• Annals of Pediatric Endocrinology and Metabolism
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• 제23권4호
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• pp.196-203
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• 2018

Purpose: The hemoglobin glycation index (HGI) represents the degree of nonenzymatic glycation and has been positively associated with cardiometabolic risk factors (CMRFs) and cardiovascular disease in adults. This study aimed to investigate the association between HGI, components of metabolic syndrome (MS), and alanine aminotransferase (ALT) in a pediatric nondiabetic population. Methods: Data from 3,885 subjects aged 10-18 years from the Korea National Health and Nutrition Examination Survey (2011-2016) were included. HGI was defined as subtraction of predicted glycated hemoglobin ($HbA1_c$) from measured $HbA1_c$. Participants were divided into 3 groups according to HGI tertile. Components of MS (abdominal obesity, fasting glucose, triglycerides, high-density lipoprotein cholesterol, and blood pressure), and proportion of MS, CMRF clustering (${\geq}2$ of MS components), and elevated ALT were compared among the groups. Results: Body mass index (BMI) z-score, obesity, total cholesterol, ALT, abdominal obesity, elevated triglycerides, and CMRF clustering showed increasing HGI trends from lower-to-higher tertiles. Multiple logistic regression analysis showed the upper HGI tertile was associated with elevated triglycerides (odds ratio, 1.65; 95% confidence interval, 1.18-2.30). Multiple linear regression analysis showed HGI level was significantly associated with BMI z-score, $HbA1_c$, triglycerides, and ALT. When stratified by sex, age group, and BMI category, overweight/obese subjects showed linear HGI trends for presence of CMRF clustering and ALT elevation. Conclusion: HGI was associated with CMRFs in a Korean pediatric population. High HGI might be an independent risk factor for CMRF clustering and ALT elevation in overweight/obese youth. Further studies are required to establish the clinical relevance of HGI for cardiometabolic health in youth.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.398-406
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• 2018

Objective: Hospitalization of patients with delirium after visiting the emergency department (ED) is often required. However, the readmission risk after discharge from the ED should also be considered. This study aimed to explore whether (i) immediate hospitalization influences the readmission risk of patients with delirium; (ii) the readmission risk is affected by various risk factors; and (iii) the healthcare cost differs between groups within 28 days of the first ED visit. Methods: Using the National Health Insurance Research Database, the data of 2,780 subjects presenting with delirium at an ED visit from 2000 to 2008 were examined. The readmission risks of the groups of patients (i.e., patients who were and were not admitted within 24 hours of an ED visit) within 28 days were compared, and the effects of the severities of different comorbidities (using Charlson's comorbidity index, CCI), age, gender, diagnosis and differences in medical healthcare cost were analyzed. Results: Patients without immediate hospitalization had a higher risk of readmission within 3, 7, 14, or 28 days of discharge from the ED, especially subjects with more severe comorbidities ($CCI{\geq}3$) or older patients (${\geq}65years$). Subjects with more severe comorbidities or older subjects who were not admitted immediately also incurred a greater healthcare cost for re-hospitalization within the 28-day follow-up period. Conclusion: Patients with delirium with a higher CCI or of a greater age should be carefully considered for immediate hospitalization from ED for further examination in order to reduce the risk of re-hospitalization and cost of healthcare.

• 핵의학기술
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• 제22권2호
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• pp.105-111
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• 2018

Purpose Quality control of instrument takes up a large part in the Radioimmunoassays. The gamma-ray instrument, which is one of the important instruments in the laboratory, observes the condition and performance of instrument and performs quality control of the instrument by measuring the Normalization, Calibration, Background and etc. However, there are some automation instruments which can't measure the counting efficiency of gamma-ray meters, resulting in insufficient management in terms of performance evaluation of gamma-ray meters. Therefore, the purpose of this paper is to manage the quality control continuously and regularly by suggesting how to measure the counting efficiency of gamma-ray instruments. Materials and Methods In case of a comparative measurement method to a gamma-ray instrument dedicated to nuclear medical examination, the CPM and counting efficiency can be obtained after the measurement of normalization by inserting the I-125 $200{\mu}L$(CPM 50,000~500,000) into the test tube. With this CPM and counting efficiency values, it's possible to calculate the measurement of the DPM value and count the CPM from the automation instrument from the same source, and enter the DPM to calculate the counting efficiency using a comparative measurement method. Another method is to calculate the counting efficiency by estimating the half life using the radiation source information of the tracer in B test reagents of company A. Results According to the calculation formula using the DPM obtained by counting the normalization of gamma-ray meters, the detection efficiency was 75.16% for Detector 1, 76.88% for Detector 2, 77.13% for Detector 3, 75.36% for Detector 4 and 73.2% for Detector 5 respectively. Using another calculation formula estimated from the shelf life, the data of the detection efficiency from Detector 1 to Detector 5 were 74.9%, 75.1%, 76.5%, 74.9% and 73.2% respectively. Conclusion Although the accuracy of counting efficiencies of both methods are insufficient, this is considered to be useful for ongoing management of quality control if counting efficiency is managed after setting the acceptable ranges. For example, if the measurement efficiency is set to 70% or higher, the allowed %difference between measurements is within 3% and the %difference with the detector wall is set within 5%.

• 한국산학기술학회논문지
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• 제22권1호
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• pp.445-453
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• 2021

본 연구는 암환자의 삶의 질에 영향을 미치는 요인을 인구사회학적 특성, 심신건강, 구강건강 측면에서 분석하고 암환자의 삶의 질 증진을 위한 기초자료를 제공하고자 시행되었다. 자료 수집은 국민건강영양조사 제7기 3차 년도 조사대상 중 암환자로 진단받은 235명을 최종대상자로 선정하였고 PASW Statistics ver 18.0 프로그램으로 복합표본 분석을 하였다. 연구결과 암환자 중 스트레스는 74.5%, 우울증은 84.3%, 활동제한은 15.3%가 경험하고 있었고 씹는 문제는 29.0%, 발음 문제는 13.6%가 경험하고 있었다. 구강건강에서 씹기 문제는 소득이 낮고(3.35±.21), 활동제한이 있는 경우(2.71±.31), 우울증이 있는 경우(3.01±.27) 높게 경험하고 있었다(p<0.05). 삶의 질에 영향을 미치는 요인은 소득이 낮은 경우 3.43배, 활동제한이 있는 경우 8.39배, 스트레스가 있는 경우 2.74배, 우울증이 있는 경우 4.58배, 씹기 문제가 있는 경우 2.68배, 말하기 문제가 있는 경우 4.92배 유의하게 높게 나타났다(p<0.05). 본 연구결과를 통해 암환자의 삶의 질 증진을 위해서는 심신 건강관리뿐만 아니라 구강 관리가 요구되었고, 암 치료 과정 중 합병증으로 발생하는 심신 및 구강 불건강 예방을 위해 암 치료과정에서 의료진의 통합적인 관리방안이 요구되었다.

• Animal Bioscience
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• 제34권1호
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• pp.93-101
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• 2021

Objective: Temperature could influence protein and amino acid deposition as well as gut microbiota profile and composition. However, the specific effects of ambient temperature on amino acids deposition and gut microbiota composition remain insufficiently understood. Methods: A total of 300 one-day-old Avian broilers were randomly divided into three groups and reared at high, medium, and low temperature (HT, MT, and LT), respectively. Breast muscle and fecal samples were collected for amino acid composition analysis and 16S rRNA gene sequence analysis. Results: Our data showed that compared to the MT group, there was a decrease of muscle leucine and tyrosine (p<0.05), as well as an increase of methionine in the HT group (p<0.05) and a decrease of serine in the LT group. Examination of microbiota shift revealed that at genus level, the relative abundance of Turicibacter and Parabacteroides was increased in the HT group (p<0.05) and that the relative abundances of Pandoraea, Achromobacter, Prevotella, Brevundimonas, and Stenotrophomonas in the LT group were higher than those in the MT group (p<0.05). In addition, there were substantial correlations between microbes and amino acids. In the HT group. Turicibacter was negatively correlated with aspartic acid and tyrosine, whereas Parabacteroides was positively correlated with methionine (p<0.05). In the LT group, there were multiple positive correlations between Achromobacter and arginine, isoleucine or tyrosine; between Prevotella and cysteine or phenylalanine; between Brevundimonas and cysteine; and between Stenotrophomonas and cysteine as well as a negative correlation between Stenotrophomonas and serine. Conclusion: Our findings demonstrated that amino acid content of breast muscle and intestinal microbiota profile was affected by different ambient temperatures. Under heat exposure, augmented abundance of Parabacteroides was correlated with elevated methionine. Low temperature treatment may affect muscle tyrosine content through the regulation of Achromobacter.

• 대한골절학회지
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• 제30권4호
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• pp.186-191
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• 2017

목적: 이번 연구의 목적은 고령 인구의 골반 부전 골절에 대한 방사선적, 역학적 특징과 임상 경과를 알아보는 것이다. 대상 및 방법: 2010년 3월부터 2017년 5월까지 골반 부전 골절 환자를 대상으로 후향적 조사를 시행하였다. 환자의 인구학적 정보, 골밀도, 골표지자를 조사하였다. 단순 방사선 촬영과 컴퓨터 단층촬영을 비교하였다. 임상 경과 평가를 위해 이환된 합병증과 골절 6개월 이후 보행 능력을 비교하였다. 결과: 연구 대상 총 42명의 평균 나이는 76.5세였고, 1명을 제외하고는 모두 여성이었다. 초진 병원이 타 병원인 5예 중 골절 진단을 받지 못한 경우가 3예였다. 단순 방사선 사진에서 발견된 골절 외 컴퓨터 단층촬영에서 추가로 골절이 발견된 경우가 81.0%였다. 모두에서 보존적 치료를 시행하였다. 골절 후 보행 시작까지 걸린 시기는 평균 2.8주였으며 42명 중 1예를 제외한 전체 예(97.6%)에서 수상 전 보행 상태로 회복이 가능하였다. 결론: 골반 부전 골절을 진단하는 경우 단순 방사선 사진으로는 제한점이 있는 것을 확인하였다. 골반 부전 골절은 보존적 치료로 좋은 결과를 얻을 수 있었으며, 치명적인 합병증이 비교적 적게 발생하였다.

• 융합정보논문지
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• 제11권7호
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• pp.278-287
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• 2021

본 연구는 직업군별 좌식시간과 고위험음주가 고요산혈증의 유병률과 위험도에 차이가 있는지 성별 분석을 중심으로 수행되었다. 이를 위해 국민건강영양조사 자료를 활용하였으며, 연구대상으로 16,366명을 선정하였다. 분석방법으로 카이제곱 독립성 검정과 로지스틱 회귀분석을 사용하였다. 남성은 여성보다 좌식시간과 고위험음주에 따른 고요산혈증 유병률이 각각 22.2%와 25.2%로 상대적으로 높았으며 위험도는 1.274와 1.310으로 유의하였다. 고요산혈증에 대한 좌식시간의 유병률과 위험도는 남성에서만 '농림어업종사자' 직업군에서 유의하였다. 반면, 고위험음주의 유병률과 위험도는 남녀 모두 '관리자, 전문가 및 관련종사자', '사무종사자'에서 유의한 차이를 보였으며, 여성에서만 '서비스 및 판매종사자', '기능원, 장치 및 기계조립 종사자', '무직'에서 유의한 차이를 보였다. 이러한 결과는 남성에서 고요산혈증의 유병률과 위험도가 높다는 것을 알릴뿐만 아니라 직업군별로 이를 예방할 수 있는 보건의료정책과 의료서비스가 필요함을 시사한다.

• 한국엔터테인먼트산업학회논문지
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• 제14권7호
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• pp.633-640
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• 2020

본 연구는 국민건강영양조사 제5기(2010-2012) 원시자료를 이용하여 한국 농어업종사자의 무릎 OA 유병률을 파악하고 관련요인을 알아보기 위해 시행하였다. 국민건강영양조사 5기(2010-2012) 원시자료 중 50세 이상 농어업에 종사하는 50세 이상 성인 1,264명(2010년 440명, 2011년 448명, 2012년 376명)을 연구대상자로 선정하였다. 연구대상자 중 X-ray 판독 결과 Kellgren Lawrence grade가 2 이상이고 최근 3개월 동안 30일 이상 무릎관절통이 있었다고 응답한 215명과 X-ray 판독 결과 Kellgren Lawrence grade가 1 이하이고 최근 3개월 동안 30일 이상 무릎관절통이 없었다고 응답한 601명, 총 816명을 최종 연구대상자로 선정하였고 무릎 OA 유병률과 인구사회학적 또는 건강관련 요인별 유병교차비를 분석하였다. 연구결과 무릎 OA 유병률은 26.3%였고, 인구사회학적 측면에서 여성, 연령이 증가할수록, 교육수준이 낮을 수록, 월소득이 적을수록 무릎 OA 유병률은 증가하였다. 건강관련 요인에서는 비흡연군, BMI가 높을수록 무릎 OA 유병률이 증가하였다.

• 대한지역사회영양학회지
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• 제28권3호
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• pp.235-244
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• 2023

Objectives: Based on the results from the Korean Total Diet Study (KTDS), the sodium (Na) and potassium (K) intake of Koreans were estimated and compared with intake estimates from the Food & Nutrient Database (FNDB), as in the Korea National Health and Nutrition Examination Survey (KNHANES) to verify the validity of these estimates. Methods: One hundred and thirty-four representative foods (RFs) covering 92.5% of the total food intake of Koreans were selected, and 228 pairs of corresponding 'RF x representative cooking method' were derived by reflecting the methods used mainly in terms of frequency and quantity in their cooking. RF samples were collected from three cities with a larger population size in three regions (nine cities) nationwide, and six composite samples were made for each RF, considering its regional and/or seasonal characteristics. One thousand three hundred and sixty-eight 'RF x representative cooking method' pair samples were prepared, and the Na and K contents were assessed using inductively coupled plasma atomic emission spectrometry (ICP-MS). The Na and K intake of the Korean population was estimated by linking the content with the food intake data from the 7th KNHANES. Results: The mean Na and K intake of Koreans were 2,807.4 mg and 2,335.0 mg per person per day, respectively. A comparison with the Na and K intake from KNHANES, including only RFs of KTDS, showed comparable results with less than 5% variation. While the contribution and ranking of food items to Na intake were similar between KNHANES and KTDS, there were differences in K intake. This was attributed to the large discrepancies in the K content of rice and coffee between KTDS results and the values in the 9th Revision of the National Food Composition Table used in KNHANES. Conclusions: The Na and K intake of Koreans estimated based on the KTDS, which performed nutrient analysis on samples prepared to a 'table-ready' state using foods of the representative collection, was similar and comparable with that of KNHANES. This supports the validity and usefulness of FNDB-based nutrient intake estimation at the population level. The list of nutrients studied in KTDS is expected to be expanded, allowing for intake estimation of nutrients with currently insufficient or absent information in the FNDBs in use.

• 대한이식학회지
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• 제28권3호
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• pp.144-153
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• 2014

Background: Normal renal function and health have been recognized as important factors in living donors after kidney donation. The purpose of this study was to evaluate the health status and health-promoting lifestyle in living donors after kidney donation. Methods: A total of 678 living-kidney donors were counted in our center from January 1990 to December 2011. Only 84 donors agreed to participate in the survey by telephone. We received consent for participation in our survey from 48 donors (57.1%). Data were collected from May to August 2013 using donor characteristics, health status, and Health Promoting Lifestyle Profile I (HPLP-I). Results: The donors were predominantly female (62.5%) and the average age was 48.9±11.8 years, and the average period after nephrectomy was 9.7±5.7 years. The characteristics of donors included ideal body weight (37.5%), overweight (37.5%) in body mass index, and good health status (81.3%). Most donors underwent an annual medical check-up (56.2%), no health problem (81.3%), and no disease (64.6%). However, one patient was treated with dialysis for renal failure due to diabetes. The total average score for HPLP-I was 128.3±13.9. Higher than average scores (116.3±19.1) were observed for the general middle-aged woman. There were statistically significant differences in self-realization and nutrition in subsection of HPLP-I. Self-realization showed a higher score for Christian (F=2.743, P=0.041) and good health (F=3.389, P=0.017). Nutrition showed a higher score for overweight, obesity (F=6.783, P=0.000), and older than 60 (F=3.854, P=0.009). Conclusions: Most living kidney donors were healthy after their donation and had relatively high scores for health-promoting lifestyle. However, one patient had a serious health problem. In addition, younger, longer period after donation, and the rare health examination of donors showed a lower health-promoting lifestyle. Designed and continuous health-care management after transplantation is needed for kidney donors.