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Glycididazole Sodium Combined with Radiochemotherapy for Locally Advanced Nasopharyngeal Carcinoma

  • Li, Ming-Yi;Liu, Jin-Quan;Chen, Dong-Ping;Qi, Bin;Liang, Yu-Ying;Yin, Wen-Jing
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2641-2646
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    • 2014
  • Background: To evaluate efficacy and side effects of glycididazole sodium (CMNa) combined with chemotherapy (cisplatin plus 5-FU/folic acid, PLF) and radiotherapy in treating patients with locally advanced nasopharyngeal carcinoma. Materials and Methods: Patients with III~IV stage nasopharyngeal carcinoma (NPC),were randomly divided into treatment group (46 patients) and control group (45 patients). Both groups received radiotherapy concomitant with PLF chemotherapy. The treatment group at the same time cwas given CMNa ($800mg/m^2$ before radiotherapy), by l h intravenous drip, three times a week. Results: When the dose of radiation was over 60 Gy, complete response rates of nasopharyngeal tumor and lymph node metastases in treatment group were significantly higher than in the control group (93.5% vs 77.8%; 89.1% vs 93.5%, p<0.05). Three months after radiotherapy, complete response rate of nasopharynx cancer and lymph node metastases in treatment group was both 97.8%, again higher than in the control group (84.4% and 82.2%) (p<0.05). In the treatment group, 1, 3, 5 year disease-free survival rates were 95.7%, 86.7% and 54.5%; and in control group, the corresponding disease-free survival rates were 93.3%, 66.2% and 38.6%, respectively, the difference being statistically significant (log-rank =5.887, p=0.015). One, 3, 5 year overall survival rates in two groups of patients were 97.8%, 93.5%, 70.4% and 95.5%, 88.07%, 48.4%, respectively, again with a statistically significant difference (log-rank=6.470, p=0.011). Acute toxicity and long-term radiotherapy related toxicity in the two groups did not differ (p>0.05). Conclusions: Glycididazole sodium could improve curative effects without increasing adverse reactions when treating paitents with locally advanced nasopharyngeal carcinoma.

The Influencing Factors forming the Atmosphere of Ward (병실 분위기 조성에 영향을 주는 요인)

  • 윤정인;이미라
    • Journal of Korean Academy of Nursing
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    • v.25 no.4
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    • pp.641-652
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    • 1995
  • Working as nurses, authors found that some patients were not content with their hospital life. Some patients wanted to move to another ward, and others complained about their ward atmosphere. In spite of patients' discomfort, nurses didn't know what made some patients complain about their ward. So, authors tried to find factors that influence atmosphere of hospital wards of the neurosurgery patients. To know the atmosphere of wards, authors selected five neurosurgery ward of a university hospital in Seoul. Observation took a month. An author observed using molar approach, in the morning, in the day time, and in evening time. Authors used concealment /no intervention technique. An author checked condition of people in the wards, and observed their verbal and nonverbal communication behavior their activities and environmental characteristics, and interpreted their meaning through ethnographic research methodology by Spradly. Authors found there was an important factors that influence the atmosphere of ward. It was a human and his attitude. At least one person who was willing to help others made ward atmosphere better. Helping others physically whenever needed, sup-porting the depressed emotionally, offering foods, or talking to others friendly brought good atmosphere. On the contrary, if everyone was indiffernt to others, the atmosphere became cold. Self-centered or selfish behaviors such as occupying too much area, using the toilet too long, covering other's suction bottle without permission and seeing others delicate or urinate were hurtful. In addition to the attitude of patients and their families, unkindness of medical teams including nurses and doctors and tasteless meal caused bad ward atmosphere. Based on this research finding, authors suggest the followings. A For the better atmosphere of ward 1. Nurses should try to make the ward atmosphere better by introducing new patient to older ones. 2. Every ward should have dividing curtains to keep patient's privacy. 3. All hospital personnel should be kind enough to make patients feel that they are repected. 4. Hospital should serve high quality meals to patients. 5. Patients had better stay with those in the similar condition. B. For the future studies 1. Repeated researches are necessary to check reliability of this results. 2. Researches for patients in different area such as ICU, or hemodialysis unit are necessary.

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Effects of Nursing and Care=giving Integrated Service on nursing work performance, nurses' job satisfaction and patient safety (간호간병통합서비스 운영병동 간호사의 간호업무성과, 직무 만족 및 환자안전사고)

  • Park, Jung Hee;Lee, Mi Hyang
    • Journal of Korean Academic Society of Home Health Care Nursing
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    • v.24 no.1
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    • pp.14-22
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    • 2017
  • Purpose: To study aimed to examine the impact of the Nursing and Care=giving Integrated Service on nursing work performance, nurse' job satisfaction, and patient safety. Methods: A total of 66 nurses were selected as participants, comprising 30 nurses working in Nursing and Care=giving Integrated Service hospital ward, and 33 nurses working in a general hospital ward with a similar patient and disease group and distributed moderately. For data analysis, t-tests, ANOVA, and $X^2$ tests were conducted. Results: Nursing work performance in the Nursing and Care=giving Integrated Service ward was higher than that in the general hospital ward, but this difference was not statistically significant. Conversely, job satisfaction was lower among nurses in the Nursing and Care=giving Integrated Service ward, although again the difference was not significant. However, the Nursing and Care=giving Integrated Service ward had a significantly lower rate of safety-related accidents in patients compared to the general hospital ward. Conclusion: In order to expand and improve patient safety and other aspects of the Nursing and Care=giving Integrated Service, there is a need to establish a mediation strategy for increasing nurses' work performance and job satisfaction.

A Study on the Architectural Planning of the Ward in Infectious Disease Hospitals (감염병 전문병원의 병동부 건축계획에 관한 연구)

  • Choi, Kwangseok
    • Journal of The Korea Institute of Healthcare Architecture
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    • v.27 no.1
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    • pp.7-15
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    • 2021
  • Purpose: This study analyzed the architectural planning factors of the ward in infectious disease hospitals, such as functional unit planning, ward configurations, spatial compositions & circulation, and detailed architectural planning. Through these, the facility guidelines of infectious disease hospitals are summarized, focusing on the differences from the wards of non-infectious hospitals. Methods: This study was conducted by literature review of research reports, papers, design cases, and guidelines, based on the experiences of field surveys for infectious disease hospitals. Results: The result of this study can be summarized into a few points. 1) Infectious disease hospitals need to establish an operation plan with the concept of continuity of care, as an extension of existing facilities. 2) The types of ward configuration for infectious disease hospitals has many variables, so an appropriate type should be selected according to the hospital's operating policy. 3) Various spatial composition types of the ward can be planned by the arrangement of traffic cores and areas of patient groups. At this time, the main planning considerations are safety, efficiency, and comfort. 4) As elements of the detailed plan, It is necessary to consider the types & dimensions of patient rooms, the relationships between nursing stations & sub-stations, and supplementations of medical support functions & convenience facilities. Implications: Since there are many differences in function from the ward of non-infectious hospitals, appropriate facility guidelines for infectious disease hospital are required.

A Comparative Study regarding Health Condition and Work Stress of Nurses Working in Cancer Ward and General Ward (암병동간호사와 일반병동간호사의 건강상태와 직무스트레스 비교 연구)

  • Kim, Hyun-Sook
    • Asian Oncology Nursing
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    • v.1 no.2
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    • pp.191-203
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    • 2001
  • The health of a nurse is very important because her mental and physical health can influence toward nursing patients directly, Especially, Cancer patients are growing annually. Also, terminal cancer patients' nursing and dead place are increasingly using hospital and the period of nursing for cancer patients are increasing. Nursing for cancer patients are different with acute disease. Therefore, I analysed comparing nurses' health working in cancer and general ward so that nurses working at cancer ward could be developed as a professional nurse, and I wanted to establish the foundation of nursing administration and reasonable manpower management to supply good quality of nursing to patients. In my research, I selected 117 nurses working in cancer ward and 134 nurses working in general word to analyse the stress rate and nurse's health comparing nurses working in general ward and cancer ward. The survey was conducted of nurses working in cancer ward nurses in 2 university hospitals, nurses working in a cancer hospital, and general ward nurses working in 3 public hospital. Also, the data was collected from Sep. 13, 2001 to Sep. 28, 2001. As health measuring tool, I used Cornell Medical Index(CMI) which are developed to fit Koreans by Ko Ungrin and Park Hang-bas (1980) using Cornell Medical Services which were designed by Weiser, Brosman, Mittelman, Wechler, Wolff in Cornell University(1945). As working stress measuring tool, I used Questionaries which were designed by Kim Mae-ja and Ku Mi-ok(1984) and then developed by Bae In-sook(1996). For managing the data, I used frequency, percentage, ${\chi}^2$ verification, t-test, and F-test (ANOVA). And in the case of significant data(p<.05). I did Duncan's test for post verification. The mutual relation between health condition and working stress rate have been conducted using Pearson's Correlation Coefficient. Followings are the results of my research. 1. Two groups showed significant differency at age after testing homogeneous character between two groups (${\chi}^2$ =9.919, p=.007). 2. Comparing two group's health condition, cancer ward(average 19.35${\pm}$18.34) were higher than general ward(14.42${\pm}$10.59) and showed statistical significant differency(p=.009). And, comparing two group's mental condition, cancer ward(9.00${\pm}$9.79) were higher than general ward(7.13${\pm}$6.35) and statistically no differency. 3. After comparing two group's working stress rate, the rate of cancer ward nurse's working stress(3.36${\pm}$.50) is higher than general ward nurse (3.32${\pm}$.48). There are no significant differency. However, in the detailed verification test, there were significant differency at inappropriate compensation (t=3.254, p=.001) and medication issue (t=2.170, p=.031). 4. After comparing health condition at general points, physical health condition showed significant differency at age(p=.020), the number of children (p=.015), religion (p=.015), position(p=.005), career(p=.008), working satisfaction(p=.003), activity after office hour(p=.045); and mental health condition showed significant differency at position(p=.010), career (p=.017), working satisfaction (p=.003). 5. After comparing the working stress rate according to general points, there were significant differency at working satisfaction (F=5.285, p=.006), predicted nursing(F=3.822, p=.023). 6. At the relation of health condition and working stress rate between two groups. physical and mental condition showed significant relation with working stress rate. i.e, if a nurse's health condition is not good, she are feeling much more stress than others. After considering all the factors in my research, I found that the health condition and stress rate of cancer ward nurses is much higher than general ward nurses. Considering that cancer ward nurses is necessary to care for increasing cancer patients with mental and physical nursing, the less stress for cancer ward nurses is very important to develop nursing quality and working efficiency by keeping good health condition, specializing cancer ward nurses. Therefore, we need following studies to find the factors which are effecting to cancer ward nurses' health and specialization. Also, we need to improve managing working condition to decrease working stress by improving working condition.

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Assessment of Thermal Comfort in a General Hospital in Winter Using Predicted Mean Vote (PMV) (Predicted Mean Vote(PMV)를 이용한 겨울철 종합병원의 실내 온·열 환경의 평가)

  • Lee, Boram;Kim, Jeonghoon;Kim, KyooSang;Kim, Hyejin;Lee, Kiyoung
    • Journal of Environmental Health Sciences
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    • v.41 no.6
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    • pp.389-396
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    • 2015
  • Objectives: A hospital is a complex building that serves many different purposes. It has a major impact on patient's well-being as well as on the work efficiency of the hospital staff. Thermal comfort is one of the major factors in indoor comfort. The purpose of this study was to determine thermal comfort in various locations in a hospital. Methods: Various indoor environmental conditions in a general hospital were measured in February 2014. The predicted mean vote (PMV) and carbon dioxide ($CO_2$) concentration were measured simultaneously in the lobby, office, restaurant, and ward. Results: The ward was the most thermally comfortable location (PMV=0.44) and the lobby was the most uncomfortable (PMV = -1.39). However, the $CO_2$ concentration was the highest in the ward (896 ppm) and the lowest in the lobby (572 ppm). The average PMV value was the most comfortable in the ward and the lowest in the lobby. In contrast, for concentration of carbon dioxide, the highest average was in the ward and the lowest in the lobby. Due to air conditioner operation, during operating hours the PMV showed values close to 0 compared to the non-operating time. Correlation between PMV and $CO_2$ differed by location. Conclusion: The PMV and concentration of carbon dioxide of the hospital lobby, office, restaurant and ward varied. The relationship between PMV and carbon dioxide differed by location. Consideration of how to apply PMV and carbon dioxide is needed when evaluating indoor comfort.

A Study of the Spatial Composition and the Facility Criteria of In-patient Rooms in General Hospitals after MERS 2015 (2015년 메르스 사태 이후 신축된 종합병원 병동부의 공간구성 특징 및 입원실 세부시설기준에 관한 연구)

  • Lee, Hyunjin;Kwon, Soonjung
    • Journal of The Korea Institute of Healthcare Architecture
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    • v.25 no.2
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    • pp.27-35
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    • 2019
  • Purpose: This study is to address the spacial composition of a standard ward and bedroom size for sake of infection control and efficient medical service. Methods: Spacial composition of a standard ward has been proposed by comparative analysis of 5 big hospitals' wards. Bedroom sizes have been explored on the ground of Health care facility regulations from Korea, USA, Australia and Canada. Of course, Literature and field survey have been conducted in order to draw out various bedroom sizes. Results: 16 basic and some other additional spaces have been proposed for the composition of hospital standard ward. Area of Single bedroom is $11.6m^2$, and that of multi-beded room is $7.4m^2$. Bed to bed Clearance is 1.5m, spacing between bedsize and hard wall is 0.9m in 1~2 beded room, 0.75m in 4-beded room. Space clearance between Foot side of bed and curtain is proposed as 0.3m and additional 0.9m is necessary for the circulation. Implications: The result of this study can be applied to the new cons.

Evaluation of Airborne Bacteria and Fungi in Surgical Areas at the Animal Hospital

  • Jeong, Seongsoo;Kang, Yuntae;Hwang, Yawon;Yoo, Seungwon;Jang, Hyejin;Oh, Hyejong;Kang, Jihoon;Chang, Dongwoo;Na, Kijeong;Kim, Gonhyung
    • Journal of Veterinary Clinics
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    • v.34 no.2
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    • pp.76-81
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    • 2017
  • Studies on the concentration of airborne microorganisms in human medicine as a part of a study on the nosocomial infections have been conducted properly, but in veterinary medicine, there has been rarely performed in Korea to the best of study's knowledge. The purpose of this study was to evaluate the distribution of airborne microorganisms and to identify their species in different places in the animal hospital to alert the necessity of thorough cleanliness management. This study evaluated the concentrations of airborne bacteria and fungi in hospital areas, such as patient waiting room, internal medicine ward, surgical ward and radiological diagnostic ward. The concentration of bacteria and fungi was significantly lower (p < 0.05) in two operating rooms and higher in the patient waiting room. The dominant species of bacteria were Micrococcus spp., Staphylococcus spp., and fungi were Penicillium spp., Dermatophyte mold. Animal hospitals need to perform proper procedures for disinfection, sterilization, and environmental cleaning as well as appropriate employee training and monitoring in order to the maximum prevention of the risk of nosocomial and surgical infections.

Use of Neurologic Assessment Performance and Education Needs of Neurologic Ward Nurses (신경계 간호사의 신경학적 검진 수행정도와 교육요구도에 대한 조사연구)

  • Kim, Jeoung Hee;Choi, Eun Mee;Ko, Young Mi;Park, Hee Ra;Kim, Yoon Kyoung;Koo, Chong Mo;Park, Ju Yoon;Seong, Sun Suk;Kwon, Mi Hee;Yun, Yeoun Sook;Park, Yun Rye
    • Journal of Korean Clinical Nursing Research
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    • v.22 no.1
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    • pp.46-55
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    • 2016
  • Purpose: The purpose of this study was to describe performance and education needs related to neurologic assessment by neurologic ward nurses. Methods: The study was conducted with a cross-sectional descriptive design. Participants, 297 neurologic ward nurses working in ten major hospitals in Seoul and Gyeonggi were surveyed from September 7 to October 1, 2015. Results: The mean score for performance of neurologic assessments was 3.04 points. Performances performed with high quality were orientation exam, mental status documentation, and muscle strength of extremities in that order. Performances performed with low quality were assessment of accessory nerves, hypoglossal nerves, and cerebellum function in that order. There were significant differences according to whether there was ward education programs on neurologic assessment and teaching experiences within a year. These variables significantly affected the quality of neurologic assessment performance. The need for neurologic assessment training was 3.14 points. Conclusion: Amount of performance and demand for education on neurologic assessment, which are required in the clinical setting, were significantly high. To perform neurologic assessments with high quality, development of education program for neurologic assessment and continuous education courses are required at either the department or neurological nursing organization level.

Comparison of Multiple Chronic Obstructive Pulmonary Disease (COPD) Indices in Chinese COPD Patients

  • Zhang, Jinsong;Miller, Anastasia;Li, Yongxia;Lan, Qinqin;Zhang, Ning;Chai, Yanling;Hai, Bing
    • Tuberculosis and Respiratory Diseases
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    • v.81 no.2
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    • pp.116-122
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    • 2018
  • Background: Chronic obstructive pulmonary disease (COPD) is a serious chronic condition with a global impact. Symptoms of COPD include progressive dyspnea, breathlessness, cough, and sputum production, which have a considerable impact on the lives of patients. In addition to the human cost of living with COPD and the resulting death, COPD entails a huge economic burden on the Chinese population, with patients spending up to one-third of the average family income on COPD management in some regions is clinically beneficial to adopt preventable measures via prudent COPD care utilization, monetary costs, and hospitalizations. Methods: Toward this end, this study compared the relative effectiveness of six indices in predicting patient healthcare utilization, cost of care, and patient health outcome. The six assessment systems evaluated included the three multidimensional Body mass index, Obstruction, Dyspnea, Exercise capacity index, Dyspnea, Obstruction, Smoking, Exacerbation (DOSE) index, and COPD Assessment Test index, or the unidimensional measures that best predict the future of patient healthcare utilization, cost of care, and patient health outcome among Chinese COPD patients. Results: Multiple linear regression models were created for each healthcare utilization, cost, and outcome including a single COPD index and the same group of demographic variables for each of the outcomes. Conclusion: We conclude that the DOSE index facilitates the prediction of patient healthcare utilization, disease expenditure, and negative clinical outcomes. Our study indicates that the DOSE index has a potential role beyond clinical predictions.