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온포음(溫胞飮)이 자성생쥐의 생식능력과 Caspase-3, MAPK 및 MPG 유전자 발현에 미치는 영향 (The Effect of Onpoeum on the Ovarian Functions and Differential Gene Expression of Caspase-3, MAPK and MPG in Female Mice)

  • 박영선;백승희;김은하;김동철
    • 대한한방부인과학회지
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    • 제20권4호
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    • pp.1-23
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    • 2007
  • Purpose: These experiments were undertaken to evaluate the effect of Onpoeum on ovarian functions and differential gone expressions related with cell viabilities caspase-3, MAPK and MPG in female mice. Methods: We administered the Onpoeum to 6-week-old female ICR mice for 4, 8, or 12 days. With different concentration of Onpoeum, the female mice were injected PMSG and hCG for ovarian hyperstimulation. The mice divided into 3 different groups for each experiment. We chose the Caspase-3 for cell apoptosis, MAPK and MPG genes for cell viability and DNA repair. Results: In case of 4, 8, 12 day of Onpoeum, we were examined the mean number of total ovulated oocytes and the number of morphologically normal oocytes. We were also examined the embryonic developmental competence in vitro. In audition we were examined the differential expression of cell apoptosis, viability and DNA repair related genes, Caspase-3, MAPK and MPG according to concentration and duration of Onpoeum. From these results showed that the administration of Onpoeum played a role of prevention of cell apoptosis and DNA damages and also increased cell proliferation resulted in ovarian functions. Conclusion: It is suggested that the medication of Onpoeum may have beneficial effect on reproductive functions of female mice via prevention of cell apoptosis and DNA damaging and promotion of cell proliferation.

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설진의 부위별 장부 대응 형식 변천 (Historical Review on Area to Viscera Correspondence in Tongue Diagnosis)

  • 남승현;박정호;김기왕
    • 동의생리병리학회지
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    • 제33권6호
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    • pp.322-333
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    • 2019
  • The purpose of this thesis is to show the historical context of tongue-viscera correspondence scheme based on as wide investigation as possible. For this purpose, we collected and investigated 35 books related to tongue diagnosis. As a result, we faound the following: There were some tentative trials to associate viscera or viscera meridians with tongue areas since shown in the Effective formulae of inherited medical works (世醫得效方, 1337). The main stream of tongue-viscera correspondence scheme was the form in which the apex, the center, and the root of tongue are associated with Heart, Spleen (and Stomach), and Kidney. On the viscera correspondence to the sides of tongue, there had been two streams. The first one is originated from the Upper-most Book on Shanghan (傷寒第一書, 1780), in which the sides of tongue are assumed to be associated with Liver and Gall-bladder. The second one is originated from the Ikeda Family's Chant on the Tongue (池田家舌函口訣, 1807), in which the left side and the right side of tongue are assumed to be associated with Liver and Lung separately. The former type have been accepted as the standard form in modern traditional Asian medicine education. In addition to the above types, three other correspondence schemes were also existed, but have disappeared now. These days, some new correspondence schemes are being suggested based on new approaches.

디지털 의료영상에서 슬릿법에 의한 Modulation Transfer Function의 보정방법 (Correction Method of Slit Modulation Transfer function on Digital Medical Imaging System)

  • 김정민;정회원;민정환;임은경
    • 대한방사선기술학회지:방사선기술과학
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    • 제29권3호
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    • pp.133-139
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    • 2006
  • 디지털 X선영상으로 출력한 화상데이터를 Personal Computer로 가져와서 디지털 특성곡선, MTF, 위너스펙트럼을 계산할 수가 있다. 여기서는 디지털화상의 선예도를 후지타(藤田) 등의 이론에 의한 프리샘플링(presampling) Modualtion Transfer Function(MTF)을 산출하고 보정하는 방법에 대하여 검토하였다. 사용한 프로그램은 엑셀이며 슬릿의 촬영, 디지털 특성곡선, 합성 LSF법, 이산 퓨리어 변환, 고속 퓨리어 변환 등의 순서로 기술하였다. 이 방법의 커다란 장점은 퓨리어트랜스폼의 공식과 MTF 산출과정을 완전히 이해할 수 있다는 점과, 별도로 값비싼 프로그램이나 컴퓨터언어를 배우지 않았어도 MTF 결과를 산출할 수가 있다는 것이다. 그리고 워크시트 표시되는 엑셀의 장점을 그대로 살려 X선 영상계의 오류나 산출결과의 부적합성을 발견하기 쉽다는 점이다.

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국내 의과대학 교수의 암정보 활용 현황과 요구도 (The Current Status of Utilization and Demand on Cancer Information in the Faculties of Medical School in Korea)

  • 임민경;박숙경;양정희;이영성
    • Journal of Preventive Medicine and Public Health
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    • 제36권1호
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    • pp.39-46
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    • 2003
  • Objectives : To investigate the availability and demand for overall cancer-related information, and to establish a basic plan for the construction of a cancer database and information system based on the research results from Korea. Methods : Postal and telephone surveys were carried out, between August 2001 and November 2001, of 323 affiliated faculty professors from medical universities and colleges in Korea. The data were analyzed with descriptive statistical methods, with regard to the present status and demand for health and cancer-related information. Results : Most (over 80%) subjects studied utilized the health-related information provided on Internet website from foreign countries, such as Medline, but similar comprehensive information system lacked in Korea. The construction of a cancer-related database of domestic research results was revealed to be in a great demand. Information on registration and statistics (52.8%), study results (48.5%) and study resources (37.4%) were the major ingredients required in the database. In constructing a database of the cancer-related research results, a full-text service, continuous updating of data, and the development of standardized user-friendly searching tool were regarded as the necessary components. The formulation of an information sharing system, regarding cancer-related clinical trials, was investigated as being quite feasible. Conclusion : This study demonstrated the great importance of cancer information systems, and much demand for an available cancer-related database based on Korean research results.

An Edutainment Game Prototype for Sasang Constitutional Food Therapy

  • Yea, Sang-Jun;Zhao, Dapeng;Ryu, Il-Han;Yang, Changsop;Kim, Chul;Gweon, Gahgene
    • 대한예방한의학회지
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    • 제19권2호
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    • pp.159-167
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    • 2015
  • Objective : Recently many kinds of food therapies have sprung up to prevent or manage disease and to promote health. Seeing Korean history, the Korean medical doctors have been applying food therapy based on the thought that the dietary sources were as important as the medicine. Therefore, in this study, we designed a mobile edutainment game prototype with the goal of providing education about healthy food knowledge for users who belongs to different constitutional types. Materials and Method : We adopted the Sasang Constitutional Medicine as the medical background knowledge for our edutainment game design. Based on the user study, we developed the process of edutainment system which is composed of 'My game', 'My constitution', and 'My food'. Among the whole process, we developed a prototype for the core module - the 'My game' part. This prototype used a jumping game for mobile devices that is composed of training, level 1 and level 2 stages. Results : From the target user evaluation, it was proved that 1) in terms of the learning effect of healthy diet, the edutainment game we developed has a significant advantage over the conventional learning media. 2) after playing the edutainment game, the good and bad food identification accuracy based on picture and text format were increased by 44% and 42% respectively, and 3) target users perceived enjoyment while using this prototype, as well as showed positive intention to use this game as edutainment tool in the future. Conclusion : We designed and developed mobile edutainment game prototype to educate healthy food knowledge based on Sasang Constitutional Medicine. Through user evaluation, we proved that our prototype enhanced healthy food knowledge and that user accepted the prototype as a beneficial edutainment tool.

태극침법(太極鍼法)의 확장형인 오장원혈침법(五臟原穴鍼法)의 적응증 연구 - "황제내경(黃帝內經).영추(靈樞)"를 중심으로 - (A study on the indications of Five Viscera Source Point Acupuncture extended from Taegeuk Acupuncture : Focused on Yeoungchu(靈樞))

  • 모한영;임교민;백진웅
    • 대한한의학원전학회지
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    • 제25권4호
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    • pp.123-147
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    • 2012
  • Objective : By establishing the Five Viscera Source Point Acupuncture as the targeted acupuncture treatment for stadardization, as the first step, this study was conducted to sort the indications of each acupuncture remedies, which can be referred as one of the most important factors in acupuncture treatment, based on Yeoungchu. Method : This study selected only the contents related to indications of five viscera, by extracting the relevant sentences from Yeoungchu using the search words Liver(Liver Meridian, First Yin), Heart(Pericardium, Heart Meridian, Second Yin), Spleen(Spleen meridian, Third Yin), Lung(Lung Meridian, Third Yin), and Kidney(Kidney Meridian, Second Yin). Result & Conclusion : 1. We selected and extracted text related to liver disease from Chapter 16, heart (pericardium) disease from Chapter 16, spleen disease from Chapter 19, lung disease from Chapter 17, and finally kidney disease from Chapter 17 of Yeoungchu. 2. The basic theory of applying Five Viscera Source Point Acupuncture to five viscera diseases is first assorting the diseases according to its state (i.e. deficiency or excess), then draining the source point of the appropriate viscus in case of excess, or supplementing the source point of the appropriate viscus in case of deficiency. 3. For the correct application of Five Viscera Source Point Acupuncture, the classification of the disease, not only the judgement on its state, must be presented systematically and synthetically in combination with Four Examinations. Therefore the follow-up studies needs to be conducted.

『동의수세보원(東醫壽世保元)』 인용문(引用文) 연구(硏究)에 적용할 수 있는 방법론(方法論)에 관한 고찰(考察)(3) (A study on research methodology of the quoted verses in Dong-uisusebowon(3))

  • 박수현;정창현;백유상;장우창
    • 대한한의학원전학회지
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    • 제27권2호
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    • pp.1-23
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    • 2014
  • This paper is sequel to the paper titled 'A study on research methodology of the quoted verses in Dong-uisusebowon(2)'. In the previous study, Tao-ren-cheng-qi-tang(桃仁承氣湯) and Di-dang-tang (抵當湯) lines from Shanghanlun quoted in the Dong-uisusebowon were examined. Through this study, we learned that Heo, Jun corrected these texts in the Dong-uibogam to avoid logical contradiction, which were again quoted by Yi, Jema in the Dong-uisusebowon. Thus the quotations in Yi's book were also corrected of the contradictory lines as found in the source text, Shanghanlun. In this paper, I would like to examine the lines regarding Jeokseokji-uyeoryang-tang(赤石脂禹餘糧湯) and Gan-cao-xie-xin-tang(甘草瀉心湯). Firstly, in the case of Jeokseokji-uyeoryang-tang(赤石脂禹餘糧湯) lines, many changes in contents were made to resolve contradiction within the lines as previous cases. By quoting the Dong-uibogam directly, Yi, Jema inherited the thoughts of Heo, Jun in his work. Secondly, in the case of Gan-cao-xie-xin-tang(甘草瀉心湯) lines, Heo, Jun suggested new perspectives on Pi(痞, stuffiness) and Jie-xiong(結胸, chest bind) different to those of Zhang Zhong Jing, based on empirical knowledge of later days. Yi, Jema quoted these corrected lines, which implies Yi's agreement to the theories of Heo. However, Yi made clear his difference in perspective with Heo through his unique theory of the Four(Sasang) Constitutions. I conclude my research regarding quotations in the Dong-uisusebowon by stressing the necessity of research on the Dong-uibogam prior to any further research regarding quotations in the Dong-uisusebowon.

조경산(調經散)이 자성 생쥐의 생식능력과 Caspase-3, MAPK 및 MPG 유전자 발현에 미치는 영향 (The Effect of JokyungSan on the Ovarian Functions and Differential Gene Expression of Caspase-3, MAPK and MPG in Female Mice)

  • 이형곤;백승희;김은하;김동철
    • 대한한방부인과학회지
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    • 제20권2호
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    • pp.1-24
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    • 2007
  • Purpose : These experiments were undertaken to evaluate the effect of adminis tration of JokyungSan on ovarian functions and differential gene expressions related cell viabilities caspase-3, MAPK and MPG in female mice. Methods : We administered the JokyungSan to 6-week-old female ICR mice for 4, 8, or 12 days. The female mice were injected PMSG and hCG for ovarian hyperstimulation. We chose the caspase-3 for cell apoptosis, MAPK and MPG genes for cell viability and DNA repair. To compare the differences, we set a control group treated with plain water at the same volume by the same way. Results : In case of 4-day administration of JokyungSan, the mean number of total ovulated oocytes and the number of morphologically normal oocytes increased significantly compared to a control group. The administration of JokyungSan, were beneficial effect of embryonic development in preimplantation period and play a role of prevention of cell apoptosis and DNA damages and also increased cell proliferation resulted in ovarian functions. Conclusion : From our results suggested that the medication of JokyungSan has beneficial effect on reproductive functions of female mice via prevention of cell apoptosis and DNA damaging and promotion of cell proliferation.

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대학교육과정에 있어서 보건교육에 대한 조사 (A Study on Public Health Education in Curriculums of Universities)

  • 박신애
    • 대한간호학회지
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    • 제5권1호
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    • pp.31-40
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    • 1975
  • A study on public health education curriculums of 14 universities located in Seoul city was carried out from Oct. 15 1974 to Nov. 15 1974. The data were obtained from 11 universities bulletins & 3 universities administration officers. The contentments of public health were obtained by the interview with the teaching professors on the syllabuses. The results were as follows: 1. General Public health topics were taught at 4 universities (28.6%) out of 14 universities & 129 departments (25.3%) out of 509 departments. General public health education were taught at 2 universities (28.6%) out of 7 universities with medical school of the colleges of education 2 collages (18.2%) had the public health education in the curriculums. 2. Academic administration of Public health education by universities 2 hrs for 2 credits were allocated at 2 universities (50%), while 4 hrs for 2 credits at the rest universities (50% ), Pubic health education were taught as an essential general education at 4 universities. Public health education were taught in freshman course at 2 universities in senior course at 2 other universities. Text books on public health education were chosen at 2 universities and at other 2 universities, just references were introduced to students. Contents of public health education. In two universities teaching programs of public health were undertaken & in other two universities no particular leaching programs were undertaken. And contents of tuberculosis, V. D. & communicable disease control Pregnancy & delivery, precaution ok post paestum maternal & child health were taught at 4 universities. Contents of health & college students, alcohol tobacco & coffee, chosen of sports were taught at few university. 3. General public health education instructors: The instructors were consisted of 13 men(81.2%) & 3 women (18.8%) Physicians were 11 (68.8%), nurses 2 (12.5%) & others 3(18.7%) Full time instructors were 7 (43.7%) part time instructors 9 (56.3%) Position & organization instructors belong to ; instructors (75.0%) had the teaching position in universities & research workers & others were 3 (18.8%) & medical practitioner was I(6.2%) 4. Public health & home nursing education by general home economic departments. Home nursing & public health were taught as an compulsory general education program in 10 departments 50.5% & as an alternative major course in 7 departments (35.0%) 2 hrs for 2 credits were allocated at 9 departments (45.0%) while eve. 4hrs for 4credits were 8 departments (40.0%).

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Cervical Cancer Screening: Recommendations for Muslim Societies

  • Khodakarami, Nahid;Farzaneh, Farah;Yavari, Parvin;Akbari, Mohamad Esmaeil
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권1호
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    • pp.239-247
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    • 2016
  • Background: The overall cervical cancer incidence rate is low in Iran; however, because of a higher risk of death for cervical cancer, a disease that kills women in middle age, a cervical cancer control program is needed. The aim of this study was to provide consensus recommendation for cervical cancer prevention in Iran and other Muslim societies with low incidences of cervical cancer. Materials and Methods: Through a practical guideline development cycle, we developed six questions that were relevant to produce the recommendation. We reviewed 190 full text records of cervical cancer in Iran (1971 to 2013) of which 13 articles were related to the data needed to answer the recommendation questions. We also reviewed World Health Organization, IARC, GLOBOCAN report, Iran Ministry of Health cancer registry report and 8 available foreign countries guidelines. Lastly, we also evaluated the Pap smear results of 825 women who participated in the Iranian HPV survey, of whom 328 were followed-up after a 5-year interval. Results: The obtained data highlighted the burden of HPV and cervical cancer situation in Iran. Experts emphasized the necessity of a cervical cancer screening program for Iranian women, and recommended an organized screening program with a cytological evaluation (Pap smear) that would start at the age of 30 years, repeated every 5 years, and end at the age of 69 years. Meanwhile, there is no need for screening among women with a hysterectomy, and screening should be postponed to post-partum among pregnant women. Conclusions: An organized cervical cancer screening is a necessity for Iran as more than 500-900 women in middle age diagnosed with an invasive cervical cancer every year cannot be ignored. This recommendation should be taken into account by the National Health System of Iran and Muslim countries with shared culture and behavior patterns. CUBA HPV test could be consideration in countries Muslim country with appropriate budget, resources and facility.