• YAKHAK HOEJI
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• v.40 no.1
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• pp.84-89
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• 1996

This study was done to investigate the effect of glycyrrhizin on the lethality induced by galactosamine and lipopolysaccharide coadministration in mice. Glycyrrhizin was injecte d intravenously as a multiple dose at 20, 15, 10, 5, and O hr before galactosamine and lipopolysaccharide coadministration. Lethality and tumor necrosis factor (TNF${\alpha}$) level in serum were surveyed as markers of glycyrrhizin effect. Glycyrrhizin had no effect on the lethality induced by galactosamine and lipopolysaccharide when glycyrrhizin was administered as a single dose. Glycyrrhizin reduced the lethality induced by galactosamine and LPS in dose-dependent manner when glycyrrhizin was administered as a multiple dose at 20, 15, 10, 5 and O hr before galactosamine and lipopolysaccharide coadministration. Glycyrrhizin reduced the serum TNF${\alpha$ level.

• Journal of Applied Biological Chemistry
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• v.63 no.3
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• pp.175-180
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• 2020

The purpose of this study was to investigate the cultivation site of Cornus officinalis (C. officinalis) by analyzing the contents of loganin and morroniside according to the cultivation environment of C. officinalis. The loganin and morroniside contents were analyzed by ultra performance liquid chromatography. Mg content and pH in soil data were found to have the greatest effect on logainin content. In soil data, Mg, Na content, pH, salinity, silt ratio and clay ratio were found to have the greatest effect on morroniside content. Therefore, Mg content, pH, and clay ratio were found to have a high effect on the contents of loganin and morroniside, which are indicators of C. officinalis. In conclusion, Mg content, pH, and clay ratio in soil may have a high effect on the contents of loganin and morroniside, which are indicators of C. officinalis.

• Culinary science and hospitality research
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• v.19 no.4
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• pp.268-278
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• 2013

The purpose of this research is to examine the effects of selection attributes of medicinal food on customer satisfaction and purchase attitude in Jinju area. A survey was conducted to 300 people who live in Jinju area, and 252 completed copies of questionnaire was returned. Statistical package 'SPSS WIN 20.0' was used to analyze the sample data, and the result of the analysis is as follows. First, for the hypothesis, 'selection attributes of medicinal food have a significant effect on satisfaction,' food quality, health food and services have a significant effect on customer satisfaction. Second, customer satisfaction with medicinal food has a significant effect on revisit. Third, customer satisfaction leads to recommendation to others. In conclusion, this research shows that medicinal food restaurants in Jinju area should provide healthy food menu, high-quality food and high-class services, which could be effective to promote the specialty of medicinal food restaurants for costumers.

• Archives of Pharmacal Research
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• v.23 no.5
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• pp.501-506
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• 2000

We examined the antifibrotic effect of a methanol extract from Stephania tetrandra (ST) on experimental liver fibrosis. liver fibrosis was induced by bile duct ligation and scission (BDL/S) in rats. In BDL/S rats, activity levels of aspartate transaminase (AST), alanine transaminse (ALT), alkaline phosphatase (ALP), concentration of total bilirubin in serum, and hydroxyproline content of the liver were significantly increased. The ST treatment (either 100 ${m}g/kg/day$ or 200 ${m}g/kg/day$, p.o. for 4 weeks) in BDL/S rats reduced the serum AST, ALT and ALP activity levels significantly (p<0.01). Similarly, when compared to the control group, the concentration of hydroxyproline in the livers of the BDL/S rats treated with 100${m}g$ or 200${m}g$ ST treated rats decreased by 40% and 33% respectively, when compared to the BDL/S control group (p<0.01). The morphological characteristics of fibrotic liver that were observed in the BDL/S control group, improved in the ST treated BDL/S group. In the fibrotic liver of BDL/S rats treated with ST, a marked reduction in the numbers of alpha smooth muscle cell actin positive stellate cells was observed. These results indicate that doses of either 100 or 200 ${m}g/kg/day$ of methanol extract from S. tetrandra, had an antifibrotic effect in rats with liver fibrosis induced by bile duct ligation and scission.

• Advances in Traditional Medicine
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• v.1 no.2
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• pp.21-28
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• 2000

We compared the effect between CAS and WAS(root, stem) on mast cell-mediated allergic reaction. CAS, WAS-root and WAS-stem, significantly inhibited compound 48/80-induced systemic allergic reaction(1g/kg) and histamine release from RPMC(1mg/ml). CAS, WAS-root and WAS-stem also inhibited passive cutaneous anaphylactic reaction. In addition, IgE-induced $TNF-{\alpha}$ secretion from RBL-2H3 was inhibited by pretreatment of CAS, WAS-root or WAS-stem$(0.01{\mu}g/ml)$. Taken together, inhibitory effect on mast cell-mediated allergic reactions of WAS-root is greater than those of WAS-stem but less than those of CAS.

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.41-42
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• 2007

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.135-136
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• 2007

• Korean Journal of Environmental Biology
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• v.22 no.4
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• pp.513-518
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• 2004

Pine needle oil and Korean medicinal herbs (KMH) are known as effective therapeutic agents on various blood vessel disease. We have already reported the ameliorative effect of complex of pine needle oil and Korean medicinal herbs against hyperlipidemia. But safety and non - toxicity of pine needle oil and Korean medicinal herbs to normal animal cells have not been studied clearly. In this study, we investigated whether pine needle oil and Korean medicinal herbs show side effects on rat or not. These materials were administered to rats, and subacute toxicity was examined by measuring the hematological values, CBC differentiation, biochemical levels of blood (TP, total protein; albumin; ALP, alkaline phosphotase; AST, aspatate aminotrans- ferase; ALT, alanine aminotransferase; T-Chol., total cholesterol; T-Bil., total bilirubin) and urine analysis, suggesting that the sample have no side effects and cytotoxicity. These results indicate that the complex of pine needle oil and Korean medicinal herbs may effective non- toxic, safety therapeutic agents on hepatocytes and hyperlipidemia.

• 한국약용작물학회:학술대회논문집
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• 2012.05a
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• pp.349-350
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• 2012

• 한국약용작물학회:학술대회논문집
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• 2009.05a
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• pp.151-152
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• 2009