• The Korea Journal of Herbology
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• v.27 no.6
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• pp.43-48
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• 2012

Objectives : This study was investigated to determine the contents of pesticide residues and sulfur dioxide residues in commercial herbal medicines in Korea. Methods : Chromatographic test was performed on 100 samples consisted with 10 kinds of medicinal plants including improted and domestic products. To establish 19 pesticide residues (DDE, DDD, DDT, Dieldrin, Methoxychlor, BHC isomers, Aldrin, Endosulfan isomers, Endrin, Captan, Procymidone, Chlorpyrifos and Imidacloprid) in commercial herbal medicines, chromatographic equipments were used with the gas chromatography-mass detector and gas chromatography-electron capture detector for qualitative analysis. The imidacloprid analysis was performed by high performance liquid chromatograpgy-ultraviolet detector at 270 nm UV wavelength. The contents of sulfur dioxides were analyzed by modified Monnier-Williams method. All methods were based on notification procedure of Korea Food & Drug Administration (KFDA). Results : The residual pesticides were not founded in improted and domestic samples. Among 100 samples, the residues of sulfur dioxide in 73 samples were not detected and 25 samples showed contents in the range of 0~21.90 mg/kg. The excess samples of MRLs were 2 samples (30 mg/kg to medicinal herbs), Asiasari Radix et Rhizoma (Imported product) and the average amount of sulfur dioxide in 2 unsuitable samples were 14.83 mg/kg. These samples were found to transgress KFDA regulatory guidance of residual sulfur dioxide. Conclusion : These results are able to use as basic data to improve the reliability and value of commercial medicinal herbs.

• 한국약용작물학회:학술대회논문집
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• 2011.09a
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• pp.104-105
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• 2011

• 한국약용작물학회:학술대회논문집
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• 2011.04a
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• pp.210-211
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• 2011

• 한국약용작물학회:학술대회논문집
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• 2012.05a
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• pp.127-128
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• 2012

• Korean Journal of Oriental Medicine
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• v.15 no.1
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• pp.23-29
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• 2009

The value of Dongeuibogam has been officially acknowledged as a Memory of the World. However, we should not overlook the forward-looking value of Dongeuibogam in addition to its backward-looking value. For the past 200 years, Western medicine has attained great achievements in therapeutic medicine based on Descartes' mind-body dualism, which focuses on the body as a separate entity from the mind. Recently, Western medicine modified its previously one-sided track into a new orientation towards holistic mind-body medicine in recognition of the two as an organic whole. At this point in time, it is essential to draw attention to the forward-looking value of Dongeuibogam, which pioneered mind-body medicine based on the medicinal philosophy of Jing Qi Shen more than 400 years ago.

• Korean Journal of Medicinal Crop Science
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• v.7 no.3
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• pp.218-228
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• 1999

This study was conducted to obtain the information on dry matter productivity in Angelica gigas Nakai for establishing the cultivation method. Cultivation methods such as direct seeding on Mar. 31, Apr. 15 and Apr. 30, and transplanting of $8^{\frac{1}{2}}$, 9, 12 months old seedling were investigated. There were similar tendencies in changes of agronomic characters for all cultivation methods. Dry weight started to increase from 120 DAS. Direct seedling showed vigorous growth for aerial part, whereas transplanting showed better underground part. The quadratic polynomial was suitable to dry weight of root after 120 DAS (or DAT) .Short growing time had higher RGR and NAR independent of cultivation method but Direct seeding on Mar. 31 and transplanting of 9 months old seedling had the highest CGRs. LAI was positively correlated with CGR, and CGR had the highest value as $6.74\g/m^2/day$ when LAI was 1.97. RGR and NAR increased as mean temperature was increased and showed the highest value around . The highest net production of leaf and petiole was obtained at 20 and$23^{\circ}C$, respectively.

• Food Science and Preservation
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• v.20 no.2
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• pp.272-277
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• 2013

The physicochemical and sensory properties of herb samgyetang, ginseng chicken soup added with medicinal herbs were investigated to determine the optimum addition level of medicinal herbs. The pH of herb samgyetang decreased with increasing addition level of the Acorus gramineus addition level, and the soluble solid content increased as the Codonopsis lanceolata addition level increased. The herb samgyetang with the highest Codonopsis lanceolata addition level had the lowest $L^*$ and $b^*$ value. In contrast, the $a^*$ value increased with increasing Codonopsis lanceolata addition level. In sensory evaluation, the highest color, taste, and overall acceptability scores were obtained by the herb samgyetang with the highest Codonopsis lanceolata addition level. In conclusion, the optimum addition levels of medicinal herbs for herb Samgyetang are as follows: Platycodon grandiflorum 4 g, Acorus gramineus 4 g, Codonopsis lanceolata 12 g, Schizandra chinensis 6 g, Atractylodeslancea 4 g, Glycyrrhiza uralensis 4 g, and Zizyphus jujube 4 g.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.3
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• pp.421-427
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• 2009

A mixture of three dietary medicinal herb extracts (MHE, mulberry leaf:Japanese honeysuckle:goldthread = 48.5: 48.5:3.0) was prepared as an additive of hen's feed. One hundred-eight, 28-wk-old Lohmann Brown hens were assigned randomly with three levels of MHE in the diet (0, 0.3, and 1%). Hens were fed for 6 wks and eggs were collected in the 6th week, and stored at $4^{\circ}C$ for 14 days to investigate the effect of MHE on the quality and oxidative stability of eggs. Internal quality of the egg including weight, shell color, albumen height, yolk color, shell weight, shell thickness, and Haugh units was not different among the dietary treatments. The oxidation stability of raw and cooked egg was determined by 2-thiobarbituric acid reactive substances (TBARS) value, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and 2,2'-azinobis(3-ethylbenzonthianoline-6-sulfonic acid) ($ABTS^{+}$) radical reducing ability. Results indicated that TBARS value at day 0 and $ABTS^{+}$ radical reducing ability of eggs from hens fed MHE were higher than from the control group. However, DPPH radical scavenging activity showed no difference in both raw and cooked samples. Results of the present study indicate that dietary MHE may slightly enhance the oxidative stability of eggs.

• Korean Journal of Medicinal Crop Science
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• v.15 no.5
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• pp.362-366
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• 2007

This study was conducted to evaluate the status of habitat distribution, environmental characteristics and plant species growing with Lonicera japonica in its habitats. In the distribution of plant coverage below 30%, it was 84.6% in the inland area and 80.7% in the seashore area. There was similar coverage in both inland and seashore areas. But the average relative coverage in the seashore area was 26.1%, which is a little higher than that of the inland area (22.5%). In the habitats, both inland and seashore areas showed a high distribution ratio below 10 degrees. But among them, inland areas showed a high distribution ratio (62.4%) below 10 degrees, which was about twice as much as the seashore areas (32.2%). Habitat distribution was most often found on the southern slopes in both inland and seashore areas. The average soil pH of Lonicera japonica habitat was 5.2 in the inland areas and 6.9 in the seashore areas. Also, the seashore areas showed little content of $P_2O_5$, but high content of K, Mg, Na on the other hand compared to the inland area. Miscanthus sinensis was the highest importance value (16.4) among plants growing with Lonicera japonica in their habitats in both inland and seashore areas. But in the inland areas, Artemisia princeps showed the highest importance value, and Miscanthus sinensis was the highest in the seashore areas.

• The Journal of Korean Medicine
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• v.42 no.3
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• pp.44-55
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• 2021

Objectives: As the use of herbal medicinal products (HMPs) increases worldwide, systematic verification of the safety of HMPs is required. The induction of cardiotoxicity is one of the major factors in post-approval withdrawal of medicinal products, and drug-induced cardiotoxicity assessment is emerging as an important step in drug development. In the present study, we evaluated human ether-à-go-go-related gene (hERG) potassium channel-related cardiotoxicity to predict the risk of cardiac arrhythmia in thirteen herbal medicines known to have cardiac toxicity. Methods: We measured the inhibition rate of hERG potassium channel activity of 13 medicinal herbal extracts in hERG-expressing HEK 293 cells using an automated patch-clamping system. Quinidine was used as a positive control for inhibition of hERG activity. Results: Extracts of Evodiae Fructus, Strychni Semen, and Corydalis Tuber potently inhibited the activity of hERG, and IC₅₀ values were 3.158, 19.87, and 41.26 ㎍/mL, respectively. Cnidi Fructus, Ephedra Herba, Lithospermi Radix, Polygoni Multiflori Radix, Visci Ramulus et Folium, Asiasari Radix et Rhizoma, and Scolopendra weakly inhibited hERG activity, and the IC₅₀ value for each herbal medicine was more than 400 ㎍/mL. Aconiti Kusnezoffii Tuber and two types of Aconiti Lateralis Radix Preparata (Po and Yeom) had weak inhibitory activity against hERG, and the IC₅₀ values were more than 700 ㎍/mL. The IC₅₀ value of quinidine against hERG was 1.021 𝜇M. Conclusion: Evodiae Fructus, Strychni Semen, and Corydalis Tuber acted as potent inhibitors against hERG. These herbal medicines may cause cardiac arrhythmia through QT prolongation, so care should be taken when taking them.