• 한국산학기술학회논문지
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• 제15권3호
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• pp.1650-1662
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• 2014

본 연구는 고위험약물의 투약조정을 위한 스마트 폰 어플리케이션의 내용을 구축하고 개발된 어플리케이션의 만족도를 평가하기 위해 수행되었다. xcode 4.5와 ios 6.1 SDK(software development kit)을 이용하여 시스템을 구축하였다. 4주간의 중재 후 35명의 중환자실 간호사들에게 기능적, 내용적, 화용적 측면의 만족도를 물었다. 또한 하루의 사용횟수와 사용의 빈도에 따른 만족도의 차이를 평가하였다. 이를 위해서는 SPSS WIN 18.0을 활용하여 서술적 분석, ANOVA를 적용하였다. 약물계산 식을 개발하고 과다 혹은 과소 용량에 대한 알람을 주는 과정을 개발하였고, 고위험 약물에 대한 정보를 구축하였다. 만족도와 관련된 문항 중 이 어플리케이션은 약물계산을 수행하는데 도움이 된다는 문항이 3.14점이었으나 이 어플리케이션에 만족한다는 문항은 2.94에 그쳤다. 하루의 사용횟수와 사용빈도와 관련해서 만족도의 차이는 없었다. 이 연구의 결과에 근거할 때 추후 더욱 진보된 고위험약물을 위한 투약조정용 스마트폰 어플리케이션은 환자안전을 위한 중요한 기반을 제공해 줄 수 있을 것이다.

• 한국융합학회논문지
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• 제8권6호
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• pp.121-130
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• 2017

본 논문은 간호대학생의 환자안전관리 수행자신감에 영향을 미치는 요인을 파악함으로써 간호대학생의 환자안전관리역량 증진 융합교육프로그램을 개발하는데 필요한 근거를 마련하고자 수행하였다. 본 연구는 간호학과 4학년 재학생 228명을 대상으로 하였다. 간호대학생의 환자안전관리 수행자신감에 영향을 미치는 요인을 규명하기 위해 다중회귀분석을 실시하였다. 간호대학생이 임상에서 경험한 환자안전 사고는 낙상(50.0%), 주사바늘 찔림(18.5%), 환자확인 오류(12.0%), 주사투약 오류(7.5%), 경구투약 오류(4.3%)순이었다. 간호대학생의 환자안전관리 수행자신감의 유의한 영향요인은 환자안전관리 태도(t=6.09, p<.001), 임상의사결정능력(t=3.97, p<.001) 및 성별(t=2.56, p=.011)로 나타났다. 이와 같은 연구결과를 근거로 간호대학생의 환자안전관리 수행자신감을 증진시키기 위해서는 환자안전관리 태도, 임상의사결정능력 및 성별을 고려한 융합교육 프로그램을 개발할 것을 제안한다.

• 대한디지털의료영상학회논문지
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• 제11권2호
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• pp.79-84
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• 2009

Recently, there has been a rapid increase of interest in u-Health systems or instruments. The importance of testbeds has been discussed deeply also. However, beyond laboratory or ward environments, testbeds covering metropolitan area cannot be found easily. Moreover, there has been few papers which discuss the results of testbed operations for various instruments in different age groups. In this paper, the results of testbed which operated in Daegu metropolitan area are discussed and improvement directions to strengthen the competitiveness are proposed using user analysis. In particular, the results of trial services using the u-Life support instruments (medication reminder, falling safety phone, bio-patch and shirts, etc) for super aging societies in the near future are discussed.

• Journal of Acupuncture Research
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• 제31권4호
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• pp.71-79
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• 2014

Objectives : The aim of this study is to evaluate the safety of acupuncture therapy when applied to patients who are undergoing anticoagulants / antiplatelet medication therapy combined with herbal medicine using a retrospective, case-control study. Methods : 428 charts of patients were reviewed in this study. Odds ratio between case of bleeding-related adverse event and control was calculated as main analysis. Exposures were anticoagulants / antiplatelet medication, Hwalhyeolgeoeo herbal medicine and combination of both drugs. Additionally, odds ratios were calculated according to the severity of bleeding-related adverse events. Results : The results were as following: 1. Analysis of all bleeding-related adverse events showed there was no increased risk of combined therapy compared with other exposures and control group. 2. Analysis of only clinically significant adverse events showed there was no increased risk of combined therapy compared with other exposure and control group. 3. Hwalhyeolgeoeo herbal medicine group showed a tendency of increased risk of bleeding-related adverse events in all analysis but was not statistically significant. Conclusions : The results suggest that Hwalhyeolgeoeo herbal medicine-anticoagulant / antiplatelet medication combined therapy may not increase risk of bleeding-related adverse events in acupuncture therapy. By executing various modules of analysis, it was possible to acquire useful data for possible future studies. Further research is needed to confirm such results.

• 한국임상약학회지
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• 제30권2호
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• pp.92-101
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• 2020

Background: Delirium is a neuropsychiatric disorder characterized by sudden impairments in consciousness, attention, and perception. The evidence of successful pharmacological interventions for delirium is limited, and medication recommendations for managing delirium are not standardized. This study aimed to provide evidence of antipsychotics for symptomatic treatment of delirium in cancer patients receiving palliative care. Methods: We retrospectively reviewed adult cancer patients in palliative care who received antipsychotic delirium treatment at Severance Hospital between January 2016 and June 2019. The efficacy was evaluated primarily by resolution rates. The resolution of delirium was defined as neurological changes from drowsiness, confusion, stupor, sedation, or agitation to alertness or significant symptomatic improvements described in the medical records. The safety was studied primarily by adverse drug reaction incidence ratios. Results: Of the 63 enrolled patients, 60 patients were included in the statistical analysis and were divided into three groups based on which antipsychotic medication they were prescribed [quetiapine (n=27), haloperidol (n=25) and co-administration of quetiapine and haloperidol (n=8)]. The resolution ratio showed quetiapine to be more effective than haloperidol (p=0.001). No significant differences were seen in adverse drug reaction rates among the three groups (p=0.332). Conclusions: Quetiapine was considered the most effective medication for delirium, with no significant differences in adverse drug reaction rates. Therefore, quetiapine may be considered a first-line medication for treating delirium in cancer patients receiving palliative care. However, further studies comparing more diverse antipsychotics among larger populations are still needed.

• 한국임상약학회지
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• 제25권3호
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• pp.159-165
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• 2015

Objective: Polypharmacy is one of the main causes of inappropriate medication use, adverse drug-related events and cost. It aimed to investigate the status of polypharmacy and potentially inappropriate medication (PIM), the factors affecting polypharmacy and cost in elderly outpatients. Method: A pharmacy claim data were retrospectively analyzed with elderly patients prescriptions at a pharmacy located near a top tier general hospital. The numbers of medications per person, prevalence of polypharmacy and PIM according to the 2012 Beers criteria and Korea PIM list, medication cost and the factors affecting polypharmacy were investigated. Results: Forty-six percentages of the elderly outpatients received polypharmacy and over 21% of them had medications listed in Beers or Korean PIM. In multiregressional analysis, we found that age, gender and insurance types were affective factors of polypharmacy. (p < 0.001, 0.047, 0.009, respectively). The cost of polypharmacy with PIM in elderly outpatients was increased with age. Various approaches of interventions would be further required.

• Food Science and Biotechnology
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• 제18권2호
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• pp.533-536
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• 2009

Withdrawal time of erythromycin in the cultured black rockfish (Sebastes schlegeli) was investigated to provide regulatory authority and fishery industry with full information needed to secure food safety of the fish treated with erythromycin. Medication was carried out using the experimental diet containing erythromycin of which concentration was 200 mg/kg diet and its daily dose was about 40 mg/kg body weight. The withdrawal time needed to reduce antibiotic contents around 10.0 mg/kg accumulated during 9 days medication below 0.2 mg/kg was identified about 10 days. The antibiotic with 13.7 mg/kg of fish on the $9^{th}$ days of medication was completely depleted after 30 days from stop of medication.

• 한국의료질향상학회지
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• 제27권2호
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• pp.57-72
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• 2021

Purpose: At present, there are a variety of serious patient safety incidents related to problems in health information technology (HIT), specifically involving electronic medical records (EMRs). This emphasizes the need for an enhanced electronic medical record system (EMRS). As such, this study analyzed both the nature of and potential to prevent incidents associated with HIT/EMRS based on data from the Korea Patient Safety Reporting and Learning System (KOPS). Methods: This study analyzed patient safety incidents submitted to KOPS between August 2016 and December 2019. HIT keywords were used to extract HIT/EMRS incidents. Each case was reviewed to confirm whether the contributing factors were related to HIT/EMRS (HIT/EMRS-related incidents) and if the incident could have been prevented (HIT/EMRS-preventable incidents). The selected reports were summarized for general clarity (e.g., incident type, and degree of harm). Results: Of the 25,515 obtained reports, 2,664 incidents (10.4%) were HIT-related, while 2,525 (9.9%) were EMRS-related. HIT/EMRS-related incidents were the third largest type of incident followed by 'fall' and 'medication incidents.' More than 80% of HIT/EMRS-related incidents were medication-related, accounting for approximately one-third of the total number of medication incidents. Approximately 10% of HIT/EMRS-related incidents resulted in patient harm, with more than 94% of these deemed as preventable; further, sentinel events were wholly preventable. Conclusion: This study provides basic data for improving EMR use/safety standards based on real-world patient safety incidents. Such improvements entail the establishment of long-term plans, research, and incident analysis, thus ensuring a safe healthcare environment for patients and healthcare providers.

• 대한한의학회지
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• 제28권3호통권71호
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• pp.144-155
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• 2007

Background : In western medicine, there has been much interest in medication teaching since the separation of dispensary from medical practice in 2000. On the other hand, few investigations have been carried out about medication teaching for herbal medicine. Objectives : The purpose of this study wasto investigate the current status of medication teaching of herbal medicine and develop a better guide. Methods : Pharmaceutical affairs law in Korea was searched and some medication teaching guides were compared and analyzed to develop a better guide suitable for herbal medicine. Results and Conclusions : The future guide should be based on scientific evidence and include the following: (1)the origin of each herbal formula (2)the constitution of each herbal formula and proportion of each herb included (3)the chief virtue of each herbal formula (4)the efficacy of each herbal formula (5)the safety of each herbal formula (6)combined treatment with herbal formulas and western drugs (7)the way of decocting each herbal formula (8)the way of safekeeping and period of circulation of each herbal formula (9)a summary and evaluation for each herbal formula (10)references of each herbal formula.

• International Journal of Contents
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• 제14권3호
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• pp.39-45
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• 2018

Purpose: Food Allergen Immunotherapy (Oral) is a form of immunotherapy administered to patients who are allergic to foods such as egg, milk, and peanut. The food allergen is orally administered to the patient in an escalating dose for desensitization or tolerance development. The safety and effectiveness of the therapy were assessed using a systematic literature review and meta-analysis. Methods: For a literature search, 8 national databases and a number of international databases including Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library were used; and 13 articles (all from international databases) were selected. The target of Food Allergen Immunotherapy (Oral) included patients with food allergy, and the intervention was food allergen immunotherapy without limiting the food type. The safety and effectiveness of Food Allergen Immunotherapy (Oral) were assessed by reviewing all the articles reporting on the therapy. The control group received standard therapies including aversion therapy, no treatment, anti-histamine treatment, and placebo. Safety was assessed through the incidence of complication and emergency medication. Effectiveness was assessed based on therapy success rate, symptomatic improvement, and quality of life. Results: Although Food Allergen Immunotherapy (Oral) was shown to have successful desensitization in patients with food allergy, the safety of the technique has not yet reached an acceptable level; the possible reason is due to the high rate of complication and frequency of emergency medication. Also, each study employed varying protocols while relying on a small number of participants and a short monitoring period. Conclusion: The results of assessment suggest that the level of evidence from current literature review is low and further research is necessitated for the verification of the safety and effectiveness of the therapy (Grade of Recommendation: A; Level of Technology: II-b).