• 산업공학
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• 제21권4호
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• pp.394-402
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• 2008

The objective of this paper is to design segmentation algorithm for applying the breast ultrasound image to CAD(Computer Aided Diagnosis). This study is conducted after understanding limits, used algorithm and demands of CAD system by interviewing with a medical doctor and analyzing related works based on a general CAD framework that is consisted of five step-establishment of plan, analysis of needs, design, implementation and test & maintenance. Detection function of CAD is accomplished by Canny algorithm and arithmetic operations for segmentation. In addition to, long computing time is solved by extracting ROI (Region Of Interests) and applying segmentation technical methods based morphology algorithm. Overall course of study is conducted by verification of medical doctor. And validity and verification are satisfied by medical doctor's confirmation. Moreover, manual segmentation of related works, restrictions on the number of tumor and dependency of image resolution etc. was solved. This study is utilized as a support system aided doctors' subjective diagnosis even though a lot of future studies is needed for entire application of CAD system.

• Clinics in Shoulder and Elbow
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• 제24권2호
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• pp.93-97
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• 2021

Background: Injection therapy around the distal biceps tendon insertion is challenging. This therapy may be indicated in patients with a partial distal biceps tendon tear, bicipitoradial bursitis and tendinopathy. The primary goal of this study was to determine the accuracy of manually performed injections without ultrasound guidance around the biceps tendon. Methods: Seven upper limb specialists, two general orthopedic specialists, and three orthopedic surgical residents manually injected a cadaver elbow with acrylic dye using an anterior and a lateral infiltration approach. After infiltration the cadaveric elbows were dissected to determine the location of the acrylic dye. Results: In total, 79% of the injections were localized near the biceps tendon. Of these injections, 20% were localized on the radius near the bicipitoradial bursa. In total, 53% of the performed infiltrations were injected by anterior and 47% by lateral approaches. Of the injections near the distal biceps (79%), 47% were injected by an anterior and 53% by a lateral approach. Of the injections on the radius (20%), 33% were injected by anterior and 67% by lateral approach. Of the inaccurate injections (21%), 75% were injected anterior and 25% lateral. Conclusions: Manual infiltration without ultrasound guidance for distal biceps pathology lacks accuracy. We therefore recommend ultrasound guidance for more accurate infiltration.

• Clinical Endoscopy
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• 제56권2호
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• pp.169-179
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• 2023

Background/Aims: This meta-analysis analyzed the effect of an indwelling biliary stent on endoscopic ultrasound (EUS)-guided tissue acquisition from pancreatic lesions. Methods: A literature search was performed to identify studies published between 2000 and July 2022 comparing the diagnostic outcomes of EUS-tissue acquisition (TA) in patients with or without biliary stents. For non-strict criteria, samples reported as malignant or suspicious for malignancy were included, whereas for strict criteria, only samples reported as malignant were included in the analysis. Results: Nine studies were included in this analysis. The odds of an accurate diagnosis were significantly lower in patients with indwelling stents using both non-strict (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.52-0.90) and strict criteria (OR, 0.58; 95% CI, 0.46-0.74). The pooled sensitivity with and without stents were similar (87% vs. 91%) using non-strict criteria. However, patients with stents had a lower pooled sensitivity (79% vs. 88%) when using strict criteria. The sample inadequacy rate was comparable between groups (OR, 1.12; 95% CI, 0.76-1.65). The diagnostic accuracy and sample inadequacy were comparable between plastic and metal biliary stents. Conclusions: The presence of a biliary stent may negatively affect the diagnostic outcome of EUS-TA for pancreatic lesions.

• International Journal of Stem Cells
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• 제16권4호
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• pp.406-414
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• 2023

Dedifferentiated fat cells (DFATs) isolated from mature adipocytes have a multilineage differentiation capacity similar to mesenchymal stem cells and are considered as promising source of cells for tissue engineering. Bone morphogenetic protein 9 (BMP9) and low-intensity pulsed ultrasound (LIPUS) have been reported to stimulate bone formation both in vitro and in vivo. However, the combined effect of BMP9 and LIPUS on osteoblastic differentiation of DFATs has not been studied. After preparing DFATs from mature adipose tissue from rats, DFATs were treated with different doses of BMP9 and/or LIPUS. The effects on osteoblastic differentiation were assessed by changes in alkaline phosphatase (ALP) activity, mineralization/calcium deposition, and expression of bone related genes; Runx2, osterix, osteopontin. No significant differences for ALP activity, mineralization deposition, as well as expression for bone related genes were observed by LIPUS treatment alone while treatment with BMP9 induced osteoblastic differentiation of DFATs in a dose dependent manner. Further, co-treatment with BMP9 and LIPUS significantly increased osteoblastic differentiation of DFATs compared to those treated with BMP9 alone. In addition, upregulation for BMP9-receptor genes was observed by LIPUS treatment. Indomethacin, an inhibitor of prostaglandin synthesis, significantly inhibited the synergistic effect of BMP9 and LIPUS co-stimulation on osteoblastic differentiation of DFATs. LIPUS promotes BMP9 induced osteoblastic differentiation of DFATs in vitro and prostaglandins may be involved in this mechanism.

• 대한의용생체공학회:의공학회지
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• 제34권4호
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• pp.177-181
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• 2013

It is known that ultrasound affects action potentials in neurons, but the underlying principles of ultrasonic neural stimulation are not clearly elucidated yet. In this study, we measured the action potentials of rat hippocampal neurons cultured on multi-electrode arrays during ultrasound stimulation. From most of electrodes, it was observed that the ultrasound stimulation increased the frequencies of action potentials (i.e., spikes) during ultrasound stimulation.

• 한국산학기술학회논문지
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• 제14권12호
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• pp.6066-6071
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• 2013

본 논문에서는 의료용 초음파를 이용하는 로봇 시스템을 위한 3차원 캘리브레이션 방법을 제안한다. 고정된 기준점을 구성하기 위한 캘리브레이션 블록을 제작한 후 옵티컬 트래커(optical tracker)를 이용하여 초음파 프루브(probe)의 위치와 기준점의 위치를 측정한다. 초음파 영상의 픽셀 좌표와 센서로 측정된 위치를 비교하여 6개의 파라미터로 이루어진 초음파 프루브와 영상 내의 픽셀 좌표와의 관계 행렬을 구하고 2개의 파라미터로 이루어진 스케일링 행렬을 계산한다. 정밀한 캘리브레이션을 위해 캘리브레이션 블록 내부 모양과 매질 선택에 대한 적절성을 실험을 통해 검증한다. 제안된 방법은 간단한 형태의 캘리브레이션 블록과 옵티컬 트래커를 사용하여 설치에 많은 시간이 필요하지 않는 장점이 있기 때문에 초음파 영상을 이용하는 로봇 작업에 널리 적용이 가능하다.

• 한국정보통신학회논문지
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• 제14권4호
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• pp.959-966
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• 2010

정량적 초음파 분석(Quantitative Ultrasound Analysis)은 반향된 초음파 신호의 짧은 시간 간격의 주파수 성분을 추출하여 개별 초음파 지수의 값을 예측한다. 따라서 반향 신호의 정확한 주파수 특성 추출은 분석의 정확도와 정밀도 향상에 기본이 된다. 본 논문에서는 초음파 지수의 정량적인 예측 및 분석에 이용할 수 있는, 짧은 시간 간격의 반향 신호의 주파수 특성 추출 방법을 제안한다. 제안된 알고리듬은 인접한 반향 초음파 신호간의 위상 차이를 보상하고, 동일 반향 깊이를 가지는 작은 영역의 신호를 가중치 평균함으로써 보다 정확한 주파수 특성을 추출한다. 컴퓨터 모의 실험을 통한 수치 분석 결과, 제안된 알고리듬은 일반적인 주파수 추출 알고리듬보다 정확한 예측 결과를 보였으며, 예측 결과의 정밀도도 10% 이상 향상되었다.

• 적정기술학회지
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• 제6권1호
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• pp.45-50
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• 2020

우리는 전세계 최초로 무선 초음파 진단기를 개발하였다. 임산부의 원활한 출산을 위해 WHO에서는 4번의 사전 진찰을 받도록 하고 있으며, 이를 위해 초음파 진단기의 사용이 필수적이다. 하지만, 개발도상국의 소득수준과 의료시설은 이에 미치지 못하고 있다. 우리는 자체개발한 무선 초음파 진단기를 이용해 KOICA의 CTS 프로그램을 베트남에서 진행하였다. 우리는 베트남 흥화현 내 보건소 및 병원에 휴대용 무선 초음파 진단기인 Sonon300C를 보급하였고, 사업성과를 더욱 높이기 위한 노력으로 진단 교육과 실습을 병행하고 아웃리치(Outreach) 프로그램을 실시하였다. 그 결과, 해당 지역의 초음파 진단기 보급률은 100%를 달성하였고, 교육 수료인원 비율은 59%까지 끌어올리는 성과를 얻었다.

• Korean Journal of Radiology
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• 제19권6호
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• pp.1196-1197
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• 2018

• Korean Journal of Radiology
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• 제23권4호
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• pp.492-493
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• 2022