• Title/Summary/Keyword: Medical laboratory

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Factors Potentially Associated with Chemotherapy-induced Anemia in Patients with Solid Cancers

  • Cheng, Ke;Zhao, Feng;Gao, Feng;Dong, Hang;Men, Hai-Tao;Chen, Ye;Li, Long-Hao;Ge, Jun;Tang, Jie;Ding, Jing;Chen, Xin;Du, Yang;Luo, Wu-Xia;Liu, Ji-Yan
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.10
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    • pp.5057-5061
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    • 2012

  • Purpose: Chemotherapy-induced anemia (CIA) is one of the most important causes of anemia in cancer patients. This study was conducted to describe the prevalence and characteristics of CIA in solid cancer patients in the Chinese population, and to explore the relationship of white blood cell (WBC) or platelet decrease with CIA. Methods: Data on age, gender, tumor diagnosis, anti-cancer treatment and blood cell analyses were available from 220 untreated non-anemic cancer patients who received at least 2 cycles of chemotherapy, and the data were analyzed to assess their relationship with CIA or its severity. Results: 139 patients (63.2%) presented anemia, most being Grade 1 or 2. Esophageal and lung cancers were associated with a high prevalence. G3/4 leucopenia and decrease of platelets were identified as independent risk factors for the occurrence of CIA. Moreover, G3/4 leucopenia, decrease of platelet and G3/4 thrombocytopenia were found to be also associated with the severity of CIA. Cisplatin-containing regimens were a main potential factor in causing CIA, although significant association was only found on univariate analysis. Conclusion: Anemia or decrease in hematoglobin are common in Chinese cancer patients receiving chemotherapy. Cisplatin-containing regimens might be an important factor influencing the occurrence of CIA. Our analysis firstly described some risk factors, such as decrease of platelets or WBCs, severity of leucopenia or thrombocytopenia, associated with the occurrence and severity of CIA.

  • https://doi.org/10.7314/APJCP.2012.13.10.5057 인용 PDF KSCI

Transgene Expression of Biologically Active Human Follicle-Stimulating Hormone in Milk and Histological Analysis

  • Myoung-Ok Kim;Kil-Soo Kim;Eun-Ju Lee;Sung-Hyun Kim;Jun-Hong Park;Kyoungin-Cho;Boo-Kyung Jung;Hee-Chul Kim;Sol-ha Hwang
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.214-214
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    • 2004

  • Follicle stimulating hormone (FSH) is a pituitary glycoprotein composed of two post translationally modified subunits, which must properly assemble to be biologically active. We developed a transgenic (TG) mouse model that overexpresses the human Follicle-Stimulating hormone (FSH) -subunit under the bovine -casein promoter, displaying in females an excessive levels express in mammary gland. (omitted)

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The subcellular distribution of MnSOD alters during sodium selenite-induced apoptosis

  • Guan, Liying;Jiang, Qian;Li, Zhushi;Huang, Fang;Ren, Yun;Yang, Yang;Xu, Caimin
    • BMB Reports
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    • v.42 no.6
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    • pp.361-366
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    • 2009

  • It was reported that high doses of sodium selenite can induce apoptosis of cancer cells, but the molecular mechanisms are poorly understood. Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antioxidant enzymes. In this study, we showed that 20 ${\mu}M$ sodium selenite could alter subcellular distribution of MnSOD, namely a decrease in mitochondria and an increase in cytosol. The alteration of subcellular distribution of MnSOD is dependent on the production of superoxide induced by sodium selenite.

  • https://doi.org/10.5483/BMBRep.2009.42.6.361 인용 PDF