• Journal of Biomedical Engineering Research
• /
• v.31 no.3
• /
• pp.177-186
• /
• 2010

In 3D ultrasound color Doppler imaging (CDI), 8-16 pulse transmissions (ensembles) per each scanline are used for effective clutter rejection and flow estimation, but it yields a low volume acquisition rate. In this paper, we have evaluated three flow estimation methods: autoregression (AR), eigendecomposition (ED), and autocorrelation combined with adaptive clutter rejection (AC-ACR) for a small ensemble size (E=4). The performance of AR, ED and AC-ACR methods was compared using 2D and 3D in vivo data acquired under different clutter conditions (common carotid artery, kidney and liver). To evaluate the effectiveness of three methods, receiver operating characteristic (ROC) curves were generated. For 2D kidney in vivo data, the AC-ACR method outperforms the AR and ED methods in terms of the area under the ROC curve (AUC) (0.852 vs. 0.793 and 0.813, respectively). Similarly, the AC-ACR method shows higher AUC values for 2D liver in vivo data compared to the AR and ED methods (0.855 vs. 0.807 and 0.823, respectively). For the common carotid artery data, the AR provides higher AUC values, but it suffers from biased estimates. For 3D in vivo data acquired from a kidney transplant patient, the AC-ACR with E=4 provides an AUC value of 0.799. These in vivo experiment results indicate that the AC-ACR method can provide more robust flow estimates compared to the AR and ED methods with a small ensemble size.

• Journal of Biomedical Engineering Research
• /
• v.8 no.2
• /
• pp.117-117
• /
• 1987

The medical image processing system is intended for a diverse set of users in the medical Imaging Parts. This system consists of a 640 Kbyte IBM-PC/AT with 30 Mbyte hard disk, special purpose image processor with video input devices and display monitor. Image may be recorded and processed in real time at sampling rate up to 10 MHz. This system provides a wide range of image enhancement processing facilities via a menu-driven software packages. These facilities include point by point processing, image averaging, convolution filter and subtraction.

• Journal of Biomedical Engineering Research
• /
• v.15 no.4
• /
• pp.377-382
• /
• 1994

In the conventional Fourier imaging method in MRI (Magnetic Resonance Imaging), intramotion such as pulsatile flow makes zipper-like artifact along the phase encoding direction. On the other hand, line-integral projection reconstruction (LPR) method has advantages such as imaging of short T2, object and reduction of the flow artifact by elimination of the flow-induced phase fluctuation. The LPR, however, necessarily requires time consuming filtering and back-projection processes, so that the reconstruction takes long time. To overcome the long reconstruction time of the LPR and to obtain the flow artifact reduction effect, we adopted phase corrected concentric square raster sampling (CSRS) method and improved its imaging performance. The CSRS is a fast reconstruction method which has the same properties with the LPR. In this paper, we proposed a new method of flow artifact reduction using the CSRS method. Through computer simulations and experiments, we verified that the proposed method can eliminate phase fluctuations, thereby reducing the flow artifact and re- markably shorten the reconstruction time which required long time in the LPR.

• Journal of Biomedical Engineering Research
• /
• v.17 no.3
• /
• pp.305-312
• /
• 1996

A new three dimensional fractal coding is proposed with a perceptually enhanced matching. Since most of medical images (e.g. computed tomoyaphy or magnetic resonance images) have three dimensional characters, searching regions are extended to adjacent slices. For a perceptually enhanced matching, a high frequency boost filter is used for pre-filtering images to be encoded, and a least mean square error matching is applied to the edge enhanced Images rather than the original images. From simulation with magnetic resonance images($255\times255$, 8bits/pixel), reconstructed images by the proposed compression algorithm show much improved subjective image quality with higher peak signnal-to-noise ratio compared to those by existing fractal coding algorithms at compression ratios of about 10.

• Proceedings of the KOSOMBE Conference
• /
• v.1985 no.06
• /
• pp.26-28
• /
• 1985

• Journal of Biomedical Engineering Research
• /
• v.12 no.1
• /
• pp.43-48
• /
• 1991

As the computerized methods and equipments In nuclear medicine imaging increases, quantitative information is needed on the single photon emission computed tomographic Images as well as on the conventional nuclear medicine images. In this paper, the authors investigated the effect of several clinician - friendly reconstrution filters on the resultant transverse slices of backprojected Profiles of radioisotope distribution from the Quantitative point of view, and reduced the filter parameters such as cutoff frequency and order of filter which are neces mary to minimize the quantification error using computer-generated phantoms.

• Journal of Biomedical Engineering Research
• /
• v.3 no.1
• /
• pp.51-54
• /
• 1982

As the computerized methods and equipments in nuclear medicine imaging increases, quantitative information is needed on the single photon emission computed tomographic images as well as on the conventional nuclear medicine images. In this paper, the authors investigated the effect of several clinician - friendly reconstrution filters on the resultant transverse slices of backprojected profiles of radioisotope distribution from the quantitative point of view, and reduced the filter Parameters such as cutoff frequency and order of filter which are necessary to minimize the quantification error using computer -generated phantoms.

• 대한핵의학회:학술대회논문집
• /
• 1995.05a
• /
• pp.219-219
• /
• 1995

• Journal of Biomedical Engineering Research
• /
• v.10 no.2
• /
• pp.157-164
• /
• 1989

Three-dimensional imaging and manipulation of CT data are becoming increasingly important for deterRing the complex structure and pathologies. Octree which is a hierarchical data model is used to reconstruct three- dimensional objects from CT scans. Orthogonal cross sections are displayed by traverse the octree partially. Arbitrary oblique planes are derived by intersecting the square region of plane and cubic volume of octal node. Thia method enables the display of multi-structured complex organ ann the realization by personal computer.

• Bulletin of the Korean Chemical Society
• /
• v.31 no.5
• /
• pp.1177-1181
• /
• 2010

The synthesis and characterization of gold nanoparticles coated by Gd-chelate (GdL@Au) is described, where L is a conjugate of DTPA (DTPA = diethylenetriamine-N,N,N',N",N"-pentaacetic acid) and 4-aminothiophenol. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of GdL@Au is 12 nm with a loading of GdL reaching up to $1.4{\times}10^3$ per particles, and they demonstrate very high r1 relaxivity (${\sim}10^4mM^{-1}s^{-1}$) and the r1 relaxivity per [Gd] is as high as $10mM^{-1}s{-1}$. Here, we also describe the use of bimodality of this contrast agent (CA) as a highly efficient CT contrast agent based on gold nanoparticles (GNPs) that overcome the limitations of iodine based contrast agent. The MTT assay performed on this CAs reveals the cytotoxicity as low as that for Omniscan$^{(R)}$ in the concentration range required to obtain intensity enhancement in the in vivo MRI study.