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http://dx.doi.org/10.5012/bkcs.2010.31.5.1177

Gold Nanoparticles Coated with Gd-Chelate as a Potential CT/MRI Bimodal Contrast Agent  

Sk Md., Nasiruzzaman (Department of Applied Chemistry, Kyungpook National University)
Kim, Hee-Kyung (Department of Medical & Biological Engineering, Kyungpook National University)
Park, Ji-Ae (Laboratory of Nuclear Medicine Research Molecular Imaging Center, Korea Institute of Radiological Medical Science)
Chang, Yong-Min (Department of Medical & Biological Engineering, Kyungpook National University)
Kim, Tae-Jeong (Department of Applied Chemistry, Kyungpook National University)
Publication Information
Bulletin of the Korean Chemical Society / v.31, no.5, 2010 , pp. 1177-1181 More about this Journal
Abstract
The synthesis and characterization of gold nanoparticles coated by Gd-chelate (GdL@Au) is described, where L is a conjugate of DTPA (DTPA = diethylenetriamine-N,N,N',N",N"-pentaacetic acid) and 4-aminothiophenol. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of GdL@Au is 12 nm with a loading of GdL reaching up to $1.4{\times}10^3$ per particles, and they demonstrate very high r1 relaxivity (${\sim}10^4mM^{-1}s^{-1}$) and the r1 relaxivity per [Gd] is as high as $10mM^{-1}s{-1}$. Here, we also describe the use of bimodality of this contrast agent (CA) as a highly efficient CT contrast agent based on gold nanoparticles (GNPs) that overcome the limitations of iodine based contrast agent. The MTT assay performed on this CAs reveals the cytotoxicity as low as that for Omniscan$^{(R)}$ in the concentration range required to obtain intensity enhancement in the in vivo MRI study.
Keywords
MRI; MRI CA; Bimodality; Gd-DTPA; MRI-CT;
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