• Proceedings of the KOSOMBE Conference
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• v.1993 no.05
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• pp.21-24
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• 1993

The experimental results of visual stimulation with the tailored RF pulse are reported. Tailored RF pulse is used for the susceptibility effect imaging. Around 25% signal change of visual cortex area is detected during photic stimulation. Interestingly, with the tailored RF pulse, the signal intensity of visual cortex is deceased during photic stimulation. It is, however, increased with normal $T_2$ weighted imaging. The comparison between normal $T_2$ weighted imaging and the tailored RF pulse imaging are performed with 4T NMR system and the results with human volunteer are also presented.

• Journal of Biomedical Engineering Research
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• v.9 no.1
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• pp.87-92
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• 1988

In this paper, a new focusing method, to be called the pipelined sampled delay focusing (PSDF), is implemented. This method improves the lateral resolution in ultrasound imaging system. In PSDF, the analog belay lines are no longer necessary because sampling sum process can replace the conventional delay sum process. Also, the method offers continuous dynamic focusing on the resolution pixel basis, and eliminates the constraint that the maximum delay time is less than the sampling interval. Second order sampling is adopted in order to extend the sampling interval.

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.102-107
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• 2007

In molecular imaging studies via magnetic resonance imaging, in vivo cell tracking is an important issue for the observation of cell therapy or disease behavior. High resolution imaging and longitudinal study are necessary to track the cell movement. Since the field inhomogeneity extends over several voxels, we have performed the numerical analysis using the sub-voxel method dividing a voxel of MR image into several elements and the information about the field inhomogeneity distribution around the micro-beads. We imbedded ferrite-composite micro-beads with the size of $20-150{\mu}m$ in the subject substituted for cells to induce local field distortion. In the phantom imaging with the isotropic voxel size of $200{\mu}m^3$, we could confirm the feasibility of sub-voxel tracking in a 3.0 T MRI.

• Nuclear Medicine and Molecular Imaging
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• v.41 no.2
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• pp.118-131
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• 2007

Neurotransmitter imaging with radiopharmaceuticals plays major role for understanding of neurological and psychiatric disorders such as Parkinson's disease and depression. Radiopharmaceuticals for neurotransmitter imaging can be divided to dopamine transporter imaging radiopharmaceuticals and serotonin trnasporter imaging radiopharmaceuticals. Many kinds of new dopamine transporter imaging radiopharmcaeuticals has a tropane ring and they showed different biological properties according to the substituted functional group on tropane ring. After the first clinical trials with $[^{123}I]{\beta}-CIT$, alkyl chain substituent introduced to tropane ring amine to decrease time for imaging acquisition and to increase selectivity. From these results, $[^{123}I]PE2I$, [18F]FE-CNT, $[^{123}I]FP-CIT$ and $[^{18}F]FP-CIT$ were developed and they showed high uptake on the dopamine transporter rich regions and fast peak uptake equilibrium time within 4 hours after injection. $[^{11}C]McN$ 5652 was developed for serotonin trnasporter imaging but this compound showed slow kinetics and high background radioactivity. To overcome these problems, new diarylsulfide backbone derivatives such as ADAM, ODAM, AFM, and DASB were developed. In these candidates, $[^{11}C]AFM$ and $[^{11}C]DASB$ showed high binding affinity to serotonin transporter and fast in vivo kinetics. This paper gives an overview of current status on dopamine and serotonin transporter imaging radiopharmaceuitcals and the development of new lead compounds as potential radiopharmaceuticals by medicinal chemistry.

• Proceedings of the KOSOMBE Conference
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• v.1990 no.11
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• pp.38-41
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• 1990

A new spline function for resampling discrete signal adaptively is proposed. In general, B-spline function is used for an image interpolation because of its smoothness and continuity, but accompanies a large amount of blurring effect. Hence, we developed a new spline function to remedy this effect, with two procedures ; deblurring of Gaussian blurring and diminishing of aliasing effect caused by deblurring procedure. The proposed function has a parametric expression with $\alpha$ which is related to the variance of Gaussian blurring model. Locally adaptive resampling scheme is obtained by changing a according to statistical characteristics of an image. The proposed, interpolation function shows edge-sharpening effect as well as noise smoothing, with comparison to the conventional schemes.

• Journal of Biomedical Engineering Research
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• v.5 no.1
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• pp.85-92
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• 1984

A new architecture of the Digital Scan Converter (DSC) for the linear-scan ultrasound medical imaging systems is proposed and its hardware implementation is reported. While the conventional DSC merely displays the acquisited data and does nor allow access to the frame memory, it is possible, in the new system, to access to the frame memory for further imaging processing so as to obtain useful information for medical diagnosis. Image processing can be performed either by a special pupose processor, or by VAX 11/780. The system is made to operate asyncronously to increase the frame rate with tags assigned to the data. The proposed DSC was designed to be used without much modification for the sector scan system as well.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.287-290
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• 1997

• Journal of Biomedical Engineering Research
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• v.44 no.4
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• pp.255-263
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• 2023

Clinical ultrasound (US) is a widely used imaging modality with various clinical applications. However, capturing a large field of view often requires specialized transducers which have limitations for specific clinical scenarios. Panoramic imaging offers an alternative approach by sequentially aligning image sections acquired from freehand sweeps using a standard transducer. To reconstruct a 3D volume from these 2D sections, an external device can be employed to track the transducer's motion accurately. However, the presence of optical or electrical interferences in a clinical setting often leads to incorrect measurements from such sensors. In this paper, we propose a deep learning (DL) framework that enables the prediction of scan trajectories using only US data, eliminating the need for an external tracking device. Our approach incorporates diverse data types, including correlation volume, optical flow, B-mode images, and rawer data (IQ data). We develop a DL network capable of effectively handling these data types and introduce an attention technique to emphasize crucial local areas for precise trajectory prediction. Through extensive experimentation, we demonstrate the superiority of our proposed method over other DL-based approaches in terms of long trajectory prediction performance. Our findings highlight the potential of employing DL techniques for trajectory estimation in clinical ultrasound, offering a promising alternative for panoramic imaging.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.05
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• pp.230-232
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• 1995

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.303-304
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• 1998

We investigated the effects of scintillation crystal surface treatment on gamma camera imaging. The NaI(Tl) and CsI(Tl) (20 mm (dia.) $\times10mm$ (thick) plate) scintillators were chosen for this study. Two different surface treatments, white and black reflectors, were applied to NaI(Tl) and CsI(Tl). The optical properties of generated scintillation light were evaluated using Monte Carlo simulation and postion sensitive photo multiplier tube (PSPMT). We measured sensitivity, energy resolution and spatial resolution of a gamma camera system with the scintillators coupled to a PSPMT. Based on the results, we concluded that the careful consideration of surface treatments of the scintillator was necessary in order to develop the gamma camera having good sensitivity and spatial resolution.