• 제목/요약/키워드: Medical radiation

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두개 내 다형성아교모세포종 환자의 방사선치료 결과 (The Outcome of Glioblastoma Patients Treated with Surgery and Radiation Therapy)

  • 남희림;임도훈;안용찬;이정일;남도현;김종현;홍승철;이정은;강민규;박영제;김경주;박원;허승재
    • Radiation Oncology Journal
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    • 제22권2호
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    • pp.91-97
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    • 2004
  • 목적 : 두개 내 다형성아교모세포종 환자의 방사선치료 후 생존율을 조사하고 그 예후 인자의 중요성을 알아보고자 하였다. 대상 및 방법: 1994년부터 2003년까지 삼성서울병원에서 병리학적으로 다형성아교모세포종으로 확진된 환자 중 근치적 목적으로 방사선치료를 시행한 120명을 대상으로 분석하였다. 남자는 64명(53$\%$), 여자는 56명(47$\%$)이었으며, 20례(17$\%$)의 종양은 다발성이었다. 수술은 육안적 완전 절제, 부분 절제 및 조직검사를 각각 22례(18$\%$), 59례(58$\%$), 29례(24$\%$)에서 시행하였고, 방사선치료는 4$\~$10 WV 선형가속기를 이용하여 54$\~$72Gy (중앙값 60 Gy)를 조사하였다. 대상 환자의 추적관찰기간은 2개월에서 62개월(중앙값 12개월)이었다. 결과 : 전체 환자군의 1년 및 2년 생존율은 52$\%$와 14$\%$이었으며, 중앙생존기간은 13개월이었다. 예후 인자에 따른 1년 생존율은 50세 미만은 64$\%$, 50세 이상은 41$\%$ (p<0.01), 수술 전 활동도가 ECOG 0 혹은 1인 경우 는 57$\%$, 2 이상은 44$\%$ (p=0.03)였다. 두개 내 병변 수에 따른 1년 생존율은 단일병변은 57$\%$, 다발성 병변은 23$\%$ (p=0.02)이었으며, 절제정도에 따른 생존율은 육안적 완전 절제, 부분 절제, 조직검사만 시행한 경우에 각각 67$\%$, 48$\%$, 47$\%$ (p=0.04)였다. 다변량 분석에 따른 예후인자로는 여자(p<0.01), 50세 미만(p<0.01), 활동도가 ECOG 0 혹은 1 (p=0.05), 육안적 완전절제(p=0.05)가 좋은 예후 인자이었다 결론 : 근치적 목적으로 방사선치료를 시행한 두개 내 다형성아교모세포종 환자의 중앙생존기간은 13개월로 기존의 문헌보고와 비슷한 수준이었다. 치료성적의 향상을 위하여 다양한 방사선치료 기술의 적용을 통한 방사선량의 증가와 효과적인 항암화학요법 약제의 개발 및 사용 등의 연구가 필요하고, 환자의 예후인자에 따라 개별화된 치료방법이 적용되어야 할 것으로 판단된다

원발성(原發性) 후두(候頭) 임파종(淋巴腫) (Localized Primary Laryngeal Lymphoma Treated by Irradiation)

  • 김귀언;서창옥;김주항;김병수;이광길;김광문;홍원표
    • 대한두경부종양학회지
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    • 제1권1호
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    • pp.81-86
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    • 1985
  • A case of primary laryngeal non-Hodgkin's lymphoma is detailed with a review of the literature, on this rare site of presentation. Histologic findings and radio-therapeutic technique are included with longterm follow-up data. Local radiotherapy is a curative treatment of choice due to longterm NED survival with preservation of voice.

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The Properties of Beam Intensity Scanner(BInS) in IMRT

  • Vahc Young W.;Park, Kwang-Yl;Park, Kyung-R.;Kwon, Oh-Yun;Lee, Yong-H.;Ji, Young-H.;Lee, Myung-H.;Kim, Keun-M.
    • 한국의학물리학회:학술대회논문집
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    • 한국의학물리학회 2006년도 제33회 추계학술대회 발표논문집
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    • pp.75-75
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    • 2006
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Peroxiredoxin 6 Promotes Lung Cancer Cell Invasion by Inducing Urokinase-Type Plasminogen Activator via p38 Kinase, Phosphoinositide 3-Kinase, and Akt

  • Lee, Seung Bum;Ho, Jin-Nyoung;Yoon, Sung Hwan;Kang, Ga Young;Hwang, Sang-Gu;Um, Hong-Duck
    • Molecules and Cells
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    • 제28권6호
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    • pp.583-588
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    • 2009
  • The peroxiredoxin family of peroxidase has six mammalian members (Prx 1-6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells' survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.

6MV 선형가속기를 사용한 유방암 치료 (A Trial of 6-MV Linear Accelerator Radiation Therapy (RT) for Breast Cancer)

  • 윤세철;권형철;오윤경;김종우;박용휘
    • Radiation Oncology Journal
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    • 제2권2호
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    • pp.303-309
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    • 1984
  • Radiation therapy(RT) has been used in the treatment of breast cancer for over 80years. Technically, it should include a part or all of such areas as chest wall or breast, axilla, internal mammary nodes (IM) and supraclavicular nodes (SCL). Authors tried three-field technique for the treatment of breast cancer using 6-MV linear accelerator, exclusively the department of radiology. Kang-Nam St. Mary's Hospital, at Catholic Medical College. The field junction was checked by a Phantom study and radiation doses measured by film densitometry and TLD. The 3 fields we used in this study were two isocentric opposing tangential fields encompassing the breast, chest wall and occasionally IM and one single anterior field encompassing the axilla and SCL. sing appropriate beam blocks and boluses, we were able to avoid unwanted intrinsic divergency of photon beam. Blocking also enabled us to set-up precise radiation field with ease.

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Radiation medicine infrastructure in north korea

  • Kim, Heejin;Lee, Kyo Chul;Lim, Sang Moo;Lee, Yong Jin;Jung, Sung Chul;Kim, Jung Young
    • 대한방사성의약품학회지
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    • 제4권2호
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    • pp.95-98
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    • 2018
  • Recently, South and North Korea summits agreed to implement the cooperation and promotion of medical healthcare at the third inter-Korean summit in Pyeongyang on September 18, 2018. Therefore, the South Korean government and its affiliated organizations have been looking for ways to establish a specific plan for support and exchanges in the field of healthcare and medical technology. In the background of the above new policy, radiation medicine technology can also contribute to the exchange in the field of healthcare and science & technology for the peaceful coexistence of one Korea. In this review, we analyzed and showed the status of healthcare and radiation medicine infrastructure in North Korea in order to further develop a plan to share the benefits of radiation medicine with North Korea in the exchange of healthcare and science & technology.

Bremsstrahlung Kernel of Beta-Particles

  • Yi, Chul-Young;Chun, Kook-Jin;Hah, Suck-Ho;Kim, Hyun-Moon
    • 한국의학물리학회:학술대회논문집
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    • 한국의학물리학회 2006년도 제33회 추계학술대회 발표논문집
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    • pp.130-130
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    • 2006
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