• Microbiology and Biotechnology Letters
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• v.50 no.4
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• pp.512-521
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• 2022

Since the main symptoms of COVID-19 involve the respiratory system, the infection rate of this disease is predicted to be higher in patients with other respiratory conditions such as allergic rhinitis. In such a situation, it will be meaningful to conduct research on an allergy treatment that has fewer side effects and can effectively reduce allergy symptoms. Here, we prepared experimental samples under various fermentation conditions with mixed extracts of six medicinal plants. To examine the anti-allergic efficacy of these samples, an egg albumin-induced allergic rhinitis animal model experiment, a serum histamine and IgE experiment, and a COX and LO inhibitory activity experiment were conducted. As a result of animal experiments, OVA+SP-4 showed superior efficacy compared to OVA+SP-1 in nasal rubbing and sneezing experiments and had anti-allergic efficacy similar to that of OVA-cetirizine. The serum histamine concentration of OVA+SP-4 was also 1.3 times higher than that of the OVA+cetirizine group, showing a high histamine reduction ability, and IgE showed the same trend. An analysis of COX inhibitory efficacy also confirmed that COX-1 and COX-2 inhibitory efficacy is high, and the longer the fermentation time, the higher the antiallergic efficacy. The composition proposed by this study is expected to have a significant effect on sustainable allergy prevention and treatment in the future by applying it to human patients.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2022.09a
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• pp.106-106
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• 2022

The cone of Red Pine (Pinus densiflora), which has been used as a drug in traditional medicine. Its ethyl acetate fraction was reported to exert antioxidant, anti-melanogenesis, and anti-inflammation activites. Apoptosis of hepatic stellate cells (LX-2) is regarding as a potential strategy for alleviation of hepatic fibrosis. We conducted to investigated whether the treatment of cone has a potential to control of some factors related in apoptosis and autophagy in cell signaling pathways. We suggest that the cone induced apoptosis through confirming the expression levels of genes (cPARP, Bcl-XL, Bax, p53, and caspase-3) in LX-2 cells. Also, the cone may regulate autophagy (LC3, p62, Beclin-1, and ATG12). Remarkably, the treatment of cone may affect to formation of autophagosomes in the immunofluorescence image in live cells. These findings suggest that the ethyl acetate fraction from the cone of Red Pine (P. densiflora) may have potential as an alternative therapeutic agent for the alleviation and prevention of liver fibrosis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.6
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• pp.834-841
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• 2012

We in this paper propose a mobile application for supporting medical treatment based on Korean medicine ontology. It has three processes for treating patients. First, after a pattern is decided for patient' symptoms, a formula for the pattern is selected and medicinal materials constituting the formula is added or removed. Second, formulas are searched and prescribed for patient's symptoms without the process of the pattern decision. Third, after medicinal materials are searched for patient's symptoms, formulas consisting of the medicinal materials are prescribed. Our application aims to help korean medicine doctors treat patients through providing decision supporting functions such as the recommendation of symptoms of diseases accompanying patient's symptom. Doctors generally diagnosis patients according to their experiences and knowledges. Nevertheless, our application can help them, providing diverse forms of information that they may miss in the medical treatment.

• Journal of Pharmacopuncture
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• v.20 no.3
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• pp.173-178
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• 2017

Objectives: Medicinal plants are vital sources of bioactive compounds that are useful for the treatment of patients with snake bites or are indirectly applicable for boosting the effects of conventional serum therapy. These plants are being used traditionally by local healers and tribes for the treatment of patients with snake bites and therefore can be used as an alternative against snake envenomation. Scientifically, using the secondary metabolites of plants to neutralize venom enzymes has an extra benefit of being based on traditional knowledge; also, the use of such metabolites for the treatment of patients with snake bites is cheaper and the treatment can be started sooner. Methods: All the available information on various secondary metabolites exhibiting venom neutralizing ability were collected via electronic search (using Google books, Pubmed, SciFinder, Scirus, Google Scholar, and Web of Science) and articles of peer-reviewed journals. Results:Recent interest in different plant has focused on isolating and identifying of different phytoconstituents that exhibit Phospholipase A2 activity and other venom enzyme neutralizing ability. In this support convincing evidence in experimental animal models are available. Conclusion: Secondary metabolites are naturally present, have no side effect, are stable for a long time, can be easily stored, and can neutralize a wide range of snake enzymes, such as phospholipase A2, hyaluronidase, protease, L-amino acid oxidase, 5'nucleotidase, etc. The current review presents a compilation of important plant secondary metabolites that are effective against snake venom due to enzyme neutralization.

• Bulletin of Food Technology
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• v.18 no.4
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• pp.150-157
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• 2005

This article presents a review of indigenous medicinal plants used in folk medicine in Fergana valley (Uzbekistan) for treatment of gastro-intestinal problems. The 29 different plantsbelong to18 different plant spices are presented. The methods of preparation of remedies and utilized parts of plants are described.

• Korean Journal of Medicinal Crop Science
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• v.10 no.4
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• pp.288-293
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• 2002

Allergen-removed-extract was produced from Rush verniciflua by two phase methods. Phase one was high temperature treatment of Rush verniciflua tree to get allergen-removed-extract. Phase two was extraction of solution from phase one product using water or organic solvents. The solutions from above method show high antioxidant activity, anticancer activity, and improvement in lung function, but did not contain urushiol family compounds.

• Journal of Pharmacopuncture
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• v.21 no.4
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• pp.294-295
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• 2018

• Korean Journal of Medicinal Crop Science
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• v.16 no.1
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• pp.33-38
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• 2008

This study was carried out to reduce the number of chemical treatment by optimal apply for the disease and pest and obtain the basal data of environmental-friendly cultivation in Panax ginseng in 2006. The result by checking disease Incidence and pests fried in ginseng field of jeollabuk-Do was as follows. The kind of disease occurred in Jinan was 8 including Rhizoctonia solani, 7 with Botrytis cinerea in Jeongeup, and also 6 with Botrytis cinerea in Kochang within Jeollabuk-Do. It was required thorough disease control before the rainy season because the occurrence time was peaked around July. Also, the most serious disease in Jeollabuk-Do was Alternaria alternata, Botrytis cinerera, and Colletotrichum gloeosporioides. The actual harmful pests in ginseng field were Asusta despecta steboldiana and Holotrichia sp. and in other method using black light trap, Maladera orientalis, Ostrinia furnacalis, and Holotrichia morosa were mainly trapped.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.2
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• pp.215-219
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• 2002

Over the past decade there has been a resurgence of interest in botanical products for their medicinal uses. This present study was designed to screen medicinal plants for the treatment of brain diseases such as Alzheimer's disease or aging. We tested the effects of the water extracts from 41 species medicinal plants on acetylcholinesterase (AChE) inhibition and antioxidant activity in vitro. Among them, Euodia rutaecarpa, Rubus coreanus, Achyranthes japonica, Morus alba, Salvia miltiorrhiza, Liriope platyphylla, and Rheum palmatum showed relatively AChE inhibition potency over 80%. Among the 7 medicinal plants investigated, E. rutaecarpa showed an 25%, 65%, and 93% inhibitions on AChE activity at 2.5, 12.5, and 25 ㎍/㎖ of the extract, respectively and was found to be one of most potent AChE inhibitor. The water extracts from 4 species (E. rutaecarpa, R. coreanus, A. iaponica, and M. alba) were tested on their antioxidant capacities using radical scavenging effect against ABTS/sup ㆍ+/. Among the 4 medicinal plants investigated, both R. coreanus and E. rutaecarpa showed significant antioxidant capacity. Therefore, E. rutaecarpa and R. coreanus are expected to ameliorate the clinical symptoms in Alzheimer's disease due to significant AChE inhibition and radical scavenging effect.

• The Korea Journal of Herbology
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• v.22 no.1
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• pp.13-24
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• 2007

Objectives : The plans such as Selaginellales, Equisetales and Psilotale have been used for treatment of diseases. Therefore, we examined their effects and distributions. Methods : We examined herbalogical books and research papers which published at home and abroad. Results : 1. There were totaled to 5 genera and 33 species in Selaginellales. Equisetales, Psilotales in Korea and among them medicinal plants are 4 genera, 21 species, about 64% in total. 2. Lycopodium genus is main kind enough that it has 13 species among 33species in the Selaginellales, Equisetales, Psilotales, of which medicinal plants are 10 species. 3. The herb is the main medicinal parts of medicinal plants in the Selaginellales, Equisetales, Psilotales which is used in 21 species. 4. On the bases of nature and flavor of medicinal plants in the Selaginellales, Equisetales. Psilotales, they were classified into neutral 15 species; bitter taste 15 in the order. 5. On the bases of meridian propism of medicinal plants in the Selaginellales, Equisetales. Psilotales, they were classified into liver meridian 11 species. 6. On the bases of the properties and principal curative action, they were classified into drugs for styptic 15 species, drugs for expel wind 14, drugs for drain damp 13 in the order. 7. It has been shown that one species in the Selaginellales, Equisetales, Psilotales is toxic. Conclusion : There were totaled to 5 genera and 33species in Farinales in Korea and among them medicinal plants are 4 genera, 21 species, About 63% in total.