral ventricle, left and right inferior lateral ventricle, and 3rd ventricle. Although, in order to compared the objectification, the normalized percentage applied to the volumetric changes showed to extend the PD-MCI group than the PD-NC group. Specially, the left and right ventricle extension for the PD-MCI patients conspicuously had showed a quantitative linear relationship between the memory and the visuospatial function for the SNSB (r>0.5, p<0.05). Therefore, we were able to judge the diagnostic criteria of the PD-MCI through that can observe the volumetric variation of the specific cerebral ventricle by using Freesurfer in brain MRI, and to analyze the correlation between the SNSB.

• Journal of Korean Philosophical Society
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• no.119
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• pp.129-159
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• 2017

The study of Freud's Moses and the background of the establishment of monotheism has become a subject of attention in the new atmosphere of the spreading of political theology and the recent rediscovery of Egyptology. This paper examines the publishing background and intentions of Freud's last book, Moses and Monotheism. And it will emphasize the fact that the Moses-Egyptian theory and his criticism of monotheism hid political theological intentions to prevent the spread of anti-Semitism in Nazi Germany. According to the Egyptologist Jan Assmann, there is a difference in that Moses' Judaism is monotheism, but Akhenaten's Aton-religion is a cosmotheism, and while Freud emphasizes Moses the 'historical figure' of that name, Assmann refers to Moses as a 'mnemohistorical figure.' Just as Freud said that the source of Jewish hatred is in Moses himself who established monotheism, Assmann argues also, monotheism is based on the so-called "Mosaic distinction" that distinguishes between true religion and false religion, thus it is possible to dismantle oppression and violence through the abolition of the Mosaic distinction. Assmann estimates that Freud had a clear stance to stop the spread of anti-Semitism as "the most explicit opponent of the Mosaic distinction." While anti-Semitic hatred spread to Christians in the Nazi era, Freud regards the real founder of Christianity, a jew Paul, as both a "Judaism destroyer" and a "successor to Judaism." At this point, Taubes began to see Paul's theology from a political theological point of view, and Assmann succeeded it. The "historical Moses" described by Freud are not "Prophet Moses" but "Moses as lawmaker and political reformer", and Jewish hatred has arisen in his distinction. Thus, Freud's monotheistic criticism as "disintegration by historical reduction"(Nietzsche) has political theological power. Just as Taubes interpreted Paul as a political theologian, Assmann found political theological elements in Freud's criticism of monotheism.

• Journal of Life Science
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• v.25 no.10
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• pp.1103-1109
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• 2015

Cholinergic innervation of the hippocampus is known to be correlated with learning and memory. The cholinergic agonist carbachol (CCh) modulate synaptic plasticity and produced long-term synaptic depression (LTD) in the hippocampus. However, the exact mechanisms by which the cholinergic system modifies synaptic functions in the hippocampus have yet to be determined. This study introduces an acetylcholine receptor-mediated LTD that requires internalization of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors on the postsynaptic surface and their intracellular mechanism in the hippocampus. In the present study, we showed that the application of the cholinergic agonist CCh reduced the surface expression of GluA2 on synapses and that this reduction was prevented by the M1 muscarinic acetylcholine receptor antagonist pirenzepine in primary hippocampal neurons. The interaction between GluA2 and the glutamate receptor-interacting protein 1 (GRIP1) was disrupted in a hippocampal slice from a rat upon CCh simulation. Under the same conditions, the binding of GluA2 to adaptin-α, a protein involved in clathrin-mediated endocytosis, was enhanced. The current data suggest that the activation of LTD, mediated by the acetylcholine receptor, requires the internalization of the GluA2 subunits of AMPA receptors and that this may be controlled by the disruption of GRIP1 in the PDZ ligand domain of GluA2. Therefore, we can hypothesize that one mechanism underlying the LTD mediated by the M1 mAChR is the internalization of the GluA2 AMPAR subunits from the plasma membrane in the hippocampal cholinergic system.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.6
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• pp.356-362
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• 2019

Scutellaria baicalensis (SB) has widely used in the treatment for various brain diseases in the field of Oriental medicine. Biofermantation of SB can make major chemical constituents of SB to pass blood-brain barrier easily and to have more potent anti-oxidant ability. There is a little information about the contribution of fermented SB (FSB) to the formation or maintenance of the neural plasticity in the hippocampus. The purpose of this study was to evaluate effects of FSB extract on hydrogen peroxide (H₂O₂) - induced impairments of the induction and maintenance of long-term potentiation (LTP), an electrophysiological marker for the neural plasticity in the hippocampus. From hippocampal slices of rats, the field excitatory postsynaptic potentials (fEPSPs) were evoked by the electrical stimulation to the Schaffer collaterals - commissural fibers in the CA1 areas and LTP by theta-burst stimulation by using 64 - channels in vitro multi-extracellular recording system. In order to induce oxidative stress to hippocampal slices two different concentrations (200, 400 μM) of H₂O₂ were given to the perfused aCSF before and after the LTP induction, respectively. The ethanol extract of FBS with concentration of 25 ㎍/ml, 50 ㎍/ml was diluted in perfused aCSF that had 200 μM H₂O₂, respectively. Oxidative stress by the treatment of H₂O₂ resulted in decrease of the induction rate of LTP in the CA1 area with a dose - dependent manner. However, the ethanol extract of FSB prevented the reduction of the induction rate of LTP caused by H₂O₂ - induced oxidative stress with a dose - dependent manner. These results may support a potential application of FSB to ameliorate impairments of hippocampal dependent neural plasticity or memory caused by oxidative stress.

• The Korean Journal of Nuclear Medicine
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• v.16 no.2
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• pp.25-28
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• 1982

Estimation of liver size is essential in the diagnosis of liver disease, Many approaches have been attempted in evaluation of liver size such as the measurement of length, area and volume. Among these, area and volume measurements are accurate but complicated, so we commonly use formerly introduced various linear measurements, but in scintigraphy one must calculate the actual liver size using rate of reduction, which is time consuming. Because of these reasons, we carried out present study to represent liver size by means of a simple liver measurement like we express the cardiac size by cardiothoracic ratio. Our cases consisted of 100 clinically normal subjects as the normal group and 50 patients suffering from liver disease and diagnosed to have hepatomegaly on abdominal palpation and scintigram at Dept, of Radiology of St. Mary's Hospital, Catholic Medical College during the period of 8 months from Jan. 1980. We measured the liver size using 4 linear diameters(Fig. 1). And as the reference measurement, the distance from the right margin of the liver to the left margin of the spleen was measured. We called this "abdominal transverse diameter(ATD)". The results were as follows; 1) The smallest value was recorded in the midline vertical diameter (MVD). It was $4.2{\pm}0.4cm$ in normal group and $5.0{\pm}0.6cm$ in the hepatomegaly group. 2) The diameter using other methods ranged from 5.6 to 7.2 cm in the normal group and from 6.3 to 7.5cm in the hepatomegaly group. 3) There was significant difference in the ratio of each diameter to ATD between the normal and hepatomegaly group (<0.01). We called this "hepato-abdominal ratio". 4) The "hepato-abdominal ratio" using MVD is $0.43{\pm}0.06$ in the normal group and $0.53{\pm}0.07$ in the hepatomegaly group. The "hepato-abdominal ratio" of MVD was most significantly different between normal and hepatomegaly group. 5) The tolerance limits(99%) of "hepato-abdominal ratio" using MVD is from 0.41 to 0.45 in the normal group and from 0.51 to 0.55 in the hepatomegaly group. Therefore, by reasons of error during measurement and convenience of memory, it was warranted to suggest hepatomegaly when "hepato-abdominal ratio" using MVD is more than 0.5 in the interpretation of hepatic scintigram.

• Journal of Korea Society of Industrial Information Systems
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• v.19 no.1
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• pp.13-18
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• 2014

Sensor nodes are used for monitoring and collecting the environmental data via wireless sensor network. The wireless sensor network with various sensor nodes draws attention as a key technology in ubiquitous computing. Sensor nodes has very small memory capacity and limited power resource. Thus, it is essential to have energy efficient strategy for the sensor nodes. Since the sensor nodes are operating on the same frequency bands with ISM frequency bands, the interference by the devices operating on the ISM band degrades the quality of communication integrity. In this paper, the convolutional code is proposed instead of ARQ for the error control for the sensor network. The proposed convolutional code was implemented and the BER performance is measured. For the fixed transmitting powers of -19.2 dBm and -25dBm, the BER with various communication distances are measured. The packet loss rate and the retransmission rate are calculated from the measured BER. It is shown that the porposed method obtained about 9~12% and 12-19% reduction in retransmission rate for -19.2 dBm and -25 dBm respectively.