• 한국식품저장유통학회지
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• 제20권2호
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• pp.272-277
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• 2013

우리의 고유 음식인 삼계탕에 인지기능 향상 및 뇌질환 예방 효과를 가지고 있는 도라지, 더덕, 석창포를 부재료로 이용하여 한방 삼계탕의 제조를 위한 최적 혼합 비율을 설정하고자 한약재 부재료의 혼합 비율에 따른 품질 특성과 관능적 특성을 조사하였다. 삼계탕 국물의 pH는 석창포의 함량이 가장 많은 한약재 조합인 S2는 4.57로 가장 낮은 값을 보였으며, 당도는 더덕의 함량이 가장 높은 S3에서 $3.87^{\circ}Brix$로 다른 시료에 비해 유의적으로 높은 함량을 보였다. 명도와 황색도는 더덕의 함량이 가장 많은 한약재 조합인 S3에서 가장 낮은 값을 보였으며, 반면에 적색도는 더덕 혼합 비율이 증가함에 따라 a값도 증가하는 경향을 보였다. 관능검사 결과 향미는 도라지의 함량이 가장 많은 시료에서 가장 높은 기호도를 보였으나, 이를 제외한 색, 맛, 전체적인 기호도는 더덕의 함량이 가장 높은 한약재 혼합 비율에서 가장 높은 점수를 보였다. 본 연구 결과, 한방 삼계탕 제조를 위한 한약재의 혼합 비율은 도라지, 석창포, 삽주, 감초, 대추는 각 4 g, 오미자 6 g, 그리고 더덕 12 g이 가장 적합하다고 판단된다.

• 한국축산식품학회지
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• 제28권2호
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• pp.122-129
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• 2008

본 연구는 한약재 추출물의 첨가가 돈육 패티의 이화학적, 미생물학적 품질에 미치는 영향을 조사하고자 하였다. 약리 한약재인 상엽(Morus alba L.), 금은화(Lonicera flos), 황련(Coptis chinensis)를 48.5:48.5:3.0의 비율로 혼합하여 사용하였으며 대조구는 한약재 추출물을 무첨가, 처리구는 혼합 한약재 추출물을 0.5, 1 및 2%의 수준으로 첨가하여 제조하였다. 제조된 돈육 패티는 냉장온도($4^{\circ}C$)에서 10일간 저장하면서 일반 성분, pH, 표면색도, 미생물검사, 총 페놀함량, $ABTS^+$ radical 소거찬성, 관능적 특성을 조사하였다. 일반성분 중 조회분은 대조구보다 2% 첨가구가 높았고 조지방은 대조구보다 모든 처리구에서 높게 나타났으며 pH는 저장기간이 경과함에 따라 대조구보다 처리구에서 높게 나타났다 표면색도는 저장기간 동안 L(명도)값과 a(적색도)갈이 대조구보다 혼합 한약재 추출물을 첨가한 처리구에서 낮게 나타났으며 총균수는 혼합 한약재 추출물을 1% 이상 첨가시에 무첨가한 대조구보다 약 1 log 수준의 총균수의 감소를 보였다. 총 페놀함량은 저장기간이 경과함에 따라 처리구에서 높은 페놀함량이 나타났으며 10일째에 2% 첨가구가 약 25 ppm을 함유하였다. $ABTS^+$ radical 소거활성은 혼합 한약재 추출물 첨가 비율이 높은 처리구일수록 소거능력이 증가하였고 저장기간 10일째에 2% 첨가구가 높은 소거활성을 보였다. 관능적 특성은 0일차의 색은 대조구보다 처리구가 낮게 나타났으며 5일차에서 색은 2% 첨가구가 가장 낮게 나타났고 육즙삼출도는 5일, 10일째에 2% 첨가구가 가장 낮았으며 종합적 기호도는 대조구와 처리구가 유의적인 차이를 보이지 않았다. 이상의 결과를 종합해 보면 돈육 패티 제조시에 혼합 한약재 추출물을 첨가하는 것이 항산화성, 항균성, 관능적 품질의 개선에 효과적인 방법이라 사료되며 다만 관능적 특성을 고려하여 그 첨가량을 조정할 필요가 있다고 판단된다.

• 대한본초학회지
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• 제30권5호
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• pp.51-58
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• 2015

Objectives : This paper aimed to verify the applicability of mixed extract ofAngelica gigasNakai,Cnidium officinaleMakino,Paeoniala ctifloraPall,Rechmannia glutinosaLibosch,Scutellaria baicalensisGeorgi, which were prescribed for improving inflammation in Donguibogam, as the materials for beauty food and functional medicinal herb cosmetics by manufacturing such mixed extract and evaluating the biological activity of the extract.Methods : The mixed medicinal herb water extract(MMW) and ethanol extract(MME) were freeze-dried to be used as the specimen. We performed electron donating ability, lipid acidification inhibitory activity, anti-inflammatory activity against skin flora, MTT assay, NO inhibitory activity and the protein expression inhibitory activity of iNOS and COX-2.Results : For anti-oxidation experimentation, the electron donating abilities of MMW and MME were above 60.0% and 90.0% at 500 μg/ml, respectively. In the inhibition rate of lipid peroxidation, MMW and MME showed 43.1% and 52.1% at 1,000 μg/ml, respectively. As a result of antimicrobial activity, both the MMW and MME showed significant clear zones forPropionibacterium acnesat 4 mg/disc, but did not indicated the clearzones forStaphylococcus aureus, Escherichia coliandStaphylococcus epidermidis. Anti-inflammatory activity by NO assay showed LPS-induced NO was significantly inhibited in a concentration-dependent manner. Also, the expression of iNOS and COX-2 proteins were significantly inhibited following treatment with MMW and MME of 50 μg/ml.Conclusions : Accordingly, it can be concluded that mixed medicinal herb extract has the potential to beused as a functional food and cosmetic material.

• Clinical and Experimental Pediatrics
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• 제48권9호
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• pp.1009-1015
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• 2005

납중독은 가벼운 빈혈에서부터 경련을 동반한 신경장애에 이르기까지 다양한 임상증세를 나타내며, 뼈나 연부조직에 침착되어 비가역적인 장애를 남기므로 임상적으로 중요하다. 특히 소아는 소화관을 통한 흡수율이 높고 배설율이 낮아 납중독의 영향에 예민한데 혈중 농도와 개인차에 따라 심한 복통 및 지능저하, 경련 등의 비가역적인 신경계장애를 남길 수 있어 조기진단 및 치료가 중요하다. 이에 저자들은 살빼는 목적으로 비전문가에게 처방받은 환약으로 제조된 한약을 복용하여 빈혈을 동반한 심한 복통을 주소로 내원한 형제들에게 자칫 출혈성 장질환으로 여기고 지나칠뻔 하였으나 환약복용의 과거력을 단서로 혈중 납농도 및 환약의 납 성분 분석을 통해 확진한 2례를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다.

• Natural Product Sciences
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• 제27권3호
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• pp.201-207
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• 2021

We have previously reported that Acer tegmentosum extract, which is traditionally used in Korea to reduce alcohol-related liver injury, suppresses liver inflammation caused by excessive alcohol consumption and might improve metabolism. The active ingredient, 6-O-galloylsalidroside (GAL), was isolated from A. tegmentosum, and we hypothesized that GAL could provide desirable pharmacological benefits by ameliorating physiological conditions caused by alcohol abuse. Therefore, this study focused on whether GAL could ameliorate alcoholic fat accumulation and repair liver injury in mice. During chronic alcohol consumption plus binge feeding in mice, GAL was administered orally once per day for 11 days. Intrahepatic lipid accumulation was measured in vivo using a noninvasive method, ¹H magnetic resonance imaging, and confirmed by staining with hematoxylin and eosin and Oil Red O. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured using a Konelab system, and the triglyceride content was measured in liver homogenates using an enzymatic peroxide assay. The results suggested that GAL alleviated alcohol-induced steatosis,e as indicated by decreased hepatic and serum triglyceride levels in ethanol-fed mice. GAL treatment also correlated with a decrease in the Cd36 mRNA expression, thus potentially inhibiting the development of alcoholic steatosis via the hepatic de novo lipogenesis pathway. Furthermore, treatment with GAL inhibited the expression of cytochrome P450 2E1 and attenuated hepatocellular damage, as reflected by a reduction in ALT and AST levels. These findings suggest that GAL extracted from A. tegmentosum has the potential to serve as a bioactive agent for the treatment of alcoholic fatty liver and liver damage.

• 대한예방한의학회지
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• 제18권1호
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• pp.93-101
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• 2014

Objective : The aim of this study is to analyze medicinal herbs, the ingredients of traditional Korean liquor, focusing on efficacy in the traditional Korean medicine. Through this study, for vitalizing traditional Korean liquor market, the researchers attempt to explain the superiority of traditional Korean liquor and the advantages of using herbs to brew alcoholic beverages. Method : We conducted a research targeting traditional Korean liquors in domestic market from July through september 2012, and finally 70 kinds of liquor were selected and analyzed. Results : Among traditional liquors, fermented liquors are most common. When comparing regions of brewery, the central region of Korea, Gyeonggi-do and Chungcheongnam-do, is major brew area. 37 liquors contain just one medicinal herb. followed 10 liquors contain two medicinal herbs. The most frequently used medicinal herb is Ginseng Radix. And Lycii Fructus, Schisandrae Fructus, Angelicae Gigantis Radix and Chrysanthemi Indici Flos are well used medicinal herbs to brew traditional liquors. In the classification of efficacy of medicinal herbs, tonifying and replenishing medicinal herbs are most popular as ingredients in the traditional alcohols, astringent medicinal herbs, exterior releasing medicinal herbs and heat clearing medicinal herbs are also frequently used. Investigation of tastes and properties of the herbs, it reached a conclusion as below: sweet taste is most common, followed by sour taste and bitter taste. Warm property is account for 50% approximately, followed by cold property. Conclusion : Medicinal herbs have been widely used in the traditional Korean liquor. It came out into the open that the liquor with medicinal herbs is very good for our body in terms of longevity and invigoration. However, liquor consumers concern about not only the efficacy but also the taste, scent and color. Therefore, further study about these things would be required to demonstrate the superiority of the traditional Korean liquor.

• 한국약용작물학회지
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• 제25권2호
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• pp.108-114
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• 2017

Background: The study was conducted to investigate the distributions of faecal bacteria in commercial oriental medicine herb products. Methods and Results: A survey was conducted on the microbial contamination levels and antimicrobial specificity of Bacillus cereus and other microbes using 106 oriental medicine herb products on sale in Seoul. Pouring and isolation methods such as standard plate counts were used to identify the bacteria. The isolated bacterias included coliforms, Bacillus spp., Enterococcus spp., Staphylococcus spp., Listeria spp.were identified by using gram staining and an API (analytical profile index) kit. Antimicrobial drugs discs were determined by CLSI (clinical and laboratory standards institute). Conclusions: The bacterial isolates present in the herbal medicines included 98 coliforms, 45 Bacillus spp., 29 Enterococcus spp., and 2 Listeria spp. Among these, there were nine Bacillus cereus strains, one Enterococcus faecium strain, and one Enterococcus faecalis strain present. The 9 Bacillus cereus strains were tested for susceptibility to 36 types of antibiotics products by the disc diffusion method. The strains showed resistance to 13 of these antibiotic products and semi-resistance to 5 antibiotic products. On the basis of these results, any oriental medicine herb product can be assumed to be contain resistant or semi-resistant bacterial strains. Therefore, we suggest prescribing guidelines and special management for the use of antibiotics in farms producing oriental medicine herb products.

• 한국실내디자인학회:학술대회논문집
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• 한국실내디자인학회 2004년도 추계학술발표대회 논문집
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• pp.149-152
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• 2004

Currently, with the development of an advanced industrial form, attention to human life has risen gradually. On the basis of aboves, Oriental medical industry has been achieved revolutionarily, and moreover the new word 'Well-being' has been born due to the value of life and attention to health. All who live in the 21-century have worried about problem with health and well-being, and the substitute medical science centering around the Oriental medicine has come up as the major concern, not to speak of the Oriental the West. Domestically, Research and attention to the Oriental medicine has increased, and its importance has appeared. At the moment, locally self-governing groups have taken an active step to study the genetic resources centering around locally- breedy wild medicinal herbfor their economy growth. Accordingly, in the historic view, to discover our medicinal herb's essence and to supply professional, systemical infomation of herb genetic, the necessity of professional exhibition museum can come up. under the above circumstances, I propose the public information museum in local area.

• 환경생물
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• 제22권4호
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• pp.519-523
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• 2004

This study sought to investigate the ameliorating effects of a Korean medicinal herb (KMH) complex on the impacts of alcohol consumption in rat hepatocytes and in reducing the total cholesterol levels and the total lipid levels in the serum. We compared the body weight gain and ratio of the liver, the kidney to body weight, and also the serum biochemistry of the rats administered with both the alcohol and the KMH complex to the control rats treated with alcohol alone. The clinically important enzyme markers (Aspartate Aminotransferase, AST, and Alanine Aminotransferase, ALT) of rats, administered with both the alcohol and the KMH complex treatments, were compared with those in the control group. The treatment regimen (KMH complex) significantly reduced the serum AST and ALT levels, indicating the hepato-protective effects of the KMH complex. Furthermore, total cholesterol and total lipid levels were significantly reduced. These results indicate that the KMH complex may positively mediate the effects of alcohol on hepatocytes and the general liver functions.

• 대한한의학회지
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• 제44권3호
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• pp.163-169
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• 2023

Objectives: This study aimed to review the experimental research trends in asthma caused by particulate matter to conduct further researches, especially in clinical trials. Methods: We searched for the meaningful literature using medicinal herb for asthma through the Pubmed databases. Results: Finally, six studies were finally selected. These studies showed recent trends, from 2018 to 2021 and conducted mostly in South Korea. The type of fine dust and the method of inducing asthma are different for each paper, but the effective mechanism is relatively common. It was commonly confirmed that the ratio and number of eosinophils, th2 cells and related cytokines are decreased in BALF and lung tissue by administration of medicinal herb. Conclusions: Although the method of inducing asthma using fine dust has not yet been standardized, it is thought that more meaningful evaluation results can be derived if a standardized animal model is established in the future. Nevertheless, based on the results that herbal medicine is effective for particular matter induced asthma, it is expected that it will be the basis for expanding into future clinical studies.