• 한국지구과학회지
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• 제27권4호
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• pp.486-502
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• 2006

지구과학은 다양한 생명체가 살고 있는 지구를 연구하는 학문으로, 주로 우리 후손들을 위한 건강하고 풍요롭고 쾌적한 환경 조성에 관심을 가진다. UNESCO와 국제지질과학연맹(IUGS)은 과학자들, 의료 전문가들, 그리고 일반 대중에게 의학지질학의 중요성을 널리 알리고자 1996년 의학지질학 연구회를 설립한 이후, 5년간의 국제 지질대비 연구과제(IGCP 454 Medical Geology, 2000-2004)의 성공적인 수행에 이어 2006년에는 국제 의학지질학 연합(IMGA)의 활동에 힘쓰고 있다. 의학지질학과 IMGA는 그동안 수많은 국제회의, 세미나, 워크샵, 심포지움 및 각종 출판물들을 통해서 자연계의 지질학적 요소들과 사람 및 동물들이 고통 받는 질병 간의 관계를 알리는 데 큰 성과를 거두었다. UNESCO에 의하여 추진되고 있는 의학지질학과 IMGA에서 보여주는 바와 같이, 지구과학은 의학 및 치의학과 매우 밀접하게 관련되어 있으므로 생물, 화학, 물리 뿐 아니라 지구과학도 반드시 의 치의학 전문대학원 입시 과목으로 채택되어야 한다. 여기에서는 UNESCO IGCP 454 의학지질학 사업과 IMGA의 활동을 소개함으로써 앞으로 지구과학이 의 치의학 전문대학원 입시 과목으로 선정되어 우리나라 과학 교육의 균형 발전에 이바지하기를 기대한다.

• 자원환경지질
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• 제32권6호
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• pp.599-609
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• 1999

Talc durg has been used at Oriental Medical Hospital of Kyung San University, and was analysed for mineralogical and geochemical studies. It consists mainly of talc with small amount of tremolite, dolomite and bursite, and its chemical compositions of MgO 31.65% and $SiO_2$ 61.0%, and cotain less inpurtities. Moreover, talc from the Dong Yang Talc mine is associated with calcite, gypsum and anhydrite, which belong to more soluble mineral drugs than talc, and contains Ca and Fe. These elements may give at least medical medical to talc durg as in the case of actinolite. Therfore, talc of high quality from the Dong Yang Tacl Mine may be used instead of imported expensive talc durg. Diagrams of log $a_{Mg^{2+}}$-pH and log $a_{Mg^{2+}}/a{\array{2\\H^+} $-log $a_{H_4SiO_4}$- may be used as basic data to predict and examine soluble contents of durg for medical experiments.

• 자원환경지질
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• 제40권5호
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• pp.705-711
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• 2007

우리가 생활하면서 부딪히는 수많은 판단들 속에서 특히 인간의 권리에 대한 사안은 민감하게 다루어진다. 특히 사실로 입증된 것만 인정하는 증거재환주의에 의해 물리적 증거의 확보 여부는 범죄수사과정에서 필수적임에 따라 과학수사의 중요성 및 수요는 증가하고 있다. 과학수사지질학은 지질학과 과학수사와의 융합 분야로, 과학수사를 위하여 지질학적 지식 및 기법을 바탕으로 물리적 증거를 비교 분석하여 범죄용의자와 범죄사건의 연관성을 파악함으로써 법정에서 유용한 자료로 활용된다. 1970년대 후반 과학수사지질학의 학문적 체계를 구축한 이래로 과학수사지질학의 연구대상은 암석, 광물, 토양, 퇴적물 등의 토양학적 증거에서 역사적 유물, 지뢰, 사체 등의 사회 문화적, 정치적, 군사적, 의학적 대상으로 확대되고 있다. 과학수사지질학의 역할이 단순 위치추적에서 고고학적 학설 증명, 역사적 사실 입증, 환경오염 원인 규명, 연대기적 식생 분포 및 인류학적 발생 규명 등으로 폭넓게 작용할 수 있음을 의미하고, 이는 발전된 지질학적 방법론을 적용할 수 있으며 다양한 과학수사지질학적 수요를 만족시킬 수 있다. 과학수사지질학의 연구 활동은 과학수사 전문기관을 중심으로 이루어지고 있으나, 우리나라 국립과학수사연구소의 과학수사 활동 분포에서 과학수사지질학적 비중은 극히 일부분으로 나타나고 있다. 따라서 전문 지질자원 연구기관을 중심으로 우리나라 지질학적 특성에 기반을 둔 연구방법 확보, 연구결과 활용사례 발굴 등 과학수사지질학의 역할 정립을 위한 체계적인 논의를 이끌어 낼 필요가 있다고 사료된다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제18권6호
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• pp.56-68
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• 2013

Community drinking water (CDW), mostly naturally flowing groundwater, plays important roles in supplying drinking water for urban and rural residents in Korea. Over 1,600 CDW facilities are distributed throughout the country, many of them situated in the outskirts of metropolitan cities. A large proportion of Korean people have become dependent on CDW for drinking due to a distrust of piped water's quality and a strong belief in the special medicinal effects of some CDWs. However, administrative and official management and the control of CDW facilities have been inadequate when compared with the strict examination and control of commercial bottled water, which is physically treated groundwater from deep bedrock aquifers. In this study, even though signs of anthropogenic contamination were not generally found, the tested chemical compositions of selected CDWs featured high enrichment of some constituents including Ca, Mg, Na, and HCO3 with natural origins such as water-rock interactions. Careless consumption of particular CDWs, which has no scientific basis, will not guarantee health improvement. Consequently, more intensive management of CDW facilities and a long-term interdisciplinary examination of the health effects of CDWs are needed to effectively protect people's health.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.51-55
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• 2016

Phytochemical investigation of Pistacia integerrima has highlighted isolation of two known compounds naringenin (1) and dihydrokaempferol (2). A crude extract and these isolated compounds were here evaluated for their effects on reversion of multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). The multidrug resistance P-glycoprotein is a target for chemotherapeutic drugs from cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma cells showed excellent MDR reversing effects in a dose dependent manner. In-silico molecular docking investigations demonstrated a common binding site for Rhodamine123, and compounds naringenin and dihydrokaempferol. Our results showed that the relative docking energies estimated by docking softwares were in satisfactory correlation with the experimental activities. Preliminary interaction profile of P-gp docked complexes were also analysed in order to understand the nature of binding modes of these compounds. Our computational investigation suggested that the compounds interactions with the hydrophobic pocket of P-gp are mainly related to the inhibitory activity. Moreover this study s a platform for the discovery of novel natural compounds from herbal origin, as inhibitor molecules against the P-glycoprotein for the treatment of cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2311-2314
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• 2016

Pistagremic acid (PA) is a bioactive triterpenoid isolated from various parts of Pistacia integerrima plants. The aim of this research was to investigate PA for reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine-123 exclusion study on a multidrug resistant human ABCB1 (ATP-binding cassette, sub-family B, member 1) gene-transfected mouse T-lymphoma cell line in vitro. Results were similar to those with verapamil as a positive control. Docking studies of PA and standard Rhodamine123 were carried out against a P-gp crystal structure which showed satisfactory results. Actually, PA cannot bind exactly where co-crystallized ligand of P-gp is already present. However, the docking study predicted that if a compound gives a lesser score then it may have some potency. The docking scores of PA and Rhodamine were similar. Therefore, we can conclude that there are certain important chemical features of PA which are responsible for the inhibiting potency of P-gp.

• 지질공학
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• 제24권3호
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• pp.431-440
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• 2014

1993년 지하수법 제정 이후 정책은 지하수 보전관리를 우선하고 보조수원으로 제한적으로 활용하는데 초점을 두어왔으나, 최근 인구 증가, 물 수요 증가, 균등 분배 및 기후 변화 등으로 지하수댐, 강변여과 등의 개발 정책을 중요시 하게 되었다. 인구의 증가, 물 환경의 변화 및 위해성 증가 등은 물 산업이 급격히 증가하는 요인으로 작용하여 왔으며 물 산업의 투자 규모는 지속 증가할 것으로 전망되고 있다. 그 동안 국내 지하수 시장은 일반 개인 관정 개발과 먹는샘물이 주도해 왔으나, 최근에는 지질학 기원의 차별화된 지하수 특성을 활용한 신규 사업 영역(건강, 의학 등)으로 확대되고 있다. 향후 지하수 분야가 물 산업 클러스터 내의 핵심으로 자리 잡고 정보통신기술 및 의학 등과 연계한 연구 및 기술 개발을 적극 추진하여 공공 지하수 개발, 지하수 활용의 다변화 등이 적극 추진되어야 할 것이다.

• Geomechanics and Engineering
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• 제22권2호
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• pp.143-152
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• 2020

In this research, soil samples of the Kerman sedimentary basin, Iran, were investigated through laboratory tests such as petrography (Scanning Electron Microscopy (SEM), X-Ray Fluorescence Spectroscopy (XRF) and X-Ray Diffraction (XRD)), physical and mechanical characteristics tests. The soil in this area is dominantly CL. The petrography results showed that the dominant clay mineral is Illite. This soil has made some problems in the earth dams due to the low shear strength. In this study, a set of samples were prepared by adding different amounts of lime. Next, the petrography and strength tests at the optimum moisture content were performed. The results of SEM analysis showed substantial changes in the soil structure after the addition of lime. The primary structure was porous and granular that was changed to a uniform and solid after the lime was added. According to XRD results, dominant mineral in none stabilized soil and stabilized soil are Illite and calcite, respectively. The pozzolanic reaction resulted in the reduction of clay minerals in the stabilized samples and calcite was known as the soil hardener material that led to an increase in soil strength. An increase in the hydrated lime leads to a decrease in their maximum dry unit weight and an increase in their optimum moisture content. Furthermore, increasing the hydrated lime content enhanced the Unconfined Compressive Strength (UCS) and soil's optimum moisture. An increase in the strength is significantly affected by the curing time and hydrated lime contents, as the maximum compressive strength is achieved at 7% hydrated lime. Moreover, the maximum increase in the California Bearing Ratio (CBR) achieved in clay soils mixed with 8% hydrated lime.

• Nuclear Engineering and Technology
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• 제56권6호
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• pp.2421-2427
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• 2024

In this research, the Omicron variant of the SARS-CoV-2 virus was simulated and exposed to electron radiation with up to 20 keV energy. Absorbed energy was measured for spike protein, nucleocapsid protein, and envelope of the virus. Simulations were performed by Geant4-DNA in a water environment at temperature of 20 ℃ and pressure of 1 atm. Since the viral RNA is kept inside the nucleocapsid protein, damage to this area could destroy the viral RNA strand and create an inactive virus. Our findings showed that electron beams with an energy of 2.5 keV could cause a maximum absorption dose and consequently maximum damage to the nucleocapsid and effectively be used for inactivation virus.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2083-2087
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• 2016

A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) of the soil borne fungi. The multidrug resistant P-glycoprotein is a target for chemotherapeutic drugs in cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma which showed excellent MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. Moreover, molecular docking studies of compound-1 also showed better results as compared with the standard. Therefore the preliminary results obtained from this study suggest that screlotiumol 1 could be used as a potential agent for the treatment of cancer.