Browse > Article
http://dx.doi.org/10.5573/IEIESPC.2015.4.3.133

Power-Efficient Wireless Neural Stimulating System Design for Implantable Medical Devices  

Lee, Hyung-Min (School of Electrical and Computer Engineering, Georgia Institute of Technology)
Ghovanloo, Maysam (School of Electrical and Computer Engineering, Georgia Institute of Technology)
Publication Information
IEIE Transactions on Smart Processing and Computing / v.4, no.3, 2015 , pp. 133-140 More about this Journal
Abstract
Neural stimulating implantable medical devices (IMDs) have been widely used to treat neurological diseases or interface with sensory feedback for amputees or patients suffering from severe paralysis. More recent IMDs, such as retinal implants or brain-computer interfaces, demand higher performance to enable sophisticated therapies, while consuming power at higher orders of magnitude to handle more functions on a larger scale at higher rates, which limits the ability to supply the IMDs with primary batteries. Inductive power transmission across the skin is a viable solution to power up an IMD, while it demands high power efficiencies at every power delivery stage for safe and effective stimulation without increasing the surrounding tissue's temperature. This paper reviews various wireless neural stimulating systems and their power management techniques to maximize IMD power efficiency. We also explore both wireless electrical and optical stimulation mechanisms and their power requirements in implantable neural interface applications.
Keywords
Neural stimulation; Wireless power transfer; Implantable medical devices; Optogenetics;
Citations & Related Records
연도 인용수 순위
  • Reference
1 L. D. Cruz, et al, "The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss," Br. J. Ophthalmol. Feb. 2013.
2 A. V. Nurmikko, et al, "Listening to brain microcircuits for interfacing with external worldprogress in wireless implantable microelectronic neuro-engineering devices," Proc. IEEE, vol. 98, pp. 375-388, Mar. 2010.   DOI   ScienceOn
3 A.M. Kuncel and W.M. Grill, "Selection of stimulus parameters for deep brain stimulation," Clin. Neurophysiol., vol. 115, iss. 11, pp. 2431-2441, Nov. 2004.   DOI   ScienceOn
4 D.R. Merrill, M. Bikson, and J.G.R. Jefferys, "Electrical stimulation of excitable tissue: design of efficacious and safe protocols," J. Neuroscience Methods, vol. 141, pp. 171-198, Feb. 2005.   DOI   ScienceOn
5 S.K. Moore, "Psychiatry's shocking new tools," IEEE Spectrum, vol. 43, issue 3, pp. 24-31, Mar. 2006.
6 B. S. Wilson and M. F. Dorman, "Cochlear implants: A remarkable past and a brilliant future," Hearing Res., vol. 242, no. 1-2, pp. 3-21, Aug. 2008.   DOI   ScienceOn
7 M. Ghovanloo and K. Najafi, "A wireless implantable multichannel microstimulating system-on-a-chip with modular architecture," IEEE Trans. Neural Sys. Rehab. Eng., vol. 15, no. 3, pp. 449-457, Sept. 2007.   DOI   ScienceOn
8 M. Rasouli and L. S. Phee, "Energy sources and their development for application in medical devices," Expert review of Medical Devices, vol. 7, no. 5, pp. 693-709, 2010.   DOI   ScienceOn
9 H.-M. Lee, H. Park, and M. Ghovanloo, "A powerefficient wireless system with adaptive supply control for deep brain stimulation," IEEE J. Solid-State Circuits, vol. 48, no. 9, pp. 2203-2216, Sep. 2013.   DOI   ScienceOn
10 H.C.F. Martens, E. Toader, M.M.J. Decre, D.J. Anderson, R. Vetter, D.R. Kipke, K.B. Baker, M.D. Johnson, and J.L. Vitek, "Spatial steering of deep brain stimulation volumes using a novel lead design," Clin. Neurophysiol., vol. 122, iss. 3, pp. 558-566, Mar. 2011.   DOI   ScienceOn
11 G. Lazzi, "Thermal effects of bioimplants," IEEE Eng. Med. Biol. Mag., vol. 24, no. 5, pp.75-81, Sep. 2005.
12 H.-M. Lee and M. Ghovanloo, "A high frequency active voltage doubler in standard CMOS using offset-controlled comparators for inductive power transmission," IEEE Trans. Biomed. Circuits Syst., vol. 7, no. 3, pp. 213-224, Jun. 2013.   DOI   ScienceOn
13 J. Vidal and M. Ghovanloo, "Toward a switchedcapacitor based stimulator for efficient deep-brain stimulation," in Proc. IEEE Eng. in Med. and Biol. Conf. (EMBC), pp. 2927-2930, Sept. 2010.
14 J. Simpson and M. Ghovanloo, "An experimental study of voltage, current, and charge controlled stimulation front-end circuitry," in Proc. IEEE Intl. Symp. on Cir. and Sys. (ISCAS), pp. 325-328, May 2007.
15 E. S. Boyden, F. Zhang, E. Bamberg, G. Nagel, and K. Deisseroth, "Millisecond-timescale, genetically targeted optical control of neural activity," Nat. Neurosci., vol. 8, no. 9, pp. 1263-1268, Sep. 2005.   DOI   ScienceOn
16 K. F. E. Lee, "A timing controlled AC-DC converter for biomedical implants," in IEEE Int. Solid-State Circuits Conf. (ISSCC) Dig. Tech. Papers, Feb. 2010, pp. 128-129.
17 M. Kiani, U. Jow, and M. Ghovanloo, "Design and optimization of a 3-coil inductive link for efficient wireless power transmission," IEEE Trans. Biomed. Circuits Syst., vol. 5, no. 6, pp. 579-591, Dec. 2011.   DOI   ScienceOn
18 R. Xue, K. Cheng, and M. Je, "High-efficiency wireless power transfer for biomedical implants by optimal resonant load transformation," IEEE Trans. Circuits Syst. I, vol. 60, no. 4, pp. 867-874, Apr. 2013.   DOI   ScienceOn
19 M. Kiani, B. Lee, P. Yeon, and M. Ghovanloo, "A power-management ASIC with Q-modulation capability for efficient inductive power transmission," in IEEE Int. Solid-State Circuits Conf. (ISSCC) Dig. Tech. Papers, Feb. 2015, pp. 226-227.
20 S. Arfin and R. Sarpeshkar, "An energy-efficient, adiabatic electrode stimulator with inductive energy recycling and feedback current regulation," IEEE Trans. Biomed. Circuits Syst., vol. 6, no. 1, pp. 1-14, Feb. 2012.   DOI   ScienceOn
21 E. Noorsal, K. Sooksood, H. Xu, R. Hornig, J. Becker, and M. Ortmanns, "A neural stimulator frontend with high-voltage compliance and programmable pulse shape for epiretinal implants," IEEE J. Solid-State Circuits, vol. 47, no. 1, pp. 244-256, Jan. 2012.   DOI   ScienceOn
22 H. Xu, E. Noorsal, K. Sooksood, J. Becker, and M. Ortmanns, "A multichannel neurostimulator with transcutaneous closed-loop power control and selfadaptive supply," in IEEE Eur. Solid-Stats Circuits Conf. (ESSCIRC), Sept. 2012.
23 H.-M. Lee and M. Ghovanloo, "An integrated powerefficient active rectifier with offset-controlled high speed comparators for inductively-powered applications," IEEE Trans. Circuits Syst. I, vol. 58, no. 8, pp. 1749-1760, Aug. 2011.   DOI   ScienceOn
24 M. Ghovanloo, "Switched-capacitor based implantable low-power wireless microstimulating systems," in Proc. IEEE Intl. Symp. on Cir. and Sys. (ISCAS), pp. 2197-2200, May 2006.
25 A. Wongsarnpigoon, J. P. Woock, and W. M. Grill, "Efficiency analysis of waveform shape for electrical excitation of nerve fibers," IEEE Trans. Neural Syst. Rehab. Eng., vol. 18, no. 3, pp. 319-328, June 2010.   DOI   ScienceOn
26 A. Wongsarnpigoon and W. M. Grill, "Energyefficient waveform shapes for neural stimulation revealed with a genetic algorithm," J. Neural Eng., vol. 7, no. 4, June 2010.
27 K. Sooksood, T. Stieglitz, and M. Ortmanns, "An active approach for charge balancing in functional electrical stimulation," IEEE Trans. Biomed. Circuits Syst., vol. 4, no. 3, pp. 162-170, Jun. 2010.   DOI   ScienceOn
28 S. Kelly and J. Wyatt, "A power-efficient neural tissue stimulator with energy recovery," IEEE Trans. Biomed. Circuits Syst., vol. 5, no. 1, pp. 20-29, Feb. 2011.   DOI   ScienceOn
29 H.-M. Lee, K. Y. Kwon, W. Li, and M. Ghovanloo, "A power-efficient switched-capacitor stimulating system for electrical/optical deep brain stimulation," IEEE J. Solid-State Circuits, vol. 50, no. 1, pp. 360-374, Jan. 2015.   DOI   ScienceOn
30 K. Chen, Z. Yang, L. Hoang, J. Weiland, M. Humayun, and W. Liu, "An integrated 256-channel epiretinal prosthesis," IEEE J. Solid-State Circuits, vol. 45, no. 9, pp. 1946-1956, Sep. 2010.   DOI   ScienceOn
31 F. Zhang, A. Aravanis, A. Adamantidis, L. de Lecea, and K. Deisseroth, "Circuit-breakers: optical technologies for probing neural signals and systems," Nat. Rev. Neurosci, vol. 8, no. 8, pp. 577-581, Aug. 2007.   DOI   ScienceOn
32 H.-M. Lee, K.-Y. Kwon, W. Li, and M. Ghovanloo, "A wireless implantable switched-capacitor based optogenetic stimulating system," IEEE Eng. Med. Biol. Conf. (EMBC), pp. 878-881, Aug. 2014.
33 V. Gilja, C. A. Chestek, I. Diester, J. M. Henderson, K. Deisseroth, and K. V. Shenoy, "Challenges and opportunities for next-generation intracortically based neural prostheses," IEEE Trans. Biomed. Eng, vol. 58, no. 7, pp. 1891-1899, Jul. 2011.   DOI   ScienceOn
34 K. Kwon, H.-M. Lee, M. Ghovanloo, A. Weber, and W. Li, "A wireless slanted optrode array with integrated micro LEDs for optogenetics," in Prof. IEEE Int. Conf. Micro Electro Mech. Systems (MEMS), Jan. 2014.
35 C. T. Wentz, J. G. Bernstein, P. Monahan, A. Guerra, A. Rodriguez, and E. S. Boyden, "A wirelessly powered and controlled device for optical neural control of freely-behaving animals," J. Neural Eng., vol. 8, no. 4, Jun. 2011.