• Journal of Biomedical Engineering Research
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• v.21 no.2
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• pp.109-118
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• 2000

본 논문에서는 일반적인 초음파 의료 영상 시스템에서 제공되는 단면 영상의 화질을 현저히 향상시킬 수 있는 영향 개선 기법들을 제안하였다. 제안된 기법들은 현재 대부분의 초음파 영상 시스템에 적용되는 접속기법과는 달리 한 프레임에 해당하는 RF 수신 신호들을 저장하고 합성구경 기법에 기반해서 수신신호들을 처리함으로써, 초음파 영상의 화질을 결정하는 주요 성능 변수인 해상도, 신호 대 잡음비, 주사속도 등을 개선시킬 수 있다. 제안된 기법들을 검증하기 위하여 RF 수신신호들을 저장할 수 있는 실험 장치를 제작한 후 실제 실험을 통하여 성능 평가를 수행하였다. 실험 결과 기존 시스템에 비해서 매우 우수한 영상을 얻을 수 있었으며, 시편 및 인체 데이터 경우에 모두 동일한 효과가 나타남을 확인 할 수 있었다.

• Journal of Biomedical Engineering Research
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• v.18 no.1
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• pp.9-16
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• 1997

We develop an automatic imaging matching technique for combining portal image and simulator image for improvements in localization of treatment in radiation therapy. Fusion of images from two imaging modalities is treated as follows. We archive images thxough a frame-yabber. The simulator and portal images are edge detected and enhanced with interpolated adaptive histouam equalization and combined using geometrical parameters relating the coordinates of two image data sets which are calculated using Fourier descriptors. We don't use any kind of imaging markers for patient's convenience. clinical use of this image matching technique for treatment planning will result in improvements in localization of treatment volumes and critical structures. These improvements will allow greater sparing of normal tissues and more precise delivery of energy to the desired irradiation volume.

• Journal of Biomedical Engineering Research
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• v.31 no.5
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• pp.335-343
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• 2010

This article presents a review of technologies for an endoscope. The classification according to the clinical applications and the imaging modalities are summarized. The major parts are focused on describing the gastrointestinal endoscope's structures and mechanisms. The details of the image enhanced endoscopic techniques, such as NBI (narrow band imaging), OCT (optical coherence tomography), and EUS (endoscopic ultrasound), are also explained. Finally, the trend of NOTES (natural orifice transluminal endoscopic surgery) which is new fusion technology in the field of endoscopic diagnosis and surgery is introduced.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.127-130
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• 1997

Phase-contrast(PC) methods have been used for quantitative measurements of velocity and volume flow rate. In addition, phase contrast cine magnetic resonance imaging (MRI) combines the flow dependent contrast of PC MRI with the ability of cardiac cine imaging to produce images throughout the cardiac cycle. In this method, the through-plane velocity has been encoded generally. However, the accuracy of the flow data can be reduced by the effect of flow direction, finite slice thickness, resolution, pulsatile flow pattern, and so on. In this study we calculated the error caused by misalignment of tomographic plane and flow directon. To reduce this error and encode the velocity for more complex flow, we suggested 3 directional velocity encoding method.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.4 no.2
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• pp.65-72
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• 2018

Prostate specific membrane antigen (PSMA) is a cell surface membrane protein, which is overexpressed in most prostate cancer. Recently, PET imaging with $[^{68}Ga]$PSMA-HBED-CC has been widely used for the diagnosis of recurrent prostate cancer and the studies on the diagnostic potential of $^{64}Cu$-labeled PSMA ligands reported actively. In this study, we monitored with biological evaluation in vivo and PET imaging of $^{64}Cu$-labeled PSMA ligand ($[^{64}Cu]$PSMA-617). The radiolabelling efficiency and stability of $[^{64}Cu]$PSMA-617 were confirmed by radio-thin layer chromatography. The radiolabeling efficiency of $[^{64}Cu]$PSMA-617 showed over 95%, and stabilities of intact remained over 98% in both human and mouse serum for 48 h. In normal male mice, in vivo uptake of $[^{64}Cu]$PSMA-617 in several organs was measured at 2, 4, 6, 24, 48 h after injection. Rapid blood clearance was observed for $[^{64}Cu]$PSMA-617. The high uptake was observed in the lung, liver, intestines and kidneys at 2 h postinjection, but was low in the other organs (1-2 %ID/g) at 4 h. The dynamic PET/CT images of 22RV1 tumor-bearing nude mice were acquired during 60 min and additionally acquired 24 h and 48 h after injection. In dynamic PET images, $[^{64}Cu]$PSMA-617 uptake ratio in tumors versus muscle was increased as time elaplsed until 60 minutes and remained in tumors at 48 h. In these results, the PET/CT imaging using $[^{64}Cu]$PSMA-617 in prostate cancer is expected to be useful for the diagnosis and treatment of prostate cancer patients.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.550-554
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• 1997

Acoustic or sound noise due to gradient pulsing has been one of the problems in MRI, both in patient scanning as well as in many areas of psychiatric and neuroscience research, such as unctional MRI (fMRI). Our recent observations in MRI or the visual and motor cortex show very different results with sound noise in comparison with the results obtained without sound noise. Although a number of ideas has been suggested in the literature about the possible elimination or reduction of sound noise, progress has been slow due to the basic role of gradient pulsing in MR imaging. Therefore, we report on some typical behavior of sound noise observed from MRI scanners and the analyses of their characteristics. Data are obtained both from a commercial MRI scanner (GE Signa 1.5-T EPI system).

• Investigative Magnetic Resonance Imaging
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• v.21 no.4
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• pp.223-232
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• 2017

Purpose: To report the use of multiband accelerated echo-planar imaging (EPI) for resting-state functional MRI (rs-fMRI) to achieve rapid high temporal resolution at 3T compared to conventional EPI. Materials and Methods: rs-fMRI data were acquired from 20 healthy right-handed volunteers by using three methods: conventional single-band gradient-echo EPI acquisition (Data 1), multiband gradient-echo EPI acquisition with 240 volumes (Data 2) and 480 volumes (Data 3). Temporal signal-to-noise ratio (tSNR) maps were obtained by dividing the mean of the time course of each voxel by its temporal standard deviation. The resting-state sensorimotor network (SMN) and default mode network (DMN) were estimated using independent component analysis (ICA) and a seed-based method. One-way analysis of variance (ANOVA) was performed between the tSNR map, SMN, and DMN from the three data sets for between-group analysis. P < 0.05 with a family-wise error (FWE) correction for multiple comparisons was considered statistically significant. Results: One-way ANOVA and post-hoc two-sample t-tests showed that the tSNR was higher in Data 1 than Data 2 and 3 in white matter structures such as the striatum and medial and superior longitudinal fasciculus. One-way ANOVA revealed no differences in SMN or DMN across the three data sets. Conclusion: Within the adapted metrics estimated under specific imaging conditions employed in this study, multiband accelerated EPI, which substantially reduced scan times, provides the same quality image of functional connectivity as rs-fMRI by using conventional EPI at 3T. Under employed imaging conditions, this technique shows strong potential for clinical acceptance and translation of rs-fMRI protocols with potential advantages in spatial and/or temporal resolution. However, further study is warranted to evaluate whether the current findings can be generalized in diverse settings.

• Proceedings of the KOSOMBE Conference
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• v.1990 no.11
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• pp.15-18
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• 1990

In abdominal NMR imaging the respiratory ordering techniques have been successfully used to remove the ghosting artifacts arising from the respiratory motion. In the existing respiratory ordering schemes, however, it is generally accepted that blurring of the moving parts still remains as in the signal averaging technique. A new optimal respiratory ordering scheme which can correct the blurring as well as the ghosting artifacts is theoretically derived through the analysis of the phase encoding directional motion effects in Fourier imaging. The performance of the optimal respiratory ordering scheme is experimentally confirmed together with a suboptimal ordering scheme which is suggested as a compromise for the practicality.

• Journal of Biomedical Engineering Research
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• v.24 no.3
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• pp.141-149
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• 2003

This paper proposes a method of measuring and imaging the stiffness of human soft tissue to diagnose cancers or tumors which have been difficult to detect in ultrasound B-mode imaging systems. To measure the soft tissue stiffness, sinusoidal vibrations are applied to it, and the magnitude of its mechanical vibration is determined by estimating the temporal variation of speckle pattern brightness in ultrasound B-mode images. It is verified by simulation and experiment that the proposed method can estimate the relative tissue stiffness from B-mode images with a relatively small amount of computation.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.157-160
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• 1996

In this paper, reconstruction algorithms of spiral scan imaging which has been used for ultra fast magnetic resonance imaging have been reviewed, and some simulation results using two different algorithms are reported. Since the trajectory of the spiral scan in k-space is the spiral, reconstruction of the spiral scan is not as straight forward as that used in Fourier imaging technique where the sampling points are usually on the rectangular grids. Originally the reconstruction of the spiral scan imaging was based on the convolution backprojection algorithm modified with a shift term, however, some other reconstruction techniques have also been tried by remapping sampling points from spiral trajectory to Cartesian grids. Some experimental aspects of MR spiral scan imaging will also be addressed.