• The Journal of Korean Medical History
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• v.36 no.1
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• pp.23-30
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• 2023

Objective : The role of female medical personnel in traditional East Asian societies was limited. It might be said that there are no known female medical practitioners in the history of East Asian medicine. However, in the case of Joseon, there was a system for female medical personnel, Euinyeo(醫女). After the late 19th century, women's social activities in Joseon were expanded by Christian missionaries who entered Joseon In somehow, and efforts to train female medical personnel were also growing. The authors are trying to get the actual operation aspect of Gyeongseong Women's Medical College, established in 1938 after ten years of effort from establishing the Gyeongseong Women's medical school in 1928. Methods : Through the 『Gyeongseong Women's Medical College Catalog(京城女子醫學專門學校一覽)』 in 1941, owned by the Handok Museum, the authors researched the operation aspects of Gyeongseong Women's Medical College from the application for establishment in 1937 and the opening of the school in 1938 to 1941 when the College Catalog was published. Results & Conclusion : In the early 20th century, when various medical institutions were appearing in Joseon, it could be said that the role of Gyeongseong Women's Medical College is noteworthy with the fact that a specialized medical college for women has been established and operated to train female medical personnel separately.

• Korean Journal of Radiology
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• v.25 no.4
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• pp.384-394
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• 2024

Objective: To evaluate the image quality of novel dark-blood computed tomography angiography (CTA) imaging combined with deep learning reconstruction (DLR) compared to delayed-phase CTA images with hybrid iterative reconstruction (HIR), to visualize the cervical artery wall in patients with Takayasu arteritis (TAK). Materials and Methods: This prospective study continuously recruited 53 patients with TAK (mean age: 33.8 ± 10.2 years; 49 females) between January and July 2022 who underwent head-neck CTA scans. The arterial- and delayed-phase images were reconstructed using HIR and DLR. Subtracted images of the arterial-phase from the delayed-phase were then added to the original delayed-phase using a denoising filter to generate the final-dark-blood images. Qualitative image quality scores and quantitative parameters were obtained and compared among the three groups of images: Delayed-HIR, Dark-blood-HIR, and Dark-blood-DLR. Results: Compared to Delayed-HIR, Dark-blood-HIR images demonstrated higher qualitative scores in terms of vascular wall visualization and diagnostic confidence index (all P < 0.001). These qualitative scores further improved after applying DLR (Dark-blood-DLR compared to Dark-blood-HIR, all P < 0.001). Dark-blood DLR also showed higher scores for overall image noise than Dark-blood-HIR (P < 0.001). In the quantitative analysis, the contrast-to-noise ratio (CNR) values between the vessel wall and lumen for the bilateral common carotid arteries and brachiocephalic trunk were significantly higher on Dark-blood-HIR images than on Delayed-HIR images (all P < 0.05). The CNR values were significantly higher for Dark-blood-DLR than for Dark-blood-HIR in all cervical arteries (all P < 0.001). Conclusion: Compared with Delayed-HIR CTA, the dark-blood method combined with DLR improved CTA image quality and enhanced visualization of the cervical artery wall in patients with TAK.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2009.04a
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• pp.238-238
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• 2009

• Proceedings of the Korean Nuclear Society Conference
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• 2004.10a
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• pp.1131-1132
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• 2004

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2008.10a
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• pp.189-189
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• 2008

• Proceedings of the Ginseng society Conference
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• 1993.09a
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• pp.69-73
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• 1993

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2004.11a
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• pp.43-43
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• 2004

• BMB Reports
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• v.42 no.6
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• pp.361-366
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• 2009

It was reported that high doses of sodium selenite can induce apoptosis of cancer cells, but the molecular mechanisms are poorly understood. Manganese superoxide dismutase (MnSOD) converts superoxide radical to hydrogen peroxide within the mitochondrial matrix and is one of the most important antioxidant enzymes. In this study, we showed that 20 ${\mu}M$ sodium selenite could alter subcellular distribution of MnSOD, namely a decrease in mitochondria and an increase in cytosol. The alteration of subcellular distribution of MnSOD is dependent on the production of superoxide induced by sodium selenite.

• BMB Reports
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• v.45 no.11
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• pp.641-646
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• 2012

It has been reported that ubiquitin-conjugating enzyme 9 (Ubc9), the unique enzyme2 in the sumoylation pathway, is up-regulated in many cancers. However, the expression and regulation of UBC9 in glioma remains unknown. In this study, we found that Ubc9 was up-regulated in glioma tissues and cell lines compared to a normal control. UBC9 knockdown by small interfering RNA (siRNA) affected cell proliferation and apoptosis in T98G cells. Further experiments revealed that microRNA (miR)-214 directly targeted the 3' untranslated region (UTR) of UBC9 and that there was an inverse relationship between the expression levels of miR-214 and UBC9 protein in glioma tissues and cells. miR-214 overexpression suppressed the endogenous UBC9 protein and affected T98G cell proliferation. These findings suggest that miR-214 reduction facilitates UBC9 expression and is involved in the regulation of glioma cell proliferation.

• 대한예방의학회:학술대회논문집
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• 1999.10a
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• pp.183-184
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• 1999