• Korea Journal of Hospital Management
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• v.16 no.4
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• pp.67-84
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• 2011

The open Hospital Attending Physician System has been discussed and operated for developing the efficiency and the substitutes for an increase in medical expenses, for overlapping investment in medical resources, and for normalization of medical delivery system. This study assessed the related factors to the acceptance and introduction of Attending Physicians on ophthalmologist. Data was collected mail response to 179 ophthalmologists in 2005. Applying multilevel logistic regression, we examined the relationship between their acknowledgment, attitude and acceptance of the open Hospital Attending Physicians System. The percentage of participation in Hospital Attending was indicated to be 3.9%. The 44.7% of all participants agreed to adopting the Hospital Attending, 33.5% of doctors are willing to participate in the future. The positive and normal attitude of physician toward the Hospital Attending is 6.6 times (95%CI 1.315, 33.138) and 55.2 times(95%CI 11.352, 268.347) more than that of negative after adjustment for other variables. Attitude was found to be the important factor influencing physicians' participation in the Attending Hospital. Thus, it is need to development and implication for the strategies that lead the practical necessity and positive attitude toward the Attending Hospital.

• IEIE Transactions on Smart Processing and Computing
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• v.4 no.3
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• pp.133-140
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• 2015

Neural stimulating implantable medical devices (IMDs) have been widely used to treat neurological diseases or interface with sensory feedback for amputees or patients suffering from severe paralysis. More recent IMDs, such as retinal implants or brain-computer interfaces, demand higher performance to enable sophisticated therapies, while consuming power at higher orders of magnitude to handle more functions on a larger scale at higher rates, which limits the ability to supply the IMDs with primary batteries. Inductive power transmission across the skin is a viable solution to power up an IMD, while it demands high power efficiencies at every power delivery stage for safe and effective stimulation without increasing the surrounding tissue's temperature. This paper reviews various wireless neural stimulating systems and their power management techniques to maximize IMD power efficiency. We also explore both wireless electrical and optical stimulation mechanisms and their power requirements in implantable neural interface applications.

• Journal of Biomedical Engineering Research
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• v.17 no.4
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• pp.491-498
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• 1996

The development of a compact two-wavelength Nd:YAG laser for dental and ENT applications is presented. The Nd:YAG resonator generates either 1.06$\mu$m or 1.32$\mu$m. The wavelength selection is made at the control panel. The Nd:YAG laser parameters at 1.06$\mu$m are ; the maximum pulse duration of 150$\mu$s, repetition rates of I-100Hz, and the maximum average power of 25W. At 1.32$\mu$m, the pulse duration is the same where the repetition rates and the maximum average power are I-30Hz and lOW respectively. High voltage power supply consists of a simmer module and two identical high voltage DC converters. In order to make a complete medical laser system, an optical fiber delivery unit, foot pedal and water spray handpiece are also developed. The wavelength selection is reliable since no movement of optical or mechanical components is required. The high voltage power supply is compact, easy to be maintained and applicable for other laser systems due to its modular design.

• Journal of Preventive Medicine and Public Health
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• v.54 no.1
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• pp.81-84
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• 2021

The delivery of high-quality antenatal care is a perennial global concern for improving maternal and neonatal outcomes. Antenatal care is currently provided mainly on a one-to-one basis, but growing evidence has emerged to support the effectiveness of group antenatal care. Providing care in a small group gives expectant mothers the opportunity to have discussions with their peers about certain issues and concerns that are unique to them and to form a support system that will improve the quality and utilization of antenatal care services. The aim of this article is to promote group antenatal care as a means to increase utilization of healthcare.

• The Korean Journal of Pain
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• v.12 no.1
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• pp.101-107
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• 1999

Background : In order to improve the quality of life of dying patients, they need to receive not only the physical, psychological, social, and spiritual care, but also systematic and continuous care to die with dignity. However, no adequate medical services are available for these terminal cancer patients. We studied their behavior patterns of health care utilization to understand more of their medical and social needs. Methods : We investigated 108 bereaved families through the telephone interview with structured questionnaires. They were randomly selected through the retrospective chart review of the terminal patients who passed away due to cancer. Results : Most of the terminal cancer patients received their care from proper medical services including admission to hospital (45.4%), outpatient clinic (22.2%), emergency room (16.7%), and oriental medicine (12.0%). But during the terminal phase of their illness, 32.4% of patients never received medical care including oriental medicine, and 28.7% received alterative natural care. 26 bereaved families (24.1%) pointed out the indifference of medical staff as a problem receiving proper hospital care, and 22 (20.4%) emphasized emotional strain of their helplessness with the patients' suffering as a problem of caring at home. Over 90% suggested availability of continuous care, hospice care, home care, and 24 hour telephone service to be improved. Conclusions : Due to various reasons, adequate medical care is not delivered to the terminal cancer patients in our present medical system. These problems can be approached with the establishment of proper education and medical delivery system. The role of comprehensive medical specialty cannot be overly emphasized to accomplish this most effectively.

• Proceedings of the KOSOMBE Conference
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• v.1992 no.11
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• pp.157-160
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• 1992

표면에 여러 가지 기능성기를 가지는 microspheres는 immunoassay, drug delivery system, cell separation등 의용공학분야에 응용이 기대되고 있다. 이들 분야의 응용을 위하여 유화제를 사용하지 않으면서, 기존의 회분식, 반회분식, seed 중합법등의 문제점을 극복한 two stage shot growth technique올 개발하여 여러 가지 기능성기가 표면에 도입된 microspheres를 제조하였으며, 응용의 전단계로서 이들 microspheres에 대한 모델 단백질(BSA)의 흡착실험을 pH, 기능 성기의 종류와 양, BSA농도를 변수로 행하여 최대 흡착량을 보이는 조건을 결정하였다.

• Nanomaterials
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• v.12 no.24
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• pp.4392-4416
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• 2022

Premature drug release and poor controllability is a challenge in the practical application of tumor therapy, which may lead to poor chemotherapy efficacy and severe adverse effects. In this study, a reactive oxygen species (ROS)-cleavable nanoparticle system (MXene-TK-DOX@PDA) was designed for effective chemotherapy drug delivery and antibacterial applications. Doxorubicin (DOX) was conjugated to the surface of (3-aminopropyl)triethoxysilane (APTES)-functionalized MXene via an ROS-cleavable diacetoxyl thioketal (TK) linkage. Subsequently, the surfaces of the MXene nanosheets were coated with pH-responsive polydopamine (PDA) as a gatekeeper. PDA endowed the MXene-TK-DOX@PDA nanoparticles with superior biocompatibility and stability. The MXene-TK-DOX@PDA nanoparticles had an ultrathin planar structure and a small lateral size of approximately 180 nm. The as-synthesized nanoparticles demonstrated outstanding photothermal conversion efficiency, superior photothermal stability, and a remarkable extinction coefficient (23.3 L g^-1 cm^-1 at 808 nm). DOX exhibited both efficient ROS-responsive and pH-responsive release performance from MXene-TK-DOX@PDA nanoparticles due to the cleavage of the thioketal linker. In addition, MXene-TK-DOX@PDA nanoparticles displayed high antibacterial activity against both Gram-negative Escherichia coli (E. coli) and Gram-positive Bacillus subtilis (B. subtilis) within 5 h. Taken together, we hope that MXene-TK-DOX@PDA nanoparticles will enrich the drug delivery system and significantly expand their applications in the biomedical field

• Korean Journal of Clinical Pharmacy
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• v.13 no.2
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• pp.82-90
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• 2003

Dopamine is an effective pressor for the treatment of shock and hypotension when patients do not respond to plasma volume expansion. Two dopamine intravenous delivery systems are currently available in Korea. The objective of this study was to compare dopamine premixed with prefilled system in terms of supply costs (preparation costs + personnel time), contamination rates and convenience. Time-and-motion studies were conducted to determine the time and costs associated with preparation and administration of the two systems. They were analyzed and compared by Mann-Whitney test. To evaluate the contaminaton rates of the two systems, both systems were prepared in an open environment similar to that of practical situations. Premixed and compounded solutions were then filtered by $0.22{\mu}m$ membrane filters, which were cultured at $37^{\circ}C$ for 10 days and their contents were visually checked for bacterial contamination. The convenience of the two systems was compared by itemized user assessments on preparation, dose calculation, admixture, administration and disposal of waste matters. They were analyzed by Wilcoxon's signed rank test and 100 part percentage. It was found that the preparation costs $(mean{\pm}SD)$ for premixed and prefilled systems were $271.70\pm293.55\;Won$ (Korean currency) and $1521.04\pm510.63\;Won$, respectively. The preparation time $(mean{\pm}SD)$ for premixed system was $68.10\pm35.69\;sec.$ while at for prefilled system was $154.03\pm50.06\;sec.$ (n=59 each, p<0.001). No bacterium was observed in the samples of both systems (n=20, each). User assessments indicated that the premixed system was more convenient than the prefilled system except for the item of dose calculation (n=24, p<0.001). Subjective evaluations have proven that the use of the dopamine premixed system resulted in increased efficiency of intravenous preparation by allowing personnel to devote more time to other labor-intensive duties and lower total medical costs.

• Progress in Medical Physics
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• v.23 no.2
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• pp.123-126
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• 2012

For the purpose of quality assurance (QA) of the blood irradiator, QA programs for daily, monthly, and yearly were developed. For daily tests, simple items for basically operating the machine are recommended. For monthly and yearly tests, the measurement of dose to assure the dose delivery system are performed by a dosimetry devices (Glass dosimeter jig) developed in this study. The QA program is practical for clinical environment.

• Journal of Pharmaceutical Investigation
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• v.39 no.2
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• pp.111-115
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• 2009

The pharmacokinetics of cyclosporin A (CsA) after single and multiple oral dosing of new CsA self-micro-emulsifying drug delivery system (SMEDDS) in dogs were estimated. A single dose study was performed following a two-way crossover design against six dogs with reference SMEDDS. For a multiple dose study, three dogs were allocated for each drug, and 100 mg of drug was administered daily for 6 days. Whole blood concentration of CsA was analyzed by radio-immunoassay. Both drug showed identical blood concentration profiles in both studies, and no statistical difference was detected in pharmacokinetic parameters. The relative bioavailabilities of test SMEDDS were 91.4% and 89.1%, respectively, in the single dose study and the last day of multiple dose study. Especially, multiple dose study proved the good relationship between C-0/C-2 and AUC for reference SMEDDS, which is an indispensable part of therapeutic drug monitoring. These results suggest newly formulated CsA SMEDDS possibly shows identical pharmacokinetics and pharmacodynamic behaviors in clinical trials.